BGC0002745 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002745 (Penicillium polonicum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	30,951	verrucosidin	PKS	100%

BGC0002745 - Region 1 - T1PKS

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Location: 1 - 30,951 nt. (total: 30,951 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 30,952
Label		BGC0002745

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002745	1.00	Polyketide	verrucosidin	Penicillium polonicum
BGC0001254	0.35	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.32	Polyketide	FR901512	fungal sp. No.14919
BGC0002139	0.26	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001998	0.24	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0000064	0.24	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001268	0.24	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0002538	0.23	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0002429	0.23	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002505	0.23	Polyketide, NRP	xenoacremone A	Xenoacremonium sp. BF-2018a

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002745	1.00	Polyketide	verrucosidin	Penicillium polonicum
BGC0001254	0.68	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0002192	0.65	Polyketide	FR901512	fungal sp. No.14919
BGC0002139	0.60	Polyketide	burnettiene A, preburnettiene B, preburnettiene A	Aspergillus burnettii FRR 5400
BGC0001998	0.58	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4
BGC0000064	0.57	NRP, Polyketide	fusarin	Fusarium verticillioides
BGC0001268	0.57	NRP, Polyketide	fusarin C	Fusarium fujikuroi
BGC0002538	0.56	Polyketide	chaetolivacine A, chaetolivacine B, chaetolivacine C	Chaetomium olivaceum
BGC0002429	0.56	Terpene, Polyketide	higginsianin B	Colletotrichum higginsianum IMI 349063
BGC0002505	0.56	Polyketide, NRP	xenoacremone A	Xenoacremonium sp. BF-2018a

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 30951:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

PENPOL_c002G03804

PKS_AT (553..869): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Ethylmalonyl-CoA: 62.5%; Methylmalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 77.0
Methoxymalonyl-CoA: 70.2
Ethylmalonyl-CoA: 53.8
Propionyl-CoA: 43.5
Malonyl-CoA: 41.6
2-Methylbutyryl-CoA: 36.4
Isobutyryl-CoA: 30.7
trans-1,2-CPDA: 28.6
fatty_acid: 27.7
Benzoyl-CoA: 19.4
3-Methylbutyryl-CoA: 15.3
Acetyl-CoA: 9.8
inactive: 9.6
CHC-CoA: 6.6