LOCUS       BGC0002749             18262 bp    DNA     linear   CON 30-DEC-2017
DEFINITION  Aspergillus candidus strain CBS 102.13 unplaced genomic scaffold
            BDW47scaffold_57, whole genome shotgun sequence.
ACCESSION   BGC0002749
VERSION     BGC0002749
KEYWORDS    .
SOURCE      Aspergillus candidus
  ORGANISM  Aspergillus candidus
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus.
COMMENT     URL -- http://genome.jgi.doe.gov/Aspcand1
            JGI Project ID: 1051943
            The DNA was provided by Scott Baker (scott.baker@pnnl.gov)
            The strain is available from CBS-KNAW culture collection
            Contacts: Scott E. Baker (scott.baker@pnnl.gov)
            Assembly and annotation done by JGI.
            The JGI and collaborators endorse the principles for the
            distribution and use of large scale sequencing data adopted by the
            larger genome sequencing community and urge users of this data to
            follow them. It is our intention to publish the work of this
            project in a timely fashion and we welcome collaborative
            interaction on the project and analysis.
            (http://www.genome.gov/page.cfm?pageID=10506376).
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 18:19:40
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 18262
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     protocluster    1..18262
                     /aStool="rule-based-clusters"
                     /category="NRPS"
                     /contig_edge="True"
                     /core_location="[6609:14106]"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6610..14106
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="0"
                     /detection_rule="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /neighbourhood="20000"
                     /product="NRPS-like"
                     /protocluster_number="1"
     protocluster    1..18262
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[6609:14106]"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      6610..14106
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="2"
     cand_cluster    1..18262
                     /SMILES="NC([*])C(=O)CC(O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /detection_rules="cds((PP-binding or NAD_binding_4) and
                     (AMP-binding or A-OX))"
                     /kind="chemical_hybrid"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /protoclusters="2"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..18262
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002749"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..18262
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /product="NRPS-like"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /rules="cds((PP-binding or NAD_binding_4) and (AMP-binding
                     or A-OX))"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(<1723..>3476)
                     /locus_tag="BDW47DRAFT_120076"
     mRNA            complement(join(<1723..2892,2954..3168,3359..>3476))
                     /locus_tag="BDW47DRAFT_120076"
                     /product="kynurenine 3-monooxygenase"
     CDS             complement(join(1723..2892,2954..3168,3359..3476))
                     /codon_start=1
                     /db_xref="InterPro:IPR002938"
                     /db_xref="JGIDB:Aspcand1_120076"
                     /gene_functions="other (smcogs) SMCOG1087:hypothetical
                     protein (Score: 147.8; E-value: 8.7e-45)"
                     /gene_kind="other"
                     /locus_tag="BDW47DRAFT_120076"
                     /product="kynurenine 3-monooxygenase"
                     /protein_id="PLB34718.1"
                     /transl_table=11
                     /translation="MAPSSNHKVVIVGAGPVGSLAALYAAARGDEVEVYELRGDLRDPS
                     TIPLNFTKSINLALSERGINAMKHTRRDNMIQKILGEAIPVYGRMIHGRNDEKLWEASQ
                     AYDVHGRHINAADRCHLNNALLDELEQTPNVKLFFNHKLTGADFRAKKAWFEQRTPADN
                     TSRAPEVEITFDYLVGADGAHSISRYHMMKYARVDYQQQYIDALWCEFHIPPTEEGEFR
                     ISPNHLHIWPGKEFMFIALPSADKSFTCTLFASTSYYTLLESSPESLLESFDKNFPGVC
                     PDLITPADLQTQFETNPHLPLISIKCSPYHFGSSAVIVGDAAHAVVPFYGQGLNAGLED
                     IRVLFECLDQHGVYDLNASPESRALSRQAALQAYTDQRTKDAHAINDLSKDNYIEMRWG
                     VQLPLYKLRKSLEETLDRYMPSLGWQTQYVRVSFSTQPYSEVIKAVERQGTLLLYGSIS
                     AIISSAAIVGVLAWNYPMRVSLLSMLQSPIQQLWSVWRNYHC"
     gene            <4196..>5774
                     /locus_tag="BDW47DRAFT_120077"
     mRNA            join(<4196..4800,4856..>5774)
                     /locus_tag="BDW47DRAFT_120077"
                     /product="major facilitator superfamily domain-containing
                     protein"
     CDS             join(4196..4800,4856..5774)
                     /codon_start=1
                     /db_xref="InterPro:IPR011701"
                     /db_xref="JGIDB:Aspcand1_120077"
                     /gene_functions="transport (smcogs) SMCOG1106:major
                     facilitator transporter (Score: 82.4; E-value: 4.2e-25)"
                     /gene_kind="transport"
                     /locus_tag="BDW47DRAFT_120077"
                     /note="GO_component: GO:16021 - integral to membrane;
                     GO_process: GO:55085 - transmembrane transport"
                     /product="major facilitator superfamily domain-containing
                     protein"
                     /protein_id="PLB34719.1"
                     /transl_table=11
                     /translation="MSPNAPAVDIGAAPSLDTPEGDTKQPAEDHVEKDSNLVDWDGPDD
                     PEHPQNLTRLRKWGITFSLASMTMWITFSSSVLSVATHPISEEYNVSTKVMPLATTLVI
                     FGFALGPLCWAPLSELYGRRLPTFLGYGVFAIFQVPVAVAPNLQTIMVCRFFVGVFGSS
                     ALSVGPGVMADIWDPVDRGIATPFFFAANLLGPILGPIIGGFITESQLGWRWTAWLTLI
                     TSIFFGVLALLIVPETYSPVLLQQRASRLRRATQNQSLYSFLDQHRPTLAEFGYKYLAR
                     PFMMFLLEPILICFTVYLSLIYGILYLFLEAYPVAFAEERHWTNKGIAGLPFLGILVGM
                     VLGIGIIIYNTRTRFARHLAEQGQVAPEERLVEMMLTSITMPIGLFWFGWAAHTHWMVQ
                     TIAGVPLGIGLFVLFMQGMNYLIDVYLTLSNSAIAANTLARSFLGGSFPLFATAMYHNL
                     GVDWASTILGFISVAMVPIPFAFYIFGARIRAMSRYTVKAGNGIGPPIP"
     gene            6325..14227
                     /locus_tag="BDW47DRAFT_71441"
     mRNA            join(6325..6514,6568..14227)
                     /locus_tag="BDW47DRAFT_71441"
                     /product="polyketide synthase"
     CDS             6610..14106
                     /NRPS_PKS="Domain: AMP-binding (33-427). E-value: 5.9e-105.
                     Score: 343.0. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_AMP-binding.1"
                     /NRPS_PKS="Domain: PCP (536-602). E-value: 1.4e-18. Score:
                     58.7. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_PCP.1"
                     /NRPS_PKS="Domain: PKS_KS(Modular-KS) (629-1059). E-value:
                     2.3e-165. Score: 542.5. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (1164-1465). E-value: 2e-96.
                     Score: 314.7. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_KR (1738-1916). E-value: 7.8e-43.
                     Score: 138.4. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_PKS_KR.1"
                     /NRPS_PKS="Domain: ACP (2021-2091). E-value: 6.3e-18.
                     Score: 56.8. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_ACP.1"
                     /NRPS_PKS="Domain: TD (2146-2379). E-value: 1.1e-48. Score:
                     157.4. Matches aSDomain:
                     nrpspksdomains_BDW47DRAFT_71441_TD.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR000873"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="InterPro:IPR013120"
                     /db_xref="InterPro:IPR013968"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR025110"
                     /db_xref="JGIDB:Aspcand1_71441"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: AMP-binding"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: NAD_binding_4"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     NRPS-like: PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     344.6; E-value: 1.3e-104)"
                     /gene_kind="biosynthetic"
                     /locus_tag="BDW47DRAFT_71441"
                     /note="GO_function: GO:3824 - catalytic activity;
                     GO_process: GO:8152 - metabolic process"
                     /product="polyketide synthase"
                     /protein_id="PLB34720.1"
                     /sec_met_domain="AMP-binding (E-value: 3.6e-115, bitscore:
                     372.8, seeds: 400, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 5.6e-16, bitscore:
                     47.1, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 7.4e-181, bitscore:
                     589.6, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.4e-97, bitscore: 314.7,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short (E-value: 2e-46, bitscore:
                     146.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 1.2e-46, bitscore:
                     147.0, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTIRSAEEDPRRLLEEFNLTDNAATLGSCFPWLFEQAAHAHFDRT
                     AVICGDAQLTYGTLNGRANIIAQILVNRNIGSGDVVGVALDRSVDLLVVLLAVMKSGAA
                     YVPIDPALPAQRILQMMNDTAPKVVLTDHSVLDTLSLWNGPQLSIEELRVEMSLNPANT
                     PNIRRDIQPEDLAYVIYTSGSTGKPKGVEISHGAVANFVLSMQVVPGCNKHDRILAVST
                     ISFDMTLWDLYAPLACGACTVIAQTHEQKDAEALIELIRENGITSMLATPATWQMLFHA
                     GWQGQPRLKTIKTGGESLSQHLSERLLAAAEKVYNGYGPTEATGCVSLWPVQAGEEVLI
                     GTPIANTKLYVLDADLSPMPLGCAGELYIGGAGVACGYRNNPELTRSRFLANPFHEGLM
                     YRTGDLACLVTPKKLKFLGRADSQVKIRGQRLELGEVEAAITSHGDVAHAIVINREGQL
                     AAYCVRDLHRAVEIDPAKVSLSSILRPWLVERLPAYMVPSFIMEVDHIPLTLNGKVDHK
                     SLPAPMAETTTTNQPATELERDIAAIWSTVLGHDHIGRDDNFFQIGGDSVRLVRMQADL
                     KKLLGRSVPITVLFQQYTIKSLAGYLMDMDRPIPADESIHQPNPKPHHVDSDDIAVVSM
                     ACRLPGGIETPEAFWELLERGGDATTDVPPERWDADALYDPDPDAPGKSYCRRGGFVPS
                     FGAFDTKFFHLLPNEARALDPAQYIMLETSWEAFERAGYRTQQLRGSSTGVFIGVNNTV
                     AHGSPSTHAHGLADLQGYTGTGTAGGTMSGRVSYVLGLEGPSLTIDTACSSSLVATHLA
                     CTALRQGECDMAVTGAVTHLPAPGLHVEFSRLRGVAPDGRCRAFAADAQGIGIAEGAAV
                     VVLKRLSDARRDGDTIYGVLRGSAVNHGGQGAAGLTVPSGAAQERVIRAALASSRLLPD
                     DIDYIEAHGTGTRLGDPIEGMALTEVFGGSRSNTSQSLWIGSSKTNVGHTQAAAGLVGL
                     IKVLLALRYNTLPPTLHITQPTPAIDWHRANMAPVQTKQHWLAGGERPRRAGVSSFGIG
                     GTNAHVIVEEPPRCSVSTESTLYVPLPHPVPFLLSSPVEAGLQPQADKLHMYLSQSMSK
                     GDPGNIAYSLATTRNHFPQRIVLLAQDTTDLVAQLVDLPRKAIVSPRGSSPEPRLAMLF
                     AGQGSQQLGRGKTLAKHYRVFRETLEEIATQFYGILQEPLLDVMHAAADSALAALLQRS
                     DYAQPALFALEVALWRLWQSWGVQPDMVLGHSIGELTAAHIAGVMDLPDACRLVAARGR
                     LMETLPCHGGMASLEASASEVSLAITTLDLGGQVGIAAYNTPSQTVISGDRDALDILIA
                     YFSGQDRQSKTLPVSRAFHSHHIDGMLTAYQAVVQSVQLNAPSLPIVSTLTGRRVEPCE
                     LQQPTYWVRQAREAVRYSDGIQALADHGMNVFLELGPQSVLCGMGAAVLDGSENRTTWL
                     PSLAPNKDEVVAIQEILARLHVQHVPVNWQGYFQPFGCRRLELPTYAFQRERVHSGTKE
                     RDHGKREARPQASAFYDKVFQIDWRPFAIQHVQPRGIWGLQCSSGYVKWAEAVRAALFQ
                     GGIQCILLPSLSLQGTKTLDGVLCLWDSHGDVISQVHEFAAQGLTQLKEAANTRPSLPL
                     VWLTSQAVGTARDDQPLALGAGLLWGLMRTARNEHPERSLRLIDLGRDDQNRVDASGLA
                     PLLMLHTEPECALRQGMVLVPRMQRMELEFGDATQTLLRSDGAVLITGGLSGLGARIAE
                     WLASTHGIRDLVLTSRRGMDTPGAATLVRRLAHLGTKTTVVSGDTTDPSHLNSLLSMFS
                     HARPLRGVVHAAGVRDTSMLGTSTPQRCVGALAPKVIGAWYLHQFTRTRNDLDLFVVVS
                     SFWGVMGTSGHATDAAANAVLDSLVYTRQSQGLPAVCVAYGPLPDINIPPGLLPTIRDQ
                     LQQMGIKTLTPDDTISLFELAARRSHGVTVAAALDLHQLQSYSSQRGGIPALLRLLLDR
                     DTPQKHQGPALYDVLRRTAPDQRREILLRTIQEAVATTLGFSQPDEVDIHRSLPDMGID
                     SLGALLVRNQLAGLLGQALPANIVFIHPSLDELSRYLLPQLVDSNRDASSVAEPDMASA
                     STAADVSGLNLMAIRKGCVDSSFTFDNALPKPTPQSVFVTGATEFVGAFLVHELLDQGK
                     VTYCLVHAHSIDHARQQIVSWLQDYNLWKIGYAELLRPLVGDVCQVRLGLDESVFDDLA
                     HRVDTIYHASCLVDWMRPLDDYIGPNVTSTHEVLRLASTSHAKTIHYLSTSATLPYHLG
                     YDIPEDALTYGYAMSKLMAERMVIAARCRGAQAFIYRLPFITASATSGHFQLNNRDFLH
                     NLISGSLEMGCFPSLDADLSLVFPVDYVCRTIITLAHTTPGSTHIRYDYDFKNPQAQSF
                     DHYFNLLATVGKDLESLAFSTWRQRALAYAAAKPASSLTSIADILKNSTEEAVVKMFQC
                     PPIVTPFLGGEEFPVPSVNDQSVRKYLHRMDLTL"
     aSDomain        6709..7890
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_AMP-binding.1"
                     /evalue="5.90E-105"
                     /label="BDW47DRAFT_71441_AMP-binding.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="427"
                     /protein_start="33"
                     /score="343.0"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="FEQAAHAHFDRTAVICGDAQLTYGTLNGRANIIAQILVNRNIGSG
                     DVVGVALDRSVDLLVVLLAVMKSGAAYVPIDPALPAQRILQMMNDTAPKVVLTDHSVLD
                     TLSLWNGPQLSIEELRVEMSLNPANTPNIRRDIQPEDLAYVIYTSGSTGKPKGVEISHG
                     AVANFVLSMQVVPGCNKHDRILAVSTISFDMTLWDLYAPLACGACTVIAQTHEQKDAEA
                     LIELIRENGITSMLATPATWQMLFHAGWQGQPRLKTIKTGGESLSQHLSERLLAAAEKV
                     YNGYGPTEATGCVSLWPVQAGEEVLIGTPIANTKLYVLDADLSPMPLGCAGELYIGGAG
                     VACGYRNNPELTRSRFLANPFHEGLMYRTGDLACLVTPKKLKFLGRADSQVKIR"
     aSModule        6709..8415
                     /complete
                     /domains="nrpspksdomains_BDW47DRAFT_71441_AMP-binding.1"
                     /domains="nrpspksdomains_BDW47DRAFT_71441_PCP.1"
                     /locus_tags="BDW47DRAFT_71441"
                     /monomer_pairings="X -> X"
                     /starter_module
                     /tool="antismash"
                     /type="nrps"
     CDS_motif       6895..6936
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0001"
                     /evalue="1.80E-05"
                     /label="NRPS-A_a2"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="109"
                     /protein_start="95"
                     /score="17.9"
                     /tool="antismash"
                     /translation="LAVMKSGAAYVPID"
     CDS_motif       7135..7194
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0002"
                     /evalue="4.50E-10"
                     /label="NRPS-A_a3"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="195"
                     /protein_start="175"
                     /score="31.4"
                     /tool="antismash"
                     /translation="AYVIYTSGSTGKPKGVEISH"
     CDS_motif       7687..7776
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0003"
                     /evalue="1.90E-15"
                     /label="NRPS-A_a6"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="389"
                     /protein_start="359"
                     /score="48.9"
                     /tool="antismash"
                     /translation="PLGCAGELYIGGAGVACGYRNNPELTRSRF"
     CDS_motif       7855..7920
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0004"
                     /evalue="4.40E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="437"
                     /protein_start="415"
                     /score="34.8"
                     /tool="antismash"
                     /translation="FLGRADSQVKIRGQRLELGEVE"
     aSDomain        8218..8415
                     /aSDomain="PCP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_PCP.1"
                     /evalue="1.40E-18"
                     /label="BDW47DRAFT_71441_PCP.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="602"
                     /protein_start="536"
                     /score="58.7"
                     /tool="antismash"
                     /translation="ERDIAAIWSTVLGHDHIGRDDNFFQIGGDSVRLVRMQADLKKLLG
                     RSVPITVLFQQYTIKSLAGYL"
     aSDomain        8497..9786
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_PKS_KS.1"
                     /domain_subtypes="Modular-KS"
                     /evalue="2.30E-165"
                     /label="BDW47DRAFT_71441_PKS_KS.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1059"
                     /protein_start="629"
                     /score="542.5"
                     /tool="antismash"
                     /translation="IAVVSMACRLPGGIETPEAFWELLERGGDATTDVPPERWDADALY
                     DPDPDAPGKSYCRRGGFVPSFGAFDTKFFHLLPNEARALDPAQYIMLETSWEAFERAGY
                     RTQQLRGSSTGVFIGVNNTVAHGSPSTHAHGLADLQGYTGTGTAGGTMSGRVSYVLGLE
                     GPSLTIDTACSSSLVATHLACTALRQGECDMAVTGAVTHLPAPGLHVEFSRLRGVAPDG
                     RCRAFAADAQGIGIAEGAAVVVLKRLSDARRDGDTIYGVLRGSAVNHGGQGAAGLTVPS
                     GAAQERVIRAALASSRLLPDDIDYIEAHGTGTRLGDPIEGMALTEVFGGSRSNTSQSLW
                     IGSSKTNVGHTQAAAGLVGLIKVLLALRYNTLPPTLHITQPTPAIDWHRANMAPVQTKQ
                     HWLAGGERPRRAGVSSFGIGGTNAHVIVEEP"
     aSModule        8497..13746
                     /complete
                     /domains="nrpspksdomains_BDW47DRAFT_71441_PKS_KS.1"
                     /domains="nrpspksdomains_BDW47DRAFT_71441_PKS_AT.1"
                     /domains="nrpspksdomains_BDW47DRAFT_71441_PKS_KR.1"
                     /domains="nrpspksdomains_BDW47DRAFT_71441_ACP.1"
                     /domains="nrpspksdomains_BDW47DRAFT_71441_TD.1"
                     /final_module
                     /locus_tags="BDW47DRAFT_71441"
                     /monomer_pairings="mal -> ohmal"
                     /tool="antismash"
                     /type="pks"
     CDS_motif       8986..9033
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0005"
                     /evalue="7.00E-07"
                     /label="PKSI-KS_m3"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="808"
                     /protein_start="792"
                     /score="21.1"
                     /tool="antismash"
                     /translation="GPSLTIDTACSSSLVA"
     CDS_motif       9409..9456
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0006"
                     /evalue="2.20E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="949"
                     /protein_start="933"
                     /score="13.3"
                     /tool="antismash"
                     /translation="YIEAHGTGTRLGDPIE"
     aSDomain        10102..11004
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_PKS_AT.1"
                     /evalue="2.00E-96"
                     /label="BDW47DRAFT_71441_PKS_AT.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1465"
                     /protein_start="1164"
                     /score="314.7"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LFAGQGSQQLGRGKTLAKHYRVFRETLEEIATQFYGILQEPLLDV
                     MHAAADSALAALLQRSDYAQPALFALEVALWRLWQSWGVQPDMVLGHSIGELTAAHIAG
                     VMDLPDACRLVAARGRLMETLPCHGGMASLEASASEVSLAITTLDLGGQVGIAAYNTPS
                     QTVISGDRDALDILIAYFSGQDRQSKTLPVSRAFHSHHIDGMLTAYQAVVQSVQLNAPS
                     LPIVSTLTGRRVEPCELQQPTYWVRQAREAVRYSDGIQALADHGMNVFLELGPQSVLCG
                     MGAAVLDGSENRTTWLPSLA"
     CDS_motif       10276..10344
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0007"
                     /evalue="4.90E-06"
                     /label="PKSI-AT-mM_m2"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1245"
                     /protein_start="1222"
                     /score="19.4"
                     /tool="antismash"
                     /translation="QRSDYAQPALFALEVALWRLWQS"
     CDS_motif       10348..10470
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0008"
                     /evalue="1.70E-23"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1287"
                     /protein_start="1246"
                     /score="75.0"
                     /tool="antismash"
                     /translation="GVQPDMVLGHSIGELTAAHIAGVMDLPDACRLVAARGRLME"
     CDS_motif       10570..10608
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0009"
                     /evalue="1.00E-03"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1333"
                     /protein_start="1320"
                     /score="12.4"
                     /tool="antismash"
                     /translation="AAYNTPSQTVISG"
     CDS_motif       10831..10866
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0010"
                     /evalue="2.90E-03"
                     /label="PKSI-AT-M_m8"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1419"
                     /protein_start="1407"
                     /score="11.2"
                     /tool="antismash"
                     /translation="YWVRQAREAVRY"
     aSDomain        11824..12357
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_PKS_KR.1"
                     /evalue="7.80E-43"
                     /label="BDW47DRAFT_71441_PKS_KR.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1916"
                     /protein_start="1738"
                     /score="138.4"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C1"
                     /tool="antismash"
                     /translation="GAVLITGGLSGLGARIAEWLASTHGIRDLVLTSRRGMDTPGAATL
                     VRRLAHLGTKTTVVSGDTTDPSHLNSLLSMFSHARPLRGVVHAAGVRDTSMLGTSTPQR
                     CVGALAPKVIGAWYLHQFTRTRNDLDLFVVVSSFWGVMGTSGHATDAAANAVLDSLVYT
                     RQSQGLPAVCVAYGP"
     CDS_motif       11830..11928
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0011"
                     /evalue="3.70E-09"
                     /label="PKSI-KR_m1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1773"
                     /protein_start="1740"
                     /score="29.2"
                     /tool="antismash"
                     /translation="VLITGGLSGLGARIAEWLASTHGIRDLVLTSRR"
     CDS_motif       11980..12006
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0012"
                     /evalue="2.60E+01"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1799"
                     /protein_start="1790"
                     /score="-1.1"
                     /tool="antismash"
                     /translation="GTKTTVVSG"
     CDS_motif       12208..12318
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_BDW47DRAFT_71441_0013"
                     /evalue="3.90E-08"
                     /label="PKSI-KR_m4"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="1903"
                     /protein_start="1866"
                     /score="25.8"
                     /tool="antismash"
                     /translation="LDLFVVVSSFWGVMGTSGHATDAAANAVLDSLVYTRQ"
     aSDomain        12673..12882
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_ACP.1"
                     /evalue="6.30E-18"
                     /label="BDW47DRAFT_71441_ACP.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="2091"
                     /protein_start="2021"
                     /score="56.8"
                     /tool="antismash"
                     /translation="TIQEAVATTLGFSQPDEVDIHRSLPDMGIDSLGALLVRNQLAGLL
                     GQALPANIVFIHPSLDELSRYLLPQ"
     aSDomain        13048..13746
                     /aSDomain="TD"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_BDW47DRAFT_71441_TD.1"
                     /evalue="1.10E-48"
                     /label="BDW47DRAFT_71441_TD.1"
                     /locus_tag="BDW47DRAFT_71441"
                     /protein_end="2379"
                     /protein_start="2146"
                     /score="157.4"
                     /tool="antismash"
                     /translation="VFVTGATEFVGAFLVHELLDQGKVTYCLVHAHSIDHARQQIVSWL
                     QDYNLWKIGYAELLRPLVGDVCQVRLGLDESVFDDLAHRVDTIYHASCLVDWMRPLDDY
                     IGPNVTSTHEVLRLASTSHAKTIHYLSTSATLPYHLGYDIPEDALTYGYAMSKLMAERM
                     VIAARCRGAQAFIYRLPFITASATSGHFQLNNRDFLHNLISGSLEMGCFPSLDADLSLV
                     FPVDYVCRTII"
     gene            <16130..>17470
                     /locus_tag="BDW47DRAFT_134043"
     mRNA            join(<16130..16423,16483..17094,17159..>17470)
                     /locus_tag="BDW47DRAFT_134043"
                     /product="indoleamine 2,3-dioxygenase"
     CDS             join(16130..16423,16483..17094,17159..17470)
                     /codon_start=1
                     /db_xref="InterPro:IPR000898"
                     /db_xref="JGIDB:Aspcand1_134043"
                     /locus_tag="BDW47DRAFT_134043"
                     /note="GO_function: GO:20037 - heme binding"
                     /product="indoleamine 2,3-dioxygenase"
                     /protein_id="PLB34721.1"
                     /transl_table=11
                     /translation="MADRSDIIIENYQVSPRIGFLPDKPPLARLPHPYYAGWEETISRV
                     APSRGDGRAREYIDEMPLLSTGKLRVLPEWHRAYTLLSILSQVYIWDGDEPSNRIPASI
                     ASPLLAVSEHLGLNPCASFASFCLWNIRPVGRHGLNYAAAYEPENLGQITSFTGTTDEE
                     WFFSISAAIEARGGCLIPGMFDTIEAAREGNSQRVQEFLGTLASCVRHMCKDLKRMYEG
                     CAPSVFYHDVRPFLNGGKGVNKDTQTPGGVFYENESGGGQWHQYQGGSNAQSSLIQLLD
                     IFLGVDHSITAANKPHEGYHREMQSYMPGKHRQFLQLMSRLSNVREFVLCHPVTAEIRI
                     EYSRATAELVALRQTHMIMASRYIVMQGRKGSMCRDSSKGTGGTEFMPFLKDARDCTLA
                     TCCPRP"
ORIGIN
        1 ataagaatat aaagttaaaa gaattttaaa taataaacaa gttaataaaa aactattata
       61 tttaattaaa taaaaagatt ataatatctt agaaaatact taagagttta ttaagaattt
      121 aagagattat tactagctag tttaataata ttactagtaa aaaaattaat atttatttag
      181 aagaaagaat tatttattac ctaagaaaaa ctagaaatat ctaatattat aataagctaa
      241 gtattatctt aagtattaac tagataatta agctcttaaa gattcttgat acttaataaa
      301 ttttttttat taaattattt tattataaaa aaattatagt caagtattta gttattataa
      361 tcttttagaa attattcttg cttttttagt taaagaatct taaatataat ctataatatt
      421 tattaagaat attcaagcta ttatttttta atcttaatga aattattaat taaatatttt
      481 ttatcttact caagagactc ctactcttat ttactatata attattttat atacttctaa
      541 tcataataag tatacttaac atagttttta ttttttaaat ttataatata gttaatatta
      601 taagtagaat aagatttata agaaatatta ataataagac cagtggcaag aataaagtta
      661 tactagtaaa gatagttata tttttagata ttattattta ctagtataat aatattagta
      721 ctagaataag aaaagaagta aaatttatta aaaatcatga ctaagagaaa cttatcttta
      781 taagttttaa gaataaaata ctaaaagaga agagagtaat attataaaaa tctaatataa
      841 ttaatatttt ataaagataa catagtcagg cagaagtcta atattaatta ataaattata
      901 aaatcaggat tcctgtatta taaaagtatt atattatata attatctact tctatatcta
      961 cttccagaga gtaactaaag aagtatatat taaaaagata tctaattaga gtaactctag
     1021 agtaattata aaagagttat ttaagaaata gctaataaag aatatataag aatacttatt
     1081 tacctatatt tataatttag ttaattatat ttaatatata gttcaagtct gagtatatat
     1141 ttagtctagt ttctacttat ttatacttaa ttaagtaatc aggtttttat atctaatata
     1201 tcttactttt cttcttactt attagttatc ttcagattat taaattactt tattaattaa
     1261 tataattagc atgattatta tataaggcct caggttagta taaacttatt attaatagct
     1321 aataggaaga ttacagggtg ttctttatct taaataatct aagttactaa tactagtaca
     1381 gcagaagcat caagggatcc tagggtcttg acaacagccc ttatctctaa tctcttaact
     1441 ttaatatact cttatagcta tcacagtgtc tttaaaattc tagaaaaata tgtattattc
     1501 tcatgaaagg cagtgctatc taataatact aaattcaata ctataccaag tattggtagg
     1561 tgttatgttt acctggaata tgcctattag actcggaaac tctagtaaca tggtgatttt
     1621 ggctgacata ttcaagaaac ggaggcacaa tgcctcctga cgtggctagg aagaaaaaaa
     1681 agaaagaaaa gaaaagaaag agataaaaga ggaaagaaat cattaacagt gataatttct
     1741 ccacacactc caaagttgct ggattgggga ctgcaacata gaaagcaatg aaacccgcat
     1801 agggtaattc catgcgagca ctccaacaat tgctgcactg gaaatgatcg cggaaataga
     1861 cccatacaga agaagcgtgc cttgtctttc aactgccttg atgacctccg agtagggctg
     1921 ggtgctgaag ctgaccctga catattgggt ttgccagcct aggctaggca tataacgatc
     1981 cagagtttct tcgagtgact tgcgcagctt gtacagtggc aattgcacac cccaccgcat
     2041 ttcgatgtag ttatccttag aaagatcatt gatagcatga gcatctttcg tgcgctgatc
     2101 cgtatacgcc tgcaaggctg cctgacgaga caaagcacgc gactcgggac tggcattcag
     2161 atcataaacc ccgtgttgat ctaaacactc aaataagacg cgaatatctt ccaacccggc
     2221 attcaaaccc tggccgtaaa acggcacaac agcatgtgcc gcatcaccga caatgaccgc
     2281 actcgagcca aagtgataag ggctgcactt gatgctaatt agtggcaggt gagggttggt
     2341 ttcaaactgc gtctgaaggt ccgcgggagt aatgaggtct ggacagacgc cagggaagtt
     2401 cttatcaaat gactccaaca aactctctgg cgagctttct aagagagtat aataacttgt
     2461 ggaagcgaac aaggtgcagg taaaggattt gtctgcggac gggagagcaa tgaacatgaa
     2521 ttccttcccg ggccaaatat gcaaatgatt aggagaaatg cggaattcac cctcttcggt
     2581 cggcggaatg tggaattcgc accacagagc atcgatatat tgctgctggt agtcaactcg
     2641 ggcgtatttc atcatatgat atctcgagat tgagtgagca ccatccgcac cgaccaagta
     2701 gtcgaaggtg atttcgacct caggggcacg actagtgtta tctgcaggag tacgctgctc
     2761 gaaccatgcc tttttggcac ggaagtcggc tcctgtcagc ttgtggttga aaaaaagttt
     2821 gacatttggc gtctgttcca gctcatccaa gagagcgtta tttaaatggc atctatcagc
     2881 tgcatttata tgctatgatt gggttagaac cggattcgag caaagtaaaa ttacagccaa
     2941 gataaagacc aacccggccg tgtacatcgt aagcctgaga ggcttcccaa agcttctcgt
     3001 cgttcctgcc atggatcatc cgcccataga cggggatggc ctcgccgagg atcttctgga
     3061 tcatgttgtc ccgacgagtg tgcttcatgg cgttaatccc acgctcagac agagccaggt
     3121 tgatggattt ggtgaagttc agggggatgg tagatgggtc acggaggtct atgaagtcac
     3181 gaggcatgag aaaggtacca acagaatcag gtagatattc catcttctag agtcactaga
     3241 tccgggtctc atatgcttct gtcaacgtag acaatatttg gacgctgaaa attggtgaag
     3301 cagcaccgga gactgtagac ttggattacg actgttggag taacattgat aggcttacct
     3361 ccacgcaact cgtacacttc cacctcatcg cctcgggcgg ctgcatacaa agcagccaaa
     3421 gagccgacag ggccggcgcc aacaatgacg actttatgat tgcttgatgg agccatacta
     3481 tacgggatcg gcaggattat tccaaagtat agacggcaag agaagggaag gacggatgtt
     3541 gaatgacagt caatgttgga gatcgcccta cctccaggtg atctcggagg gctgctggta
     3601 gaccatatga aatggcgtgt tgggttgggt tttcatcttc gatttcccag tccctgggat
     3661 agtcacgtga actaggagca tgtatatttg gcctccagtc tttttgtatt taatacacaa
     3721 gaaaaataca acaaggatat gaatctcgag gcattaggta gggtttgatg gctgagaccc
     3781 aaaatccgcc cctgggccag gttcttggta ggtacctacc catgggcttg gtcgggtgtt
     3841 ggcgaggtct cgttgctgaa ctttcggata tccctggaga agatcaccct ggaatatctc
     3901 cagtgcgatg ggtcgatatc attggttcta cgcgccatga ggtatgaagg attgcagaca
     3961 cagtgagcag gccacgtccc ttcctaacgc aaggggctac atgaatcctg tttatccatg
     4021 atgatgacat gacggaccag tcctccggaa caatgcgtta catgtgaggg aaggtctcct
     4081 tgcgtggtca gctcttcctc cggatcgaga aattgaacca aaagcgaggt gaaaatggag
     4141 ggagagtctg ctctccacgt ctcaatgggt catgctttcc tcaccttcag ttaccatgtc
     4201 cccaaacgcc ccggccgtcg acattggtgc tgctccttcc ctcgacactc ccgagggaga
     4261 taccaaacag ccagccgagg accatgtcga aaaggattcc aatctcgtgg actgggatgg
     4321 gcctgatgac ccggaacacc cccagaacct gacccggcta cggaaatggg gcatcacctt
     4381 ctcgttagcc tcgatgacca tgtggatcac attctcctcc agtgtcctct ctgtcgcgac
     4441 gcacccgata tcggaggagt acaatgtgtc aacaaaagtc atgccgctgg caactaccct
     4501 ggtaattttt gggttcgccc tgggaccgct gtgctgggcc ccgttgagtg aattgtatgg
     4561 ccgtcgcctg ccgacatttc tgggatatgg ggtgtttgcc atcttccagg tccccgtggc
     4621 ggtggcccca aacctccaga ccatcatggt ctgccggttt ttcgtgggcg tctttggcag
     4681 ttcagcgcta tcagtgggcc caggtgtcat ggccgacatc tgggatccgg tggatcgtgg
     4741 tattgccacc cctttcttct tcgcagccaa cctgctcggc ccgatcctcg ggcccattat
     4801 gtacgttgtg ttgcgtttct caccacgaac gagctatggc taacacgaat gatagaggcg
     4861 gatttatcac ggaatcccag cttggttggc gatggactgc gtggctgact ctcatcacct
     4921 caatcttctt cggagtcctc gccctcctta tcgtgcccga aacttacagt cccgttctgc
     4981 tccagcagcg cgccagccgg ctccgccgtg caacgcagaa ccagtctctc tactcgttcc
     5041 tcgaccagca tcgtccgacc ctcgccgagt ttggatataa gtaccttgcc cgtccgttca
     5101 tgatgttcct actcgaaccg atcctgatct gtttcaccgt ctatctgtcg ctgatctatg
     5161 ggattctcta tctcttcctc gaagcttacc ccgtcgcttt cgccgaagaa cgacactgga
     5221 ctaataaagg cattgccggg ctcccgtttc ttggtatcct ggtcggcatg gtcctaggca
     5281 tcggcatcat catctacaac accaggacgc gattcgcgcg acatctcgca gagcagggac
     5341 aggtagcccc ggaggagcgt ctagtcgaga tgatgctcac ctcgatcacc atgccaatcg
     5401 gtctcttttg gtttggctgg gcagctcaca cccactggat ggtgcagaca attgccgggg
     5461 tgcccctcgg catcggtctg ttcgtcctct tcatgcaggg catgaactac ctgattgacg
     5521 tctatctgac tctttccaac tcggccatcg cggctaatac tctggcccgt tcgtttctgg
     5581 gcggatcgtt cccgctcttc gccacggcca tgtatcataa cctcggggtt gattgggcat
     5641 cgaccatact gggattcata tcggttgcca tggttcctat cccctttgca ttttatatat
     5701 tcggtgcaag gattcgggct atgtctaggt atacggtcaa ggctggaaat ggtatagggc
     5761 ccccgatacc ctaatttatg gtcagatact atgtctgatt cacgagctat tgttgagtaa
     5821 atgcatacgt ggagatagta acaggagatg tgtttttggg ctagaatttg tgatgaacca
     5881 taataattac caaacactcg aagcgtgtat aatttgtgga tatagcataa agtgttccct
     5941 atcagaattt ctaagctaaa cctagttttc catcagctgt actctgtcgt gcgtctcgag
     6001 taccacaatg gtcctgccag ttgcagtccg acatgtccca ggattatgcg ctacggcatt
     6061 ccttgcataa acttggtagc aactttcctg ccattcaagt ggtttgatgg cgtcagctaa
     6121 tatagagcct gtactgtagt aatgtgacaa cgatctctta cctcaattgc caacccggca
     6181 gagacattgc ggccgcgcct tacattctct gcccatcagt gaaaaaacct cagcaaaacg
     6241 tatccaggtg atgtaacttc gaaaggtaag gaggcgtgga ggggtgacgg catctgtgag
     6301 acacgacgtc actgaatggg gtgccttgct tatcaactcg ccattgccgg cattcagtcc
     6361 cagaatacaa aaaaatgcga atagtcaaat tccaaacctg atacagcgga gccattcata
     6421 tttgaattga aaaacggtaa tcttcgcccc gaagagaacc agaaccacaa gacttaaaat
     6481 cacgctgttt atagccgcac aggaccggag agaggtgggt tgcaagtgat cattatcaaa
     6541 gtgcgggtct aaaaccggct gaaaaaggtt aacaggaacg acttctcagg aggcattgaa
     6601 atcggcagta tgaccatccg ttcagccgaa gaagatcccc ggcgtctcct cgaggagttc
     6661 aaccttactg acaacgcggc gactctggga tcgtgtttcc cctggctatt cgagcaggcc
     6721 gcacacgccc actttgaccg gacggccgtc atctgcgggg atgcgcaatt gacatatggt
     6781 acgctcaatg gtcgtgcaaa tattatagcg cagattctgg tcaaccgaaa catcggttct
     6841 ggcgatgttg tcggtgtcgc gctggaccgg tcggtcgacc tcctcgtcgt gctgctagcg
     6901 gtcatgaagt ctggtgcggc ctatgtgcct attgatccgg ccttgcctgc acagcgcatt
     6961 ctccagatga tgaatgatac ggctcccaag gtggttctga cggaccacag cgtgcttgat
     7021 accctgtcat tatggaatgg gccacaactg agcatagaag aactgcgagt tgaaatgagc
     7081 ttaaacccgg ccaacacccc aaacatccgt cgggacatcc aacccgaaga tcttgcctat
     7141 gtcatctata cgtccgggtc gacagggaaa cccaagggcg tagaaatcag ccatggggcc
     7201 gtggccaact tcgtcttgtc gatgcaagtt gtccctggat gcaacaaaca cgatcgaatt
     7261 ctggcggtga gcaccatttc cttcgacatg accctttggg acctatacgc ccccttggct
     7321 tgtggtgcgt gcaccgtcat agcccagacc cacgagcaga aagacgcgga agcgctgatt
     7381 gagctgatcc gggaaaatgg cattacgagc atgctcgcta ccccggccac ctggcagatg
     7441 ttgttccacg ccggctggca aggccagccg cgcctgaaaa cgatcaaaac cgggggggaa
     7501 agcttatccc aacatctgtc cgagcggtta ctcgccgcgg ccgaaaaggt gtacaacggc
     7561 tatggtccca ccgaggccac tgggtgtgtt agcctctggc cggtgcaggc aggggaagag
     7621 gtgctcattg gcacaccaat tgccaacacg aagctctacg tgctagatgc cgacctgtcc
     7681 cccatgccgc ttggctgcgc tggagagctg tatattggcg gggccggagt cgcttgtggc
     7741 taccgcaaca atccagagct gacccggtca cggtttttgg caaacccctt ccatgagggg
     7801 ctcatgtacc gcaccggcga tttggcgtgc ttagtgacgc caaagaagct gaagtttctc
     7861 ggccgcgcag acagccaggt caagattcgg ggccagaggc tcgaactggg ggaagtcgag
     7921 gcggcgatca ccagccatgg agacgtcgcc catgccatcg tgatcaatcg tgagggacag
     7981 ttagccgcgt actgcgtgcg ggacctgcac agggcagtgg aaatcgaccc ggccaaggta
     8041 tcactaagca gcatcctgcg tccatggctg gtcgagcgtc tgccggccta tatggtaccg
     8101 tcgttcatca tggaagtgga tcacattccg ctgacgttga acggtaaagt cgaccacaag
     8161 tccctgccag ctcccatggc agagacgacg accacgaatc agccggctac ggaactggag
     8221 cgcgacatcg cggctatctg gtccacggtt ctgggccatg accatattgg gcgggacgac
     8281 aactttttcc aaatcggggg agactcggtg cgactggtac gtatgcaggc ggacttgaag
     8341 aagctgctag gccgctctgt gccgattact gtgctgtttc agcaatacac catcaagtca
     8401 ttggccgggt atctgatgga tatggaccgg cccataccgg cagacgagtc cattcatcag
     8461 cctaacccca agccgcatca tgtcgactcc gatgacattg ctgttgtatc catggcatgc
     8521 cgactgcccg gcggcattga gacacccgag gcattctggg aacttctcga gcgcggtgga
     8581 gatgctacca cagatgtacc tccggaacgc tgggatgctg acgccctcta tgatccagat
     8641 ccagatgcgc cgggcaagtc ttactgtcgc cgggggggct ttgtcccctc atttggtgcg
     8701 tttgacacaa aatttttcca cctcttgccc aatgaggctc gcgcgcttga tcctgcccag
     8761 tatattatgc tggagactag ctgggaagca ttcgagcgtg ctggctacag gactcagcag
     8821 ctccggggca gctcaacggg agtgtttatc ggtgtcaaca acactgtcgc ccatggaagc
     8881 ccgtccaccc atgcgcacgg gctggcggac ctgcagggct atacaggcac gggcacagca
     8941 ggggggacga tgtccggtcg tgtttcatat gtccttggcc ttgaaggtcc gtcgctcaca
     9001 attgacacgg catgctcctc ctccttggtg gccacccatc tcgcctgtac cgcgctgcgg
     9061 cagggcgaat gcgacatggc tgtgaccggt gccgtgactc atttgcccgc gccaggacta
     9121 catgtggagt tcagccggtt gcgcggcgtg gcccctgatg gccgttgtcg ggcctttgcg
     9181 gctgatgcgc aaggaatcgg gattgctgaa ggggcggccg ttgtggtgct taaacgcctg
     9241 tccgacgccc gccgagatgg tgacaccatc tatggtgtac tgcgcggctc tgccgtcaac
     9301 catggcggac aaggtgctgc cggcctaacc gtgcccagtg gtgctgccca ggagcgggtg
     9361 attcgtgcag cgctggcgtc ttcaaggctc cttccagacg atatcgacta catcgaggcg
     9421 catggcaccg gcaccagact cggcgacccc attgaaggaa tggcgctgac ggaggtgttt
     9481 ggcgggagcc gatctaacac atctcagtcg ctgtggatcg gttcgtccaa gaccaatgtt
     9541 ggccacactc aggccgctgc cgggttggtc ggcctcataa aggtcctgct cgccttgcgg
     9601 tataacacat tgccacccac actgcacatc actcagccga caccagctat tgattggcac
     9661 agggccaaca tggcgccggt gcaaacaaaa caacactggt tggcgggggg cgagcgccca
     9721 cgccgcgctg gagtcagttc atttggaatt gggggcacaa acgcccatgt gattgttgaa
     9781 gaaccacctc ggtgtagtgt cagcacagag tcgacactat acgttccact gccgcatccc
     9841 gtgccattcc tgctgtcaag cccagtggag gcgggcctcc aaccacaagc cgacaagctg
     9901 catatgtacc tcagccagtc catgtccaag ggtgacccgg gcaatatcgc gtactcactg
     9961 gcaaccacgc gcaaccactt cccccaacgc attgtgctac tggcccagga cactacagat
    10021 ttagtggctc agctggtgga tttacccagg aaggctattg taagcccaag gggctcaagt
    10081 ccagaaccgc gtctcgccat gctttttgcc ggccagggaa gccagcaact ggggaggggg
    10141 aagaccctcg cgaaacacta ccgggtattc cgggagacgc ttgaggagat tgctactcaa
    10201 ttttatggga ttttgcagga accacttttg gatgtcatgc atgcggcggc agacagtgca
    10261 ttggctgcgc tgctgcagcg cagtgactac gcccaaccgg cgctcttcgc cctcgaagtc
    10321 gctctctggc ggctgtggca gagctgggga gtacagcccg acatggtcct gggtcatagc
    10381 atcggcgagc tgacggcggc gcatattgcg ggagtcatgg acctccccga cgcctgccgg
    10441 cttgtggcgg cgcgtggtcg cttgatggag accctccctt gccacggagg aatggcctct
    10501 ttagaagcca gcgccagcga agtatctctg gcaatcacaa cgctcgacct tggcggccaa
    10561 gtgggtattg cggcatataa tacgcccagc cagactgtta tctccgggga ccgggatgct
    10621 ctggacatcc tcatagctta tttttcgggt caggaccggc aatctaagac gttgcctgtg
    10681 tctcgcgcat ttcattccca ccacatcgac gggatgctga cggcttacca ggcggtggtg
    10741 cagagcgtgc agttgaacgc accctcgctg ccaatagtga gcaccctcac gggccggcga
    10801 gtagaaccct gtgagctcca gcagccgacc tactgggtcc ggcaggcacg tgaggcggtc
    10861 cgctacagcg acgggattca agcgttggca gaccatggca tgaatgtgtt cctcgagctg
    10921 gggcctcagt cagtactatg tggcatgggt gcagccgtgc tcgatggctc agagaacagg
    10981 acgacatggc taccatctct cgcaccaaac aaggatgagg tggtcgccat ccaggaaatc
    11041 ttggcacggc tccatgttca gcatgtccca gttaactggc aaggttactt tcagcccttt
    11101 ggctgccgtc gtctggagct gccaacctac gcgtttcagc gggagcgtgt ccactcaggc
    11161 accaaggaga gagaccatgg gaaacgtgaa gcgcgtcctc aggcaagtgc cttctatgac
    11221 aaggtattcc agattgactg gcggccattt gctattcagc atgttcagcc ccgtggaatt
    11281 tggggcctgc aatgctcttc tggctacgtg aagtgggcgg aagcagtcag agcagccctt
    11341 tttcagggcg gcatacaatg cattttgtta cctagtctca gtctccaggg aacgaagacg
    11401 ctggatggcg tattgtgctt gtgggattcc catggggatg tgatttcaca ggtgcacgag
    11461 ttcgctgcac aagggctgac gcagctcaaa gaggccgcca acacacgacc ctccttgcca
    11521 ctggtctggc ttacttcaca ggcggtaggc acagcccgcg acgaccagcc cctggccctg
    11581 ggagctgggc tgttgtgggg cctaatgcgc acggcccgaa atgagcatcc tgagcgatct
    11641 ctgcgcctga ttgatctagg tcgggacgac cagaacagag tcgacgccag tggacttgcg
    11701 ccattgctca tgctccacac tgagccagaa tgtgcgcttc gccaggggat ggtgctggtg
    11761 ccccggatgc agcgcatgga gctcgaattc ggggatgcga cccagactct cctccggtcc
    11821 gacggcgccg tcctcattac cggtggcctg agtgggctag gcgcgcgcat cgccgaatgg
    11881 ctagcaagca cgcacggcat tcgcgatctg gtgctgacct cgcgccgtgg gatggacacg
    11941 ccgggggcag ccacattggt aaggaggctg gcgcatctag gcacgaagac gactgtggtt
    12001 tctggcgaca ccaccgatcc tagccatctc aactccctcc taagcatgtt ctcccacgcg
    12061 cggccgctgc gtggtgtagt tcatgctgcg ggtgtgcgag atacaagcat gctggggacc
    12121 tcaacgccac aacggtgtgt cggagctttg gcgcccaagg taattggcgc gtggtatcta
    12181 catcagttca ctcggacgcg aaacgactta gacctctttg tcgtggtgtc ctccttctgg
    12241 ggcgtgatgg gcacatcggg tcatgctaca gatgctgcgg cgaacgcggt tcttgattct
    12301 ctcgtttata cgcgccaatc acaggggctg cccgcggtct gcgtggccta cggaccttta
    12361 ccagacatta acataccacc gggacttctc cccacaatac gtgatcagct ccagcaaatg
    12421 ggtatcaaga cgctcacgcc agatgataca atcagcctgt tcgagctggc tgcccgtcga
    12481 agccacgggg tcaccgtagc agcagcactc gacttgcatc agttgcagag ctacagcagc
    12541 cagcgagggg gtataccagc tttacttcgc ttactcctag accgggatac accacagaag
    12601 caccagggcc ccgctctgta cgatgtgctt cgcagaacgg ccccagacca acgcagagag
    12661 attttgctgc gcacaattca agaagccgtg gccacaacac tgggcttttc tcagcctgac
    12721 gaagttgata tccaccggtc cttgccagac atggggattg actcactggg ggccctgttg
    12781 gtccggaatc aactagcggg gctccttggt caggcactgc cagccaacat tgtcttcatt
    12841 cacccgagtc tggacgagct tagccggtat ctgctgcccc agttggtaga cagcaacagg
    12901 gacgcatcca gcgtggccga gccggacatg gcgagtgcct cgacagcagc agacgtctct
    12961 ggcctcaact tgatggcgat ccgcaaaggc tgtgtggact caagcttcac atttgacaat
    13021 gcgctgccaa agcccacacc tcagtcagtg tttgtgacgg gtgcgacgga gtttgtcggc
    13081 gcgttcctcg tccacgaact gctcgatcag ggaaaggtca cctattgtct tgtacatgcc
    13141 cacagcattg accatgcgcg gcagcagatc gtgagctggc tgcaagacta taatctgtgg
    13201 aagatcggct acgcagagct cctccggccc cttgttggcg acgtgtgcca ggttcggctg
    13261 ggtttggatg aaagcgtgtt cgacgattta gcgcaccgtg tcgacaccat ctaccatgca
    13321 agctgcttgg tggactggat gcgtccgctg gacgactata ttggtcccaa tgtcaccagc
    13381 actcacgagg tgctgcggct ggcgtccacg agccatgcta agaccattca ctacctctct
    13441 accagtgcca ctctgcccta ccatctggga tacgacatcc cagaggacgc tctcacgtac
    13501 ggctatgcca tgtctaagtt gatggcggag cgaatggtca tcgccgcacg ctgccgcggc
    13561 gcccaagcat tcatctaccg tctacccttt atcaccgcat ccgccacgag cggccacttc
    13621 cagctcaaca acagagactt cctgcacaac ctcatcagtg ggagtttaga aatgggctgt
    13681 ttcccatcct tggatgccga cttatccctc gtctttcccg tcgactatgt gtgccggact
    13741 atcatcacac ttgcccatac aacaccggga tccactcata tccgctacga ctacgacttc
    13801 aagaatccac aggcccagag tttcgaccac tacttcaatc tcctcgcgac cgtcggcaag
    13861 gatctggagt cccttgcttt ttctacctgg cgacaacggg ccctcgctta tgcggccgcg
    13921 aaaccagcta gctcactaac ttcgatcgca gacatcctca aaaacagcac ggaggaggcg
    13981 gtggtaaaaa tgttccaatg cccaccgatt gtcacaccat ttcttggtgg cgaggagttt
    14041 cccgtcccat cggtcaacga tcagtcagta cgaaagtacc tacaccggat ggatctgacc
    14101 ctctgaggag gagccatatc tgagtgcttc gaaataatct cgacgctcca tggagtgtgg
    14161 ttgttttaca gtcccctggg atgataaaaa tcgactgatg gggtttacct tcggccgatg
    14221 gaagtgactg ggataaataa gagtgaggat gcggtgggga acaaccagac aaaatgtttt
    14281 gtttggttgt gaccagcatt tgacactcgt tatgtcttct gccagccctg gtatatgggc
    14341 aaaccaggtc agctatgtat atggacaaga atggcttgga aacgaatctg cgaggatact
    14401 gcatttaggt tggctgagag aacagaatca aagcgtcggt agtgaaaggc aaatcaacta
    14461 cttgtcactc tcactaaact tagcatccac attctcaagg atacatagga acctgatgtg
    14521 aacgtattga accacgaata tgtacacaac tacagggatt atcataatct gagcttatca
    14581 atgttgttat ggggagaggg ctaggtcaag ccatagactc attttttaaa aaatgacttg
    14641 accgaaaaaa tttatgttgt cacattccat atacaaccca gaaattcaac cacgaagccg
    14701 cccgtctcta cgtgtctcct cctcctttgc atcctctttc aaccacgcag ccgcctcaaa
    14761 acaagcgagc ccgagacccc tgacggggac ttatatacct cttctctcta taccaccagg
    14821 ggactggtaa aacccctgaa aaccccctaa ttacctctca ctacctagct acctacctag
    14881 gggtcccaca aaggattact tcttactaaa taggcttaga tctgcaaaaa atacctgtcc
    14941 cgggtacttg acctagaata tgtatactta tagacttgtt tcatgttatt aagaatacta
    15001 agtaactatc agtgtcatat atctagagtc agacttatta gatattttta tagatctaag
    15061 tcatgaattc tctagtttat aaatactctt ccagagatat taaaactata aatatattaa
    15121 atctatcttt atcttattaa aataataaac atcctttata ttaagtacta ggactagctt
    15181 gttctaggaa atatatataa tactaaaaat ttagacatgt ctagcaagct gtatctctat
    15241 atctactatt aattctagac ctataaagct aagataggct aagaaccata gttttagagt
    15301 tatgtgggga ggctaagatg tcctgctagt attactcctc tctcacgctt atatcacgta
    15361 cccaagataa tataatccca tgaccatatt actgatgcga gctgactagc tctattcggg
    15421 cctttcggcc gtcagtgact ggaaggatcc cggaaacaga gataaaatca agtataaggc
    15481 ctttctctct ctctctctct cgttacaacc cagagtcctg gagagaggga tctgacaccc
    15541 aatcacggtg agcgcgcaag atttcgctgg acaccaacaa atatacgaca ctggaaagta
    15601 tttagggcgt gggaaccatg ctaagtgata cagctatgct aggagtacat gtcagctgat
    15661 gacaataaac ttgttttatg cctccagaac cttcagatga tggttgtaga atgacttatc
    15721 tatttggaat gttgtcactt cacagaatga ggtaagggat ttcacacaat tccattgtaa
    15781 acctgatcct aatttgccaa gaagtgctag tgtaaccagt caaccaggta gggatattta
    15841 gaggatatat ggggttcaga tttgccctgt aattccgcgt gttgatatga cgaaaccgcc
    15901 aagccctcaa tacattggaa tacttagggc tcagtgagca tagacagatc attctcggtc
    15961 agaaatgagg gatatacctt gtacccctgg acaggcggaa caggcggagg gataagtcat
    16021 acatgacagg gaggattccg tgcattcaaa acaaagaatt gtagatataa gaggttcagt
    16081 cacccagaga tttaccacac agcatagttt ccgtccaccc tgaaaaaaga tggctgatag
    16141 atctgatatt atcattgaga actatcaagt atctccaaga ataggattcc tccccgacaa
    16201 accaccacta gcccgtctgc cacatccata ctatgccggg tgggaggaga caatttcccg
    16261 agtggctcca agtcgtggag atggtcgagc ccgggagtat attgatgaga tgccgctgtt
    16321 atctaccggc aagctccgtg tcctccctga gtggcatcga gcatataccc tgctgtccat
    16381 tctctctcag gtatacatct gggacggcga tgaacccagc aacgtgcgtg tctcgctctg
    16441 gaacttcccg caacctatat acgcccctaa cactacatac agagaatccc tgcgtcgatt
    16501 gcatccccct tgctggcagt ctcggagcat cttggcctta acccgtgtgc ctcgtttgct
    16561 agtttctgcc tctggaacat cagaccagtt gggcggcacg gtttgaacta tgcagctgcg
    16621 tacgagccgg aaaatcttgg acagatcacc agcttcacag gaacaacaga cgaagagtgg
    16681 ttctttagca tctccgccgc catcgaggcc aggggtggat gcttgatacc cgggatgttt
    16741 gacaccatcg aggctgcccg tgaaggcaac agtcaacgtg tccaagaatt cctcggcacc
    16801 ctagctagtt gtgtccgcca tatgtgcaag gatctgaaga gaatgtatga gggatgcgcc
    16861 ccatcagtct tctatcatga cgtgcggcca ttcttgaacg gaggcaaggg ggtcaacaag
    16921 gacacacaga caccaggcgg ggttttctac gagaacgaga gtggcggtgg gcagtggcac
    16981 cagtatcagg gaggcagcaa tgcgcaaagc tcgctcatcc agctgctcga tatcttccta
    17041 ggggtggatc actcgattac cgcggccaat aaaccccacg agggttatca tcgcgtacgc
    17101 attgcacctg tacagtcacc accttttgac tagattgtta acccttgata ttgcatagga
    17161 gatgcaatcg tatatgcccg gtaaacatcg gcaatttctg caactcatgt cgcgactctc
    17221 aaacgtgcga gagtttgttc tgtgccaccc ggtgacagca gaaattagga tagaatacag
    17281 ccgggccact gctgagcttg ttgctctacg gcagacccat atgatcatgg cttcgcggta
    17341 cattgttatg caaggaagga agggttcaat gtgtcgtgat agttcgaagg gtactggagg
    17401 aacagagttt atgccgttct tgaaagacgc aagagactgt actctggcga cttgttgtcc
    17461 caggccatag tgttatccgt ggtagcggat taggtacaat gtatcaactc tactagatga
    17521 gctttaccat catatattat cttcaagaag gtccatactg ggagctagta tgaagataag
    17581 atcttaccac ctaactaaag gatgaaagtt aaccagcatg gatggttggg tactttggtg
    17641 ctatggctgt cgtagcacct tgaagttgtg aaagatgaaa aagagaaaac gttttcagtc
    17701 aagtgtcgtg atttataata tgtgggggat caatgatatt ctgccagctg tcaccgccat
    17761 cgtcgcctcc gggttgtttg ctatagtcga gccctttgtt aggcggcagc ctaaggcagc
    17821 ctgcttgcta gagtgtcatt cggtgtggat tggtgcggat tctccctggg tagaacccaa
    17881 ctcattgcgg attcggattc taatcccagt aaccaaacca aaccatggtt tggtgtggtt
    17941 tttgactcat gatcctaaaa aatacagatt tttaccttag atagacctaa ttagagctaa
    18001 aatatgacct aagatagacg agtctacctg atattagtgc ttagtaagtt gatttataag
    18061 taaaaattat gaaaatacca actttagaat acctgtggca aatatatata tatatattca
    18121 tgttagtatt caaactacta tacatgtttt gtatgaagtc atgtaattta tgtatatctc
    18181 tatatattat tcggtacgga ttcggtgcgg attttttggt ttggtgatga cactctacct
    18241 gtgattcagc catgtatata ta
//
