BGC0002754: hectoramide B biosynthetic gene cluster from Moorena producens JHB
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Location: 3,909,117 - 3,972,303 nt. (total: 63,187 nt).
This entry is originally from NCBI GenBank CP017708.2, but has been modified (see Modifications tab for details).

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General information about the BGC

MIBiG accession | BGC0002754
Short description | hectoramide B biosynthetic gene cluster from Moorena producens JHB
Status | Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)

Loci
CP017708.2
3909711 - 3971211
via Correlation of genomic and metabolomic data, Homology-based prediction
Compounds

- hectoramide B

Species Moorena producens JHB [taxonomy]
References

- [1] Structure and Biosynthesis of Hectoramide B, a Linear Depsipeptide from the Marine CyanobacteriumMoorena producensJHB Discovered via Co-culture withCandida albicans. Ngo, T et al., preprint (2023) DOI:10.1101/2023.07.06.547815

Chemical products information
hectoramide B Evidence: MS/MS, NMR
Copy SMILES
C34H50N4O7
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
BJP36_15380 AOY81076.1 | 3909711 - 3910598 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_15385 AOY84701.2 | 3910595 - 3910993 (-) | ATP-binding protein |  |  | copy AA seq copy Nt seq
BJP36_15390 AOY84702.1 | 3911457 - 3912446 (-) | sugar transferase |  |  | copy AA seq copy Nt seq
BJP36_15395 AOY81077.1 | 3912562 - 3913341 (+) | 7-carboxy-7-deazaguanine synthase QueE |  |  | copy AA seq copy Nt seq
BJP36_39100 WAN70074.1 | 3913379 - 3913630 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_15405 AOY81079.1 | 3913703 - 3914350 (-) | DUF3318 domain-containing protein |  |  | copy AA seq copy Nt seq
BJP36_15410 AOY81080.2 | 3915036 - 3921809 (+) | translocation/assembly module TamB domain-containing protein |  |  | copy AA seq copy Nt seq
BJP36_15415 AOY81081.1 | 3922048 - 3922347 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39105 WAN70075.1 | 3922350 - 3922502 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39110 WAN70076.1 | 3922749 - 3923063 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39115 | 3923270 - 3923576 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_15430 AOY84703.2 | 3923983 - 3924807 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_15435 AOY81084.2 | 3924912 - 3927098 (+) | tetratricopeptide repeat protein |  |  | copy AA seq copy Nt seq
BJP36_39120 | 3927601 - 3927819 (-) | IS701 family transposase |  |  | copy AA seq copy Nt seq
BJP36_15445 AOY81086.2 | 3928692 - 3928910 (+) | beta-ketoacyl synthase N-terminal-like domain-containing protein |  |  | copy AA seq copy Nt seq
BJP36_15450 AOY81087.1 | 3929117 - 3934792 (+) | non-ribosomal peptide synthetase |  |  | copy AA seq copy Nt seq
BJP36_15455 AOY81088.1 | 3934795 - 3941742 (+) | SDR family NAD(P)-dependent oxidoreductase |  |  | copy AA seq copy Nt seq
BJP36_39125 WAN70077.1 | 3941739 - 3946430 (+) | amino acid adenylation domain-containing protein |  |  | copy AA seq copy Nt seq
BJP36_39130 WAN70078.1 | 3946427 - 3952303 (+) | amino acid adenylation domain-containing protein |  |  | copy AA seq copy Nt seq
BJP36_17830 AOY81497.1 | 3952861 - 3953250 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17825 AOY81496.1 proX | 3953414 - 3954454 (+) | glycine betaine/L-proline ABC transporter substrate-binding protein ProX |  |  | copy AA seq copy Nt seq
BJP36_17820 AOY81495.1 proB | 3954580 - 3955695 (-) | glutamate 5-kinase |  |  | copy AA seq copy Nt seq
BJP36_17815 AOY81494.1 | 3956226 - 3957134 (+) | MBL fold metallo-hydrolase |  |  | copy AA seq copy Nt seq
BJP36_39135 WAN70079.1 | 3957084 - 3957266 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17810 AOY81493.2 | 3957686 - 3958516 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39140 WAN70080.1 | 3959108 - 3959278 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17805 AOY81492.1 | 3959667 - 3961007 (+) | ABC transporter substrate-binding protein |  |  | copy AA seq copy Nt seq
BJP36_17800 AOY81491.1 | 3961652 - 3962533 (+) | sugar ABC transporter permease |  |  | copy AA seq copy Nt seq
BJP36_17795 AOY81490.1 | 3962533 - 3963411 (+) | carbohydrate ABC transporter permease |  |  | copy AA seq copy Nt seq
BJP36_17790 AOY81489.2 | 3963385 - 3963753 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17785 AOY81488.2 | 3963756 - 3964106 (+) | four helix bundle protein |  |  | copy AA seq copy Nt seq
BJP36_17780 AOY81487.1 | 3964481 - 3965665 (+) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
BJP36_17775 AOY81486.1 | 3966056 - 3967264 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17770 AOY84739.2 | 3967386 - 3968852 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39145 WAN70081.1 | 3968930 - 3969058 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17765 AOY81485.1 | 3969055 - 3969834 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39150 WAN70082.1 | 3969861 - 3970016 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_39155 WAN70083.1 | 3970004 - 3970258 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BJP36_17760 AOY81484.1 | 3970150 - 3971211 (-) | catalase family protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2023-11-14
Add new entry for hectoramide B

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2023-11-14
Reviewed and approved.

- (ID: 55JKZ6YQD2AUFWZ45WR2BXVC)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2023-11-21
Reviewed and approved.

- (ID: C62OJVVH7XOTOTFZSJT727YU)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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Modifications to original record

- BJP36_32295 crossed the origin and was split into two features