BGC0002758: Azanidulone biosynthetic gene cluster from Aspergillus nidulans FGSC A4
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Location: 162,823 - 193,481 nt. (total: 30,659 nt).
This entry is originally from NCBI GenBank BN001302.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General information about the BGC

MIBiG accession | BGC0002758
Short description | Azanidulone biosynthetic gene cluster from Aspergillus nidulans FGSC A4
Status | Quality: high The quality level of this entry. Status: pending The status of this entry. Completeness: partial Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- PKS (Type I)

Loci
BN001302.1
162823 - 193481
via Knock-out studies [1], [2]
Compounds

- Azanidulone
- Anhydrosepedonin
- Antibiotic C
- Tripyrnidone
- DHMBA

Species Aspergillus nidulans FGSC A4 [taxonomy]
References

- [1] Breaking the Silence: Protein Stabilization Uncovers Silenced Biosynthetic Gene Clusters in the Fungus Aspergillus nidulans. Gerke, J et al., Applied and Environmental Microbiology (2012) DOI:10.1128/AEM.01808-12
- [2] Biosynthesis of Antibacterial Iron-Chelating Tropolones in Aspergillus nidulans as Response to Glycopeptide-Producing Streptomycetes. Gerke, J et al., Frontiers in Fungal Biology (2022) DOI:10.3389/ffunb.2021.777474

Chemical products information
Azanidulone [synonyms: 8(7H)-Dione, (7S)-7-Hydroxy-3, 7-Dimethyl-6H-2-Benzopyran-6] Evidence: NMR [2], Mass spectrometry [2], Mass spectrometry [2]
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C11H10O4
Anhydrosepedonin Evidence: NMR [2], Mass spectrometry [2]
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C11H10O4
Antibiotic C Evidence: NMR [2], Mass spectrometry [2]
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C11H10O5
Tripyrnidone Evidence: NMR [2]
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C17H16O7
DHMBA Evidence: Mass spectrometry [2]
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C11H12O4
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
ANIA_07893 CBF73471.1 | 162823 - 163921 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07894 CBF73473.1 | 164656 - 164988 (+) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07895 CBF73475.1 | 166471 - 167607 (+) | Zinc-binding alcohol dehydrogenase domain-containing protein cipB (EC 1.-.-.-)(Concanamycin-induced protein B) [Source:UniProtKB/Swiss-Prot;Acc:Q5AUY5] |  |  | copy AA seq copy Nt seq
ANIA_11583 CBF73477.1 | 168268 - 168475 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07896 CBF73479.1 | 170187 - 172241 (+) | Putative Zn(II)2Cys6 transcription factor (Eurofung) |  |  | copy AA seq copy Nt seq
ANIA_07897 CBF73480.1 | 172527 - 173807 (-) | FAD binding domain protein (AFU_orthologue; AFUA_6G00660) |  |  | copy AA seq copy Nt seq
ANIA_11584 CBF73482.1 | 174377 - 174766 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07898 CBF73484.1 | 174872 - 176410 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07899 CBF73486.1 | 177195 - 178031 (+) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07900 CBF73488.1 | 178329 - 179732 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07901 CBF73490.1 | 181233 - 182734 (+) | C6 transcription factor, putative (AFU_orthologue; AFUA_4G00710) |  |  | copy AA seq copy Nt seq
ANIA_07902 CBF73492.1 | 182894 - 184346 (-) | conserved hypothetical protein |  |  | copy AA seq copy Nt seq
ANIA_07903 CBF73494.1 | 187050 - 187921 (+) | hypothetical protein similar to polyketide synthase (Broad) |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2024-05-14
MIBiG v4 annotathon

- (ID: 53FVNBIJDE5BZLVBC3DS4JVW)
- (ID: VMOLOUVCS4IRTX6AW6KNNWOL)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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