BGC0002812 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002812 (Colletotrichum higginsianum IMI 349063)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS,NRPS-like	1	50,885	High	Colletochlorin A/Colletorin A/Colletochlorin B/Colletochlorin D/Colletorin D/Colletorin D acid/Orsellinic acid/Colletorin B	PKS:Type I+terpene:Monoterpene

BGC0002812 - Region 1 - NRPS-like,T1PKS

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Location: 1 - 50,885 nt. (total: 50,885 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX) and not alpha_am_amid)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 50,886
Label		BGC0002812

Tailoring functions

Transferases: halogenase

CH63R_05468: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
smcogs: SMCOG1119: halogenase

Ligases: ligase synthase

CH63R_05469: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

CH63R_05470: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002812.2	2.00	PKS, terpene	Colletochlorin A, Colletorin A, Colletochlorin B, Colletochlorin D, Colletorin D, Colletorin D acid, Orsellinic acid, Colletorin B	Colletotrichum higginsianum IMI 349063
BGC0002608.2	1.04	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001390.3	1.01	NRPS, PKS	LL-Z1272beta	Stachybotrys bisbyi
BGC0002341.2	0.90	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0001923.3	0.89	PKS, terpene	ascochlorin	Acremonium egyptiacum
BGC0000037.4	0.86	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001284.4	0.64	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.59	PKS	asperlactone	Aspergillus ochraceus
BGC0001626.3	0.59	PKS	isoindolinone	Stachybotrys chlorohalonata IBT 40285
BGC0001258.3	0.59	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002812.2	1.00	PKS, terpene	Colletochlorin A, Colletorin A, Colletochlorin B, Colletochlorin D, Colletorin D, Colletorin D acid, Orsellinic acid, Colletorin B	Colletotrichum higginsianum IMI 349063
BGC0002608.2	0.80	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0001390.3	0.79	NRPS, PKS	LL-Z1272beta	Stachybotrys bisbyi
BGC0002341.2	0.75	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0001923.3	0.75	PKS, terpene	ascochlorin	Acremonium egyptiacum
BGC0000037.4	0.74	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001626.3	0.63	PKS	isoindolinone	Stachybotrys chlorohalonata IBT 40285
BGC0001258.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 50885:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 46628:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 7482 - 50885:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal) + (X)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

CH63R_05469: mal

PKS_AT (914..1212): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 55.6
Methoxymalonyl-CoA: 53.5
inactive: 40.0
Methylmalonyl-CoA: 39.9
Ethylmalonyl-CoA: 23.2
Propionyl-CoA: 18.7
Benzoyl-CoA: 15.5
2-Methylbutyryl-CoA: 14.6
Acetyl-CoA: 13.9
CHC-CoA: 12.5
fatty_acid: 11.9
Isobutyryl-CoA: 11.4
trans-1,2-CPDA: 10.6
3-Methylbutyryl-CoA: 0.0

CH63R_05470: X

AMP-binding (43..365): X

nrpys: Gly, Ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: GLPMGGFHLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor