LOCUS       BGC0002826              5484 bp    DNA     linear   BCT 02-DEC-2016
DEFINITION  Clostridium cavendishii DSM 21758 genome assembly, contig:
            EJ30DRAFT_scaffold00006.6, whole genome shotgun sequence.
ACCESSION   BGC0002826
VERSION     BGC0002826
KEYWORDS    WGS.
SOURCE      Clostridium cavendishii DSM 21758
  ORGANISM  Clostridium cavendishii DSM 21758
            Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
            Clostridium.
REFERENCE   1
  AUTHORS   Varghese,N. and Submissions,S.
  TITLE     Direct Submission
  JOURNAL   Submitted (30-NOV-2016) DOE - JOINT GENOME INSTITUTE, LBNL, 2800
            Mitchell Drive, Walnut Creek, CA 94598, 94598, USA
COMMENT     ##antiSMASH-Data-START##
            Version     :: 8.dev-5707d64f
            Run date    :: 2025-08-15 22:36:51
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 0
            Orig. end   :: 5484
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     region          1..5484
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..5484
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0002826"
                     /subregion_number="1"
                     /tool="antismash"
     gene            73..1278
                     /locus_tag="SAMN02745163_01864"
     CDS             73..1278
                     /NRPS_PKS="Domain: AMP-binding (63-265). E-value: 1.7e-20.
                     Score: 64.9. Matches aSDomain:
                     nrpspksdomains_SAMN02745163_01864_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAMN02745163_01864"
                     /product="phenylacetate-CoA ligase"
                     /protein_id="SHJ39796.1"
                     /sec_met_domain="AMP-binding (E-value: 2.1e-19, bitscore:
                     57.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDSNSQLITKLNSALQIATKANFYKDRLGNIEIKSLDDFSKLPLT
                     TKEDLRKLKPMEALTVDIEDLFQYHESFGTTGEPVSTWLTEKDFNAYGDQLNEFGVNFK
                     STDIVLNRFPYAISVPAHIFTNAIHKKGACVIPVSKASAISPLKRVANLIYKLRPSILT
                     GIPDELIKLNKVAKFMDISLKDLGCIRAICTAGEMLSEGRKAKLESIFGAKVYNYYGCT
                     ECGNMAASCDEGHLHISKDFYVEILDPVTLKPVKEGKGKIIVTTLNKEAFPMIRYDLGD
                     IGEIKYEKCSCGNDRPVLIHHGREIDLIKTSKGTITFKELQEEIFKLPNSVVGDVFRVK
                     IQNDEVIVECEADEELDNSNSNLNLPIEVKIKRFNHGEILNIDNLIEIKPIAKPKYVEY
                     VD"
     aSDomain        262..867
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAMN02745163_01864_AMP-binding.1
                     "
                     /evalue="1.70E-20"
                     /label="SAMN02745163_01864_AMP-binding.1"
                     /locus_tag="SAMN02745163_01864"
                     /protein_end="265"
                     /protein_start="63"
                     /score="64.9"
                     /specificity="substrate consensus: Ala"
                     /tool="antismash"
                     /translation="EDLFQYHESFGTTGEPVSTWLTEKDFNAYGDQLNEFGVNFKSTDI
                     VLNRFPYAISVPAHIFTNAIHKKGACVIPVSKASAISPLKRVANLIYKLRPSILTGIPD
                     ELIKLNKVAKFMDISLKDLGCIRAICTAGEMLSEGRKAKLESIFGAKVYNYYGCTECGN
                     MAASCDEGHLHISKDFYVEILDPVTLKPVKEGKGKIIVT"
     gene            1346..2473
                     /locus_tag="SAMN02745163_01865"
     CDS             1346..2473
                     /codon_start=1
                     /locus_tag="SAMN02745163_01865"
                     /product="3-amino-4-hydroxybenzoic acid synthase"
                     /protein_id="SHJ39836.1"
                     /transl_table=11
                     /translation="MINKKDLWFDVTKLNEGEIKCLVPLATNNGYEGFFITPDQTDVVR
                     MLPANAKVLLSVCNENTERALEVVEELKDREVIVFSESREVLNKFDNVDTGLFLSVNDR
                     ESLDNTVEMSHYYKNIIIEFKSETNIPLELVLAFSQKNNCRVCKRVFEGSDGWVASMVM
                     EMGSHAVLLTSKEMKDVLELKEQLTKLGEYKMDVKELTVVGIEHIGMGDRVCVDTTSLL
                     KEDEGLILGSNSYGGILVSSETHFLPYMELRPFRVNAGALHLYSWCRNDKTAYLSELRA
                     GSEVMTVDSKGNTRSVSVGRIKMERRPLLLVKAQDDAGIEVNVILQDDWHVRVIGPNGA
                     PLNCTELKKGDKVLGYTCIPGRHVGIKIDENIIEK"
     gene            2510..3838
                     /locus_tag="SAMN02745163_01866"
     CDS             2510..3838
                     /NRPS_PKS="Domain: AMP-binding (92-355). E-value: 5e-21.
                     Score: 66.6. Matches aSDomain:
                     nrpspksdomains_SAMN02745163_01866_AMP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_kind="biosynthetic-additional"
                     /locus_tag="SAMN02745163_01866"
                     /product="phenylacetate-CoA ligase"
                     /protein_id="SHJ39872.1"
                     /sec_met_domain="AMP-binding (E-value: 3e-21, bitscore:
                     63.8, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLIINNNFISTKEKLGFLYNFINNNKTEYTEFSVEEKEEYTLEAL
                     KSVCNWVFNNNKFYNNAFSKADIGLDAIKTLDDFKKIPFLTKEDLRKDKYYTCSIPSNE
                     IAQVFSSTGTTGGKPIYMFHSWEDLYIRDLSMSNKLFDILSEDVVLNALPYEMSSSGLS
                     FHNACQSKIGATVISTGKGGFYSTPEKTVEIIRDLKPTIIITTPTYAMYIGQMLREAIS
                     ESNESINVRKIYLTGEGCSKAFKNRLENLWDSKCYAFYGSLEAGQIGVECSDGSGYHIY
                     GSHTYVEIVDPKTGEVLPEGSNGEVVITTLLRKGSPLVRYRTGDLGYIKTIDCACGIKD
                     KKLFLIGRTVQQVVLNGKDYSPIFLEQMLLSMNEVGNDYRFIVNKDNLTIKIVLAKGYK
                     CNDSIIENIENTFMKLTGIKNKVIVVPEFPRCPGKVIRVLYED"
     aSDomain        2786..3574
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_SAMN02745163_01866_AMP-binding.1
                     "
                     /evalue="5.00E-21"
                     /label="SAMN02745163_01866_AMP-binding.1"
                     /locus_tag="SAMN02745163_01866"
                     /protein_end="355"
                     /protein_start="92"
                     /score="66.6"
                     /specificity="substrate consensus: X"
                     /tool="antismash"
                     /translation="DKYYTCSIPSNEIAQVFSSTGTTGGKPIYMFHSWEDLYIRDLSMS
                     NKLFDILSEDVVLNALPYEMSSSGLSFHNACQSKIGATVISTGKGGFYSTPEKTVEIIR
                     DLKPTIIITTPTYAMYIGQMLREAISESNESINVRKIYLTGEGCSKAFKNRLENLWDSK
                     CYAFYGSLEAGQIGVECSDGSGYHIYGSHTYVEIVDPKTGEVLPEGSNGEVVITTLLRK
                     GSPLVRYRTGDLGYIKTIDCACGIKDKKLFLIGRTVQQVVL"
     gene            3886..4653
                     /locus_tag="SAMN02745163_01867"
     CDS             3886..4653
                     /codon_start=1
                     /locus_tag="SAMN02745163_01867"
                     /product="hypothetical protein"
                     /protein_id="SHJ39914.1"
                     /transl_table=11
                     /translation="MIIDAHAHITAKNYGSVEALIERYDEIGISKGVLVPGGMIDVRMM
                     DKVVSGEKPIATKPIPNYLVKDAMNKYPDRVFGFFCVDPNDGEVSINEFTDAVKTQGFC
                     GLKLAPIVHRFSLKSNIVKELARTCSELEVPCFFHTTDFEGSFTKDCHDLIKDCPNTKF
                     ILGHMGFGFSDSLSIEYAKKFENLYLETSCASTSIVRQAIQTLGDTKVIFGSEYPMDDP
                     FYALSKITCLKLSEKSFENVTCNNILNLLQKRG"
     gene            4660..5484
                     /locus_tag="SAMN02745163_01868"
     CDS             4660..5484
                     /codon_start=1
                     /locus_tag="SAMN02745163_01868"
                     /product="2-amino-3,7-dideoxy-D-threo-hept-6-ulosonate
                     synthase"
                     /protein_id="SHJ39949.1"
                     /transl_table=11
                     /translation="MRGKYSRLNKIFDPKSKNTIIVPMDHGITLGPIKGLENLDNNVHR
                     LAQNGVNAVLMHKGMINSCTDYNAYRNVAMVMHLSGSTMYTPNSGLKSITGSVYEAIAL
                     GCDAVSVHINIGDADEGKMFNDVANISSECLKYGIPLIAMVYARGKNVINEYAVDVVKH
                     SARVGAELGADIVKVNYTGSIESFQSVVEACPIPVVIAGGNKVDSEEMFLNNIYDAMKA
                     GARGVSIGRNVFQSDNMDYLTKAISDIVHGNKRIEAVIEEFKFNVNNKFSVV"
ORIGIN
        1 ttgttattta atagtataat acattcatat ttagcaaaaa aatacacttt ttcaaactta
       61 aaggaggtaa ttatggacag taattcccaa ttaataacaa aattgaattc agcattacaa
      121 attgctacaa aagccaactt ttacaaggac aggctaggta atattgaaat taaatcttta
      181 gatgattttt caaaattacc tttaactaca aaagaagacc ttcgaaagct aaaaccaatg
      241 gaagctttaa ctgtagatat agaagacctt ttccaatatc acgaatcttt tggaacaaca
      301 ggagaacctg tttcaacttg gcttactgaa aaagatttta atgcttatgg agatcaacta
      361 aatgaatttg gagtaaattt caaaagtaca gatattgtat taaatagatt cccatatgct
      421 atttcagttc cagctcatat ctttaccaat gcaattcata agaaaggagc ttgtgttata
      481 ccggttagta aggcctcagc aatttcacca ttaaaaagag ttgctaatct aatttataaa
      541 ctacgcccaa gcattcttac tggaattcca gatgaattaa taaaacttaa taaagttgct
      601 aagtttatgg acatatccct taaagatctt ggttgcatta gagcaatatg tactgctgga
      661 gaaatgcttt ctgaaggaag gaaagctaaa ctagaaagca tctttggagc taaagtctat
      721 aattattatg gatgtacaga gtgtggaaat atggctgcaa gctgtgatga gggacatctt
      781 cacatatcaa aagactttta tgttgaaatt ttagatccag ttactttaaa accagtaaaa
      841 gaaggcaaag gtaaaattat agtaactact ctaaataaag aagcttttcc gatgataaga
      901 tatgatttag gcgacatagg tgaaattaaa tatgaaaaat gtagctgtgg aaatgataga
      961 ccagtgctta ttcaccacgg aagagaaatc gatttaataa agacttctaa aggcacaatt
     1021 acatttaaag aattacaaga agaaatattt aaattaccta attctgtagt aggtgatgta
     1081 tttagagtaa aaattcaaaa cgatgaggtt atagtagaat gtgaagctga tgaagaactt
     1141 gataattcaa attctaattt aaatttacca atagaagtta aaattaaaag atttaatcat
     1201 ggagaaatcc ttaatataga taatcttata gaaattaaac caattgctaa accaaaatat
     1261 gtagaatatg tagattaatt ttcaaaaaat aatatgctta caaaaaaaat taaaaataaa
     1321 ttaaagttac tttaggaggt taattatgat taacaaaaaa gatttatggt ttgatgttac
     1381 aaaattaaat gagggagaaa ttaaatgttt agtaccactt gctactaaca atggttatga
     1441 gggcttcttt attacaccag atcaaactga tgtagtaaga atgttaccag caaatgcaaa
     1501 agtattactt tctgtatgca atgaaaatac tgaaagagca ttagaagtag ttgaggaatt
     1561 aaaagataga gaagtaattg tattctctga aagtagagaa gtattaaaca aatttgataa
     1621 tgttgataca gggttattct taagtgtaaa tgatagagaa tcattagata atactgttga
     1681 aatgtcacat tattataaaa acataataat agaatttaag tctgaaacta acattccgtt
     1741 agaattagta cttgcattct ctcaaaagaa taattgtaga gtttgtaaaa gggtttttga
     1801 aggaagcgat ggttgggtag cttcaatggt tatggaaatg ggaagtcatg ctgtactttt
     1861 aacatctaaa gaaatgaaag atgttttaga attgaaagaa caattaacaa aacttggtga
     1921 atacaagatg gatgttaagg aattaacagt tgttggtatt gagcatatag gtatgggaga
     1981 tagagtatgt gtagatacta cctcattatt aaaagaggat gaaggtttaa tcttaggttc
     2041 taactcatat ggtggaattc ttgtaagctc tgaaactcac ttcttaccat acatggaact
     2101 tagaccattt agagtaaatg ctggtgcatt acacttatat tcatggtgca gaaatgataa
     2161 aacagcgtat ctttctgaat taagagcagg tagcgaagtt atgactgttg attctaaagg
     2221 aaatactcgt tcagtttcag ttggcagaat aaaaatggaa agaagacctt tacttttagt
     2281 caaagctcaa gatgatgctg gaatagaagt aaatgttata ttacaagatg attggcatgt
     2341 tagagtaata gggcctaatg gagctccttt aaactgtaca gaacttaaaa agggtgataa
     2401 agttcttggt tatacttgta ttcctggtcg tcatgttggt ataaaaattg atgaaaatat
     2461 aatagaaaaa taagtgacta ttttagaatt atgttagaag gtgactgtat tgttaataat
     2521 caataataac tttattagta caaaagagaa actgggtttt ttatataatt ttattaataa
     2581 taacaaaaca gaatacacag aattttctgt agaagaaaaa gaagagtata ctttagaagc
     2641 tttaaaatct gtatgcaatt gggtttttaa caataacaaa ttttataata atgcattttc
     2701 taaagctgac ataggcttag atgccattaa aacattagat gactttaaaa agattccttt
     2761 tttgactaaa gaagatttac gtaaagacaa atattatact tgctctatac cttcaaatga
     2821 aatagctcaa gtattttcat ctactggtac aaccggaggt aaacctatat atatgtttca
     2881 ttcttgggaa gatttatata taagagatct ttctatgagc aacaaacttt ttgatatact
     2941 ctctgaggat gttgtattaa atgcattacc ttatgaaatg agttcttctg ggctttcatt
     3001 tcataatgca tgccaaagta aaataggtgc aacagtaata tctactggaa aaggtggctt
     3061 ttattcaact cctgaaaaaa cagtagaaat tattcgtgac ttaaaaccta ctataattat
     3121 aactacgcca acttatgcta tgtatatagg ccaaatgtta agagaagcta tttctgaaag
     3181 taatgaaagt attaatgtta gaaaaatata tcttactggt gaaggttgtt caaaagcatt
     3241 taaaaatcgt cttgaaaacc tttgggattc aaaatgttat gctttttatg gctctctaga
     3301 agctggtcaa ataggagttg aatgtagtga tggtagtggt tatcatatat acggttctca
     3361 tacctatgta gaaatagtgg acccaaagac aggagaagta ttacctgagg gcagtaatgg
     3421 agaagttgtt ataactacat tacttagaaa aggttctcca cttgtaagat atagaactgg
     3481 tgatttaggc tatataaaaa ctatagattg tgcctgcggt attaaggata aaaagttatt
     3541 tttaattggt agaactgtac agcaagtagt tttaaatggc aaggattatt ctcctatctt
     3601 cttagaacaa atgcttttat caatgaatga agttggtaat gactatagat ttatagtaaa
     3661 caaagacaat cttactataa aaatagtatt agctaaaggt tataaatgta atgactcaat
     3721 tatagaaaat atagaaaata catttatgaa gcttacagga ataaaaaata aagtcattgt
     3781 agttcctgaa ttccctagat gtccaggtaa agttatacga gtactttacg aagactagcc
     3841 taaattaatt atactatttt tatagatttt aaggaggtgt tatatatgat tatagatgca
     3901 catgctcata ttacggccaa aaactacggt tctgtagaag ctttaattga aagatatgat
     3961 gaaataggca tttctaaagg tgttttagtt cctggtggaa tgattgatgt aagaatgatg
     4021 gataaagttg tttctggtga aaagccaatt gcaactaagc ctatacctaa ctatttagtt
     4081 aaagatgcca tgaataaata tccagacaga gtatttggtt ttttctgcgt tgaccctaat
     4141 gacggtgaag tatctattaa tgagtttaca gatgcagtaa aaactcaagg gttttgtgga
     4201 ttaaaactag ctccgatagt tcataggttc tcgcttaaat ctaatatagt taaagaactt
     4261 gcaagaactt gttcagaact cgaagtacct tgtttctttc acacaacaga ttttgaaggt
     4321 tctttcacta aagattgcca tgacttaatt aaagattgtc caaatacaaa atttatctta
     4381 ggtcatatgg gttttggttt ttctgatagt ttatctattg aatatgctaa aaaatttgaa
     4441 aatttatatt tagaaacatc ttgtgcttct acttcaattg ttagacaagc aattcaaact
     4501 ttaggagaca ctaaagtaat attcggtagt gaatatccaa tggatgatcc attttatgcc
     4561 ttgtctaaaa taacatgttt gaaattaagt gaaaagtcat ttgagaatgt aacttgtaat
     4621 aatatattaa atttattaca gaaaagaggt taatattata tgagaggtaa atacagtaga
     4681 ttaaataaaa tattcgatcc aaaatctaaa aatacaataa tcgtacctat ggaccacgga
     4741 ataacactag gtccaattaa aggtttagaa aatttagata ataacgttca tagactagct
     4801 caaaatggtg taaatgcagt tctaatgcat aaaggtatga taaatagttg taccgactat
     4861 aatgcttata gaaatgtggc aatggtaatg catttatctg gtagcactat gtatacacct
     4921 aactctggtt tgaaatctat tacaggtagc gtatatgaag ctattgcatt aggttgcgat
     4981 gctgtttctg ttcatattaa tattggtgat gctgatgaag gcaagatgtt caatgatgta
     5041 gctaatattt catctgaatg ccttaaatat ggtattcccc taattgcaat ggtctatgct
     5101 aggggaaaaa atgttataaa tgaatatgct gttgatgttg taaaacattc agctagagta
     5161 ggagccgaac taggtgctga cattgttaaa gttaattata ctggctctat agagagtttc
     5221 caaagtgttg ttgaggcatg tcctattcct gtagtaattg caggagggaa taaggtggac
     5281 tctgaagaaa tgtttttaaa taatatatat gatgctatga aggcaggtgc cagaggggta
     5341 tccataggaa gaaatgtatt ccaaagcgat aatatggact acttaactaa ggctatctct
     5401 gatatagtac acggaaataa aagaattgaa gctgttatag aagaatttaa atttaacgta
     5461 aataacaagt tttcagttgt ataa
//
