BGC0002850: Lenziamide A biosynthetic gene cluster from Streptomyces PC5
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Location: 1 - 58,983 nt. (total: 58,983 nt).
This entry is originally from NCBI GenBank OR050662.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002850
Short description Lenziamide A biosynthetic gene cluster from Streptomyces PC5
Status Quality: high
The quality level of this entry.

Status: pending
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
Loci
OR050662.1
1 - 58983
via Homology-based prediction [1]
Compounds
  • Lenziamide A
  • Lenziamide B
Species Streptomyces PC5 [taxonomy]
References
Chemical products information
Lenziamide A Evidence: NMR [1]
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C57H87N11O11
Lenziamide B Evidence: NMR [1]
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C59H88N12O11
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • WMP36085.1
  • orf1
 1 - 669 (-) ABC transporter
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    • WMP36086.1
    • orf2
    		 666 - 1568 (-) ABC transporter
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      • WMP36087.1
      • orf3
      		 1586 - 2260 (-) AIM24 family protein
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        • WMP36088.1
        • orf4
        		 2332 - 3081 (+) peptidyl-tRNA hydrolase
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          • WMP36089.1
          • orf9
          		 3296 - 3508 (-) MbtH family protein
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            • WMP36090.1
            • orf10
            		 3604 - 4374 (-) thioesterase
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              • WMP36091.1
              • orf11
              		 5015 - 6019 (+) ParB N-terminal domain-containing protein
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                • WMP36092.1
                • lnzpA
                		 6103 - 6510 (-) aspartate 1-decarboxylase
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                  • WMP36093.1
                  • lnzpB
                  		 6492 - 7250 (-) N-N bond formation enzyme (KztT)
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                    • WMP36094.1
                    • lnzpC
                    		 7237 - 8595 (-) L-ornithine N-hydroxylase (KtzI)
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                      • WMP36095.1
                      • lnzpD
                      		 9020 - 46081 (+) Lenziamides core NRPS
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                        • WMP36096.1
                        • orf12
                        		 46350 - 47099 (+) DUF4142 domain-containing protein
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                          • WMP36097.1
                          • orf13
                          		 47221 - 48549 (+) DUF692 domain-containing protein
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                            • WMP36098.1
                            • orf14
                            		 48555 - 49610 (+) TIGR04222 domain-containing membrane protein
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                              • WMP36099.1
                              • orf15
                              		 49760 - 51322 (+) alpha/beta hydrolase
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                                • WMP36100.1
                                • orf16
                                		 51479 - 52207 (-) chlorite dismutase family protein
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                                  • WMP36101.1
                                  • orf17
                                  		 52212 - 53675 (-) protoporphyrinogen oxidase
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                                    • WMP36102.1
                                    • orf18
                                    		 53802 - 54767 (+) DUF4349 domain-containing protein
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                                      • WMP36103.1
                                      • orf19
                                      		 54834 - 56225 (+) FAD-dependent oxidoreductase
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                                        • WMP36104.1
                                        • orf20
                                        		 56256 - 57353 (-) uroporphyrinogen decarboxylase
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                                          • WMP36105.1
                                          • orf21
                                          		 57524 - 58108 (+) DUF3000 domain-containing protein
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                                            • WMP36106.1
                                            • orf22
                                            		 58321 - 58983 (+) response regulator transcription factor
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                                              Biosynthesis information
                                              Annotation changelog

                                              Entry version: next

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2024-07-23
                                              MIBiG v4 annotathon
                                              • (ID: 6NSEHDSBVKYTX3SHWHOOIJMO)
                                              • (ID: DG4477I3NOB53FE2RWVWGK44)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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