BGC0002867: chlorogeumsanol B biosynthetic gene cluster from Penicillium meliponae MMSRG-058
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Location: 1 - 74,487 nt. (total: 74,487 nt).
This entry is originally from NCBI GenBank ON087600.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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General
Compounds
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Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0002867
Short description chlorogeumsanol B biosynthetic gene cluster from Penicillium meliponae MMSRG-058
Status Quality: high
The quality level of this entry.

Status: pending
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
ON087600.1
1 - 74487
via Knock-out studies [1]
Compounds
  • chlorogeumsanol B
  • 7-deacetylisochromophilone VI
  • isochromophilone VI
  • ochrephilone
  • isorotiorin
  • Sclerotiorin
  • geumsanol B
Species Penicillium meliponae MMSRG-058 [taxonomy]
References
Chemical products information
chlorogeumsanol B Evidence: NMR [1], [4]
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C23H29Cl1O7
7-deacetylisochromophilone VI Evidence: NMR [1], [4]
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C22H28Cl1N1O4
isochromophilone VI Evidence: NMR [1], [4]
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C23H28Cl1N1O5
Chemical database entries
ChEMBL
ochrephilone Evidence: NMR [1], [3]
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C23H26O5
isorotiorin Evidence: NMR [1], [5]
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C23H28O5
Chemical database entries
PubCHEM
Sclerotiorin Evidence: NMR [1], [4]
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C21H23Cl1O5
Chemical database entries
ChEBI
geumsanol B Evidence: NMR [1], [2]
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C23H30O7
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • WDW19270.1
 1245 - 2780 (-) hypothetical protein
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    • WDW19271.1
    		 3922 - 5901 (-) putative carotenoid oxygenase
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      • WDW19272.1
      		 7042 - 8409 (+) phytoene desaturase
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        • WDW19273.1
        		 9982 - 11362 (+) terpene cyclase
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          • WDW19274.1
          		 11911 - 13659 (+) phytoene desaturase
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            • WDW19275.1
            • sclA
            		 14959 - 23010 (+) HR polyketide synthase
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              • WDW19276.1
              • sclB
              		 23433 - 25507 (+) DUF4246
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                • WDW19277.1
                • sclC
                		 26778 - 28580 (-) trp halogenase
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                  • WDW19278.1
                  • sclD
                  		 30324 - 31863 (-) FAD-dependent monooxygenase
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                    • WDW19279.1
                    • sclE
                    		 34660 - 36733 (+) putative Zn(II)2Cys6 transcription factor
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                      • WDW19280.1
                      • sclF
                      		 38190 - 39353 (+) enoyl reductase-like protein
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                        • WDW19281.1
                        • sclG
                        		 39865 - 41894 (-) MFS general substrate transporter
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                          • WDW19282.1
                          • sclH
                          		 42621 - 43970 (+) 3-O-acetyltransferase
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                            • WDW19283.1
                            • sclI
                            		 46074 - 54296 (+) NR polyketide synthase
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                              • WDW19284.1
                              • sclJ
                              		 55547 - 57084 (+) FAD-oxidoredutase
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                                • WDW19285.1
                                • sclL
                                		 57796 - 58544 (+) membrane protein
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                                  • WDW19286.1
                                  • sclM
                                  		 59670 - 60950 (-) hypothetical protein
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                                    • WDW19287.1
                                    		 62969 - 63922 (-) hypothetical protein
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                                      • WDW19288.1
                                      • sclN
                                      		 65991 - 67016 (+) enoyl reductase-like protein
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                                        • WDW19289.1
                                        		 67648 - 70131 (+) hypothetical protein
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                                          • WDW19290.1
                                          		 70367 - 71054 (-) hypothetical protein
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                                            • WDW19291.1
                                            		 71823 - 74135 (-) DUF3176
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                                              Biosynthesis information

                                              No biosynthesis information available for this record.

                                              Annotation changelog

                                              Entry version: 1

                                              Date
                                              Changes
                                              Submitters
                                              Reviewers
                                              2024-07-23
                                              MIBiG v4 annotathon
                                              • (ID: HQK5QRJG545WJNJ7WXNPOI57)
                                              • (ID: WGYEEFADVXA7X4KRF2R4CDK4)
                                              • (ID: EKZKD775F36BLONCQ7EXF7ZS)
                                              • (ID: T7MU7F6CABXHLLSWTBE26RIT)
                                              • (ID: RKFOW2BJ2UIGZ6GYHFZX4BHF)
                                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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