BGC0002886: Dolastatin 10 biosynthetic gene cluster from Caldora penicillata FK14-30
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Location: 1 - 37,338 nt. (total: 37,338 nt).
This entry is originally from NCBI GenBank OR852429.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0002886
Short description Dolastatin 10 biosynthetic gene cluster from Caldora penicillata FK14-30
Status Quality: questionable
The quality level of this entry.

Status: pending
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "NCBI Taxonomy ID is given for C. penicillata. ID for this particular strain is not available. Changed coordinates to exclude additional unrelated genes."
Biosynthetic class(es)
  • NRPS (Type I)
  • PKS (Type I)
Loci
OR852429.1
1 - 37338
via Enzymatic assays [1]
Compounds
  • Dolastatin 10
Species Caldora penicillata FK14-30 [taxonomy]
References
Chemical products information
Dolastatin 10 Evidence: NMR [2]
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C42H68N6O6S1
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • WZC35271.1
  • dolA
 199 - 1854 (+) class I SAM-dependent methyltransferase
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    • WZC35272.1
    • dolB
    		 1896 - 5039 (+) non-ribosomal peptide synthetase
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      • WZC35273.1
      • dolC
      		 5039 - 12988 (+) non-ribosomal peptide synthetase
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        • WZC35274.1
        		 12999 - 13838 (+) class I SAM-dependent methyltransferase
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          • WZC35275.1
          • dolE
          		 13851 - 14720 (+) class I SAM-dependent methyltransferase
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            • WZC35276.1
            • dolF
            		 14949 - 19628 (+) polyketide synthase
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              • WZC35277.1
              • dolG
              		 19671 - 23027 (+) non-ribosomal peptide synthetase
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                • WZC35278.1
                • dolH
                		 23030 - 27700 (+) polyketide synthase
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                  • WZC35279.1
                  • dolI
                  		 27886 - 35310 (+) non-ribosomal peptide synthetase
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                    • WZC35280.1
                    • dolJ
                    		 35374 - 36459 (+) nonheme diiron monooxygenase
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                      • WZC35281.1
                      		 36466 - 37338 (-) cyclase
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                        Biosynthesis information
                        Annotation changelog

                        Entry version: next

                        Date
                        Changes
                        Submitters
                        Reviewers
                        2024-06-13
                        MIBiG v4 annotathon
                        • (ID: 5EV2ZHN6GEKCSCIWNEHXDURC)
                        • (ID: E3BGRDDSXQC4BVVGLJQTVJNI)
                        • (ID: Q4G2APLPZNOU4XV72H6GYP54)
                        • (ID: B54ZPFB4PBVBWY2K6JZNBOD5)
                        • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                        Detailed domain annotation
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