BGC0002892: kistamicin biosynthetic gene cluster from Actinomadura parvosata subsp. kistnae
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1,780,967 - 1,852,209 nt. (total: 71,243 nt).
This entry is originally from NCBI GenBank CP017717.1.

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset view
zoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC

MIBiG accession | BGC0002892
Short description | kistamicin biosynthetic gene cluster from Actinomadura parvosata subsp. kistnae
Status | Quality: questionable The quality level of this entry. Status: pending The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)

Remarks "Nonomuraea sp. ATCC55076"
Biosynthetic class(es)

- NRPS (Type I)

Loci
CP017717.1
1780967 - 1852209
via Gene expression correlated with compound production [1], [2]
Compounds

- kistamicin

Species Actinomadura parvosata subsp. kistnae [taxonomy]
References

- [1] Kistamicin biosynthesis reveals the biosynthetic requirements for production of highly crosslinked glycopeptide antibiotics. Greule, A et al., Nature Communications (2019) DOI:10.1038/s41467-019-10384-w
- [2] Nonomuraea sp. ATCC 55076 harbours the largest actinomycete chromosome to date and the kistamicin biosynthetic gene cluster. Nazari, B et al., MedChemComm (2017) DOI:10.1039/C6MD00637J

Chemical products information
kistamicin [synonyms: kistamycin] Evidence:
Copy SMILES
C61H51Cl1N8O15
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
BKM31_07955 AQZ61417.1 | 1782026 - 1782319 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_07960 AQZ61418.1 | 1782320 - 1783009 (-) | NAD(P)H dehydrogenase |  |  | copy AA seq copy Nt seq
BKM31_07965 AQZ61419.1 | 1783104 - 1783556 (+) | MarR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_07970 AQZ61420.1 | 1783574 - 1784461 (-) | aminoglycoside phosphotransferase |  |  | copy AA seq copy Nt seq
BKM31_07975 AQZ70222.1 | 1784775 - 1785410 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_07980 AQZ70223.1 | 1785500 - 1786669 (+) | acyltransferase |  |  | copy AA seq copy Nt seq
BKM31_07985 AQZ70224.1 | 1786762 - 1787301 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_07990 AQZ61421.1 | 1787298 - 1787981 (+) | DNA-binding response regulator |  |  | copy AA seq copy Nt seq
BKM31_07995 AQZ61422.1 | 1787978 - 1789426 (+) | two-component sensor histidine kinase |  |  | copy AA seq copy Nt seq
BKM31_08000 AQZ61423.1 | 1789498 - 1791510 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08005 AQZ61424.1 | 1791575 - 1791832 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08010 AQZ61425.1 | 1791973 - 1792551 (-) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08015 AQZ61426.1 | 1792548 - 1793339 (-) | retinol dehydrogenase |  |  | copy AA seq copy Nt seq
BKM31_08020 AQZ70225.1 | 1793373 - 1794326 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08025 AQZ61427.1 | 1794453 - 1795121 (+) | methyltransferase |  |  | copy AA seq copy Nt seq
BKM31_08030 AQZ61428.1 | 1795134 - 1796462 (-) | FAD-linked oxidase |  |  | copy AA seq copy Nt seq
BKM31_08035 AQZ61429.1 | 1796522 - 1797940 (+) | GntR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08040 AQZ61430.1 | 1798031 - 1798696 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08045 AQZ61431.1 | 1799087 - 1799575 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08050 AQZ61432.1 | 1799596 - 1802586 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08055 AQZ61433.1 | 1802654 - 1803745 (+) | sugar ABC transporter substrate-binding protein |  |  | copy AA seq copy Nt seq
BKM31_08060 AQZ61434.1 | 1803745 - 1804515 (+) | ABC transporter ATP-binding protein |  |  | copy AA seq copy Nt seq
BKM31_08065 | 1804529 - 1805518 (+) | iron transporter |  |  | copy AA seq copy Nt seq
BKM31_08070 AQZ61435.1 | 1805620 - 1806972 (+) | MFS transporter |  |  | copy AA seq copy Nt seq
BKM31_08075 AQZ70226.1 | 1807126 - 1808454 (+) | flavoprotein |  |  | copy AA seq copy Nt seq
BKM31_08080 AQZ61436.1 | 1808514 - 1808852 (+) | transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08085 AQZ61437.1 | 1808857 - 1809228 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08090 AQZ61438.1 | 1809558 - 1810301 (+) | short-chain dehydrogenase |  |  | copy AA seq copy Nt seq
BKM31_08095 AQZ70227.1 | 1810436 - 1811305 (+) | RNA polymerase subunit sigma-70 |  |  | copy AA seq copy Nt seq
BKM31_08100 AQZ61439.1 | 1811649 - 1812092 (-) | MarR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08105 AQZ61440.1 | 1812179 - 1813534 (+) | MFS transporter |  |  | copy AA seq copy Nt seq
BKM31_08110 AQZ61441.1 | 1813571 - 1813996 (+) | cobalamin adenosyltransferase |  |  | copy AA seq copy Nt seq
BKM31_08115 AQZ61442.1 | 1814101 - 1814466 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08120 AQZ61443.1 | 1814566 - 1815462 (-) | LLM class F420-dependent oxidoreductase |  |  | copy AA seq copy Nt seq
BKM31_08125 AQZ61444.1 | 1815562 - 1816140 (+) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08130 AQZ61445.1 | 1816185 - 1819526 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08135 AQZ61446.1 | 1819767 - 1820768 (-) | LysR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08140 AQZ61447.1 | 1820998 - 1822224 (+) | MFS transporter |  |  | copy AA seq copy Nt seq
BKM31_08145 AQZ61448.1 | 1822355 - 1824409 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08150 AQZ70228.1 | 1824375 - 1825259 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08155 AQZ61449.1 | 1825372 - 1825791 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08160 AQZ61450.1 | 1825844 - 1827559 (+) | copper oxidase |  |  | copy AA seq copy Nt seq
BKM31_08165 AQZ61451.1 | 1827713 - 1829806 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08170 AQZ61452.1 | 1829799 - 1831751 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08175 AQZ61453.1 | 1831862 - 1833637 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08180 AQZ61454.1 | 1833627 - 1833806 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08185 AQZ61455.1 | 1834058 - 1836799 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08190 AQZ61456.1 | 1836796 - 1838136 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08195 AQZ61457.1 | 1838124 - 1839326 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08200 AQZ61458.1 | 1839445 - 1840092 (-) | GntR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08205 AQZ61459.1 | 1840194 - 1840775 (+) | kinase inhibitor |  |  | copy AA seq copy Nt seq
BKM31_08210 AQZ61460.1 | 1840772 - 1841176 (+) | cupin |  |  | copy AA seq copy Nt seq
BKM31_08215 AQZ61461.1 | 1841216 - 1841950 (+) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08220 AQZ61462.1 | 1842055 - 1842912 (-) | NAD(P)-dependent oxidoreductase |  |  | copy AA seq copy Nt seq
BKM31_08225 AQZ61463.1 | 1842983 - 1843789 (-) | NADPH-dependent ferric siderophore reductase |  |  | copy AA seq copy Nt seq
BKM31_08230 AQZ61464.1 | 1843803 - 1844711 (-) | phthalate 4,5-dioxygenase |  |  | copy AA seq copy Nt seq
BKM31_08235 AQZ61465.1 | 1844727 - 1845371 (-) | flavin-nucleotide-binding protein |  |  | copy AA seq copy Nt seq
BKM31_08240 AQZ61466.1 | 1845442 - 1846056 (+) | TetR family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08245 AQZ61467.1 | 1846067 - 1847317 (-) | cytochrome |  |  | copy AA seq copy Nt seq
BKM31_08250 AQZ61468.1 | 1847400 - 1848317 (-) | AraC family transcriptional regulator |  |  | copy AA seq copy Nt seq
BKM31_08255 AQZ61469.1 | 1848400 - 1849245 (+) | NAD(P)-dependent oxidoreductase |  |  | copy AA seq copy Nt seq
BKM31_08260 AQZ61470.1 | 1849405 - 1850532 (+) | hypothetical protein |  |  | copy AA seq copy Nt seq
BKM31_08265 AQZ70229.1 | 1850549 - 1851706 (-) | rod shape-determining protein RodA |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2024-07-23
MIBiG v4 annotathon

- (ID: TVYWRCMOBR5VOOLSE2IIZG7H)
- (ID: W3QOK3QPXTRJDCB4DPJ3LOBQ)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Similar known clusters from MIBiG 4.0
Shows clusters from the MIBiG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
Detailed help and explanations are available here.
Click on reference genes to show details of similarities to genes within the current region.
Double click on a reference drawing to reverse the display of the genes.
Click on an accession to open that entry in the MIBiG database.
Location:
Identifier
Identity
Coverage