BGC0002906: arabidiol biosynthetic gene cluster from Arabidopsis thaliana
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Location: 8,730,499 - 8,813,593 nt. (total: 83,095 nt).
This entry is originally from NCBI GenBank NC_003076, but has been modified (see Modifications tab for details).

#### Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
Modifications
General information about the BGC

MIBiG accession | BGC0002906
Short description | arabidiol biosynthetic gene cluster from Arabidopsis thaliana
Status | Quality: high The quality level of this entry. Status: pending The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- terpene (Triterpene)

Loci
NC_003076
8730499 - 8813593
via Heterologous expression [2]
Compounds

- arabidiol
- baruol

Species Arabidopsis thaliana [taxonomy]
References

- [1] An Oxidosqualene Cyclase Makes Numerous Products by Diverse Mechanisms:  A Challenge to Prevailing Concepts of Triterpene Biosynthesis. Lodeiro, S et al., Journal of the American Chemical Society (2007) DOI:10.1021/ja073133u
- [2] A specialized metabolic network selectively modulates Arabidopsis root microbiota. Huang, A et al., Science (2019) DOI:10.1126/science.aau6389

Chemical products information
arabidiol [synonyms: 5E)-2-hydroxy-6, 3aR, 9bR)-3-[(2R, 9a-tetramethyldodecahydro-1H-cyclopenta[a]naphthalen-7-ol, 10-dimethylundeca-5, 14-diol, (3R, (13R)-malabarica-17, 5aR, 21-diene-3beta, 9aR, 7S, 6, 9-dien-2-yl]-3a] Evidence: Mass spectrometry [2]
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C30H52O2
Chemical database entries
PubCHEM
ChEBI
baruol [synonyms: 6a, 4aS, 21-dien-3-ol, 3, 8, 10b, 6aS, 4b, 4a, 9, (2S, 4, 11-hexadecahydrochrysen-2-ol, 10bS)-1, 2, 10a, D:B-friedobaccharan-5, 1, 10a-hexamethyl-8-(4-methylpent-3-en-1-yl)-1, 8R, 10, 10aR, 6, 7, 4bR, 5] Evidence: Mass spectrometry [1]
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C30H50O1
Chemical database entries
PubCHEM
ChEBI
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AT5G25220_rename1 NP_001031938.1 KNAT3 | 8736208 - 8738087 (+) | homeobox protein knotted-1-like 3 |  |  | copy AA seq copy Nt seq
AT5G25220 NP_197904.1 KNAT3 | 8736208 - 8738115 (+) | homeobox protein knotted-1-like 3 |  |  | copy AA seq copy Nt seq
AT5G25230 NP_001318643.1 | 8739709 - 8743594 (+) | Ribosomal protein S5/Elongation factor G/III/V family protein |  |  | copy AA seq copy Nt seq
AT5G25240 NP_197906.1 | 8746779 - 8747174 (-) | stress induced protein |  |  | copy AA seq copy Nt seq
AT5G25250 NP_197907.1 FLOT1 | 8749774 - 8751430 (+) | SPFH/Band 7/PHB domain-containing membrane-associated protein family |  |  | copy AA seq copy Nt seq
AT5G25260 NP_197908.1 | 8752751 - 8754282 (+) | SPFH/Band 7/PHB domain-containing membrane-associated protein family |  |  | copy AA seq copy Nt seq
AT5G25265 NP_680219.1 | 8754794 - 8756855 (-) | Hyp O-arabinosyltransferase-like protein |  |  | copy AA seq copy Nt seq
AT5G25270 NP_001318644.1 | 8757783 - 8762002 (-) | Ubiquitin-like superfamily protein |  |  | copy AA seq copy Nt seq
AT5G25280 NP_001332588.1 | 8773882 - 8774544 (+) | serine-rich protein-like protein |  |  | copy AA seq copy Nt seq
AT5G25290 NP_197911.1 | 8778592 - 8779785 (+) | F-box protein (DUF295) |  |  | copy AA seq copy Nt seq
AT5G25300 NP_197912.4 | 8780258 - 8783093 (+) | F-box protein |  |  | copy AA seq copy Nt seq
AT5G25310 NP_197913.4 | 8784820 - 8787235 (+) | Exostosin family protein |  |  | copy AA seq copy Nt seq
AT5G25320_rename1 NP_001330098.1 | 8787403 - 8789209 (-) | ACT-like superfamily protein |  |  | copy AA seq copy Nt seq
AT5G25320 NP_197914.1 | 8787403 - 8789530 (-) | ACT-like superfamily protein |  |  | copy AA seq copy Nt seq
AT5G25320_rename2 NP_001330097.1 | 8787865 - 8789530 (-) | ACT-like superfamily protein |  |  | copy AA seq copy Nt seq
AT5G25330 NP_197915.1 | 8791564 - 8792664 (+) | Core-2/I-branching beta-1,6-N-acetylglucosaminyltransferase family protein |  |  | copy AA seq copy Nt seq
AT5G25340 NP_197916.1 | 8793238 - 8794211 (+) | Ubiquitin-like superfamily protein |  |  | copy AA seq copy Nt seq
AT5G25350 NP_197917.1 EBF2 | 8794842 - 8796882 (-) | EIN3-binding F box protein 2 |  |  | copy AA seq copy Nt seq
AT5G25360_rename1 NP_001330286.1 | 8799934 - 8802161 (-) | uncharacterized protein |  |  | copy AA seq copy Nt seq
AT5G25360 NP_197918.1 | 8799934 - 8802333 (-) | uncharacterized protein |  |  | copy AA seq copy Nt seq
AT5G25370_rename1 NP_001331648.1 PLDALPHA3 | 8804240 - 8807237 (-) | phospholipase D alpha 3 |  |  | copy AA seq copy Nt seq
AT5G25370 NP_001318645.1 PLDALPHA3 | 8804240 - 8807547 (-) | phospholipase D alpha 3 |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2024-07-23
MIBiG v4 annotathon

- (ID: AP4OPPCC6CSE5F433WMY7TMD)
- (ID: Q4G2APLPZNOU4XV72H6GYP54)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Similar known clusters from MIBiG 4.0
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No significant matches found.

Modifications to original record

- renamed CDS with name AT5G25220 at join{[8736207:8736888](+), [8737163:8737284](+), [8737372:8737557](+), [8737634:8737766](+), [8737844:8737981](+), [8738083:8738087](+)} to AT5G25220_rename1 to avoid duplicates
- removed an exact duplicate of CDS feature AT5G25230
- removed an exact duplicate of CDS feature AT5G25280
- removed an exact duplicate of CDS feature AT5G25280
- renamed CDS with name AT5G25320 at join{[8789088:8789209](-), [8788931:8788999](-), [8788136:8788844](-), [8787949:8788054](-), [8787402:8787786](-)} to AT5G25320_rename1 to avoid duplicates
- renamed CDS with name AT5G25320 at join{[8789459:8789530](-), [8789301:8789353](-), [8789088:8789203](-), [8788931:8788999](-), [8788136:8788844](-), [8787949:8788054](-), [8787864:8787879](-)} to AT5G25320_rename2 to avoid duplicates
- removed an exact duplicate of CDS feature AT5G25360
- renamed CDS with name AT5G25360 at join{[8801964:8802161](-), [8801504:8801749](-), [8800764:8800852](-), [8800068:8800135](-), [8799933:8799987](-)} to AT5G25360_rename1 to avoid duplicates
- removed an exact duplicate of CDS feature AT5G25370
- removed an exact duplicate of CDS feature AT5G25370
- renamed CDS with name AT5G25370 at join{[8806153:8807237](-), [8805048:8805756](-), [8804239:8804685](-)} to AT5G25370_rename1 to avoid duplicates