{"accession":"BGC0002929","version":1,"changelog":{"releases":[{"version":"1","entries":[{"contributors":["XHGUMDYTPFJLKYNSR4GE4XPC","SKC4XYF2AQLXBPOFDVNEXQZ2"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2024-05-17","comment":"MIBiG v4 annotathon"}],"date":"2024-11-15"}]},"quality":"high","status":"pending","completeness":"unknown","loci":[{"accession":"CM000151.3","location":{"from":499181,"to":506804},"evidence":[{"method":"Knock-out studies","references":["doi:10.1073/pnas.2116122119"]},{"method":"Gene expression correlated with compound production","references":["doi:10.1073/pnas.2116122119"]}]}],"biosynthesis":{"classes":[{"class":"PKS","subclass":"Type I","cyclases":[],"ketide_length":9}]},"compounds":[{"name":"Dictyodene A","evidence":[{"method":"NMR","references":["doi:10.1073/pnas.2116122119"]}],"classes":["Linear polyketide"],"bioactivities":[{"name":"antifungal","observed":false,"references":["doi:10.1073/pnas.2116122119"],"assays":[{"concentration":"12.5 µg/mL","target":"antifungal"}]}],"structure":"C[C@@H](O)C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C(/C)C(O)=O","mass":300.1725,"formula":"C19H24O3"},{"name":"Dictyodene B","evidence":[{"method":"NMR","references":["doi:10.1073/pnas.2116122119"]}],"classes":["Linear polyketide"],"bioactivities":[{"name":"inhibitor","observed":false,"references":["doi:10.1073/pnas.2116122119"],"assays":[{"concentration":"58.0 µg/mL","target":"inhibitor"}]},{"name":"antifungal","observed":false,"references":["doi:10.1073/pnas.2116122119"],"assays":[{"concentration":"12.5 µg/mL","target":"antifungal"}]}],"structure":"C[C@@H](O)C\\C=C\\C=C\\C=C\\C=C\\C=C\\C=C(/C)\\C=C\\C(O)=O","mass":300.1725,"formula":"C19H24O3"}],"taxonomy":{"name":"Dictyostelium discoideum AX4","ncbiTaxId":352472},"comment":"Authors used strain AX2, but the identification of this PKS gene is based on genetic sequence of AX4, as that is the only available. Also, they directly reference the works done on strain AX4 when discussing DNA and RNA sequence data. "}