BGC0002959 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0002959 (Streptomyces albospinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	HR-T2PKS	1	41,227

BGC0002959 - Region 1 - HR-T2PKS

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Location: 1 - 41,227 nt. (total: 41,227 nt) Show pHMM detection rules used

Region on contig edge.

HR-T2PKS: (hr-t2pks-ksa and (t2fas or APE_KS2 or ketoacyl-synt))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 41,228
Label		BGC0002959

Tailoring functions

Oxidoreductases: dehydrogenase

IEZ17_RS15975: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase aminotransferase

IEZ17_RS16030: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

IEZ17_RS16035: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Lyases: lyase

IEZ17_RS16025: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Ligases: ligase synthase

IEZ17_RS15985: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

IEZ17_RS15995: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

IEZ17_RS16005: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.52	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000853.3	0.45	other (other)	ectoine	Streptomyces anulatus
BGC0001850.4	0.44	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0002711.2	0.44	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002000.4	0.44	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Reference	Similarity score	Type	Compound(s)	Organism
BGC0002458.3	0.52	NRPS	alazopeptin	Streptacidiphilus griseoplanus
BGC0000231.5	0.47	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000858.3	0.47	other (other)	ectoine	Methylobacter marinus
BGC0001197.5	0.45	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000853.3	0.45	other (other)	ectoine	Streptomyces anulatus
BGC0001850.4	0.44	other (shikimate-derived)	diazaquinomycin A, diazaquinomycin E, diazaquinomycin F, diazaquinomycin G	Streptomyces sp. F001
BGC0002711.2	0.44	PKS	nostovalerolactone, 9-dehydronostovalerolactone	Nostoc punctiforme PCC 73102
BGC0002000.4	0.44	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0001987.2	0.44	PKS	koreenceine A, koreenceine B, koreenceine C, koreenceine D	Pseudomonas koreensis
BGC0000234.5	0.43	PKS	jadomycin	Streptomyces venezuelae ATCC 10712

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

IEZ17_RS15985: X

AMP-binding (43..381): X

nrpys: Gly, Ala, Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GGLVGCLVK
Nearest Stachelhaus code(s):: Thr DGMLVGAIVK (47% 8Å match); fa MGGGFGCLMK (32% 8Å match)
Stachelhaus code match:: 60% (weak)

IEZ17_RS16005: X

AMP-binding (48..433): X

nrpys: (unknown)

SVM prediction details:

NOTE: uncertain match

Predicted physicochemical class:: hydrophilic (Arg, Asp, Glu, Asn, Lys, Gln, Orn, Aad)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: NSAYWT--EK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

Link to PARAS substrate predictor