LOCUS       BGC0003054             20599 bp    DNA     linear   PLN 01-DEC-2021
DEFINITION  Aspergillus flavipes strain CNL-338 tnd gene cluster, complete
            sequence.
ACCESSION   BGC0003054
VERSION     BGC0003054
KEYWORDS    .
SOURCE      Aspergillus flavipes
  ORGANISM  Aspergillus flavipes
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Eurotiomycetes; Eurotiomycetidae; Eurotiales; Aspergillaceae;
            Aspergillus; Aspergillus subgen. Circumdati.
REFERENCE   1  (bases 1 to 20599)
  AUTHORS   Zhang,P., Wu,G., Heard,S.C. and Winter,J.M.
  TITLE     Genome Mining for Bifunctional Terpene Synthases in a Marine-Derived
            Fungus Unveils a New Type I Diterpene Synthase Involved in the
            Formation of an Unprecedented 5-8-6 Tricyclic Ring System
  JOURNAL   Unpublished
REFERENCE   2  (bases 1 to 20599)
  AUTHORS   Zhang,P., Wu,G., Heard,S.C. and Winter,J.M.
  TITLE     Direct Submission
  JOURNAL   Submitted (11-NOV-2020) Medicinal Chemistry, University of Utah, 30
            South 2000 East, Salt Lake City, UT 84112, USA
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: SOAPdenovo v. SOAPdenovo2
            Sequencing Technology :: Illumina
            ##Assembly-Data-END##
            ##antiSMASH-Data-START##
            Version               :: 8.dev-5707d64f
            Run date              :: 2025-08-15 23:00:55
            NOTE :: This is a single region extracted from a larger record!
            Orig. start           :: 0
            Orig. end             :: 20599
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..20599
                     /db_xref="taxon:41900"
                     /geo_loc_name="Bahamas"
                     /host="Laurencia sp."
                     /mol_type="genomic DNA"
                     /organism="Aspergillus flavipes"
                     /strain="CNL-338"
     misc_feature    1..20599
                     /note="tnd gene cluster"
     region          1..20599
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="terpene"
                     /region_number="1"
                     /rules="(PT_phytoene_like or phytoene_synt or Lycopene_cycl
                     or Lycopene_cycl_fung or T1TS or T1TS_KS or T2TS or TS_UbiA
                     or TS_Pyr4)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..20599
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0003054"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..20599
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /kind="single"
                     /product="terpene"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..20599
                     /aStool="rule-based-clusters"
                     /category="terpene"
                     /contig_edge="True"
                     /core_location="[9448:12176](+)"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      9449..12176
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(PT_phytoene_like or phytoene_synt or
                     Lycopene_cycl or Lycopene_cycl_fung or T1TS or T1TS_KS or
                     T2TS or TS_UbiA or TS_Pyr4)"
                     /neighbourhood="10000"
                     /product="terpene"
                     /protocluster_number="1"
     mRNA            join(<358..525,592..830,1090..1287,1366..1578,1666..2416,
                     2480..2745,2831..3090,3147..3202,3273..3950,4013..>4969)
                     /gene="tndA"
                     /product="TndA"
     gene            <358..>4969
                     /gene="tndA"
     CDS             join(358..525,592..830,1090..1287,1366..1578,1666..2416,
                     2480..2745,2831..3090,3147..3202,3273..3950,4013..4969)
                     /codon_start=1
                     /gene="tndA"
                     /gene_functions="transport (smcogs) SMCOG1000: ABC
                     transporter ATP-binding protein"
                     /gene_kind="transport"
                     /note="pleiotropic drug resistance family protein"
                     /product="TndA"
                     /protein_id="QVR97760.1"
                     /transl_table=11
                     /translation="MDVPMEKRENDTIEEAHEQDDIEQLVGDFVASQTGSSERLGDIVF
                     QDLSVIGAGVGHELVNNVPEALNRLLKLASPAAWWSKRPAPSRVLLRKLTGTIREGEML
                     MVVGRPGSGCTTALKAIANMREEYLATEGNVWFALNARHSTADPDRASHLEQDLQTVLQ
                     LMGLEQAAGVRIGNDHIRGISGGQRRRVSLTEAFCTRASLYCFDNPTRGLDSSTAIRFL
                     NVLRQYTTRSRCATVMSLYQASDVAVSLFDKILVLNEGHVAYYGPASSAKRTPQDGMQR
                     PVPLRPADFEARFWESSFYQQAVDAAIAPQSTASLPKPSGYALPFYRQIYECTVRHYQI
                     FLTDRGTWIAEATGTIVQALLLGTLFRDQQDVTQGLYTRCSALFFCVLIMGLQASAEFG
                     NTFVQRPILLKQKALRFYRPGAYALGQILADIPWKLIFILYSLPIYWMINFQRTAGHFF
                     TWLVCLYMGLMALSVMFRAIAVFTNSPTRAVLPVGLLLNVFIMYTGFYITPPGMKVWLS
                     WIRYLDPMYYIFESIALNEIGDGSYQCSSDHIVPRGAKYNDTTFQTCAVSGSVPGNLNL
                     SGNLYILAEYGFKYMHKWRNVGINAAFFVFFAILVTIGMERFRNATERMSTIYYQKLPW
                     TNTSTSDLADVEKPPVTTDLGGFDVTSNDEAASSRLEEDHHVFAWEELSLELGDGKRLL
                     HEVSGWLQPGSMTALMGMSGAGKTTLLDTLAQRINIGVLSGGLYLDGCPLPQSMGRRTG
                     FVHQNDIHLDSSTVREALQLSARLRRPESISLEEKMAHVEVIIKLLEMEDIADAVIGVP
                     GAGLNLERRKRVSIGVELAARPDILLFLDEPTSGLDGNSALSIVQLMRKLSNAGQTILC
                     TIHQPSSQMIEQFDSLLLLIPGGKTTYFGPLGPRCKTIIDYFARYTRPCRDTENPADYL
                     LEVSSNTETDWYQIWKESPEFLSTQEQLQDLLHEKEDASSSGSDKAYAVPYLEQLGVVT
                     RRAFINYWRDSDYVLGKVQLNIWMGLMNGLTFLQLSNDLADSRGRMFSIFVSVITGPVL
                     SLQIEPRFIILRDQFLARENESRVYHWSVFTISALLVEIPFTLLGGLIYWLLWHYMVGY
                     YYTSDRAGYAFLMYELYSLFVASLAQLTAALFPTVLAAQTATGFVWLVVNTFNGPLSPP
                     PLTPRGWRWFYNISPLFYYIEGIGTNAMHALDITCKGSEIQMFNAPLSETCGSFAAEFF
                     NMSKATGYLINPDATDQCKYCSYADGDQYVSAFHPH"
     mRNA            complement(join(<6052..6301,6372..6724,6780..6968,
                     7026..7300,7350..7481,7546..>7804))
                     /gene="tndB"
                     /product="TndB"
     gene            complement(<6052..>7804)
                     /gene="tndB"
     CDS             complement(join(6052..6301,6372..6724,6780..6968,
                     7026..7300,7350..7481,7546..7804))
                     /codon_start=1
                     /gene="tndB"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /note="cytochrome P450"
                     /product="TndB"
                     /protein_id="QVR97761.1"
                     /sec_met_domain="p450 (E-value: 2.4e-58, bitscore: 186.5,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEGLYKEAVTFADRYNLLNVYGISAVIAVGLAIYSASLAIYRLYF
                     HPLAGFPGPRIAAATRWYEFYYDVIKRGQYVYKIEEMHQKYGPIIRINPHEIVINDPDF
                     YNSVYVAGNTRRTAIWPRYRTGIGFDGSHTMTENHELHRRRRKPLEPFFSRMGIDKMEP
                     MIIEEAKLLNDRLTGLKGSGNVIRLDHVFSAFAGDVIGRICSESPPDMMNHPEFGKEWS
                     AQFDREYRETAPFVHARPATGLVSSLSQSTSACPNRDRLARMIPTGFLLRVYPGAAGFN
                     VFRQLAISHIVDAKKDNFSKEKVEKNSKSSVFRYIITSEMPASECETERLSREAMVLFG
                     AGTATTARTMGFMCYYILTNPHMRERLADELRDVMADYPHKLPSWQELERLPYLQAMIK
                     EGLRLSYGVMRRLPRISPDIPLVYKQWSIPAGTPVGMAAYSLHTDPEVYPEPFKFIPER
                     WLGKYDSRMDRNWVPFSRGSRNCLGMK"
     mRNA            join(<9449..9725,9781..9803,9856..10115,10171..11017,
                     11071..11225,11281..11444,11503..11604,11661..11806,
                     11856..>12176)
                     /gene="tndC"
                     /product="TndC"
     gene            <9449..>12176
                     /gene="tndC"
     CDS             join(9449..9725,9781..9803,9856..10115,10171..11017,
                     11071..11225,11281..11444,11503..11604,11661..11806,
                     11856..12176)
                     /codon_start=1
                     /gene="tndC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: T1TS"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     terpene: PT_FPPS_like"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1182: Polyprenyl synthetase"
                     /gene_kind="biosynthetic"
                     /note="talarodiene synthase"
                     /product="TndC"
                     /protein_id="QVR97762.1"
                     /sec_met_domain="T1TS (E-value: 1.9e-82, bitscore: 266.5,
                     seeds: 237, tool: rule-based-clusters)"
                     /sec_met_domain="PT_FPPS_like (E-value: 1.2e-115, bitscore:
                     374.3, seeds: 145, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MEYRYSTVVDPSTYETHGLCDGIPLRCHESPELEEIETLRCQEDW
                     RRWVGPLGFYKGGLGPRWNFMAITVPECLPERLGVLGYANELAFLHDDVTDVADYGDLH
                     NDDLKAAFEQAASTGHIEGSASGKRAIQAHIANEMMSIHKQHAITTLEAWAKFAELGSG
                     RQHTTHFKTEDEYIKYRMIDIGTMFWYGMVTFGMGISIPEHELEMCHRLADTAYLNLGL
                     TNDLYSWQKEYETAVAMDRDYVANIIGVIMEERNISEAEAKEVCREKIKKTIVDFRKIV
                     DDTKARDDVSLDTKRYLEGLLYSLSGNLVWSIDCPRYHPWSSYNERQLDWMKNGIPKSP
                     PKVNGNATANGNGVHHAPKESLANGTLNGHDRIHAPAVNGNGASHTSSIKGSTGGNGVT
                     HSPVSNGSAVVNSALSMEIDTDLVNVFARKEYKSINGFKMHEGDNHPSNGQTKLNGNVT
                     SWKVPGDVQTKVIQAPYDYISSLPSKGVRDHAIDALNVWCRVPAAKLDLIKLITNMLHN
                     TSLMLDDLEDGSHLRRGRSSTHTIFGAGQTVNAANYHVIRALEEVQKFGDAESIVIFIE
                     ELKSLYVGQSLDLYWTNNAICPSVDEYFQMVENKTGGLFRLFGRLMSLHSSHPVKADLT
                     GFLNQFGRYFQTRDDYQNLTSPEYTKQKGFCEDLDEGKFSLPLIHLMHSAPSNLVVRNI
                     WTQRLVNNKASPAHKQTILELMKENGSLQFTMDALDVLHAKVEKSISDLEARFGVENFQ
                     LRLILEMLRKA"
     mRNA            join(<12896..13460,13521..14509,14600..>14662)
                     /gene="tndD"
                     /product="TndD"
     gene            <12896..>14662
                     /gene="tndD"
     CDS             join(12896..13460,13521..14509,14600..14662)
                     /codon_start=1
                     /gene="tndD"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /note="MFS multidrug transporter"
                     /product="TndD"
                     /protein_id="QVR97763.1"
                     /transl_table=11
                     /translation="MSLSGSDSHLAVSPTLAEDMNSSDTSAGLAETPPADEEKRSIVDT
                     GESVVAMNEPHIVDWDGPDDPGNPVNFSRHIKITNVGIVSALTFITPLASSMFAPGVPQ
                     LMEEFHSSSRLLAGFVVSVYVLGFAIGPLILAPASELLGRVPIYHICNICFTVFSIACA
                     LSTNLGMLIAFRFFQGCFGSAPVTNGGGTIADLIVQEKRGGVIAIYALGPLLGPVIGPV
                     AGGYLAAARGWRWVFWVLAIVGGGCTLASFLFLRETYPMVLLKRKTQRLIQETGNTHLR
                     SKNDNGMSTRQRFVQAIVRPSRILFRSPIVAASSVYVGIVYGYQYLMFSTFTYVFEDQY
                     AFPTSSAGLTFLGTGVGSLLGLFVIGAVSDRILKAKSKPTPEAPSGAMKPEYRLPPLVW
                     GAFFIPAGLFMYGWSAYYRTHWIVPIIGTGLVGIGNIAVFMCITSYLVDAFTIFAASAL
                     AANTVVRSILGALLPMAGQSMYDSMGLGWGNSLLGFIAVVCIPIPWAMMRYGERMREAF
                     DGATIFTIFSGSVSVTRSTFT"
     mRNA            complement(<16217..>17308)
                     /gene="tndE"
                     /product="TndE"
     gene            complement(<16217..>17308)
                     /gene="tndE"
     CDS             complement(16217..17308)
                     /codon_start=1
                     /gene="tndE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /note="aldehyde reductase 2"
                     /product="TndE"
                     /protein_id="QVR97764.1"
                     /transl_table=11
                     /translation="MQSTVVPPGGLVLITGVNGFLASHLALQLIQRGYMVKGTVRTAES
                     ASWITEAIMRRHPTGKFQAVVIPILSASGVMDDLVKDVDGIAYVAADTSLNPDPDQVIT
                     PGLEALKVALQSATQTQSVKRFVLTSSYTAAVDTFVPSAPDALITRDSWNQTSTPRAWA
                     PPPYDALRALDVYQSLKTESETLFWKFASEAKPSFIQNSVLPGFVVGPIIHRKQRGSTA
                     ALVKAYFDDVTCNQAFAWISAPWVVDVVDNALLHLAGLIDEDVQNERLLALAEPFKLGN
                     FARVFEQIDPSRSWPAGDNKHGVKDEGGTKWVADTKRSVAILQRLGQDEGFTPFLESVR
                     RTCLDSDPAWTFGNFLPKSDSQE"
     mRNA            <18980..>20017
                     /gene="tndF"
                     /product="TndF"
     gene            <18980..>20017
                     /gene="tndF"
     CDS             18980..20017
                     /NRPS_PKS="Domain: PKS_ER (21-229). E-value: 4.5e-32.
                     Score: 103.4. Matches aSDomain:
                     nrpspksdomains_tndF_PKS_ER.1"
                     /codon_start=1
                     /gene="tndF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ADH_zinc_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase"
                     /gene_kind="biosynthetic-additional"
                     /note="alcohol dehydrogenase"
                     /product="TndF"
                     /protein_id="QVR97765.1"
                     /sec_met_domain="ADH_N (E-value: 3.5e-09, bitscore: 25.3,
                     seeds: 66, tool: rule-based-clusters)"
                     /sec_met_domain="ADH_zinc_N (E-value: 4.2e-13, bitscore:
                     38.2, seeds: 86, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAREHQAAILPQPGGPLSVGMRPTPKPGPNDVLIEVKAVALNPCD
                     YYQRDYGMPPVLIYPAVLGSDTAGVVVKLGSNVTTVPGPGSRVIAFASSFYQGGSPDHG
                     AFQTYTLAQSEGVIPLPDSLSFEEGAVFPLAVLTALTAWTTIGMRLDTRYSPVDQQAVL
                     IWGASSSVGSFAVQSAKTLGFTIYATASPEHHDLVKTLGADAVFDYKAGDVVSQIVSAV
                     RRDGVQLHTAHCVVDGALQPTLDILKETKGDAPAKVAHSPVLPEGHPTLDNTQIIFNFP
                     SLDEVARSKHMKEVFHGWLNLSLQTGEIVSSPNIQVENGGLSAVHAALDKLKNGVSGTK
                     IVVAL"
     aSDomain        19043..19666
                     /aSDomain="PKS_ER"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_tndF_PKS_ER.1"
                     /evalue="4.50E-32"
                     /label="tndF_PKS_ER.1"
                     /locus_tag="tndF"
                     /protein_end="229"
                     /protein_start="21"
                     /score="103.4"
                     /tool="antismash"
                     /translation="RPTPKPGPNDVLIEVKAVALNPCDYYQRDYGMPPVLIYPAVLGSD
                     TAGVVVKLGSNVTTVPGPGSRVIAFASSFYQGGSPDHGAFQTYTLAQSEGVIPLPDSLS
                     FEEGAVFPLAVLTALTAWTTIGMRLDTRYSPVDQQAVLIWGASSSVGSFAVQSAKTLGF
                     TIYATASPEHHDLVKTLGADAVFDYKAGDVVSQIVSAVRRDGVQL"
ORIGIN
        1 cgtgtacaat tcgactggat gagacagaaa cacggaagaa agatgcgagt tggacaggga
       61 cagattcagt tcactctccc ctgttatatt tttcttgccc ttccctttat ctctgcgact
      121 cgatgataat aactcttttc cgtccgaccc cactcatgcc acttcgggct gatcgcccct
      181 cctctaaccg aaaggagtat gtgttacccc tttcggtaac ccggcgcaaa ctatcgctac
      241 tctgcattgt gaacggtacc gcgcaagagg tcgataccta taagtcgtga aagtccgcat
      301 tggcttttgt tgactgcagc cctctctcgc cagccagaca agcggtatcc cctcatcatg
      361 gatgttccca tggagaagag agagaacgac acaatcgaag aggctcacga gcaggatgac
      421 attgagcaat tggtgggcga ctttgttgcc agccagactg gctcttccga gcgccttggg
      481 gacattgtgt ttcaggacct gtccgtgata ggagccggag ttggggttcg ttcattccat
      541 aattgaagtc tttctcatgt cagctcacta actcttccca ccacgccata gcatgaactt
      601 gtgaacaacg tgcccgaagc tttgaatcgg ttgctcaagc ttgctagccc ggctgcttgg
      661 tggtctaaga ggcctgcccc gtctcgggtc ttacttcgca aactgactgg cactattcgc
      721 gagggggaga tgttgatggt tgtgggccgg ccaggtagcg ggtgtacgac tgctctcaaa
      781 gcgatagcca atatgcggga ggagtatctg gctacggagg gtaatgtctg gtacgggccg
      841 tttgatgcta tgacagcgaa ggtcatcagg cctgatcaag ttgcttttgt tggtactgta
      901 acaccgattt caatccaagg ctactgcgcc ttctgcgagt actaacgggt aatgttctgc
      961 acaggggaag atgatattca ttttccatca ttgtcagtca atactacgct tcggtatggt
     1021 tatcctggac gcgatctact gcctattccc aatggataga gagaagtcat actgataacc
     1081 gagatatagg tttgcactga atgcccggca ctcaactgca gatcctgatc gagcatcaca
     1141 cctcgaacaa gacctacaaa ctgtactaca acttatgggt ctcgaacaag cggcaggggt
     1201 tcgtattggg aatgatcata ttcgtggtat cagtggtgga cagcgtcgtc gagtatctct
     1261 tacggaagcc ttttgcacgc gtgcaaggtg agttcacagt tcgcgtctgc aggataggat
     1321 gggagttcga aagacaggaa agagctaacc tatgactgaa ttcagtttat attgttttga
     1381 caatcctaca cggggtctgg attcctccac tgcgattcgc ttcctcaatg ttctccgaca
     1441 atataccaca cgcagccgat gtgcgacggt aatgtctctg taccaagcca gcgacgtggc
     1501 tgtttcactt ttcgacaaga ttttggtgtt gaatgaaggc catgtcgcgt attacggccc
     1561 agcatcctct gccaaaaggt attttgagtc cttgggtttt tattgctcgc cgcgcacttc
     1621 catatcggat tttcttgcat ctatgtcagg taccccagat ggcagaacac cccaggatgg
     1681 catgcaacga ccggtgcctc ttcggccggc tgatttcgag gcccgatttt gggagagtag
     1741 cttctatcag caggccgtgg atgcagccat agctccccag tctaccgcat cgttaccaaa
     1801 gccttccgga tacgctctgc ccttctatcg tcaaatatac gagtgtactg tccgccatta
     1861 tcagatcttt ctgaccgatc gtggtacttg gattgcagag gcaacaggaa ccattgttca
     1921 agctcttctg ctgggcactt tgtttcgtga ccagcaagat gtgactcaag gactatatac
     1981 gcgttgctca gccttattct tctgcgtact cattatgggt ctacaagctt ctgctgagtt
     2041 tggaaatacc ttcgtccagc gcccaatctt gctcaagcag aaggctttgc ggttttaccg
     2101 accaggagca tatgcccttg gacaaattct cgctgatatt ccttggaagc tcatcttcat
     2161 tctctactcg cttccaattt actggatgat caacttccag cgcacagctg gtcatttctt
     2221 cacctggctc gtctgtctct atatgggttt gatggctttg agcgtcatgt tccgggccat
     2281 tgcggttttt acaaattctc ccactcgagc cgttcttccg gtcggtcttc tgctcaacgt
     2341 gttcattatg tacaccggct tctacatcac tccaccgggg atgaaagtct ggctgtcatg
     2401 gatccggtac cttgatgtaa gtctgagatg cggctataag agtttcgtgt gcgttcacta
     2461 acatctgtac cactcgtagc cgatgtacta cattttcgag tccattgctt tgaacgaaat
     2521 cggggacggc agttatcaat gcagctctga tcacattgtt ccccgtggag cgaaatataa
     2581 tgacaccaca ttccaaacat gcgcggtgtc cggttctgta ccaggcaacc tgaacctatc
     2641 cggaaatctt tatatcctcg ctgaatacgg gttcaagtac atgcacaagt ggcgcaacgt
     2701 tggtatcaat gcggcatttt ttgtcttctt tgcgatcttg gtgacgtatg ttacctccca
     2761 atttatgaat aactctatgc catctttatc tttcatatcg ctgaccaagc ctgcgttatg
     2821 ctctgtatag gattggaatg gagagattcc gcaatgccac tgaacgcatg tcaactatct
     2881 actatcagaa gctaccatgg acaaacacct caacttcaga tctcgcagat gttgaaaagc
     2941 cgccagtgac caccgatttg ggcgggtttg atgtcacctc caatgacgag gcggctagca
     3001 gtcgcctcga agaagatcat catgtctttg catgggaaga attatctctt gagcttggcg
     3061 acgggaaacg attacttcat gaagtttccg gtaagaatat tagtgggcaa taggtcaggg
     3121 gagctctctg ttgacaatta atgcaggttg gcttcaacct ggatcaatga ctgccttgat
     3181 gggaatgtca ggcgcaggca aggtacgcaa atggataatg tttaggttca tgattgagct
     3241 gggacactac aactaacgcg ggtgcaattt agactacact tctcgacacc cttgcccaac
     3301 gcatcaatat tggtgtgtta tcgggaggcc tctatctcga tggatgtcca ttaccacaat
     3361 ccatgggacg ccgaactggg tttgtacacc agaatgatat tcacctcgat tcttctacgg
     3421 tgcgagaggc tctgcagttg agcgcacggc ttcgccgccc agaaagtatt tctctggaag
     3481 agaagatggc tcatgttgaa gtcatcatca agctattgga aatggaagat atcgctgatg
     3541 cagtcattgg tgttccagga gctggactga atctggagag acgcaagcgt gtaagtattg
     3601 gagttgagct ggcggccaga ccggacatcc tcctctttct cgacgagccg acctcggggc
     3661 tggatggcaa ttcggccctg tccattgtcc aactgatgcg taagctatca aatgctgggc
     3721 aaacgatcct ctgtacaatc catcagccgt catctcaaat gattgaacag ttcgattcgt
     3781 tgcttcttct gatccccggt ggaaaaacta catactttgg cccacttggt cctcggtgca
     3841 aaacgatcat tgattacttt gctcgctata cacggccctg cagagataca gagaacccgg
     3901 ctgattattt attggaggtc agctccaata ccgaaacaga ctggtatcag gtacttaaaa
     3961 cccttattcc caatgcatac cagccgtgtc tgatgttcat cttccgaaac agatttggaa
     4021 ggagtccccg gaattcttgt ctacacagga gcagcttcag gatctactcc atgagaaaga
     4081 agatgccagc tcatcagggt ccgataaagc gtatgcggtg ccttaccttg agcagctcgg
     4141 tgtagttacc cgacgggcct tcatcaacta ctggcgtgat tcagactatg tattgggcaa
     4201 agtacagctc aatatttgga tggggttgat gaacggactt acctttctac aactctccaa
     4261 cgacttggcc gactcccgtg ggcgaatgtt ttccatcttc gtgagtgtca ttaccgggcc
     4321 cgttctcagt ttgcaaatcg agccccggtt catcattctg cgtgaccagt tcctggcaag
     4381 ggaaaatgag tcacgcgtct atcattggag cgtgttcacc atcagtgctt tgcttgtgga
     4441 gatccccttc acattgctag gagggctcat atactggctt ctgtggcact atatggtcgg
     4501 atattattat acctcggatc gtgccggcta tgcattcctt atgtatgagc tctattcgct
     4561 cttcgtcgcg agtctggcac agctgactgc ggctcttttc cccaccgtgc tagctgcgca
     4621 gacggcaacc ggtttcgtct ggttggtggt gaacacattc aacggcccgc tatccccccc
     4681 gccgttgaca ccgcgtggat ggcgttggtt ctataatatt tcacctttgt tttactatat
     4741 cgaaggcatc ggcaccaatg ccatgcacgc tttggatatt acatgcaaag gatccgagat
     4801 acagatgttc aacgctcctt tatcagagac atgtggatcc tttgcggctg agttttttaa
     4861 catgtccaaa gccacgggat atctcatcaa tccagacgcc actgaccagt gcaaatactg
     4921 cagttacgct gatggagacc aatatgtaag tgcattccat cctcactagc tttgttttga
     4981 cacaccaacc cactcacccc cccccccccc ccccgcccat ttgtagctga cagactgttc
     5041 tacaggttgc acaatatgac tttgaatatt cgcaaagagg aaataatatt ggaatcttca
     5101 ttggctttat cctcttcaat tacacgatgg ctgttgttgc tacgtatttg atttttatat
     5161 tcaaatggcg taagtgatag ttgcaccact tcatccattg atactgtttc cgtgatatga
     5221 tggggaaaag ggtctaccat gactaggaga aacctgttgg gtcattaatt ccaatcaaaa
     5281 ttttctgact gctatttata actttgtatt tgttagcacc tgcttgggta tacttgatcc
     5341 tagatctcat tcgttcttac accagaaact tccagaaact gcttctgatc caacctatat
     5401 gcaagcatgg cccagtaaag gagcttttcg gcagagaaca ggtactaagt acagaagaga
     5461 ccgcccgcgg gtcattatac tttctgtcat caatgggccg cttggtgtct gcgttccagg
     5521 ctagggcgtg tatctcatct ggatgctcac gccctcgccc aataagttgc aaaaactaca
     5581 acttcgtatg tcgtcaagca tctattacat atgcgcagaa cgttgccttc attcgtaccc
     5641 ggtagttaca atcggaaaca gtcaaactgt tgcagcaccc agatgttcca agtcctcctc
     5701 cccccaccca aaaaagatgc cactccctca aatccaccac atccagcaca tccacaactt
     5761 ccttcccctt tcagtttgtt catgcacaat tggctcctag tgaatcctag tgaatcgtaa
     5821 tcctcgttcc tcgactatcc aacttgggca gaggcatcaa gaaatccaca gactgcgaga
     5881 tatccgactc atccgtttcg tagagctcaa accgcggcgc attgggtcga aacatcaccg
     5941 ccattgccca atacatctca gcgtaagcca gactatcaca agtgttagca aatacttcgt
     6001 tgccattgga cgcaccacaa taacaaatga aagggtacag gatgggagct gttacttcat
     6061 gccgagacaa ttccgcgacc ctctactgaa agggacccag ttccggtcca tcctcgagtc
     6121 atatttcccc agccatcgct cgggaatgaa tttgaatggc tcaggataga cttctggatc
     6181 agtgtgtaaa ctgtacgcgg ccattcccac aggggtgccg gccgggatac tccactgttt
     6241 gtatacgagt gggatgtcgg gcgagattcg gggaagacga cgcatgacac cgtagctcag
     6301 tctggcacga acatccattc cttagtaagg gcttctttgg cttgcgaagt gggggcggac
     6361 tcgagactca ccgcagacct tccttgatca ttgcttgcag gtaaggcaga cgctccagct
     6421 cttgccagct aggcagctta tgcgggtagt ctgccatgac atctcgcagc tcgtcggcta
     6481 gacgctcccg catgtgaggg ttggtgagaa tgtagtagca cataaagccc attgtgcgag
     6541 ctgtggttgc cgtgccagct ccaaagagga ccatagcttc gcgactgagg cgttccgttt
     6601 cgcactctga cgcaggcatc tcgctcgtga tgatgtagcg gaagacagag ctctttgagt
     6661 tcttttctac cttctctttg ctgaaattat ctttcttggc atccacgatg tgcgaaatag
     6721 ctagctgcgc tgggtcagca tccatccggg agtcaaatgg tccgaacagg gcggcttacc
     6781 tggcggaaga cgttgaatcc ggcggcgcct gggtacacgc gcagcaggaa gccagtggga
     6841 atcatccggg ccagtctatc tctgttagga cacgcagacg tggactgaga aagggaactg
     6901 acgagaccag ttgcgggacg tgcatgaaca aaaggagctg tctcacgata ctctcgatca
     6961 aattgtgcct attcaccatc ttgtcagtgc ttggcaggtc tacaagggac gatgggtcgg
     7021 tctactgacc actctttccc gaactcgggg tgattcatca tgtccggcgg actctcagag
     7081 cagatgcgtc cgatcacgtc gcctgcaaag gctgagaaca catggtcaag tcggatgacg
     7141 ttgcccgacc ccttcagccc agttaggcgg tcgttgagga gcttggcctc ctcaatgatc
     7201 atcggctcca ttttatcgat gcccatgcgg gagaagaagg gttcaagggg cttccgccgg
     7261 cggcggtgca gttcgtggtt ctcagtcatg gtatgggagc ctgggccgag tcaaatgggc
     7321 tgacgttgac aaagaaaagg gaaacatacc gtcgaagccg atgccagttc ggtaacgcgg
     7381 ccagatggcc gtacggcggg tgttacctgc aacatagaca ctgttgtaga agtctgggtc
     7441 gttgatgact atctcgtggg ggttgatccg gatgattggg cctgagagta ggaattgtct
     7501 gaatcagtta ttgtttggca ttgttgtggg caaggtgtcc gttaccgtat ttctggtgca
     7561 tctcctcgat tttatagaca tattgccccc gtttgatcac atcgtaatag aattcgtacc
     7621 accgcgtggc agcggcaatc ctaggcccag gaaagccggc caggggatgg aagtacaaac
     7681 ggtagatggc tagcgaagca ctatagattg caagacctac cgcaatgacg gcagagatgc
     7741 catatacatt gaggaggttg tagcggtccg cgaaggtgac ggcctctttg tacaagccct
     7801 ccatcctttc tgtatgcgtt cctatgctag gagggaggaa tgtgaagata atactaaggg
     7861 gaaatgctcg gctgtaaggg acgactttca gcttttgata tcgctgctcc tgtcaatggt
     7921 cggatcttac ccagatatca ctccgggcct tcaggaacag attcaccgag atacggggga
     7981 agaggggtag tagaggggcg cccacatgac aatcagaaat gccacctgcc tgggataaga
     8041 aaaataaggt gtctaaagga ctgggctggt cgtttcgacg caacccggct ggagcggtct
     8101 gtgtcaacga acaatgatcc tcgtatgtga aggtgctaat ttcccgcatg taaattagta
     8161 tgaagtggcc tctatcccaa tcggtcagcc aggatagatg gttgccgtgg gtggtagata
     8221 ttctcctcgc taccgcgttt tgcattctgc attagcttag attaaattct cgtatttgca
     8281 gtttaggatc tgggtgcttc atttgtcaca tcgcgcgcta tcctgttgga atacgctatc
     8341 tgggtatagc aattgaccct actgtgctgt ccagatatgg tagtctgtcc gagagaggta
     8401 atcctacaca cacgatgctg caggacaggc ggtccaggcc cagtcacccc gttagccctc
     8461 gcttagatgt aagatagatg tgaccctttt cctgcaatcc acgatgattg gtgtgttctg
     8521 tccatgaagt gtcctcatcg tttcatcaga tggcgttcgc tagtgagtct tgcacgggag
     8581 gagtgatcct ttgatccgca gacgggggaa taacagaggt tcgccacctc catcactgac
     8641 gatagtccta atatagccgg acagacggcc tgctcgcacg aagacgactc attgggtagg
     8701 ttccacacgg aaacgcctgc aggatttctg ccggcggcgc ctctccgagc ccgaacgctt
     8761 actttccatg gcatggcttg tttcctgtct aactatcttt tgtaacctcg tatacatccc
     8821 cgctgcaacc tagatggagg cattctccgt tcttcaagaa gaattccgaa tcaaccctct
     8881 tttgccgcgc tcgccccgaa gcagggatgt tcttatgata ctggctcgcc cacatatctt
     8941 cgcggaaagg tgtagatagg atcgcgaaat aatactcctc tgggaaggtg gccaggatgc
     9001 ggattcaatt gggtcttgaa acaggattta ctcggcccaa aagaacactc tatacattcc
     9061 aataggccct tcagaatctc ctacatattc cgaatctcgt tagattgttg acggcagcaa
     9121 tctgatggtg aggccgttga accacgtgaa gacccccgcg caacggcgat gcgttgcaag
     9181 ttatgtggct gaaggggtag gttaaacgcc ggatccagag cgaaggaagg cacccgaagt
     9241 aattcaaaat tctgactcca gaatacaggg aaccatcaca atccagccga ggagatactt
     9301 aagaacaggg ttgtacgggt ggcttcgtgg ccagacatgt tttcagacgt atcccctcac
     9361 tcgtcccttg tgaccctgag atacattata ttattgcatc ttttcctcgc cttgctgtat
     9421 tcactggtat cctttgtctt ttcggaagat ggaatacagg tactctacgg tggtcgatcc
     9481 ctccacgtac gaaacccacg gactctgtga cggtattcct ctgcgatgcc acgagagccc
     9541 agagctggaa gagattgaaa cattgcgctg tcaagaggac tggcgaagat gggtcggccc
     9601 actggggttc tacaagggtg gtctcggacc acgatggaac ttcatggcta tcactgttcc
     9661 tgaatgtttg cccgaacgac tcggcgttct gggatatgcc aacgagctcg cattcctaca
     9721 tgatggtcag tactctcaga attgtgtttg gtccgacact gtgactaaat acctgtttag
     9781 acgtcaccga tgtggcagat tatgtaagtt ggttggtaga aacatttcga atgtatgcaa
     9841 ctgatcatgc cacagggaga tctgcataac gacgatttga aggctgcctt tgagcaagcg
     9901 gctagcactg ggcacattga agggtcggca tctggcaaac gagcgattca agcccatatt
     9961 gcgaatgaga tgatgagcat ccacaaacag catgcaatca ccacgttgga agcgtgggcg
    10021 aaatttgccg agttgggttc aggtcgtcaa cacaccaccc acttcaaaac ggaggatgaa
    10081 tatatcaagt atcgaatgat tgatatcggg acgatgtaag tcatctctta cgagagatta
    10141 atatcggtgt ttgaactaat gtttcgccag gttttggtac ggcatggtca ccttcggcat
    10201 gggcatcagt atccccgagc atgagctgga aatgtgccac aggctggctg acacggcata
    10261 cttaaatctt ggccttacga atgatctgta ctcctggcag aaggagtatg agactgcagt
    10321 ggccatggac agagactatg tggctaacat catcggtgtg atcatggagg agcgaaatat
    10381 ttccgaggca gaggccaagg aagtctgccg ggaaaagatc aaaaagacta tcgtggactt
    10441 ccgcaagatt gtggacgata cgaaggcacg agacgatgta tcactggata caaagcgcta
    10501 tctcgaaggc ttgttgtaca gcctgagcgg aaacctggtt tggagtatcg actgtcccag
    10561 gtatcatccg tggtcttcat acaacgaacg tcagcttgat tggatgaaaa acgggatacc
    10621 caagagccca ccaaaagtca atgggaatgc cacggccaat ggcaatggag ttcatcatgc
    10681 tccgaaagaa agcttggcca atggaacctt gaatggtcat gacaggatcc atgctccggc
    10741 tgtcaatggg aacggtgcct ctcacacttc gagcatcaaa gggagtacgg gtggaaacgg
    10801 tgttacccat tctccagtct ccaacggttc tgctgtggtg aacagtgcac taagcatgga
    10861 gattgacact gatctggtga acgtctttgc tcgaaaggaa tataaatcca tcaacgggtt
    10921 caagatgcac gaaggagata accatccatc caatggccaa actaaattga atggaaacgt
    10981 tacctcttgg aaggtaccag gggatgttca aacaaaggta agcctgcaga ccaacacgag
    11041 agaggagcct actaacaaat cgcgacctag gtgattcagg caccctacga ctatatcagc
    11101 tctctgccat cgaagggggt cagagaccac gcaatagacg ctctgaacgt ctggtgccgt
    11161 gtccctgcag cgaagctgga cctaatcaag ctgattacca atatgcttca taacacttca
    11221 ctgatgttcg tttccttccg tgctcatccg ttgtgatgtc aactaagcaa gtggatatag
    11281 gctcgatgac ttggaggatg ggtcgcatct ccggcgcgga aggtcgtcga cacatacgat
    11341 ttttggagcg ggccagacag ttaatgcagc caactaccat gtcattcggg cgctggaaga
    11401 ggtacagaaa tttggagacg ccgagagcat tgtcattttt atcggtcagt ttgccgtttc
    11461 tcccattgtc ttgacatgtg cttacctggg tttgctcaat agaggagctg aagagccttt
    11521 acgtcggcca gagtctggat ctatactgga cgaacaacgc catctgccca tccgtggacg
    11581 agtacttcca gatggttgag aatagtaagc ggggctctgg atcagcaacc gatggaaagc
    11641 attgaactaa cgtatcgcag aaacgggggg cctgttcaga ctcttcggtc gtctcatgtc
    11701 cctgcattcg agccatccgg ttaaagcaga tcttaccggt ttcctgaacc agtttggacg
    11761 gtactttcag acacgagatg attaccaaaa tctgacatct cccgaggtat gtcggagtgc
    11821 actctaccgg taacgatcaa gttaacaatt cccagtacac caagcaaaaa ggattctgcg
    11881 aggatctgga cgaggggaag ttctcactgc ccctcatcca tctcatgcat tctgcgccat
    11941 cgaacctggt ggtccgcaac atctggaccc aacggctagt caacaacaag gccagtccgg
    12001 cccacaagca gactatcctg gagttgatga aggagaatgg aagtctgcag tttacgatgg
    12061 atgcgttgga tgtcttacac gcaaaggtgg aaaagagcat atcggaccta gaggcgaggt
    12121 ttggggttga gaacttccag ttgagattga ttcttgagat gctgcggaag gcctaggtgg
    12181 caggatcctt ggagttgtgg ctttttcgtc tttttgcggg cagctttgcg tccaatgagt
    12241 tgctgtcatt atcccgagct agcctgccat tgcgtactcc tttgaattac ttcatccatt
    12301 ttgccagtga ctctcaccat gtgataggat tacaggacaa gggttaaggg tgtctgcctg
    12361 caacaaccca attcggtaag cagaatctat ctcggtagtt acaaggtgag gagatcaacg
    12421 ctgtcatctg gctggaatta gccgcctgga aaacacacta aactagcgcg caaggttata
    12481 ttccttgccg tgatctgggc cttgatttgc aggagctaag catcgcaagc acttcaaccc
    12541 gagagccaag ctccaccctc ctgcatatac gagaatgtga ctgagataaa tggccgtgaa
    12601 cacagcggac agcatcctgc ggatgtcata cgtggaacgc ctttctgctt cccccggaag
    12661 aaaagaaata cccctgtcgg cctttggcgt gatgcattct tcccgttgtc aatgtggctg
    12721 tactctgctg gatgcgcact gatctgcaaa taccctttac ggatgtactg aaattctcac
    12781 cgggggcagc accggaaagg gatcttttga ctttccacct attgctactt aagcattttc
    12841 tcttcgcttg gcaacatgaa tgttgacgcc cttcagacgc agaggacgca gcaacatgtc
    12901 attgtcaggc tcggactcac atcttgccgt gtccccaacc ctcgctgaag atatgaactc
    12961 ttccgatacc tcggcagggc tcgcggagac acccccagcc gatgaagaaa aacgctctat
    13021 tgttgacacc ggggagagtg tggtcgcgat gaacgaacct catattgtcg actgggatgg
    13081 accggatgac cctggaaatc cggtcaattt cagtcgccac atcaagatca ccaacgtggg
    13141 aatcgttagc gctctgacat tcatcacccc gttggcgtcc tcgatgtttg ccccgggggt
    13201 tccccagctc atggaggaat tccacagctc cagtaggctg ctggctgggt tcgtggtctc
    13261 tgtctacgtg ctaggatttg ccattggacc gctcattttg gctccagcat cggagctcct
    13321 gggaagagtc ccaatttacc acatctgcaa catctgtttc acggtgttca gcatagcctg
    13381 tgctctgagc acaaacctcg ggatgctcat tgcattccga ttcttccagg gttgctttgg
    13441 ctcggcgcct gtcaccaacg gtgagttgct ctcccccata tttaatgatt ccattactga
    13501 tgctatactg cgcaccgtag gaggcggcac cattgccgac cttatcgtcc aggaaaagcg
    13561 tggaggcgtc attgccattt atgcgcttgg ccctttgctg ggccccgtca ttgggcccgt
    13621 cgcaggaggc tacctggcag ctgcgagggg ctggcgctgg gtgttctggg tgctcgcgat
    13681 agttggcggc ggctgtacac tcgcttcatt cttgttccta cgcgaaacat acccaatggt
    13741 tctcctgaaa cgcaaaacac aacgcctcat ccaggaaact gggaatactc acctccgttc
    13801 gaaaaacgac aacggcatgt ccacccgcca acggtttgtc caggccatcg tgcggccatc
    13861 taggatcttg tttcggtccc ccatcgtggc cgcgagttcg gtctacgtcg gcattgtcta
    13921 cggataccag tatctgatgt tctcaacctt cacctacgtc ttcgaagacc aatatgcctt
    13981 tcctaccagt tccgccggcc tgacattcct agggacaggc gtgggctcgc tcctgggcct
    14041 cttcgttatt ggcgctgtat ccgatcgtat tctcaaggcc aagtcaaagc ctacaccaga
    14101 ggctccttct ggcgctatga agccggagta ccgtctgcct ccgctcgtct ggggggcgtt
    14161 ctttatcccg gccggtcttt tcatgtatgg ttggtcggcg tactacagaa cgcactggat
    14221 cgtgcccatc attggtacag gactcgtagg cattggaaat attgcagttt tcatgtgcat
    14281 tacgagttat ctcgtggatg cgttcacgat ctttgcggct agcgcactgg ctgccaacac
    14341 cgtcgtgcgg agcattctgg gagcgttgct tccgatggcc ggacagagca tgtatgactc
    14401 gatgggactg ggatggggga atagcctgct tgggttcatt gctgtggtct gtattcccat
    14461 cccctgggct atgatgcggt atggcgagag gatgcgggag gcatttgatg taagtaggct
    14521 atagatgcgg ttgtagtcgc gacaggcgac tcgtaattga ggatctatgc atggttatct
    14581 tgccccctct atgctctagg gagctaccat cttcaccatt ttctccgggt ctgtctcagt
    14641 gacccgatca accttcacat gagcaattct cgctgttctt gcgacgccat cgatactgcc
    14701 caccgcaaca gccgttcgtt tccccgactc gtcaagaacc catttcatcg gccccggtgg
    14761 gaactccttc tcgccattcc ataccaagcc ttcctggatg ctgacatcta tatctacacc
    14821 cttgccatgg taccagtcca actcaccacc gaacctagtc gcgatattct cgatatcgat
    14881 atccttcatc agagtcgaca gcgtctcgct cgctgtaacc accaccacct tgtctgcagt
    14941 tcccggatcc agccattttc tcatgatact ccacatcatt gcgaagtacg gcggggcatt
    15001 gaggacctat acagctgtaa gcggactgta ccctatccca gaagagaata caaaggatgc
    15061 caaacataaa gccgatggat gatctccgga taccctgtca tcagcaaatg cccaatatca
    15121 cgggtgtagt tcttgatgtc ccaaccctgt ttcatcgtaa aggcggcaat gtccaccagg
    15181 tacagtgcac tgcttatggg gacggcgggg tcgggtcgat ctctcatcgc ggtgcacagt
    15241 gggaatacaa accgggtgag ggtgtcgtgg gcgatgctgg ctcgttgaac tgctgttata
    15301 ccgatttccc cggtattggt acggctcttc tcgtactcgt ttagtgtgga ttgactaaga
    15361 tggccgatgt cgaataggca gattggtaac ccgtttttag ttcgtcggcc acaccaatgc
    15421 gggtacttag agacattatt ttgatgccca ggatactgtt tgtgtatctg aagttggcgg
    15481 ttactcacaa gcagtcgtgc agactcgaaa tccgagacgt tgatctcatt gtaaagcttg
    15541 ggaatctggt ttcgtccatg cgtaatagat gcttgttcga actgttccag ggcatcatgg
    15601 ggattgaacc cgcgcgcatg gaaatatcgt ctagcattgg tgttagggcc atggtcctca
    15661 ccagcttcaa tttacaaagt caaacaaaca gtagagtagt ctcgtcattt aatccgtcca
    15721 gtaattcatg tttcgcaagg ccagggggtc gagcgagaag gcgtttgtcg aaacaaagct
    15781 ggacgaaagt ctcaaaagcc gacaagtgct gttggggcaa atttggaata acgccagtct
    15841 gggctgccat tgtagcgatg cctttcccag ccgtggtaac cacagtcaaa ggatgaacaa
    15901 gcaggacatt gacagacacg cgggaatata attctgtgtg ctgggatctt gtctacatcc
    15961 ctggtgctgc ctcgtataca aatgctcgag gcagttccga cgttacatcg tgtgcaagat
    16021 tgcataacga cacaaaacca attagattaa cagcaagcct acagcaattc tacctttttt
    16081 agcccttttt tagccctttt ttagcggatg gcgtcaactc ttaaaacgat agattgtctc
    16141 gacactgcat aacacgaggg ctccccggtc tagggtgcag atcctccgga taatcaccca
    16201 cttagatcct ccctacctat tcttgagagt cgctttttgg cagaaaattg ccaaacgtcc
    16261 aggctggatc actgtccaga catgtgcggc gcacactctc caaaaacggg gtaaaccctt
    16321 cgtcctgccc aagccgttgc agaatcgcca cggaccgctt cgtatcagcg acccacttcg
    16381 ttcctccctc gtctttgact ccatgcttgt tgtccccagc cggccacgaa cgagatgggt
    16441 cgatttgctc aaacactctg gcaaagttgc ccaacttgaa tggttccgcc aaggcgagca
    16501 gtcgctcgtt ctgaacatcc tcgtcaatca gccccgccaa atgcaacaag gcattgtcga
    16561 ccacgtcgac gacccagggg gcgctgatcc acgcgaatgc ctggttgcag gtgacgtcgt
    16621 caaagtacgc cttcacgagg gccgccgtgc tgccccgttg cttgcggtgg ataattggcc
    16681 cgaccacgaa cccggggaga acagagttct gtataaatga gggcttcgct tcgctggcga
    16741 acttccagaa gagtgtctcg ctctccgtct tgagagattg gtacacgtcc agcgcacgca
    16801 gcgcgtcgta gggtggaggt gcccacgccc gcggggtgct ggtctgattc cagctgtccc
    16861 tggtgataag agcatctggt gcggaaggga cgaacgtatc tactgccgcg gtgtagctgc
    16921 ttgtcaagac gaaacgcttc acggattgtg tttgagtggc gctttgaaga gcgactttca
    16981 gggcttcgag tccaggggtg atgacctggt ctgggtctgg attgaggctg gtgtctgccg
    17041 cgacgtaggc aatgccatcg acatctttga caagatcatc catgacgcct gaggcggaga
    17101 ggattggaat gacaacggcc tggaactttc cagtgggatg acgtctcatg atggcctcag
    17161 taatccatga ggcactttcg gcggttcgca cagtgccctt gaccatatat cctctttgta
    17221 tgagttgtaa ggccaggtgt gaagccagaa agccattgac acctgttatg aggacaagtc
    17281 ctccaggggg aaccacagtt gattgcattc tttgggtgga tggcgagggg gacaggatag
    17341 ggaagcagag gagatgggtt tataaaattg aagtagtcgg cggggagcgc aactgattac
    17401 ttatatagac tttccgtccc ctaggcataa ttatgcagaa tatgcagtta gtacgaagga
    17461 attaagcttc cgttatacag cccgcagtcc cggcatgggg cagggactcg gtcgtactac
    17521 ttatataaat gactttaata tagatatcac tagtgctacc ttactgctgc ttttagtggg
    17581 acgtaaggct ataccataag aagtctgtag ttgaggaaag ctgagccaga ataacacaca
    17641 atatacaata caaacatgca aatagatcgt ggcttgcact ttcgttccga ctactcgatc
    17701 tctttcgcaa cgccctctgc tttttctttc ccgtacacct cttcaatcca agccaaaatg
    17761 gcgtcaatac cggcacttac accggatgat gtccgaatat ttccatcggt gatccatctg
    17821 gcgtgagtct cccaatttaa accctttttg ttgctggttg cacgtttgcc atccaacact
    17881 ccagcttgag cagctaaccg ggagccagta cacaccgtga ttcgatattt caactgtggc
    17941 tagacctttt tgatagaaga aatgttgtct ttgggattgg tccacgtctc atcgtgccca
    18001 gactgcctgg gatgagaagg acatcgggag gtggtgctgt atcaaatgtg tgtgtgggca
    18061 cgatgccttg cccagtcgcg gatttggttg tgacgggatc gagtgacgac gccaggagag
    18121 cgagagtaat atcttcctac taagagagca cattaatgca atctaaggga ccaaatgcat
    18181 cgagagcttg aaacccagga aataagacaa ccccgaaacg aagggaagct gtagcagaac
    18241 ctgccaggat gaacgtgctt gccgacatgt ccgatactag gtgagcaaca tttgcctttt
    18301 acgctccatc taatgaatga caagtatgtg tcccgcggat tctgaattgt atgtttggcg
    18361 gcttgaagac gataagcgcg gctacagata aaggcctcaa cctgagccgg tatcgtgaaa
    18421 acttgcccac tcactttggt aacgtagttg ggttgggaag tgggttggag tcgaatcaga
    18481 ctttcccgtg gactaatagt gacaactgac agagagtttt cactagagga attacctact
    18541 ccggggacta ctacgcatcg tccggcggag ttaagcttca ggctctagga acgcatccgg
    18601 atttaatggc acggcgccga gctctaacac cggaccaaca acaggcacaa cagctcagtc
    18661 tagggagggc cactgtgatt tgacgatagt ggtgctatcc tagtattgag gctggggttc
    18721 gatcatccgt caaccggggc cagtaaagcc agctttcctc ctatcatgct atggagacct
    18781 agtggatcta gatgtgcatg ggcaggacaa gcaacttctg ggatataaac cgcagtggtt
    18841 gtacacctct catcttgatg agcagttcta ccttccatct tcttctctcc tacatacatc
    18901 ctccgcctgc tccggtcgaa ccgctttttg aaccggaatt ctctcagcaa tcatcacatt
    18961 gactcgagtg acattcacca tggctcgcga acaccaagcg gctattcttc ctcagccggg
    19021 cggtcccttg tcggttggga tgcgtccgac tcccaagccc gggcccaacg atgtcctcat
    19081 cgaagtcaaa gccgtggcct tgaacccctg cgattattat caacgggact atggcatgcc
    19141 tccggtgctc atctaccctg cagtcctcgg atcggatact gcaggtgtgg tagtcaagct
    19201 gggctcaaat gtcaccacag ttcctggtcc cggcagccga gtgattgcct ttgcctcgtc
    19261 cttctaccag ggtggctccc ccgatcatgg tgcctttcaa acatacacgt tggcccagtc
    19321 cgaaggggtc attccccttc ctgacagtct ttcctttgag gagggtgcgg tcttcccttt
    19381 ggccgtcctg acagccttga cggcgtggac cacaatcggc atgcgcctcg acaccaggta
    19441 ctccccggta gatcagcaag cggtcctgat ctggggcgct tcgagcagtg tcggctcgtt
    19501 tgctgtacaa tcggccaaga cgctcggatt cacgatctat gccaccgcca gccccgaaca
    19561 ccacgacctc gtcaagacgc tcggggccga tgcagtgttc gattacaagg caggcgatgt
    19621 ggtctcccag atcgtcagcg ctgtgcgtag ggacggtgtg cagctgcaca cggcacactg
    19681 cgtggttgat ggggctctgc agcccacgtt agatatcctc aaggagacca agggcgatgc
    19741 accggccaag gtggcccatt cgcccgttct cccagaaggt cacccaaccc tcgacaacac
    19801 gcagatcatt ttcaacttcc cctccctgga cgaggttgct cggagcaagc acatgaagga
    19861 ggtcttccat gggtggctga acctcagtct gcagactggt gaaatcgtct ccagccccaa
    19921 tattcaggtc gagaatggtg ggctgagcgc agtccacgcc gcattagaca agcttaagaa
    19981 tggtgtcagt ggcacgaaga ttgttgtggc cctgtaatgg atggtctttg ttgcacgagt
    20041 accatatgga tgcaggatat cgattgaaca agcttagtta tcactcaatc tcggtgattc
    20101 actagagcac gatgcacaat tcaagacaat gatcaatcgg aaatagaaag agacatccca
    20161 gaagagatac agcactgttg aaattcgaca gttcattatc aaacgctggg gcagaccctc
    20221 ccgtagatga gccactttga tcgccaacga gcccgacaaa tcgagcatcg tctttggtag
    20281 ctcgttcgat ccggacaaga atctgaggcc gcagcacacc cttttatacc gtcgagatgc
    20341 agtggagtca ccaaggatca gcgaggaacg cggccgatcg cgtcggacgc aaggagcaca
    20401 tactatgcct gcccaccatt catgatgatc acatgctacc acagcaacat tgttcaacga
    20461 atgcgagacg cgttgaatgg ggtatgtcca tccaaacaaa ggacctgatc cctcttgtgc
    20521 ggatcttggt ggaaagccac ttgccccctc ccctgcactt gaaacagagc aaaactgccg
    20581 ggttatcatg attttagaa
//
