BGC0003094: Roseopurpurin C biosynthetic gene cluster from Phaeosphaeria sp. TTI001159
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Location: 1 - 27,529 nt. (total: 27,529 nt).
This entry is originally from NCBI GenBank OR063823.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
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KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0003094
Short description Roseopurpurin C biosynthetic gene cluster from Phaeosphaeria sp. TTI001159
Status Quality: high
The quality level of this entry.

Status: pending
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "There is a homologous BGC in the genome of Aspergillus uvarum, also described within the same paper."
Biosynthetic class(es)
  • PKS (Type I)
Loci
OR063823.1
1 - 27529
via Heterologous expression [1]
Compounds
  • Roseopurpurin C
  • Roseopurpurin D
  • Roseopurpurin G
Species Phaeosphaeria sp. TTI001159 [taxonomy]
References
Chemical products information
Roseopurpurin C Evidence: NMR [1]
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C18H20O7
Chemical database entries
NPAtlas
Roseopurpurin D Evidence: NMR [1]
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C18H20O7
Chemical database entries
NPAtlas
Roseopurpurin G Evidence: NMR [1]
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C17H16O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • WPM83318.1
  • prosJ
 667 - 8505 (-) NR-PKS
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    • WPM83319.1
    • prosK
    		 8969 - 10711 (+) Cytochrome P450
    • Cyclization
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    • WPM83320.1
    • prosA
    		 11190 - 12755 (-) Cytochrome P450
    • Oxidation
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    • WPM83321.1
    • prosB
    		 13300 - 14300 (+) Decarboxylase
    • Decarboxylation
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    • WPM83322.1
    • prosC
    		 14563 - 15700 (-) Short-chain dehydrogenases/reductase
    • Reduction
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    • WPM83323.1
    • prosD
    		 16391 - 16968 (+) Glyoxylase
    • Hydrolysis
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    • WPM83324.1
    • prosG
    		 17964 - 19017 (+) Cyclin dependent kinase / resistance gene
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      • WPM83325.1
      • prosF
      		 19361 - 20794 (-) Methyltransferase
      • Methylation
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      • WPM83326.1
      • prosH
      		 22758 - 24158 (+) Fungal transcription factor
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        • WPM83327.1
        • prosI
        		 25031 - 27498 (+) Major facilitator superfamily transporter
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          Biosynthesis information

          Biosynthetic paths

          Roseopurpurin C
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          Pathway: prosJ > prosK > prosB > prosA+prosC > prosF [1]
          Roseopurpurin D
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          Pathway: prosJ > prosK > prosB > prosA+prosC > prosF [1]
          Comment: This product forms via epimerization of roseopurpurin C
          Roseopurpurin G
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          Pathway: prosJ > prosK > prosB > prosA|prosC [1]
          Comment: This product forms through spontaneous dehydration of a pathway intermediate
          Subcluster
          Aculeatusquinone
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          Pathway: prosJ > prosK > prosB > prosA+prosC > prosF > prosD [1]
          Comment: This is a detoxification product.
          Annotation changelog

          Entry version: 1

          Date
          Changes
          Submitters
          Reviewers
          2024-07-24
          MIBiG v4 annotathon
          • (ID: XHGUMDYTPFJLKYNSR4GE4XPC)
          • (ID: RKFOW2BJ2UIGZ6GYHFZX4BHF)
          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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