LOCUS       BGC0003094             27529 bp    DNA     linear   PLN 04-DEC-2023
DEFINITION  Phaeosphaeria sp. strain HX1035 roseopurpurin gene cluster, complete
            sequence.
ACCESSION   BGC0003094
VERSION     BGC0003094
KEYWORDS    .
SOURCE      Phaeosphaeria sp
  ORGANISM  Phaeosphaeria sp.
            Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina;
            Dothideomycetes; Pleosporomycetidae; Pleosporales; Pleosporineae;
            Phaeosphaeriaceae; Phaeosphaeria.
REFERENCE   1  (bases 1 to 27529)
  AUTHORS   Dunbar,K.L., Perlatti,B., Liu,N., Cornelius,A., Mummau,D.,
            Chiang,Y.M., Hon,L., Nimavat,M., Pallas,J., Kordes,S., Ng,H.L. and
            Harvey,C.J.B.
  TITLE     Resistance gene-guided genome mining reveals the roseopurpurins as
            inhibitors of cyclin-dependent kinases
  JOURNAL   Proc Natl Acad Sci U S A 120 (48), e2310522120 (2023)
   PUBMED   37983497
REFERENCE   2  (bases 1 to 27529)
  AUTHORS   Liu,N., Perlatti,B., Dunbar,K.L., Mummau,D., Chiang,Y.-M.,
            Cornelius,A., DeNicola,A.B., Hon,L., Kvitek,D., Nimavat,M.,
            Nguyen,K., Pallas,J., Kordes,S. and Harvey,C.J.B.
  TITLE     Direct Submission
  JOURNAL   Submitted (26-MAY-2023) Synthetic Biology, HexagonBio, 1490 Obrien
            Street, Menlo Park, CA 94025, USA
COMMENT     ##Assembly-Data-START##
            Assembly Method       :: spades v. v3.14.1
            Assembly Name         :: TTI001159
            Coverage              :: 82.4
            Sequencing Technology :: Novaseq
            ##Assembly-Data-END##
            ##antiSMASH-Data-START##
            Version               :: 8.dev-5707d64f
            Run date              :: 2025-08-15 23:04:03
            NOTE :: This is a single region extracted from a larger record!
            Orig. start           :: 0
            Orig. end             :: 27529
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..27529
                     /db_xref="taxon:1715242"
                     /mol_type="genomic DNA"
                     /organism="Phaeosphaeria sp."
                     /strain="HX1035"
     region          1..27529
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T1PKS"
                     /region_number="1"
                     /rules="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or
                     hyb_KS or itr_KS or tra_KS))"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..27529
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0003094"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..27529
                     /SMILES="CC(=O)C(=O)O"
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="cds(PKS_AT and (PKS_KS or ene_KS or
                     mod_KS or hyb_KS or itr_KS or tra_KS))"
                     /kind="single"
                     /product="T1PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..27529
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[666:8505](-)"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      complement(667..8505)
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="cds(PKS_AT and (PKS_KS or ene_KS or mod_KS
                     or hyb_KS or itr_KS or tra_KS))"
                     /neighbourhood="20000"
                     /product="T1PKS"
                     /protocluster_number="1"
     misc_feature    156..27498
                     /note="roseopurpurin gene cluster"
     mRNA            complement(join(<667..7839,7906..>8505))
                     /gene="prosJ"
                     /product="ProsJ"
     gene            complement(<667..>8505)
                     /gene="prosJ"
     CDS             complement(join(667..7839,7906..8505))
                     /NRPS_PKS="Domain: SAT (85-228). E-value: 2.2e-10. Score:
                     32.5. Matches aSDomain: nrpspksdomains_prosJ_SAT.1"
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (379-802). E-value:
                     1.7e-147. Score: 483.7. Matches aSDomain:
                     nrpspksdomains_prosJ_PKS_KS.1"
                     /NRPS_PKS="Domain: PKS_AT (900-1187). E-value: 8.5e-61.
                     Score: 197.8. Matches aSDomain:
                     nrpspksdomains_prosJ_PKS_AT.1"
                     /NRPS_PKS="Domain: PKS_DH (1302-1399). E-value: 3.5e-07.
                     Score: 22.7. Matches aSDomain:
                     nrpspksdomains_prosJ_PKS_DH.1"
                     /NRPS_PKS="Domain: PP-binding (1631-1693). E-value:
                     6.6e-08. Score: 25.0. Matches aSDomain:
                     nrpspksdomains_prosJ_PP-binding.1"
                     /NRPS_PKS="Domain: PP-binding (1740-1803). E-value:
                     2.2e-08. Score: 26.5. Matches aSDomain:
                     nrpspksdomains_prosJ_PP-binding.2"
                     /NRPS_PKS="Domain: cMT (2051-2229). E-value: 8.7e-43.
                     Score: 137.7. Matches aSDomain: nrpspksdomains_prosJ_cMT.1"
                     /codon_start=1
                     /gene="prosJ"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     itr_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     hyb_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     mod_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     ene_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     tra_KS"
                     /gene_functions="biosynthetic (rule-based-clusters) T1PKS:
                     PKS_AT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /note="HR-PKS"
                     /product="ProsJ"
                     /protein_id="WPM83318.1"
                     /sec_met_domain="mod_KS (E-value: 3.6e-127, bitscore:
                     414.0, seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 5.3e-135, bitscore:
                     439.9, seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 9.1e-134, bitscore:
                     435.8, seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 2e-74, bitscore:
                     239.7, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_KS (E-value: 2.8e-148, bitscore:
                     483.7, seeds: 2284, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.9e-155, bitscore:
                     507.2, seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 5.7e-47, bitscore: 149.6,
                     seeds: 19, tool: rule-based-clusters)"
                     /sec_met_domain="PKS_AT (E-value: 1.4e-61, bitscore: 197.8,
                     seeds: 1682, tool: rule-based-clusters)"
                     /sec_met_domain="PP-binding (E-value: 3.7e-09, bitscore:
                     26.5, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAVSLAVFGPQSRAPSVPYLDSIRTFILEHPVLRCIIRDAHKLND
                     VRLLLSETNANVANLKNGQRFTDVLVQWLVDGLSEPAASFASGVVALPRLAIIQFTQYF
                     QFLKNQGLSHTDLVAQVHNRGGLQGYCGGLPAAVALSCARTEQELVESICIAIRLAFAI
                     GLYAELGDDSEIPGVTTAVIRLKHPGQAEELVRIFPHTYISAITDPKSVSVVGPIKHLG
                     ELIAYATQQGLLVQGMGIRGKTHNPENRDLAVELSALCETSDLLRLPAPQSLRTNVRSN
                     RTGRIIADGSLTSEIVETVLASRCEWYDLLCNIASDLKETDDIHHRIVSFGIGDCVPLL
                     PFNKLGLQMTKTDWSGQSKDMTRQLNPDRHDSYSYPGNAVAVIGTSLRLPGARNMQELW
                     DLISKAEDRHEEVKQDRFDIHGTFRASQSGSFTKNRKFYGNFIDSIDTFDNAFFGINAR
                     EMLNMDPQQRMLLELAYEAMECSGYTHSHIRSRGDTVGCFIGASFVEYLDNTNAYPPTA
                     YTSTGTIRAFLCGRLSYHFGWSGPAEVIDTACSSSLVAVNRAVKSIQSGECSLALTGGI
                     NLITGANNFLDLAKAGFLSPTGQCKPFDKSADGYCRAEGAGLVVLKPLKQAQLDGDHIM
                     GVIVGSATNQGGLSSSLTVPSSDAQTKLYQSVLGQAEMSPDQVTYVEAHGTGTQAGDPL
                     EVSSLRSVFGSPSRTTEMHIGSIKGNIGHCETAAGVAGLLKSICMLEHRAIPPQASHKV
                     WNPKIPSLAKDRMAISTKLSNWVAPIRAALVNSYGAAGSNAAVICCEAPQATRSAVHTP
                     TKLPVILSAQTVASLHKYKTILVDHLVKRMPQPLLLDIAATLNERRQRHKFYEVFEASS
                     TTDLIQQLTTNDSRKLPSQAGSGFPVVLAFSGQSKQTVGLDRRFYDHFDSFRNTLDECD
                     TILQDLGYPPILPSIFEDTNITDIVVLQAGFVAVQYAASVSWLRAGLEVAAIIGHSLGE
                     LTALAVSGKLSIRDCLRLVAGRADLMKSMWGPEKGSMLAVFSDRQTVAEAITGSELETA
                     CYNSETSQIITGACEAISKLEHDLASRAPPIKCLKVDTSHGFHSHLVDPILDDLDHITA
                     TLDWKEPTIPLMLCTASVTASADPYSPSKHARNPVYFVDAIRRLEQTLGKFTFLEAGMN
                     TPITAMAKRAVAQAEIHNFVSLSTKGTENPLDVIARAVCDLWTSSIKVSHWSLISYSNH
                     YSWLPPYQFENSSAWLDNIDRVSILQSQLDERIEPATSQVKSHPEILQMVTLLPESNDS
                     SNTSHCFRVSVEGVRFRGIIAGHAVRSRPLCPASVYLECVTVALSLINSEIHGSHMDFQ
                     GLDIQAPLGVAADVVHVVLEETMAPSRWAFKVISRDRKESLHARGHVSLSPDSKLETIA
                     RLVSKRVKSLPHDANVERMLSRRAYSFFSRVVTYARFLEGIANIAMSDTEALADIVTPT
                     GQPGLEESPVTKICDAVTMDNFIQVVGLLMNTSDMIGKNEVMVCSGIDSSMIAKGVNMG
                     EGRSWKVHASYTSSSPSQALGDVLVFAEDGSVAAAFTGCRFSKLDMSRLERLLDSANQV
                     AGDREAQVRSQQQPITQPGMTQVNHNASISTAQQGASIVEKQPQFPSPNQNNLRQILET
                     YTGVAAARISSDAVLGDLGLDSLAATEMAGELQSSSQISLEGQDLLCMSVKELEETIHG
                     VTTRGSVPPVFSGDNASKVDEMTFKAPNRTADQGSKLHQAVAAKLSELLIEMTGVTPSA
                     IKPDVTLDSLGVDSLAMTEISSALSELCQQSSDNEDVTTQSTVEEVLHAFVPMGKIDSS
                     DSSNDSSDFESSTRDASRLVSSSATSIALSNEDSVSLDTKVQDSRARLITDPVRGLMRS
                     DADFETAASKRGFQNYWSEVAVKQDALTLAYILEAFSKLGVKFSSVSEGEIVPQPNYLA
                     KHQRVFRRFQEILAKHGIIELGAEGSMTRGEKAATITSSSQLHEDFVETYPRYAIEAQL
                     MALTGPKLADCLIGATDPIRLLFGSPTASKILEEYYGSSPMLSAMTSQLVSMITGSLHQ
                     SELSASLRILEIGAGTGGTTAALVTSLANLDINVQYTFTDVSSTMVAKARNRFSEYNWM
                     SFERLDLEQTMPIHLQGKFDIVIGTNCVHATRDKVATTSRLRTVLNEHGFMVLSEVTRI
                     LDWYDIVFGLLEGWWLADGGLSYPLQPPESWMKAFKSAGFASTLYSQCGSEDANTQHLL
                     VGTKQTIGNHHTSGHVNKPLDSMTSPAEKITAVYKEVEGVQIEADIYYPSSIPSQPMPI
                     ALMLHGGGHMTLSKRAIRPAQTAHLLSNGILPISLDYRLCPEINVIDGAMTDVKDAFVW
                     VRQQLPSIVASRGITLDTEQIVVIGWSTGGHLAMSSAWTVEEAGGTRPKAILCFYAPVD
                     FLSRDVFPCRGTAQIPHRMSRDEIMKIDVSDSPITHYDMQGVEDAELGWVKSGDARSEL
                     LLSLFREPRIYGLSLMLNGTPHTYNTLQDLLANEPTPERQAAMCPTARLQAGKYKVPTY
                     IIHGENDEIALFESAFQFHENLKRQGVETGFLAVRNGSHIHDLRLRPGMARWDEQVAPG
                     YKFLFDHL"
     CDS_motif       complement(1300..1338)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_prosJ_0006"
                     /evalue="8.70E-03"
                     /label="NRPS-te1"
                     /locus_tag="prosJ"
                     /protein_end="2380"
                     /protein_start="2367"
                     /score="8.7"
                     /tool="antismash"
                     /translation="VVIGWSTGGHLAM"
     aSDomain        complement(1753..2286)
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_cMT.1"
                     /domain_subtypes="cMT"
                     /evalue="8.70E-43"
                     /label="prosJ_cMT.1"
                     /locus_tag="prosJ"
                     /protein_end="2229"
                     /protein_start="2051"
                     /score="137.7"
                     /tool="antismash"
                     /translation="SELSASLRILEIGAGTGGTTAALVTSLANLDINVQYTFTDVSSTM
                     VAKARNRFSEYNWMSFERLDLEQTMPIHLQGKFDIVIGTNCVHATRDKVATTSRLRTVL
                     NEHGFMVLSEVTRILDWYDIVFGLLEGWWLADGGLSYPLQPPESWMKAFKSAGFASTLY
                     SQCGSEDANTQHLLV"
     aSDomain        complement(3031..3219)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_PP-binding.2"
                     /evalue="2.20E-08"
                     /label="prosJ_PP-binding.2"
                     /locus_tag="prosJ"
                     /protein_end="1803"
                     /protein_start="1740"
                     /score="26.5"
                     /tool="antismash"
                     /translation="KLSELLIEMTGVTPSAIKPDVTLDSLGVDSLAMTEISSALSELCQ
                     QSSDNEDVTTQSTVEEVL"
     aSDomain        complement(3361..3546)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_PP-binding.1"
                     /evalue="6.60E-08"
                     /label="prosJ_PP-binding.1"
                     /locus_tag="prosJ"
                     /protein_end="1693"
                     /protein_start="1631"
                     /score="25.0"
                     /tool="antismash"
                     /translation="LRQILETYTGVAAARISSDAVLGDLGLDSLAATEMAGELQSSSQI
                     SLEGQDLLCMSVKELEE"
     aSModule        complement(3361..7302)
                     /complete
                     /domains="nrpspksdomains_prosJ_PKS_KS.1"
                     /domains="nrpspksdomains_prosJ_PKS_AT.1"
                     /domains="nrpspksdomains_prosJ_PKS_DH.1"
                     /domains="nrpspksdomains_prosJ_PP-binding.1"
                     /iterative
                     /locus_tags="prosJ"
                     /monomer_pairings="mal -> mal"
                     /tool="antismash"
                     /type="pks"
     aSDomain        complement(4243..4533)
                     /aSDomain="PKS_DH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_PKS_DH.1"
                     /evalue="3.50E-07"
                     /label="prosJ_PKS_DH.1"
                     /locus_tag="prosJ"
                     /protein_end="1399"
                     /protein_start="1302"
                     /score="22.7"
                     /tool="antismash"
                     /translation="IIAGHAVRSRPLCPASVYLECVTVALSLINSEIHGSHMDFQGLDI
                     QAPLGVAADVVHVVLEETMAPSRWAFKVISRDRKESLHARGHVSLSPDSKLE"
     aSDomain        complement(4879..5739)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_PKS_AT.1"
                     /evalue="8.50E-61"
                     /label="prosJ_PKS_AT.1"
                     /locus_tag="prosJ"
                     /protein_end="1187"
                     /protein_start="900"
                     /score="197.8"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="FSGQSKQTVGLDRRFYDHFDSFRNTLDECDTILQDLGYPPILPSI
                     FEDTNITDIVVLQAGFVAVQYAASVSWLRAGLEVAAIIGHSLGELTALAVSGKLSIRDC
                     LRLVAGRADLMKSMWGPEKGSMLAVFSDRQTVAEAITGSELETACYNSETSQIITGACE
                     AISKLEHDLASRAPPIKCLKVDTSHGFHSHLVDPILDDLDHITATLDWKEPTIPLMLCT
                     ASVTASADPYSPSKHARNPVYFVDAIRRLEQTLGKFTFLEAGMNTPITAMAKRAVAQAE
                     IHNFVS"
     CDS_motif       complement(5395..5502)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_prosJ_0005"
                     /evalue="2.20E-12"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="prosJ"
                     /protein_end="1015"
                     /protein_start="979"
                     /score="38.9"
                     /tool="antismash"
                     /translation="AAIIGHSLGELTALAVSGKLSIRDCLRLVAGRADLM"
     aSDomain        complement(6034..7302)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="1.70E-147"
                     /label="prosJ_PKS_KS.1"
                     /locus_tag="prosJ"
                     /protein_end="802"
                     /protein_start="379"
                     /score="483.7"
                     /tool="antismash"
                     /translation="VAVIGTSLRLPGARNMQELWDLISKAEDRHEEVKQDRFDIHGTFR
                     ASQSGSFTKNRKFYGNFIDSIDTFDNAFFGINAREMLNMDPQQRMLLELAYEAMECSGY
                     THSHIRSRGDTVGCFIGASFVEYLDNTNAYPPTAYTSTGTIRAFLCGRLSYHFGWSGPA
                     EVIDTACSSSLVAVNRAVKSIQSGECSLALTGGINLITGANNFLDLAKAGFLSPTGQCK
                     PFDKSADGYCRAEGAGLVVLKPLKQAQLDGDHIMGVIVGSATNQGGLSSSLTVPSSDAQ
                     TKLYQSVLGQAEMSPDQVTYVEAHGTGTQAGDPLEVSSLRSVFGSPSRTTEMHIGSIKG
                     NIGHCETAAGVAGLLKSICMLEHRAIPPQASHKVWNPKIPSLAKDRMAISTKLSNWVAP
                     IRAALVNSYGAAGSNAAVICCEAP"
     CDS_motif       complement(6253..6297)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_prosJ_0004"
                     /evalue="7.00E-03"
                     /label="PKSI-KS_m6"
                     /locus_tag="prosJ"
                     /protein_end="729"
                     /protein_start="714"
                     /score="9.3"
                     /tool="antismash"
                     /translation="GSIKGNIGHCETAAG"
     CDS_motif       complement(6355..6402)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_prosJ_0003"
                     /evalue="2.70E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="prosJ"
                     /protein_end="695"
                     /protein_start="679"
                     /score="13.1"
                     /tool="antismash"
                     /translation="YVEAHGTGTQAGDPLE"
     CDS_motif       complement(6595..6633)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_prosJ_0002"
                     /evalue="1.80E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="prosJ"
                     /protein_end="615"
                     /protein_start="602"
                     /score="14.5"
                     /tool="antismash"
                     /translation="FDKSADGYCRAEG"
     CDS_motif       complement(6775..6822)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_prosJ_0001"
                     /evalue="1.50E-05"
                     /label="PKSI-KS_m3"
                     /locus_tag="prosJ"
                     /protein_end="555"
                     /protein_start="539"
                     /score="17.1"
                     /tool="antismash"
                     /translation="GPAEVIDTACSSSLVA"
     aSDomain        complement(join(7756..7839,7906..8250))
                     /aSDomain="SAT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosJ_SAT.1"
                     /evalue="2.20E-10"
                     /label="prosJ_SAT.1"
                     /locus_tag="prosJ"
                     /protein_end="228"
                     /protein_start="85"
                     /score="32.5"
                     /tool="antismash"
                     /translation="ASGVVALPRLAIIQFTQYFQFLKNQGLSHTDLVAQVHNRGGLQGY
                     CGGLPAAVALSCARTEQELVESICIAIRLAFAIGLYAELGDDSEIPGVTTAVIRLKHPG
                     QAEELVRIFPHTYISAITDPKSVSVVGPIKHLGELIAYA"
     mRNA            join(<8969..9091,9152..>10711)
                     /gene="prosK"
                     /product="ProsK"
     gene            <8969..>10711
                     /gene="prosK"
     CDS             join(8969..9091,9152..10711)
                     /codon_start=1
                     /gene="prosK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000170: Cyclization (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /note="P450"
                     /product="ProsK"
                     /protein_id="WPM83319.1"
                     /sec_met_domain="p450 (E-value: 3.9e-56, bitscore: 180.0,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYCAETTNSQTTFSDAFRSRSWPERSQLQSIWHVSALLITGFALV
                     RLYYLAFLHPLSRYPGPKLWAISRIPWAYHVIKGDVWHSLDRFHDQYGPVVRIAPDELT
                     YISPEAWRDIYTVKPDLDKDPYSLTPPLNGADSLFTAMGENHKRIRGAFINAFSDKALR
                     EQSSILEMYAQQLIQRLKTEMHKKTSRVIDVQKFVGYAVFDIISDLTWGESPGALNSTG
                     DQNWVNRFFLHAQFSTVRNCLSRFPPLDKALYYVFLSVTSKQRVANTKLTTERIDRRLA
                     AGHSRSDFMTPLIGKIKEDGRKGITKSEVLTNGLAVVIANSQLTTIAITSALYLLLRNP
                     EKLGVAAEEILNAGFDNEAEIDVAKTQALPYLKAVISEALRLHHPTPGNLPRVAPKEGL
                     VVAGRFVPGGSIIGVSLYNIHTRPENFRRPLDFHPERFLDKTDARYNPIFQSDSLEAFQ
                     PFSMGQRNCIGSKSVQRVSIITTEYANDVFDRLFLAEARVMLAKMIWSFDMRLMEPNPS
                     TWLQQKAWLVYEPKALQVQFQERYEAGERLMQSTVLPPLDRIG"
     mRNA            complement(join(<11190..12629,12684..>12755))
                     /gene="prosA"
                     /product="ProsA"
     gene            complement(<11190..>12755)
                     /gene="prosA"
     CDS             complement(join(11190..12629,12684..12755))
                     /codon_start=1
                     /gene="prosA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000168: Oxidation (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1034: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /note="P450"
                     /product="ProsA"
                     /protein_id="WPM83320.1"
                     /sec_met_domain="p450 (E-value: 3.7e-74, bitscore: 239.4,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDTLTRPRVGSLSSLHIAVIAIGSYLVYYVSYAVYATILSPLAKI
                     PGPNYRKFSFLPCAITSLQGRESHAVRDLHVKYGPVVRVSPEMISFAAPTSWKDIYGYP
                     ASKKYLKSGYRQLRPGVPDLLTANGVDHARQRAALNRAFSDKALREQERYFQEHIDLFL
                     QRLDERCDEGDPIDMIKWLEFLAFDIIGTLAFSSSFDCLKEQEYHPWVTLLMNFFKSTH
                     YVLTARMFGVFFPLVFVFGPIRHLLKGQEHLRRSYDKVQQRLAMPEDEKRADFWAFISR
                     QNEQKEGSMSVHEMEVNAALIIPAGSDTISTTIAGCIYLLLRNPNTSERLRKELTQEFK
                     SESDINMARLANLPYIKAVIDEALRLYPPLSGDLRREVPPGGSSLSGHFLPGGTIISVY
                     ALASNENPDNFAKPRQFAPERWLKSDERPQWTQHDHLEASQPFSVGPRNCIGMSLAYAE
                     TKLILARLFWRFDLDLLDNAFEIESQRVYIMWEKPPLRVYLKRRL"
     mRNA            join(<13300..13354,13417..>14300)
                     /gene="prosB"
                     /product="ProsB"
     gene            <13300..>14300
                     /gene="prosB"
     CDS             join(13300..13354,13417..14300)
                     /codon_start=1
                     /gene="prosB"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000171: Decarboxylation (100% identity)"
                     /gene_kind="biosynthetic-additional"
                     /note="decarboxylase"
                     /product="ProsB"
                     /protein_id="WPM83321.1"
                     /transl_table=11
                     /translation="MVGTIDTHHHLIPPRFNELWFANIEKARGLHLPSWSKEGTLQTID
                     HVGLGSAIISLGHPVHPYVDDTAQVAPICREINDYTATFRDEHPSKIGFFATLPPLDQS
                     EACIGEIRYGLEQLKADGVVIFSSYSGRYLGHNDFRVVWEELNRLKAVVLIHPGFEGMA
                     PIEEPRLLAAPIIDWTHETTRTAVHLITTNVIRDFPDCKVILSHAGGSLPYVINRAANL
                     CCRLRIANKTEAEFIEEARGFYVDVAFSGHEPQLRLLKEFLKPDHVLFGSDYPWEQGDI
                     VSEQLAATDNVFGEETRRAALKLFPRLSQYG"
     mRNA            complement(join(<14563..14903,14977..>15700))
                     /gene="prosC"
                     /product="ProsC"
     gene            complement(<14563..>15700)
                     /gene="prosC"
     CDS             complement(join(14563..14903,14977..15700))
                     /NRPS_PKS="Domain: NAD_binding_4 (76-202). E-value:
                     1.1e-09. Score: 29.7. Matches aSDomain:
                     nrpspksdomains_prosC_NAD_binding_4.1"
                     /codon_start=1
                     /gene="prosC"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000169: Reduction (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010: NAD-dependent epimerase/dehydratase"
                     /gene_kind="biosynthetic-additional"
                     /note="SDR"
                     /product="ProsC"
                     /protein_id="WPM83322.1"
                     /transl_table=11
                     /translation="MYSFQGHQDLDVPPGSTILVTGVSGMIAIHIADEALRAGFRVRGT
                     VRSQQKGEQVRDLLNSPAFEFTIVPDMAAEGAFNESMRGVSAAVHCASIVSFSGIVEEV
                     ITPTVKGTMNILEAALQNPSVKSVVLTSTSGAASGPRPGVEFHMGRDTWNQEAVDLVRN
                     TAPEERGKMGFEWGYVVYVVSKIEAERAAWDFLERRKPPFRVNVTNPAMNWGKVMGSMG
                     ISGGQVMSVLDGNVPPIPSVYMADTIDDARIHVAAAIDGTVAGERIFVCDSPFNWTLVI
                     QTLRKALPDAQLPDPKPNELLDISTIDNALGADLLRKWWGQPGYKGLERTILETLEMCL
                     EKRQGHYVRVSDNQ"
     aSDomain        complement(15095..15472)
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_prosC_NAD_binding_4.1"
                     /evalue="1.10E-09"
                     /label="prosC_NAD_binding_4.1"
                     /locus_tag="prosC"
                     /protein_end="202"
                     /protein_start="76"
                     /score="29.7"
                     /tool="antismash"
                     /translation="AFNESMRGVSAAVHCASIVSFSGIVEEVITPTVKGTMNILEAALQ
                     NPSVKSVVLTSTSGAASGPRPGVEFHMGRDTWNQEAVDLVRNTAPEERGKMGFEWGYVV
                     YVVSKIEAERAAWDFLERRKPP"
     mRNA            join(<16391..16399,16459..>16968)
                     /gene="prosD"
                     /product="ProsD"
     gene            <16391..>16968
                     /gene="prosD"
     CDS             join(16391..16399,16459..16968)
                     /codon_start=1
                     /gene="prosD"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000167: Hydrolysis (100% identity)"
                     /gene_kind="biosynthetic-additional"
                     /note="glyoxylase"
                     /product="ProsD"
                     /protein_id="WPM83323.1"
                     /transl_table=11
                     /translation="MSSDSEQNTPVYKLNHVGISVPDCEAAVSWYGTIFGFQLLKPVLH
                     VKRAHFPGAPIFKVFGDELQEFKLAWLATGHSVGLELFEFIDPCHKTPEGPAFDYSRGG
                     VFHIAITVPDPEKMCVDVVRAGGKRMSDVVPMPMGNSMAYCQDPWGNAIELLTTSFSDM
                     VYNGAPKTD"
     mRNA            join(<17964..18005,18163..>19017)
                     /gene="prosG"
                     /product="ProsG"
     gene            <17964..>19017
                     /gene="prosG"
     CDS             join(17964..18005,18163..19017)
                     /codon_start=1
                     /gene="prosG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Pkinase"
                     /gene_functions="regulatory (smcogs) SMCOG1030:
                     serine/threonine protein kinase"
                     /gene_kind="regulatory"
                     /note="cyclin dependent kinase"
                     /product="ProsG"
                     /protein_id="WPM83324.1"
                     /sec_met_domain="Pkinase (E-value: 3.5e-71, bitscore:
                     229.0, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAERVLQSFQQLEKVYKGRNRNTGQLVALKEIRLDSEEGTPSTAI
                     REISLMKELAHENILTLYDVIHTDEKLILVSEFMDMDLKKYIDSRHAGESDFHRFFTAK
                     SFIYQMVRGIAYCHEKMVLHRDLKPQNLLINRSGCLKLADFGLARAFGVPVNTFSNEVV
                     TLWYRPPDVLLGSRSYNTSIDIWSMGCIIAEIFTGRPLFAGNTNEDQLQKIFRLMGTPS
                     ERSWPGVQQLPGFASLAQMRTYPMQDLVQVVPQVDVMGLDLLKRLLQPCPEARISAADA
                     LNHPWFQDVQPAHQSLT"
     mRNA            complement(join(<19361..19677,19731..20179,20272..20522,
                     20606..>20794))
                     /gene="prosF"
                     /product="ProsF"
     gene            complement(<19361..>20794)
                     /gene="prosF"
     CDS             complement(join(19361..19677,19731..20179,20272..20522,
                     20606..20794))
                     /codon_start=1
                     /gene="prosF"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000166: Methylation (100% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042: O-methyltransferase"
                     /gene_kind="biosynthetic-additional"
                     /note="methyltransferase"
                     /product="ProsF"
                     /protein_id="WPM83325.1"
                     /transl_table=11
                     /translation="MQDEVNQYVDQVSRIGQDLKKLADVKEDSPEARQKRRELLDTSRR
                     LTNALQNEGQIVEGYLYGTIDVLLFKIGTDLGLFEKLSSAEKPVPLQHLASFTGANEIL
                     LARIMRGLTSIGAVDEASTEVYAPNKVTRAFATVKGQSGIDLFHNVIHAGWMTFPKFLK
                     ETGYQNPTDPNAMPFNKQFNGEAYFDWLGKQPELLHSFHQFMTTQRVGHPQWLDFYPLE
                     QELIPGFDTSDPNAAFLVDVGGSVGHEIKAVKKRYPNVPGRLIVEDLKATIERVNLDSG
                     MEAIAHDFFTPQPIKGARAYYFRSVLHDWDDDRCRIILGHIRDAMKPGYSKILINEFNI
                     PLKGACTFATHSDFMVMSVNAAVERTERQWYALIESAGLKIDKIWTLEPDAESLLEVTI
                     KE"
     mRNA            <22758..>24158
                     /gene="prosH"
                     /product="ProsH"
     gene            <22758..>24158
                     /gene="prosH"
     CDS             22758..24158
                     /codon_start=1
                     /gene="prosH"
                     /note="fungal transcription factor"
                     /product="ProsH"
                     /protein_id="WPM83326.1"
                     /transl_table=11
                     /translation="MNEAENPKAFPAGDNATKSQPLRNSCEPCHASKLRCSREKPTCAR
                     CTKNGTECTYAPTKRPGRPRKVPAAASSISQGPAAPARHSTRGDKRTESLDTVVSSLAP
                     ASAPDDPRDHRPGPSPGRLGFGTPPTQAHVANIADNVEMFDFANAHMLDDASFFYDVLA
                     DPLEHTTNIETVRDDNEDLWMLLDAPESQPQHNVQSPFLDPAYWPIDPVKFEDDCASLK
                     HCIAVSHVLGSFTDDSERETLDEHDCLCHTAAANLMFHRKSAKAFRPKPTLEACLHLQR
                     VLDWTWAALKECNGCWDDEMIQFILVGTVKEVVMIHRALLDGITRRSKSEAYHGSVANM
                     GSHSGERRGFGRGRGSYLSHSRHGLERQQFVPMKGPQPTSSAPRPPLFESTALTFGDTA
                     IRECVKTSFLCRLISMKLRHLGGLLGELLSWTPTDLNLGAGSSPVQIHITGVLERINIT
                     AGVLAMLE"
     mRNA            join(<25031..25189,25232..25300,25357..25377,25427..25439,
                     25660..25707,25767..25973,26050..26177,26233..26374,
                     26440..26820,26876..26985,27046..>27498)
                     /gene="prosI"
                     /product="ProsI"
     gene            <25031..>27498
                     /gene="prosI"
     CDS             join(25031..25189,25232..25300,25357..25377,25427..25439,
                     25660..25707,25767..25973,26050..26177,26233..26374,
                     26440..26820,26876..26985,27046..27498)
                     /codon_start=1
                     /gene="prosI"
                     /gene_functions="transport (smcogs) SMCOG1005: Drug
                     resistance transporter, EmrB/QacA"
                     /gene_kind="transport"
                     /note="major facilitator superfamily transporter"
                     /product="ProsI"
                     /protein_id="WPM83327.1"
                     /transl_table=11
                     /translation="MALTTESAQDSVRTNSPVTDKTDIGGSMSHVPEAELAKESPTGIV
                     PEESPTLPYPSGATLLLINLSLCLSVFLAALDNTIIATAIPKITNHFSSQADIGWYGSS
                     YLLTQASVQLLFGKFYTVVSIKWVFLTAIAIFELGSLVCGVAPNSTALICGRAIAGLGA
                     AGISSGAVIIITYSVPAPKRPMYTGLIGAMYGIASVAGPLLGGAFTDKVTWRWCFYINL
                     PLGAVAVLTILFFFKSPHRKEVSNLSFKDRLAEFDLVGTAVFMPAVICLLLALQWGGTT
                     HPWSNWRIILLLVLFAVLFFVWVGIQIKQGDSATVPPSLLKKRSIAAASWYIFALGSYF
                     LVLIYYLPIWFQAVKGTTAVESGIRNLPLILGLVIVSIGSGIGVTVTGYYAPFMVASAI
                     VSSIALGLMTTFKPESGANEWIGYQAMAGIGVGFGVQQPLIVVQTILPLTQVSIGTSLM
                     YFLQSIGGALFIAIAQNVFTNKLASDLARYVPDLDASIVLRSGATSLQQTVPASQLPLV
                     QRAYNNAITRAFLVATIMAALTLVGALLVEWKNIKAAKAGEEKQDGADTEGKNAIRSKE
                     "
ORIGIN
        1 cgcaagttgg gaggtctacg atgggccaat gcgaaggctg aggcttggga cattcgacat
       61 gcgtacgctc atgcaaacat atgtgacata gaccatcgct aatttagtac tagatacgaa
      121 gacgcgatag tcaatgctgc cctcgaatac tctgatcatg caatgaaaga gttgaccgag
      181 ctagaggtgt tcacgggcac tatattcaac agcactggct cacagacgcg acggcagcgc
      241 gatggatcca tcaagctcaa agatgagttt gatagaatcg ttcgctggac tgcatcaatg
      301 attaagccag gcagccatcg cacaagaact ctgcccgagg actcgctggc actaagtatt
      361 gcgtgcttgg aagtaggatg cttgcagaca cagcgaccgt cgagacttgg tacaggtcgt
      421 cgcaaggatg agttgcaaag cttcagagtc atcgctgctt gctgtgcgat gaaagagttg
      481 gacaatgctt tagccgtgtc ggtagacttg cccacgtgaa gaatagttct tcgtcaagca
      541 aggctacaag atggaagcgc tatcggcaat tttcgtggtt cttgctatgt gaaagataga
      601 ctgaagccct tcaatacatt atcaactgca aagagagaaa ctactatgaa tatatcatac
      661 tacagtctac aaatgatcga acagaaattt ataacccgga gcaacctgtt catcccatcg
      721 agccatacca ggccgaagtc gcagatcatg aatgtgagag ccatttctga ctgcaagaaa
      781 cccagtctca acaccctgac gcttgagatt ctcatgaaat tggaatgccg attcgaacaa
      841 ggcgatttcg tcgttttcac cgtgaatgat gtaagtgggt actttgtatt tccctgcttg
      901 tagacgggca gtagggcaca tggccgcctg tctctctggg gttggttcgt ttgccaagag
      961 atcctgcaaa gtgttgtatg tgtgaggtgt tccgttgagc atcagtgata gtccgtaaat
     1021 tctgggctct ctgaagaggg atagcagtag ttccgagcgt gcatctcccg acttaaccca
     1081 tcccagctcg gcatcctcca caccctgcat gtcgtaatgc gtgatcggcg aatccgaaac
     1141 gtcgatcttc atgatttcgt cgcgcgacat acggtgtggt atttgcgcag tcccgcgaca
     1201 tgggaataca tctcgggaca gaaagtcaac tggtgcgtag aaacatagaa tggcctttgg
     1261 acgtgtgcct ccagcttctt cgacagtcca ggcagaggac atagctaggt ggcccccagt
     1321 tgaccatcct atgacgacaa tttgctccgt gtctaacgtg atgcccctgc tcgcaacgat
     1381 ggacggaagt tgctgtctca cccacacgaa agcatctttg acgtccgtca tagcaccatc
     1441 gatgacgttg atctcggggc aaagtctgta gtccaggctt atgggcaaaa ttccgttcga
     1501 gagaagatgc gccgtctgcg ccggacgaat ggcacgtttc gaaagcgtca tgtgtccacc
     1561 gccgtgcaac ataagtgcaa tgggcatggg ctgagatggt atcgatgacg ggtagtagat
     1621 gtctgcctcg atttgaaccc cttcgacttc cttatatact gctgtgatct tctccgctgg
     1681 cgatgtcatg ctgtcaagcg gtttattgac atggccagac gtatgatggt tgccaatagt
     1741 ttgcttggta ccaacaagga ggtgttgagt gtttgcatct tctgaaccgc actgtgagta
     1801 caaggtcgaa gcaaagccgg cactcttgaa agctttcatc cacgattctg gaggttgaag
     1861 cggatacgac agacctccat cagccagcca ccagccctcg aggagaccga agacgatgtc
     1921 ataccaatcg agaatgcgtg tcacctctga gagaaccatg aaaccatgtt cgtttagaac
     1981 tgtccgtaga cgactggtgg tagcgacctt gtctcttgta gcgtgaacac aattggtgcc
     2041 gatgacgatg tcgaatttgc cttgcagatg gatgggcata gtttgctcca ggtcgagtct
     2101 ctcgaacgac atccagttat actcgctgaa ccgattcctc gcttttgcga ccattgtaga
     2161 cgatacgtct gtgaacgtgt actgcacgtt gatgtccaag ttcgcgagac ttgtcacgag
     2221 tgccgctgtt gtacctccag tacccgcgcc gatctcgaga atgcgcaagg atgcgcttaa
     2281 ttcagattga tgtagcgatc ctgtgatcat ggacaccagc tgactagtca tggctgataa
     2341 cataggcgaa gagccatagt attcctcgag gatcttgctt gcggtgggcg aaccaaacag
     2401 tagtctgata gggtcggtgg ctccaataag acaatctgca agcttgggcc ctgtaagagc
     2461 catcaactga gcctcgatag cgtacctggg atacgtttcc acgaaatctt cgtgaagctg
     2521 agaggaagac gtgatcgtag ctgccttctc accacgcgtc atgctacctt ccgccccaag
     2581 ctcaatgata ccatgctttg ccaagatctc ttggaagcga cggaacacac gctgatgttt
     2641 cgcaagatag ttgggctgtg gtacgatttc tccttctgac accgagctga acttcacgcc
     2701 aagcttcgaa aatgcttcca gaatgtaggc aagggtcagg gcatcttgct tcactgcgac
     2761 ttcgctccaa taattctgaa accctcgctt cgacgccgca gtctcgaaat cagcgtctga
     2821 gcgcatcaat cccctgactg ggtcggtaat cagccttgcc cggctgtcct gaactttggt
     2881 atcaagcgag acggaatctt cgttcgagag agcaatcgac gtggcactcg agctcactaa
     2941 gcgagaggcg tcgcgagtag atgactcaaa gtcactactg tcattactgc tgtcactgct
     3001 atcaatcttg cccattggta caaacgcgtg gaggacttcc tcaacagtgg attgagtcgt
     3061 cacgtcctcg ttgtcagatg attgctggca aagttcagac agagctgagc tgatctcggt
     3121 catggcaagc gagtcgacgc ccagtgagtc cagtgtaaca tctggcttga tagctgaagg
     3181 tgtaacacca gtcatctcga tcagcaactc tgatagtttc gccgccacag cttgatgtag
     3241 cttagaccct tgatcagctg tcctgtttgg tgctttgaac gtcatttcat ccactttgct
     3301 ggcgttgtcc ccactaaaaa ctggtggcac acttcctctc gtcgtaacac cgtggatcgt
     3361 ttcttctagc tctttcaccg acatgcaaag aaggtcttga ccttcgagcg atatttgact
     3421 cgagctttgc agttcaccgg ccatctctgt ggcggcaagg gagtcaagac caagatctcc
     3481 aagtaccgca tccgacgaga ttcttgcggc ggccacgcct gtgtaggttt ctaagatctg
     3541 tcgaaggttg ttttgattag gtgacggaaa ctgtggttgc ttctcgacaa tggatgcacc
     3601 ctgttgagcg gtagaaatac tcgcgttatg gttcacttga gtcatcccag gctgcgttat
     3661 tggctgctgc tgagatcgga cttgagcttc ccggtcgcca gcaacttgat ttgctgagtc
     3721 caacagacgc tctagtcgag acatatcaag ctttgagaac cgacatccag tgaaagcagc
     3781 tgccacagat ccatcttctg caaacactag cacatcgcca agagcctggc ttggactaga
     3841 cgaagtatat gacgcgtgga ctttccatga ccggccttcc cccatgttga cgcctttggc
     3901 gatcatggag ctatcaattc cagagcagac catgacctca tttttaccaa tcatgtcgct
     3961 agtgttcatc agaaggccta caacctggat gaaattatcc attgtgactg catcacaaat
     4021 cttggtaacg ggactctcct cgagtccagg ctgaccagtg ggtgtgacga tatcagccag
     4081 ggcctcggtg tcgctcatgg cgatgttcgc gataccctcg agaaaccttg cgtatgtgac
     4141 gacgcgtgag aaaaagctgt aagcccgtct cgaaagcatc cgctcaacat tggcatcatg
     4201 cgggagactc tttacgcgct tgctaacaag gcgggcgatg gtttccaatt tcgaatccgg
     4261 tgaaagtgat acgtgccctc ttgcatgcaa actctccttg cggtcccgac tgatgacctt
     4321 aaaggcccac cggctgggtg ccatcgtttc ttccaaaacc acatggacaa catctgccgc
     4381 tacacccaaa ggggcctgta tatcgaggcc ttggaaatcc atatgcgagc catgtatctc
     4441 cgaatttatg agactcaggg ctacggtaac acactcaaga tacacagatg ctgggcaaag
     4501 tggtcgactg cggacggcat gaccagcgat gatgccccta aatcggacac cctcgactga
     4561 gactcgaaag cagtgcgatg tattggatga atcattggac tctggaagca gggtcaccat
     4621 ctggaggatc tcggggtgcg acttgacctg cgatgttgcg ggctcgatgc gttcatccag
     4681 ctgcgactgt agaatagaca ctcgatctat gttgtcaagc cacgccgaac tattctcaaa
     4741 ctggtatggc ggcagccacg agtagtggtt actgtagctt atcaaagacc aatgagaaac
     4801 cttgattgaa gatgtccaaa ggtcgcaaac tgcgcgagcg ataacgtcca gaggattctc
     4861 tgtgcccttc gtggacaggg agacgaagtt gtgaatttca gcttgtgcga ccgccctttt
     4921 cgccattgct gtgataggtg tgttcatgcc tgcttcaagg aaagtgaact tgccgagagt
     4981 ttgctccagt cgtcgtatag catctacaaa atagacaggg ttacgcgcgt gcttggatgg
     5041 actgtaaggg tctgcagagg ccgttacaga tgctgtacaa agcatcaacg ggatagtcgg
     5101 ctctttccag tcaagcgttg cggtgatatg atccagatcg tctagaatgg gatcgacgag
     5161 gtgggagtgg aagccatggc tggtgtcaac cttcaggcac ttgattggag gcgctcttga
     5221 tgccaaatca tgctcaagct tagaaattgc ttcgcatgct ccagtgatga tttggcttgt
     5281 ctctgagttg tagcacgccg tttcaagctc gctgccggta attgcttctg ctacggtttg
     5341 gcgatctgag aagacggcca acattgaacc tttctctgga ccccacatgc tcttcatgag
     5401 gtcggcacga ccagcgacga gtctgaggca atcccgaatg gacaattttc cgctgacagc
     5461 taaggctgtg agctcgccga gactgtgccc aatgatagcg gcgacctcca gaccggctcg
     5521 tagccacgat acagatgccg cgtactgaac agccacaaac cctgcttgca aaacgacgat
     5581 gtcagtgatg ttggtatctt cgaatatgga cggtagtatg ggcgggtacc caagatcctg
     5641 caggatcgta tcgcactcat cgagcgtatt gcggaaactg tcgaaatgat cataaaatct
     5701 tctgtcgagg cccactgtct gtttgctctg tccactgaat gcaagaacga cgggaaaacc
     5761 ggatccggct tgtgacggta gcttacgcga atcattggtc gtcaattgtt gtataaggtc
     5821 tgtggtgcta cttgcttcga agacctcata gaatttatgt cgctgacgcc tctcgttcaa
     5881 ggttgctgcg atgtctagaa gcagtggctg gggcatcctt ttcacgagat ggtctactag
     5941 tatcgtttta tacttatgta gactcgcgac ggtctgcgca ctcagaatca ctggcaactt
     6001 tgttggtgta tgtaccgcgg atctcgtagc ctgtggagct tcacaacaaa tgaccgcagc
     6061 attggagccg gcggcgccgt atgaattgac cagagctgca cggatcggcg ctacccagtt
     6121 gctgagcttc gttgagatag ccattcgatc tttggccagg cttggtattt tcggattcca
     6181 gactttgtga ctcgcttgag gaggtattgc tcgatgctcc agcatgcaaa ttgacttcaa
     6241 aagtccggct acaccggcgg cagtttcgca gtgaccgatg tttcctttaa tggagcctat
     6301 gtgcatctct gtcgtccttg aagggcttcc gaagactgat cgaaggctag atacctctaa
     6361 ggggtcacca gcctgggtac cggtaccatg tgcttcgaca tacgtgactt ggtcaggact
     6421 catctccgct tgcccaagga ctgattggta caatttggtt tgagcatctg aagaggggac
     6481 ggtaaggctg ctggaaagac ctccctgatt tgtagcagat ccgactatta cacccatgat
     6541 atgatcaccg tcaagctgcg cttgtttgag tggtttcagt acaaccaacc cagcgccctc
     6601 agctcgacag tacccatctg cactcttgtc gaaaggcttg cattgacctg taggactgag
     6661 aaagccggcc ttagccaagt ccagaaagtt gttagctcca gtgatcagat tgatgccacc
     6721 agtcagagcc agagagcatt ctccagattg aatcgatttg acagccctgt tcacggcgac
     6781 cagcgatgaa gagcaagcag tatcaataac ttcggcggga ccagaccacc caaagtgata
     6841 gcttaagcgc ccgcatagga acgcacgaat tgtgccagtc gaagtgtaag ctgttggtgg
     6901 ataggcattc gtattgtcaa gatactcaac aaagctcgcg ccaatgaagc atccgacagt
     6961 atcgccacgc gatctgatgt gcgagtgcgt atagccacta cactccatag cctcgtaggc
     7021 caactccagt agcatacgtt gttgaggatc catattgagc atttcgcgcg cgttgatgcc
     7081 gaagaatgca ttgtcaaacg tatcgatgct gtcgatgaaa ttgccgtaga atttacgatt
     7141 cttcgtaaaa ctgccgcttt gtgaggcgcg aaaagtacca tggatatcga aacggtcttg
     7201 tttcacctct tcgtgtctgt cttcggcctt ggagatgaga tcccacaatt cctgcatgtt
     7261 ccgcgcgcca ggcagccgca gtgatgtacc aatcaccgcg acagcatttc ctggatacga
     7321 gtaggagtcg tgccgatccg ggttgagttg tctggtcata tctttgctct gcccactcca
     7381 gtcggtcttg gtcatttgta gccctagctt attgaacggc agcaagggaa cgcagtctcc
     7441 aatgccaaaa gagacgatcc tgtgatgtat atcgtctgtt tccttcaggt cagaggcgat
     7501 attgcacagt agatcgtacc actcgcatct tgaggcaagg actgtctcga caatctcgga
     7561 agtaagggaa ccatcagcaa tgatgcggcc ggttctgttc gatcgtacat tagtacgtaa
     7621 agattggggg gcaggaagtc gaagcaagtc agatgtttcg cataaggcgg ataactctac
     7681 tgctaggtct cgattctctg ggttgtgagt cttgccacga atgcccatgc cctgcacgag
     7741 caagccttgt tgcgtggcat atgctattag ctcgcccaag tgtttgattg ggccaaccac
     7801 actgactgac ttgggatctg ttatcgctga tatgtaggtc tacggtttga gtcagtacgt
     7861 tgcaagtttc gtagatcaca ctacatatga catgtatgga cgcacatggg gaaagatgcg
     7921 aacaagttct tcagcctgcc ctgggtgctt cagcctgatg acagctgtgg tcacgccggg
     7981 aatttcggaa tcatctccca gctcagcata aagtccaatc gcgaatgcaa gacgtatggc
     8041 aatacagatc gattcgacca gttcttgctc agttctagca catgaaaggg ccacagcggc
     8101 tggcagccca ccacaatagc cttgcaaacc ccctcgattg tggacctggg ccaccaagtc
     8161 tgtgtgcgat agcccttgat tcttcagaaa ctggaagtat tgggtgaatt gtatgatggc
     8221 gaggcgcggt agggccacga ctcctgaagc gaaagaagct gcaggttccg agagtccatc
     8281 gaccaaccac tggacgagca catccgtgaa tctttgtcca ttctttaggt ttgccacgtt
     8341 ggcattggtt tctgataata gcaatcggac atcgttgagc ttgtgtgcat ctcgaattat
     8401 acatctaaga accgggtgct ccagtataaa agttcgaatt gagtctaggt agggtactga
     8461 aggagcgcga ctttgtgggc caaatacggc aagagacact gccatgttga atgaggacag
     8521 tggtatggct atgttccatg ctatgcacgg tgttgattaa gtttagctgc ctcccacgct
     8581 cggtcgcccc aacaacacgt gatttttagc atttccacga gggcgcaatc tctttcggac
     8641 taaagcatca ccgcttgtac aattgtaccg atacttcaga aagcaaaatt tgtgctgacc
     8701 taccggcaat gaagcttctc gggtggtttt ggacccatca tctgtcgccg cggagggtta
     8761 tcaaaggcgg aattctaaaa caccaaaaca gcccaaaatg cgccgaacac gataacaagc
     8821 tattttggct ccggctccat tctgccgtta gtttcaccag ctcgattatc taggcaagta
     8881 tcggtgtcgt tgtgctggtc aagccctctg ttgcccatga tatgatgatg atgaagtaag
     8941 cagaattacg catgccgtga catacacaat gtactgtgct gaaaccacaa acagtcagac
     9001 cacgtttagc gacgccttcc ggagcaggtc gtggccagag cgctcgcagc tccagtctat
     9061 ttggcacgtc tctgcgcttt tgatcacagg cgtcagtcac aaccagatcc ccctacctct
     9121 tcaaccgaag cgtgcctaac tcatatgata gtttgctctt gtacgattgt attatctcgc
     9181 cttcctccat cctctctcga gataccctgg ccccaaactc tgggcaattt ctcgtattcc
     9241 ctgggcatac cacgttatca agggggatgt gtggcactcg ctggacagat tccacgatca
     9301 atatggacca gtggtacgga ttgctccaga tgagctgaca tacatctcac ctgaagcgtg
     9361 gagagacatc tataccgtaa agccagactt ggacaaagat ccttatagtc ttacgccgcc
     9421 actgaatggt gcagattcac tttttaccgc catgggagaa aatcacaaac gtattcgagg
     9481 tgctttcatc aatgcattct ctgacaaggc tctccgagag caatcaagta tactggaaat
     9541 gtacgcgcag caacttatac agaggttgaa gaccgagatg cacaagaaga catcgcgtgt
     9601 aatcgacgtg cagaaattcg ttggttatgc tgtcttcgat atcatatcag acctgacctg
     9661 gggcgaatct ccaggcgccc tgaactcaac aggcgatcag aattgggtaa accgattttt
     9721 ccttcacgct cagttcagta cagtgcgcaa ttgtctcagc cgatttccac cactagacaa
     9781 agctctctac tacgtctttc tgagcgtgac ttcgaaacag cgtgtcgcca ataccaagct
     9841 gaccaccgaa cgaatcgatc gccgtctggc agcaggtcac tctcgctccg actttatgac
     9901 accattgatt ggaaagatca aggaagacgg tcgcaaaggt atcacgaaga gtgaagttct
     9961 taccaacggt ttggcagtag ttatagccaa ctctcaactc acaactatcg ccattacttc
    10021 cgcattgtat ctcttgctgc ggaaccccga gaagttagga gtcgctgcag aagagatact
    10081 aaacgcaggg tttgataacg aagcggagat tgatgtcgcc aaaacgcaag cacttccata
    10141 tctgaaagct gtcattagcg aggcattgag gctgcaccat cctacccctg ggaatctacc
    10201 gagagtcgcc cctaaagaag gcctcgtcgt agccggaaga tttgtacccg gcggatctat
    10261 cattggggtt agcctgtaca acattcacac tcgtccggaa aacttcagac gtccactcga
    10321 tttccatcca gagcgatttt tggataagac ggatgcgagg tacaatccca tattccagag
    10381 tgattcgttg gaagcatttc agcccttttc tatgggacaa aggaattgca tcgggtccaa
    10441 gtcagttcag cgtgtttcaa tcatcactac agaatatgct aacgatgttt tcgataggct
    10501 gttcttggca gaggcgcgtg tcatgttagc caagatgata tggtcattcg atatgagatt
    10561 gatggagcct aatccatcca catggctgca gcaaaaggcg tggctagtct atgaaccaaa
    10621 ggctctgcaa gtacaattcc aagaaagata tgaggcaggt gaaagattga tgcaaagtac
    10681 tgttctcccg cctctggatc gcattggatg aggaatctta atcagctata accttacgcg
    10741 tgatgctcga gcatcgccat ctgtagtatt gtaaaagcgt agactacaca ctttgcttga
    10801 cactgtttct ggctgtttga gtgaatggta ctcacgcgag attaaagctg atttggagtg
    10861 accctagact attgctatac tggtgcgtta gactttgtca atggcttgca atgatcatga
    10921 gggaggctat tgaaggtttg tcaatccatg ttgacttctc ctccaatgat gctggtagga
    10981 ccaaaagttc ctgcactggc cattacatac cgcacgcgcc gaaacttcgc aagccacgtt
    11041 acactacgtt ctgaacccgg ctagtcaatt taagacttga aagacagact ggatgcaact
    11101 ctctcaaaac tgacacgtta ctcacgcagc atgatatata catgatacga gaactataga
    11161 agtgagcgta gtagggcatg aattgctatt tacagccggc gtttgagata aaccctgagt
    11221 ggtggctttt cccacatgat gtataccctt tgtgactcaa tctcaaaggc attatcgagc
    11281 aggtcaagat cgaatcgcca gaataatcgc gctagtataa gctttgtctc tgcatatgcg
    11341 aggctcatgc cgatgcaatt gcggggtccg acggagaacg gctgactggc ctcgaggtga
    11401 tcatgttgcg tccattgcgg tcgttcgtct gatttcaacc aacgttctgg ggcgaattgc
    11461 cgcggtttcg cgaaattgtc tgggttttcg ttggacgcca gcgcatagac actaatgatt
    11521 gtccctcccg gcaggaagtg accagaaagc gaggatcccc ccggaggaac ttcgcgacgc
    11581 aggtccccgg aaagtggagg gtatagacgc aatgcctcgt cgatgacggc cttgatgtat
    11641 ggcagattcg ccaatcgggc catgttgata tcagactcag acttgaattc ctgggtcagt
    11701 tccttccgaa gcctctcact tgtgtttgga tttctaagaa gcaggtagat gcacccggcg
    11761 atggtcgtgg aaatcgtgtc actgccagct ggaatgatga gcgccgcgtt gacctccatt
    11821 tcgtggacag acatagagcc ctccttctgc tcattctggc gggaaatgaa cgcccagaaa
    11881 tctgctcgct tctcgtcttc gggcatggcg aggcgttgtt ggaccttatc gtaacttctt
    11941 cgcaaatgct cctggccttt caagagatga cgaatcggac cgaagacgaa aaccagtgga
    12001 aagaaaacac cgaacattct cgccgtcaga acgtagtgcg tcgacttgaa gaaattcatg
    12061 agtagcgtga cccaaggatg gtactcctgc tccttcagac agtcgaacga gctactgaat
    12121 gccagggtgc ctataatatc gaatgcgagg aactccaacc acttgatcat atcaattggg
    12181 tctccttcat cgcatcgctc atctaacctc tggaggaaca agtcgatgtg ctcttggaag
    12241 taacgctctt gctcgcgtaa tgccttgtct gaaaaagcgc gattgagtgc agctctttgg
    12301 cgtgcgtggt caacaccatt ggcggtgagt aagtctggga ctccaggacg aagctgtcga
    12361 tagcctgact tcagatactt cttcgacgca ggatacccat atatatcttt ccaagaagtc
    12421 ggcgcagcaa aagagatcat ctcaggactg acgcgcacaa ctggcccata tttgacatgg
    12481 aggtcgcgaa cggcgtggga ctctctgcct tgtaggctcg tgattgcgca tggcaagaat
    12541 gagaacttgc gataatttgg tccgggtatt ttcgcaagtg gactaaggat cgtcgcgtag
    12601 acggcgtacg atacgtagta gacaagatac taaacatatc agtacgcgca tcccggcata
    12661 tctagcaaca cagtgagact tacggaacct atagcaatca cagcgatgtg taaagaagat
    12721 aggctgccaa ctctgggcct ggtgagggta tccatgctca gtggtgctgt tgacgaggta
    12781 acagaaagaa cgagttccag aatgtcaccc tcaccacacc tacaagcacg tgcagaacgg
    12841 taatgggttt cgttacatgc atgtgtgtcg ccatatctat tccaataaca ttcttcctgc
    12901 tcagctcggc cgtggaacag atgcccactg tctcggtctg atgttgataa ccttccgaac
    12961 gataggactg gccaatcaac cctccgaaac cttccgagac gagcactcga tcatgactat
    13021 gatacggcgc caccagtcaa tacactggaa aattgtgccg aatacgagac gatagcctca
    13081 tttgtccgag ttcctgaatc gccatcgtta aaggtgattg ggcgcatcca gcaagagatc
    13141 tccaaccagg tgacttggta ggaggacgcg gatgagctga catcttatct atgctttttg
    13201 tactcaattt atcaaaatat aagcactcaa tctgcgagaa agaaaagcga agacaacccc
    13261 agatttcacc tatcacactc tgataatcca ataggaataa tggtgggcac aattgacaca
    13321 caccaccacc tcatccctcc acgcttcaac gaacgtacgt cttttgaatc atgaccctta
    13381 cctgtcaata tatagtacta agcatcacga ttttagtgtg gtttgccaac atcgagaaag
    13441 cgcgtgggct tcatcttccc tcttggtcca aagaagggac actccaaacc atagaccatg
    13501 taggactggg atcagcaata atatctctcg ggcatccagt tcatccctac gtcgatgata
    13561 ccgcacaagt agcgccaatc tgccgcgaga tcaatgacta caccgctaca tttcgcgacg
    13621 aacatcccag caagataggt ttcttcgcaa cgctacctcc actggatcag tcagaggcgt
    13681 gcattggcga gatccgttat ggcctcgagc agctcaaagc agacggtgtt gtcattttca
    13741 gcagctactc gggtcgctac ctcggccaca acgactttcg cgtggtgtgg gaggaactaa
    13801 atcgcctcaa agcggttgtc ctgatccacc caggattcga gggtatggcg ccgattgagg
    13861 agccacgatt attagctgcg ccgatcatcg attggacgca cgagactaca cgcaccgcag
    13921 tccacctcat tacgaccaat gtcatacgag attttccgga ctgcaaggtc atcctttcgc
    13981 atgctggcgg atctctccca tacgttatta accgcgctgc aaatctctgc tgccgtctgc
    14041 gtattgcgaa caagacagaa gccgaattca tcgaagaggc tcgcggattc tacgttgatg
    14101 tagcatttag tggccacgaa ccacagttgc gactattgaa ggaattcttg aagcccgatc
    14161 atgtgctctt tggtagtgat tatccatggg aacaaggtga cattgtgagt gagcagctag
    14221 cggccactga caatgtgttt ggtgaggaaa ctcgcagagc agcgctgaag ctgttccctc
    14281 gactttctca gtatggatag accgccaata tcaatgattt tgatcacatc tttttacaag
    14341 accgtctctt tatagaagtg acttttccga aatctcctat tcatttgtgt tgcaaatgac
    14401 atgatactac cttaagtgcg atcacgagta ttccctagct cgaacacata tgctggaagg
    14461 caggccaccc gccaagccaa gttgacgtga gacgggcagt catcttgtcg ctggcacctt
    14521 gtaatttaga tcatgtcgca tgtatataaa gataccacag gctcattgat tatcactaac
    14581 acgtacatag tgcccctgcc tcttctctag acacatctcc agtgtttcca ggatcgtgcg
    14641 ctccaagccc ttatagccag gctgtcccca ccatttcctc aaaaggtcgg ccccaagcgc
    14701 gttgtcaatg gtactaatgt cgagaagctc gttcggtttc ggatccggca gttgggcatc
    14761 aggcagtgct ttgcgcaatg tctggatgac aagcgtccaa ttgaacggcg aatcacaaac
    14821 gaatatcctc tcaccggcta ccgtgccgtc gatggcggct gcgacatgaa tgcgtgcatc
    14881 gtctattgtg tctgccatgt acactaagta gcgaaagtgt tagcgacaaa agcagtagag
    14941 atgaatactg tcagagacta gatggaggtg gcgtaccaga gggtatcggt gggacattgc
    15001 cgtccaaaac gctcatgacc tgcccgccgc tgattcccat agagcccata accttgcccc
    15061 aattcattgc cgggttcgta acattgactc taaacggagg tttgcggcgc tccagaaagt
    15121 cccacgcggc gcgctcagcc tcaatcttgg acacgacgta caccacgtaa ccccactcaa
    15181 agcccatttt tccccgctct tccggtgccg tgttccgcac caaatccacg gcttcttggt
    15241 tccaggtgtc acggcccatg tgaaactcca ctccaggtct gggccccgat gctgctccgc
    15301 tcgtcgaggt cagaaccacg ctcttcacac tcgggttctg caaagcggct tcgagaatgt
    15361 tcatggtccc tttcactgtt ggtgtgatca cttcctcgac gatcccggag aacgaaacga
    15421 tcgaggcgca atgtacagcg gcagagactc ccctcattga ctcgttaaat gctccttcgg
    15481 ctgccatatc tggaacaatg gtgaattcga aggctggcga attcaaaagg tcacggactt
    15541 gttcgccttt ttgttgtgat cgcacggtac cgcgcactcg aaaccccgct ctaagcgcct
    15601 cgtctgcgat gtgtatggcg atcatacctg agactccagt cacgaggatc gtcgagcctg
    15661 gcggtacatc aaggtcctgg tggccttgaa atgaatacat gttgctgcga tgcggttcca
    15721 atcgtcgtat gggacgatac tgtcagaagt aagataggta tccaccgcgt ttgtaattgg
    15781 cctctcacac gatggggaat ctggccccag actttgaaat atctcacgtt cgttatacgg
    15841 ttgtggtaag tatctggggc agggactctg gagcaagaga gccgatccgg gtcggtgcgc
    15901 ttgtggagat atcgagattg atcaggacat acaaaccgta ctagcagatg tcacagcctc
    15961 tcgttcacat tggccgagag tgctagtgga gaaattgttg gactatgcct tggctacctg
    16021 cgccgacctg gcgtggacgt cgaagacccc caacacgcag ggatttcacg aagaatcctg
    16081 gttttcgaga tggccagcgt acctgagctc ggcgtgaggg accaggcctc ggggttgctc
    16141 gaagcgatat gacaatccga ccgcacgtca aatttaaatg ctccgagacg acaaaaaaac
    16201 cacccgttga tccacgtcct agtgcggcat aatcagaaac cttgcgattc gaaattgtgt
    16261 ccaggcccgt cggtgcctta atattgtacg cacgatgctg gtgagtagag tctctaagaa
    16321 cacgtgacta gctgtacaac ttctctggct tcactaacag taatcactca agcctgcaat
    16381 cgaaggcatc atgtcctctg taagtatact tcctgaatat catcgtgcga ttgctctctg
    16441 acactaccct ccatcaagga ctccgagcaa aacacacccg tttacaaact caaccacgtc
    16501 ggcatctccg tgcccgactg cgaagcggcc gtgtcatggt acggcaccat cttcgggttc
    16561 cagcttctca agccagtgct acacgtcaaa agggcacatt tcccgggcgc tccgatcttc
    16621 aaagtgttcg gggatgagct gcaagaattc aagcttgcgt ggcttgctac agggcattct
    16681 gtaggtctag agctattcga gttcatcgat ccctgccaca agacgcccga ggggcctgcc
    16741 ttcgattact cgagaggcgg cgtctttcac attgccatca ccgtgccgga tccagagaag
    16801 atgtgtgtag acgtggtcag ggcgggtgga aaaaggatga gcgatgtagt gcctatgccg
    16861 atgggcaact cgatggcata ttgtcaggat ccgtggggga atgcgattga gcttttgaca
    16921 actagcttta gtgacatggt ctacaacggt gcgcccaaga cggattagtg tcgaaacttg
    16981 gttatccatt tgtacttggg attctctgct tttctagaga tgcggtattg tctcgatacg
    17041 tttactgtac aagatcacat ggagcgcggg acagtagtag tcatagtaaa ggaaacctga
    17101 tctcacgcgc ttgctgggct cttatatctt gccaacgcag aataagtccg ttctagtaga
    17161 ctgctcgatg cagtctcgag atgtccctgg tccagagctc tcgatctttg cgagatgcgg
    17221 tggtggatgc tcgacacaac ctcgttcata gatattatca tccctcgcag catttcctgc
    17281 agaagcaagt ctttttctga atcgtccaga acgaatttgc caatagcggc gaccgcatgt
    17341 cggctgacca cagcagaggc cggaggctgc atgattttgg acggattgct gggcaattcg
    17401 cggcaagtag tcgaccacgc catgtcggag aagtccagta gacgggcaat gcattcaaga
    17461 agtacttgtg cgtagtctag agactggtaa cagccgtcgt cgcaacgtga gggatctttg
    17521 agagtgtcaa cgagacattc ggaaagttga aagacttgcg tgacgtcgag aaagggtgtc
    17581 tgcacttggt gatagacatt gtctagttcg cgccggagac gacaagtcag gggctggtca
    17641 attgagaggt ccattgatct gcccacggat cctgtgcgac cgtgggcacg cagcttaggt
    17701 atttggccgc ggctgatgtc actccccgcc accaacgctg tcgctgtccg actgaacaag
    17761 gcgtcgcaaa atccgccgaa ttggctcacg gacgcgactc cctattcgtg tgtgcgtgac
    17821 aacgtgcgtg acacgacgtt agcggccagt cgggaacttc aacaggcgcc agcgggcggc
    17881 gccatctctg cctgcatccg caccaacttg ccaacccagt cgcgcgaata ccccgctgct
    17941 cacctccatc aaacactcgt ggcatggccg aacgagtgtt gcagtcgttc cagcagctgg
    18001 agaaggtaag cagcttggcc acggccagcc tcgtagtcat gagctaactg cgcggcccgt
    18061 tccacagctg ggcgagggca cctacgcaac ggtagacatc actaccccgg cccgggaacc
    18121 atcactcgga gctagcgctc atatctaaca caccccctgt aggtatacaa aggccgtaat
    18181 cgcaacacgg gtcagctagt cgccttgaag gagatccgcc tcgactcgga agaaggaaca
    18241 ccatcgacgg ccatccgcga gatctcgctc atgaaggagc tggctcacga gaacatcctg
    18301 accctgtacg atgtgatcca tacggacgaa aagctgatac tggtctccga gttcatggac
    18361 atggatctaa agaagtatat cgacagccgc catgcaggcg agagcgactt ccacagattc
    18421 ttcactgcca agagcttcat ctatcagatg gtccgcggca ttgcctattg tcacgagaag
    18481 atggtcttgc accgtgatct caaaccgcaa aacttgctta tcaacaggtc agggtgtctg
    18541 aagctggcag atttcggatt agctagagca tttggggtgc cagtaaacac cttctcgaac
    18601 gaggttgtaa cgttatggta tcgacctcct gatgtgctcc tcggcagtcg gtcgtacaac
    18661 acgtccatcg atatctggtc tatgggttgc ataattgcag agatcttcac cggccgtccc
    18721 ctctttgctg gtaacacgaa tgaggatcag ctgcaaaaga tattccgtct aatgggaacc
    18781 ccttcagagc gatcgtggcc cggtgtccag cagctgccag gcttcgcaag ccttgcccaa
    18841 atgagaacgt accccatgca ggatctagtg caggtggtgc ctcaagtcga cgtgatgggc
    18901 ctcgatcttc tgaagagact gttacagccg tgcccagagg ctcgcatctc agccgcagac
    18961 gcgctcaatc atccctggtt ccaggacgtc cagccagccc accaaagctt gacgtagatg
    19021 aggaactgga aaatcacggt tgataccaga cttttcgagg agacttactt gcgcagaccc
    19081 gatgatggca aggccgaatg atggtggaat cacagcaaga atacggggaa actcacgggc
    19141 ggctgatctc gggcaggacg cagcagaact gctgtagggc aatcaagaga ttttcagcat
    19201 gtgaatgaat cagtgttgtg cttatttaga aaggaagggc tatttgacat tcatcgagga
    19261 tttcgagtgc tactttgcga gcagtttatc gcgtcatacc agtaacataa ttgtagcgca
    19321 cggcgatagc ttatgctatt gcctcattga gctagccttt tcattccttg attgtgacct
    19381 cgagaaggct ctccgcatct ggctcgagtg tccagatttt gtcaattttg aggccagccg
    19441 actcaatcag cgcgtaccac tgacgctcgg tgcgctcgac cgcagcattg acagacatga
    19501 ccatgaagtc ggaatgcgtt gcaaacgtgc atgcaccctt caaagggatg ttgaactcgt
    19561 tgatcaagat cttagagtat cccggcttca tggcgtcacg aatgtgcccg aggataatgc
    19621 gacagcgatc gtcatcccaa tcatgtagca cactgcggaa gtagtatgct ctggcgcctt
    19681 tacaagtacg ttactattgt agcctatgga gatggacgac cggcacatac ctttgattgg
    19741 ttgcggcgtg aagaagtcat gggcaatagc ctccatgccg ctatcaaggt tcacacgctc
    19801 aatggttgcc ttgaggtcct cgacgattag cctgccaggc acgttggggt acctcttctt
    19861 gacagccttg atctcatggc cgacgctacc tcccacatct acaaggaaag ctgcattcgg
    19921 gtcactggtg tcgaaaccgg ggatgagttc ctgctcaaga gggtaaaagt cgagccactg
    19981 tgggtgccca acccgctgcg tagtcatgaa ctgatggaac gagtgcaata gttcgggctg
    20041 cttgccaagc cagtcaaagt atgcctcacc attgaactgc ttgttgaaag gcattgcatt
    20101 tggatccgtc gggttctgat accctgtctc cttgaggaac ttgggaaacg tcatccatcc
    20161 tgcatgaatg acattgtggc tgtgaagtta cgtcagcttc atatcgcata caagtagcag
    20221 acatgatgca tgggggaatg ttaggcaggt agcatggaag gatgcactca caagagatca
    20281 attccagatt gacccttgac cgtagcaaaa gcacgggtaa ctttgtttgg ggcgtagacc
    20341 tcggtactcg cttcgtctac ggccccaatc gatgtcaggc cgcgcattat cctagcgaga
    20401 aggatctcgt tcgccccagt gaaggaagcc aaatgctgga ggggcactgg tttctcggcg
    20461 ctgcttaatt tctcaaacag acccaggtcc gttccaatct tgaacaagag tacatctata
    20521 gtctgcgtta catctaccgt cagtaccaat catcgcgagg tgttcgtgaa ccgcatgcga
    20581 aggttccaca atgcacacca cttacaccat aaagataccc ctcgacgatc tgaccctcat
    20641 tttgcaaagc atttgtcaac cttctggagg tatcgagaag ctccctgcgc ttttggcgcg
    20701 cctctggact gtcttccttg acatctgcaa gctttttaag gtcttgacca atccgagaca
    20761 cctgatctac gtattggttg acttcgtcct gcatgctggc ggtttgatag tggtgtgcgt
    20821 ggtaagattc agttgcgcta aaaggggttg agttcccgtc ttgttcaagc tagatactga
    20881 ccagcgtgat gcttttgaag cgcccatcag ctgtgtggct cctgattatc tcggcctatc
    20941 ggttgtgaaa gcaatttcat ccttcacacg ctttgatgac gggaacaccg agttgcgagc
    21001 gagacgcagc tcccatcgga tcctatagct tcggccagtt tcgctgcaaa atcatccgag
    21061 cgtgtgacta acgtccactg gaaatattgc gacagatagg gctacatgcg tgcacatgta
    21121 agctgcgtaa gatcttcaag catgtctcct gcagacaaga tatcaggact aacgtgtagc
    21181 cccacctaac attaagtggt tgaggggtgt tttcccacca tgattcctgc ggtggggcgt
    21241 taagctctag gccaagacca acacagccat gagcgaatgt atggatggga taacatcgtg
    21301 taggagggat gctgacccgg ggttgggcgt tggatccaat gtctgatttc cccagctcgc
    21361 gaagctggtc caaaggatcc tcagaatacg agtgttacac cacttgtgcg acatgggtca
    21421 ccacaagggc acatctctgc tagtagattc atgcagattg tcgcttatgg caagtctggt
    21481 ttggacacat ggtcaacgtc tgaacggcat cggattcaaa tatgtcatct gtgcgaccaa
    21541 ctaagaattg attcacagct cagcttgtct gagtcgcaga ggtgcagcag accaaggata
    21601 tcgcaagcaa tcgcgcatgt ttcgcgttcg gccacggttg catggtggcg ttggaacctg
    21661 gcgcgcgggc cgcccgccca cccgctcttg ctcgtgggtc aacgacggga aacgttactg
    21721 ctcacaccca tggtatgtta ttgcccgccc cctaaggcga gtcttgccgc atctgctagt
    21781 catctcaagt tgttctagac ctacttgtaa atctgtctgg cgtactagtg agaggcagct
    21841 tatagcagat ttctctctta ctatgggggt gggcagtaac gtttcccgtc gacgacgcct
    21901 tgtccgctgc cgtccccact cagcatgcag ttctaaagca cacagctaga tcctgaggag
    21961 cttgaaatct ggactgaacg cccttcccat cgctacttct cttcctagct agcgctggct
    22021 ggagtttctg tgcgtgagcc aaccgtacgc gaaacaaaac ccccatattc tttctggagc
    22081 accgagctgg cccccacttg gctatccgtt catagctacg gtattctgct gccgatcaca
    22141 aaaaagcagc aagcgtcttg cgtctgacac actggtctgg catattcttc acctgtgttt
    22201 ctgcttcgat aaattagctt ggttgaagcc agaccaaagg cgcatggatg cagtgatcca
    22261 tgcccgctgc cctgcacagc acatgcgatt cgggccggcc gagagtatag tgtgatatgc
    22321 catgcgtacg gatgaagcgt gatgccacaa tcttgtcatt tagcaacacc ggcactgcca
    22381 ggactgctgt gggggtcctt cgcttacttg tatgcgggtc ttttagacag cacttgtaag
    22441 ctgacctctg gcactgaaac tgtaggatcg ttggaacatg atgcgaggcc aatagctgaa
    22501 aggataacag cctggtggcg taattgtggt gcggggtata ctcgaacggc agacagcgat
    22561 acaggacgcc ctgctatcta tatactgtta ctctgacgtc gctgctcgat ctgtggcatg
    22621 cactgtcgtg ctacgtcgac gagaacattt cgcgtgccat aatgagtgaa acgtttggca
    22681 aagacagact tttctagctt ttgttctctt cttcttcttt ctgtggcttc gttcctgctc
    22741 tctacgtcta cgacgtcatg aatgaggccg agaacccgaa ggcatttcct gctggcgata
    22801 acgcgacgaa atctcagccg ctcagaaact cctgtgagcc ttgccatgcg tcgaagctga
    22861 ggtgcagccg ggagaaacct acatgtgccc gttgcacgaa gaacgggact gagtgcacat
    22921 atgccccgac aaaacgccct gggcggccgc gaaaggttcc agctgctgct tcttcaatca
    22981 gtcaaggtcc agctgcacca gcgaggcaca gtactcgtgg tgacaagaga acggagtctt
    23041 tggatacagt agtctcgagc ttggctcccg caagcgctcc cgatgacccg cgcgaccaca
    23101 ggcccgggcc gagcccgggc aggctgggct ttgggacacc accgactcaa gcccacgtcg
    23161 ccaacatcgc agacaatgtc gagatgttcg atttcgcaaa tgcgcacatg ctcgacgacg
    23221 ccagtttctt ttatgatgta ctggctgatc ctcttgaaca cacgacaaat atcgagacgg
    23281 tgagggacga caatgaggac ctctggatgc tactggacgc ccctgagagc cagccacagc
    23341 acaacgtcca atctccgttc ctcgacccag cgtactggcc catagaccct gtcaaatttg
    23401 aagatgactg cgcttcactc aaacactgta tagctgtctc acacgtgttg gggtctttca
    23461 cggacgattc tgagagggag acccttgatg aacacgattg tctatgccac accgccgcgg
    23521 caaatctcat gttccatcgc aagagtgcca aagccttccg tccaaaaccg accctggagg
    23581 cgtgcttgca cctgcagcgc gtcttggatt ggacttgggc tgccctgaag gagtgcaatg
    23641 gctgctggga cgatgaaatg attcagttca tcttggtcgg cactgtgaag gaagtggtca
    23701 tgatacaccg agcacttctt gatggtatta ctaggcgatc gaaatcggag gcgtatcacg
    23761 gcagcgtagc gaacatgggt agtcacagcg gcgagcgacg tggatttggg cgtgggcgag
    23821 gctcatactt gtcacacagc cgccacggtc tagagcggca gcaatttgta ccgatgaagg
    23881 gtccacagcc cacatcatca gctccgagac caccgctatt cgagtcaacc gccctgacgt
    23941 ttggggatac cgcgatccga gaatgcgtga agacgtcctt tctctgcagg ctgatcagca
    24001 tgaagctgcg gcatttgggt ggtcttttgg gagagctgct ctcctggacg cccaccgatc
    24061 tcaatctggg tgcagggtcg tcgccagtcc agatacacat tacgggggtc ctagaacgca
    24121 tcaacatcac cgctggagtg cttgccatgc tagagtagat acaagtggag tactcggcct
    24181 cttagaggtg gtgttgatgg caaaaggttg tgcgtttgat gcaagattct tctacacccg
    24241 cccttgtctg agactcgata gagtaggtct gattccctcg gtcaacggac cgccatgcgc
    24301 gatttctttc atcccgctca gcctgcatgt tgcgaactta ggatcgggat catctctttg
    24361 actgatcatg agagagcgtg cgattgggtg tcacgacggc agagtactcc agatagcgac
    24421 gcgtcgaagt gtgactcata gctatgcaag ggatgagtat gggcgaaagg ctcgggacag
    24481 cgccaaccgg ccccaagctc atctcacctt gcatgaaatg cttgacgtga atgagtcata
    24541 cagcaaggtg tgcacaacaa ttccaacgac gctgcacctg ggaagcttcg tctctcatgt
    24601 acgtaccgct gcatagttgc gcaatccata aagctagtct gcatgcatcc caggcgatgt
    24661 caccccgctc tgtcgccccg ttcttgttgg agattcaccc ctgacaagcg attccaatcg
    24721 gcgggtttcc cctcccggcg gagctcccgc taaccccgac ttggagacca ctggctagat
    24781 tgtaccagtc ggatagttta catctgttca ctggcgttat tacctcgttc tttgtttatt
    24841 gcgttctcct gagtactgcg tctggcgcgt ggatgcagaa cgtcgtatga ttccgcgatt
    24901 gctttcgcga ccttaatcac gtgttctggg gatgtggttc caaatcaatt tctctttcct
    24961 caatcatctt gtgccttgcg tgtcttgcat cctctaacag ctccattgac cttcacaagg
    25021 ttctacaaac atggctttga ctacagaatc cgcgcaagac tctgtcagaa ccaatagccc
    25081 cgtcacagac aagactgaca ttggcggctc gatgtcacat gtgcccgagg ccgaactcgc
    25141 aaaagagtcc cccactggaa tcgtgcccga agaatctcca actctacctg tggagcgcag
    25201 cgatgagcct tcagacgggg actccatcga gtacccctct ggagcaacgt tgctgttgat
    25261 caatttgagt ttgtgtctct cggtcttcct ggccgcactg gtatgcgtgt ttgcttcact
    25321 tttcgcgcga aacgttgttg ctgatcgaag atgcaggata acaccatcat agcaactgta
    25381 ggtcttcctt tgagttgctg aacatgttct gacacagctt acccaggcca tcccaaaaag
    25441 taagccgcac cttaacactc gtcctgaggg caccaaggag cattgcccat tctccgtcgt
    25501 ccacgaacac cacaggcgat gttcggccaa gggatgatga cgacttcggg tttgcgagct
    25561 tgagaacagg catgaaattt tgctgcatca ggtggtcaca tacccaagcg tccggacaca
    25621 tcatttcggt ctcttgtaac ttccactaac ttcgcatagt caccaaccac ttctcgagtc
    25681 aggcagacat cggttggtat ggaagctgta agtagacacg aaatctatat gtcgcgagct
    25741 aaagctaacc acattgaatg tgacagccta tcttctcaca caggcttcgg ttcagctgct
    25801 tttcggcaag ttctacaccg tggtttccat taaatgggtc ttcctgacgg ctattgcaat
    25861 cttcgagctt ggctctctcg tttgcggagt ggctcccaat tccacagcgc tgatctgtgg
    25921 ccgagcgatc gcgggtctgg gagcggcagg catctccagt ggtgccgtca tcagtaagta
    25981 atcctgacga tgcactcgtt ctgatagtcg tcagtttcat catcaaggcc agtgctaacg
    26041 acagcatagt cattacatac tccgttccag caccaaaacg tcccatgtac actggcttga
    26101 tcggtgcaat gtacggcatc gcttctgttg ccggtccact acttggtggc gcatttacgg
    26161 ataaagtgac atggcgagta agtgttcgac aaagatatgt cgcagatatg cggtctgact
    26221 tgtcatcaat agtggtgttt ctatatcaac cttccgttgg gggctgttgc tgttctgacc
    26281 atccttttct tcttcaaatc accccacagg aaagaggtct ccaatcttag cttcaaggat
    26341 cgtcttgcag aattcgacct cgtcggcacg gcaggtgagt acacatcgtg aagaaaccag
    26401 tcgtgataac caggacatga ctaaatatag acaatatagt tttcatgccc gcggtcatat
    26461 gcttgctcct cgctctccaa tggggtggga ccacacatcc ctggtccaac tggagaatca
    26521 tcctactgct cgttctgttc gctgtcctct tcttcgtgtg ggtcggaata caaatcaagc
    26581 aaggtgactc cgcaacggtt cctccgagtc tcctcaagaa gcgatccatt gctgctgcat
    26641 catggtacat cttcgcactg ggatcctatt tccttgttct catctactat ctgcccattt
    26701 ggttccaagc tgtcaagggc acgactgcgg tcgaatcggg catccgcaac ctaccattga
    26761 tcctagggtt ggttatagtc tctattggct ccggcattgg tgtcaccgtt acaggctact
    26821 gtaagtcgcg acctctgctt catgtaccgc ttgtaacggc tctaatttcg gtcagatgcg
    26881 cccttcatgg tcgcgagtgc tatcgtctcc tctatagcgc tcggactgat gactaccttc
    26941 aagcccgaaa gtggcgcgaa tgaatggatc gggtatcaag ccatggtgag caccagctaa
    27001 aatccttact tgcttatgta caatgaactt acaacacctt cacaggcggg catcggcgtt
    27061 ggcttcggcg tccaacaacc cctcatcgtc gtacagacca tcctccctct gacccaagtt
    27121 tccatcggca cgtccctgat gtacttcctc caatccatcg gcggtgcgct cttcatcgcc
    27181 attgcgcaaa acgtcttcac caacaaactt gcctctgatc tcgcccgcta cgtgcctgac
    27241 ctcgatgcct ccatcgtgct gcgatctggt gcaacgagtc tccagcagac cgtgcctgcc
    27301 tcccagcttc cacttgttca acgggcctac aacaatgcta tcacgcgtgc ttttttggtc
    27361 gcgactatta tggctgcgct gacgcttgtc ggtgcgttgc tcgtagagtg gaagaacatc
    27421 aaggctgcga aggccggcga ggagaagcag gacggagctg atacggaagg caagaacgcc
    27481 attcgctcga aagaatgagc taccacttta tatcaatact caggtatac
//
