BGC0003094 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0003094 (Phaeosphaeria sp)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	27,529

BGC0003094 - Region 1 - T1PKS

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Location: 1 - 27,529 nt. (total: 27,529 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 27,530
Label		BGC0003094

Tailoring functions

Oxidoreductases: dehydratase oxygenase

prosA: Oxidation

MITE: MITE0000168Oxidation (identity: 100.00%)
smcogs: SMCOG1034: cytochrome P450

prosC: Reduction

MITE: MITE0000169Reduction (identity: 100.00%)
smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

prosK: Cyclization

MITE: MITE0000170Cyclization (identity: 100.00%)
smcogs: SMCOG1034: cytochrome P450

Transferases: methyltransferase

prosF: Methylation

MITE: MITE0000166Methylation (identity: 100.00%)
smcogs: SMCOG1042: O-methyltransferase

Hydrolases: Hydrolysis

prosD: Hydrolysis

MITE: MITE0000167Hydrolysis (identity: 100.00%)

Lyases: Decarboxylation dehydratase

prosB: Decarboxylation

MITE: MITE0000171Decarboxylation (identity: 100.00%)

prosC: Reduction

MITE: MITE0000169Reduction (identity: 100.00%)
smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

prosJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0000037.4	0.63	PKS	cichorine	Aspergillus nidulans FGSC A4
BGC0001273.3	0.63	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.63	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.3	0.63	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0002175.3	0.63	PKS	YWA1	Aspergillus oryzae RIB40
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000107.3	0.62	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0002192.3	0.61	PKS	FR901512	fungal sp. No.14919

Similar known clusters from MIBiG 4.0

No significant matches found.

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 27529:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (mal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

prosJ: mal

PKS_AT (900..1187): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 63.1
Methoxymalonyl-CoA: 49.3
Methylmalonyl-CoA: 42.8
fatty_acid: 34.2
inactive: 30.5
2-Methylbutyryl-CoA: 21.8
Propionyl-CoA: 21.1
Ethylmalonyl-CoA: 18.8
Benzoyl-CoA: 15.9
Acetyl-CoA: 13.7
CHC-CoA: 13.4
trans-1,2-CPDA: 10.7
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor