BGC0003168: pekiskomycin biosynthetic gene cluster from Streptomyces sp. WAC1420
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Location: 1 - 85,659 nt. (total: 85,659 nt).
This entry is originally from NCBI GenBank JX026280.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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General
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NRPS/PKS domains
General information about the BGC

MIBiG accession | BGC0003168
Short description | pekiskomycin biosynthetic gene cluster from Streptomyces sp. WAC1420
Status | Quality: high The quality level of this entry. Status: pending The status of this entry. Completeness: complete Whether the entry covers everything needed for the pathway producing the compound(s)

Biosynthetic class(es)

- NRPS (Type I)
- saccharide (None)

Loci
JX026280
via Correlation of genomic and metabolomic data [1]
Compounds

- pekiskomycin

Species Streptomyces sp. WAC1420 [taxonomy]
References

- [1] Identifying producers of antibacterial compounds by screening for antibiotic resistance. Thaker, M et al., Nature Biotechnology (2013) DOI:10.1038/nbt.2685

Chemical products information
pekiskomycin Evidence: NMR [1]
Copy SMILES
C59H62Cl1N7O25S1
List of genes involved in compound(s) production

Identifiers | Position | Product | Functions | Evidence | Extra
--- | --- | --- | --- | --- | ---
AGF91733.1 | 1341 - 1526 (-) | YbaK-like protein |  |  | copy AA seq copy Nt seq
AGF91734.1 | 1568 - 1639 (-) | hypothetical protein |  |  | copy AA seq copy Nt seq
AGF91735.1 pek1 | 1861 - 2454 (-) | tetratricopeptide domain protein |  |  | copy AA seq copy Nt seq
AGF91736.1 pek2 | 2542 - 3150 (-) | D-ala-D-ala peptidase |  |  | copy AA seq copy Nt seq
AGF91737.1 pek3 | 3147 - 4187 (-) | D-ala-D-lac ligase |  |  | copy AA seq copy Nt seq
AGF91738.1 pek4 | 4180 - 5220 (-) | D-lac dehydrogenase |  |  | copy AA seq copy Nt seq
AGF91739.1 pek5 | 5444 - 6787 (+) | MurF-like protein |  |  | copy AA seq copy Nt seq
AGF91740.1 pek6 | 6926 - 7933 (+) | XRE family transcriptional regulator |  |  | copy AA seq copy Nt seq
AGF91741.1 pek7 | 9775 - 10740 (+) | StrR family transcriptional regulator |  |  | copy AA seq copy Nt seq
AGF91743.1 pek8 | 11108 - 11611 (-) | DD-carboxypeptidase |  |  | copy AA seq copy Nt seq
AGF91744.1 pek9 | 11698 - 12393 (+) | response regulator |  |  | copy AA seq copy Nt seq
AGF91745.1 pek10 | 12386 - 13510 (+) | sensor kinase |  |  | copy AA seq copy Nt seq
AGF91746.1 pek11 | 13639 - 14502 (-) | sulfate ABC transporter permease |  |  | copy AA seq copy Nt seq
AGF91747.1 pek12 | 14489 - 15235 (-) | aliphatic sulfonate import ATB binding protein |  |  | copy AA seq copy Nt seq
AGF91748.1 pek13 | 15223 - 16494 (-) | sulfate adenylyltransferase-1 |  |  | copy AA seq copy Nt seq
AGF91749.1 pek14 | 16498 - 17403 (-) | sulfate adenylyltransferase-2 |  |  | copy AA seq copy Nt seq
AGF91750.1 pek15 | 17400 - 18158 (-) | adenylylsulfate kinase |  |  | copy AA seq copy Nt seq
AGF91751.1 pek16 | 18882 - 19967 (+) | SAM methyltransferase |  |  | copy AA seq copy Nt seq
AGF91752.1 pek17 | 20718 - 22703 (+) | ABC transporter |  |  | copy AA seq copy Nt seq
AGF91753.1 pek18 | 22700 - 32122 (+) | peptide synthetase (mod 1-3) |  |  | copy AA seq copy Nt seq
AGF91754.1 pek19 | 32453 - 33619 (+) | prephenate dehydrogenase |  |  | copy AA seq copy Nt seq
AGF91755.1 pek20 | 34191 - 46520 (+) | peptide synthetase (mod 4-6) |  |  | copy AA seq copy Nt seq
AGF91756.1 pek21 | 46252 - 52125 (+) | peptide synthetase (mod 7) |  |  | copy AA seq copy Nt seq
AGF91757.1 pek22 | 52122 - 52328 (+) | MbtH-like protein |  |  | copy AA seq copy Nt seq
AGF91758.1 pek23 | 52344 - 53648 (+) | monooxygenase (a.a. 2&4) |  |  | copy AA seq copy Nt seq
AGF91759.1 pek24 | 53694 - 54890 (+) | monooxygenase (a.a. 4&6) |  |  | copy AA seq copy Nt seq
AGF91760.1 pek25 | 54891 - 55778 (+) | sulfotransferase |  |  | copy AA seq copy Nt seq
AGF91761.1 pek26 | 55830 - 57050 (+) | monooxygenase (a.a. 5&7) |  |  | copy AA seq copy Nt seq
AGF91762.1 pek27 | 57121 - 58599 (+) | halogenase |  |  | copy AA seq copy Nt seq
AGF91763.1 pek28 | 58627 - 59886 (+) | glycosyltransferase |  |  | copy AA seq copy Nt seq
AGF91764.1 pek29 | 60000 - 60758 (+) | pseudoaglycone deacetylase |  |  | copy AA seq copy Nt seq
AGF91765.1 pek30 | 60785 - 61606 (+) | N-methyltransferase |  |  | copy AA seq copy Nt seq
AGF91766.1 pek31 | 61622 - 62908 (-) | phenylglycine aminotransferase |  |  | copy AA seq copy Nt seq
AGF91767.1 pek32 | 63024 - 63989 (+) | putative hydrolase |  |  | copy AA seq copy Nt seq
AGF91768.1 pek33 | 64084 - 65820 (+) | peptide synthetase-3 |  |  | copy AA seq copy Nt seq
AGF91769.1 pek34 | 65835 - 67034 (+) | P450 monooxygenase |  |  | copy AA seq copy Nt seq
AGF91770.1 pek35 | 67437 - 68519 (+) | hydroxyphenyl pyruvate dioxygenase |  |  | copy AA seq copy Nt seq
AGF91771.1 pek36 | 68516 - 69592 (+) | phenylglycolate oxidase |  |  | copy AA seq copy Nt seq
AGF91772.1 pek37 | 69807 - 70925 (+) | dihydroxyphenylglycine synthase |  |  | copy AA seq copy Nt seq
AGF91773.1 pek38 | 70919 - 71593 (+) | enoyl-CoA hydratase |  |  | copy AA seq copy Nt seq
AGF91774.1 pek39 | 71590 - 72888 (+) | hydroxyacyl-dehydrogenase |  |  | copy AA seq copy Nt seq
AGF91775.1 pek40 | 73083 - 74414 (+) | membrane ion transporter |  |  | copy AA seq copy Nt seq
AGF91776.1 pek41 | 74548 - 74850 (+) | putative membrane protein |  |  | copy AA seq copy Nt seq
AGF91777.1 pek42 | 74915 - 76081 (+) | VanJ-like protein |  |  | copy AA seq copy Nt seq

Biosynthesis information

No biosynthesis information available for this record.

Annotation changelog

#### Entry version: 1

Date
Changes
Submitters
Reviewers
2024-07-23
MIBiG v4 annotathon

- (ID: KTTDKEJDYAQ7MKSNPMBDOYYX)
- (ID: PK3KAPGHQJXJCKMJ4SU7V5JW)

- (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

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