BGC0003168: pekiskomycin biosynthetic gene cluster from Streptomyces sp. WAC1420
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Location: 1 - 85,659 nt. (total: 85,659 nt).
This entry is originally from NCBI GenBank JX026280.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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resistance
TTA codons
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General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0003168
Short description pekiskomycin biosynthetic gene cluster from Streptomyces sp. WAC1420
Status Quality: high
The quality level of this entry.

Status: pending
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • NRPS (Type I)
  • saccharide (None)
Loci
JX026280
via Correlation of genomic and metabolomic data [1]
Compounds
  • pekiskomycin
Species Streptomyces sp. WAC1420 [taxonomy]
References
Chemical products information
pekiskomycin Evidence: NMR [1]
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C59H62Cl1N7O25S1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AGF91733.1
 1341 - 1526 (-) YbaK-like protein
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    • AGF91734.1
    		 1568 - 1639 (-) hypothetical protein
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      • AGF91735.1
      • pek1
      		 1861 - 2454 (-) tetratricopeptide domain protein
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        • AGF91736.1
        • pek2
        		 2542 - 3150 (-) D-ala-D-ala peptidase
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          • AGF91737.1
          • pek3
          		 3147 - 4187 (-) D-ala-D-lac ligase
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            • AGF91738.1
            • pek4
            		 4180 - 5220 (-) D-lac dehydrogenase
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              • AGF91739.1
              • pek5
              		 5444 - 6787 (+) MurF-like protein
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                • AGF91740.1
                • pek6
                		 6926 - 7933 (+) XRE family transcriptional regulator
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                  • AGF91741.1
                  • pek7
                  		 9775 - 10740 (+) StrR family transcriptional regulator
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                    • AGF91743.1
                    • pek8
                    		 11108 - 11611 (-) DD-carboxypeptidase
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                      • AGF91744.1
                      • pek9
                      		 11698 - 12393 (+) response regulator
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                        • AGF91745.1
                        • pek10
                        		 12386 - 13510 (+) sensor kinase
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                          • AGF91746.1
                          • pek11
                          		 13639 - 14502 (-) sulfate ABC transporter permease
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                            • AGF91747.1
                            • pek12
                            		 14489 - 15235 (-) aliphatic sulfonate import ATB binding protein
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                              • AGF91748.1
                              • pek13
                              		 15223 - 16494 (-) sulfate adenylyltransferase-1
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                                • AGF91749.1
                                • pek14
                                		 16498 - 17403 (-) sulfate adenylyltransferase-2
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                                  • AGF91750.1
                                  • pek15
                                  		 17400 - 18158 (-) adenylylsulfate kinase
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                                    • AGF91751.1
                                    • pek16
                                    		 18882 - 19967 (+) SAM methyltransferase
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                                      • AGF91752.1
                                      • pek17
                                      		 20718 - 22703 (+) ABC transporter
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                                        • AGF91753.1
                                        • pek18
                                        		 22700 - 32122 (+) peptide synthetase (mod 1-3)
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                                          • AGF91754.1
                                          • pek19
                                          		 32453 - 33619 (+) prephenate dehydrogenase
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                                            • AGF91755.1
                                            • pek20
                                            		 34191 - 46520 (+) peptide synthetase (mod 4-6)
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                                              • AGF91756.1
                                              • pek21
                                              		 46252 - 52125 (+) peptide synthetase (mod 7)
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                                                • AGF91757.1
                                                • pek22
                                                		 52122 - 52328 (+) MbtH-like protein
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                                                  • AGF91758.1
                                                  • pek23
                                                  		 52344 - 53648 (+) monooxygenase (a.a. 2&4)
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                                                    • AGF91759.1
                                                    • pek24
                                                    		 53694 - 54890 (+) monooxygenase (a.a. 4&6)
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                                                      • AGF91760.1
                                                      • pek25
                                                      		 54891 - 55778 (+) sulfotransferase
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                                                        • AGF91761.1
                                                        • pek26
                                                        		 55830 - 57050 (+) monooxygenase (a.a. 5&7)
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                                                          • AGF91762.1
                                                          • pek27
                                                          		 57121 - 58599 (+) halogenase
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                                                            • AGF91763.1
                                                            • pek28
                                                            		 58627 - 59886 (+) glycosyltransferase
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                                                              • AGF91764.1
                                                              • pek29
                                                              		 60000 - 60758 (+) pseudoaglycone deacetylase
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                                                                • AGF91765.1
                                                                • pek30
                                                                		 60785 - 61606 (+) N-methyltransferase
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                                                                  • AGF91766.1
                                                                  • pek31
                                                                  		 61622 - 62908 (-) phenylglycine aminotransferase
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                                                                    • AGF91767.1
                                                                    • pek32
                                                                    		 63024 - 63989 (+) putative hydrolase
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                                                                      • AGF91768.1
                                                                      • pek33
                                                                      		 64084 - 65820 (+) peptide synthetase-3
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                                                                        • AGF91769.1
                                                                        • pek34
                                                                        		 65835 - 67034 (+) P450 monooxygenase
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                                                                          • AGF91770.1
                                                                          • pek35
                                                                          		 67437 - 68519 (+) hydroxyphenyl pyruvate dioxygenase
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                                                                            • AGF91771.1
                                                                            • pek36
                                                                            		 68516 - 69592 (+) phenylglycolate oxidase
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                                                                              • AGF91772.1
                                                                              • pek37
                                                                              		 69807 - 70925 (+) dihydroxyphenylglycine synthase
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                                                                                • AGF91773.1
                                                                                • pek38
                                                                                		 70919 - 71593 (+) enoyl-CoA hydratase
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                                                                                  • AGF91774.1
                                                                                  • pek39
                                                                                  		 71590 - 72888 (+) hydroxyacyl-dehydrogenase
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                                                                                    • AGF91775.1
                                                                                    • pek40
                                                                                    		 73083 - 74414 (+) membrane ion transporter
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                                                                                      • AGF91776.1
                                                                                      • pek41
                                                                                      		 74548 - 74850 (+) putative membrane protein
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                                                                                        • AGF91777.1
                                                                                        • pek42
                                                                                        		 74915 - 76081 (+) VanJ-like protein
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                                                                                          Biosynthesis information

                                                                                          No biosynthesis information available for this record.

                                                                                          Annotation changelog

                                                                                          Entry version: 1

                                                                                          Date
                                                                                          Changes
                                                                                          Submitters
                                                                                          Reviewers
                                                                                          2024-07-23
                                                                                          MIBiG v4 annotathon
                                                                                          • (ID: KTTDKEJDYAQ7MKSNPMBDOYYX)
                                                                                          • (ID: PK3KAPGHQJXJCKMJ4SU7V5JW)
                                                                                          • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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                                                                                          Shows NRPS- and PKS-related domains for each feature that contains them. Click on each domain for more information about the domain's location, consensus monomer prediction, and other details.
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