BGC0000022 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000022 (Aspergillus nidulans FGSC A4)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	41,240	chaetoviridin E / 11-epichaetomugilin A	Polyketide	27%

BGC0000022 - Region 1 - T1PKS

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Location: 1 - 41,240 nt. (total: 41,240 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 41,241
Label		BGC0000022

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000022.1	0.83	Polyketide	asperfuranone	Aspergillus nidulans FGSC A4
BGC0000099.1	0.37	Polyketide	monascorubrin	Talaromyces marneffei
BGC0001909.1	0.32	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000013.1	0.31	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001144.1	0.28	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818
BGC0000161.1	0.28	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0001541.1	0.27	Polyketide	cercosporin	Cercospora beticola
BGC0001404.1	0.26	Polyketide	sorbicillin	Penicillium rubens Wisconsin 54-1255
BGC0000048.1	0.25	Polyketide	dothistromin	Dothistroma septosporum
BGC0000862.1	0.23	Other	eicosapentaenoic acid	Shewanella pneumatophori

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000022.1	0.94	Polyketide	asperfuranone	Aspergillus nidulans FGSC A4
BGC0000099.1	0.69	Polyketide	monascorubrin	Talaromyces marneffei
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000013.1	0.64	Polyketide	alternariol	Aspergillus nidulans FGSC A4
BGC0001144.1	0.62	Polyketide	neosartoricin B	Trichophyton tonsurans CBS 112818
BGC0000161.1	0.61	Polyketide	isoterrein	Aspergillus terreus NIH2624
BGC0001541.1	0.60	Polyketide	cercosporin	Cercospora beticola
BGC0001404.1	0.59	Polyketide	sorbicillin	Penicillium rubens Wisconsin 54-1255
BGC0000048.1	0.59	Polyketide	dothistromin	Dothistroma septosporum
BGC0000862.1	0.57	Other	eicosapentaenoic acid	Shewanella pneumatophori

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 41240:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-pk) + (mal)
Non-colinear ordering:: AN1036.2 + AN1034.2

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AN1034.2

PKS_AT (975..1277): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; inactive: 58.3%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 51.4
Methoxymalonyl-CoA: 50.0
Methylmalonyl-CoA: 49.1
Ethylmalonyl-CoA: 38.6
inactive: 34.3
CHC-CoA: 28.4
Benzoyl-CoA: 22.1
2-Methylbutyryl-CoA: 19.7
trans-1,2-CPDA: 18.7
fatty_acid: 18.7
Propionyl-CoA: 18.2
Isobutyryl-CoA: 16.2
Acetyl-CoA: 14.4
3-Methylbutyryl-CoA: 0.0

AN1036.2

PKS_AT (533..876): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 61.6
Malonyl-CoA: 61.6
Methoxymalonyl-CoA: 61.5
Isobutyryl-CoA: 35.8
Ethylmalonyl-CoA: 29.3
Propionyl-CoA: 25.6
Benzoyl-CoA: 21.9
trans-1,2-CPDA: 14.9
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 2.3
inactive: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
Acetyl-CoA: -0.8