BGC0000039 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000039 (Penicillium citrinum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	38,231	monacolin K	Polyketide	77%

BGC0000039 - Region 1 - T1PKS

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Location: 1 - 38,231 nt. (total: 38,231 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 38,232
Label		BGC0000039

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000039.1	0.67	Polyketide	compactin	Penicillium citrinum
BGC0001858.1	0.34	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000098.1	0.26	Polyketide	monacolin K	Monascus pilosus
BGC0000041.1	0.24	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001909.1	0.23	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.22	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001899.1	0.22	Polyketide	abscisic acid	Leptosphaeria maculans JN3
BGC0000685.1	0.22	Terpene	brassicicene C	Alternaria brassicicola ATCC 96836
BGC0001254.1	0.22	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001399.1	0.22	NRP	fellutamide B	Aspergillus nidulans FGSC A4

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000039.1	0.87	Polyketide	compactin	Penicillium citrinum
BGC0001858.1	0.67	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000098.1	0.59	Polyketide	monacolin K	Monascus pilosus
BGC0000041.1	0.58	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001909.1	0.56	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000056.1	0.55	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001899.1	0.55	Polyketide	abscisic acid	Leptosphaeria maculans JN3
BGC0000685.1	0.55	Terpene	brassicicene C	Alternaria brassicicola ATCC 96836
BGC0001254.1	0.55	Polyketide	ACT-Toxin II	Alternaria alternata
BGC0001399.1	0.55	NRP	fellutamide B	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 38231:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-pk)
Non-colinear ordering:: mlcB + mlcA

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mlcA

PKS_AT (559..880): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 68.6
Methoxymalonyl-CoA: 55.9
Propionyl-CoA: 18.5
fatty_acid: 17.1
Malonyl-CoA: 15.5
2-Methylbutyryl-CoA: 11.3
Benzoyl-CoA: 9.2
Isobutyryl-CoA: 8.0
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.4
trans-1,2-CPDA: -3.7

mlcB

PKS_AT (567..894): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 56.3
Methoxymalonyl-CoA: 46.9
Methylmalonyl-CoA: 41.1
inactive: 25.0
Benzoyl-CoA: 19.0
Isobutyryl-CoA: 18.4
Propionyl-CoA: 9.4
fatty_acid: 8.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.6