BGC0000072 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000072 (Pyxidicoccus fallax)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	34,905	phenalamide	NRP + Polyketide	60%

BGC0000072 - Region 1 - T1PKS

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Location: 1 - 34,905 nt. (total: 34,905 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 34,906
Label		BGC0000072

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000072.1	0.67	Polyketide	gulmirecin A	Pyxidicoccus fallax
BGC0000041.1	0.31	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002057.1	0.26	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001068.1	0.25	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.24	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001201.1	0.24	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001858.1	0.24	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000067.1	0.22	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000990.1	0.22	NRP, Polyketide	epothilone	Sorangium cellulosum
BGC0001310.1	0.21	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000072.1	0.87	Polyketide	gulmirecin A	Pyxidicoccus fallax
BGC0000041.1	0.65	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002057.1	0.60	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0001068.1	0.59	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000056.1	0.58	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0001201.1	0.57	Terpene	eremophilene	Sorangium cellulosum So ce56
BGC0001858.1	0.57	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000067.1	0.55	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000990.1	0.55	NRP, Polyketide	epothilone	Sorangium cellulosum
BGC0001310.1	0.54	Terpene	naringenin	Streptomyces clavuligerus ATCC 27064

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 34905:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk) + (ohmal) + (ohmal) + (Me-ccmal) + (Me-redmal)
Non-colinear ordering:: gulE + gulD + gulB + gulC + gulF

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

gulB

PKS_AT (566..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 75.0%; Methoxymalonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 105.0
Methylmalonyl-CoA: 104.2
Methoxymalonyl-CoA: 101.6
Isobutyryl-CoA: 76.1
Propionyl-CoA: 58.5
Ethylmalonyl-CoA: 58.4
fatty_acid: 44.6
2-Methylbutyryl-CoA: 38.7
3-Methylbutyryl-CoA: 36.7
inactive: 36.3
Acetyl-CoA: 33.9
Benzoyl-CoA: 32.2
trans-1,2-CPDA: 29.3
CHC-CoA: 23.8

gulC

PKS_AT (569..866): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Methoxymalonyl-CoA: 75.0%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 165.8
Ethylmalonyl-CoA: 135.4
Methoxymalonyl-CoA: 122.7
Malonyl-CoA: 122.1
2-Methylbutyryl-CoA: 81.2
Isobutyryl-CoA: 73.7
trans-1,2-CPDA: 72.6
Propionyl-CoA: 71.7
CHC-CoA: 53.7
Acetyl-CoA: 50.3
Benzoyl-CoA: 46.4
inactive: 43.3
3-Methylbutyryl-CoA: 33.1
fatty_acid: 24.3

gulD

PKS_AT (559..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 126.8
Methylmalonyl-CoA: 118.1
Isobutyryl-CoA: 108.3
Methoxymalonyl-CoA: 94.3
Ethylmalonyl-CoA: 77.2
inactive: 47.9
Benzoyl-CoA: 47.1
fatty_acid: 34.4
Propionyl-CoA: 30.7
trans-1,2-CPDA: 29.2
Acetyl-CoA: 27.4
CHC-CoA: 26.3
2-Methylbutyryl-CoA: 18.9
3-Methylbutyryl-CoA: 9.5

gulE

PKS_AT (586..882): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 70.8%; Ethylmalonyl-CoA: 66.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 107.4
Malonyl-CoA: 104.6
Methoxymalonyl-CoA: 86.3
Propionyl-CoA: 74.0
Ethylmalonyl-CoA: 73.7
2-Methylbutyryl-CoA: 67.3
Isobutyryl-CoA: 65.8
inactive: 56.1
Benzoyl-CoA: 40.1
CHC-CoA: 38.6
trans-1,2-CPDA: 34.6
fatty_acid: 18.7
3-Methylbutyryl-CoA: 15.5
Acetyl-CoA: 14.2

gulF

PKS_AT (574..870): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 171.0
Ethylmalonyl-CoA: 134.4
Methoxymalonyl-CoA: 120.8
Malonyl-CoA: 99.9
Isobutyryl-CoA: 97.8
trans-1,2-CPDA: 88.0
Benzoyl-CoA: 78.2
Propionyl-CoA: 72.8
Acetyl-CoA: 56.6
CHC-CoA: 48.4
2-Methylbutyryl-CoA: 45.5
3-Methylbutyryl-CoA: 39.6
fatty_acid: 28.9
inactive: 26.9

gulA

PKS_AT (622..913): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 66.7%; Malonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 127.2
Ethylmalonyl-CoA: 105.6
Methoxymalonyl-CoA: 99.4
Isobutyryl-CoA: 95.0
Malonyl-CoA: 86.7
Benzoyl-CoA: 71.1
Acetyl-CoA: 63.5
Propionyl-CoA: 61.8
trans-1,2-CPDA: 61.6
2-Methylbutyryl-CoA: 55.1
CHC-CoA: 54.3
fatty_acid: 44.5
inactive: 27.2
3-Methylbutyryl-CoA: 26.6

PKS_AT (1051..1340): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 87.5%; Malonyl-CoA: 79.2%; Ethylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 167.3
Ethylmalonyl-CoA: 138.1
Methoxymalonyl-CoA: 134.1
Malonyl-CoA: 98.0
Propionyl-CoA: 91.9
2-Methylbutyryl-CoA: 87.7
Isobutyryl-CoA: 85.6
trans-1,2-CPDA: 80.2
Acetyl-CoA: 79.6
Benzoyl-CoA: 77.2
CHC-CoA: 51.2
fatty_acid: 45.9
3-Methylbutyryl-CoA: 45.4
inactive: 31.0