Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000072.1:
Cluster 1Polyketide134905

BGC0000072, gulmirecin biosynthetic gene cluster from Pyxidicoccus fallax. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: gulmirecin A
SMILES string: Copy to clipboard
Molecular formula: C27H42O11
Exact molecular mass: 541.266 Da ([M-H]-)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Macrolide (cyclic)
Polyketide synthase subclass:
Modular type I
Starter unit:
Acetyl-CoA
Thioesterase type:
Type I
Release / cyclization type:
Macrolactonization

Modular polyketide synthases:
gulA (AIT55264.1)
Module 0
AT specificity: Acetyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None
Module 1
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: Unknown
Scaffold-modifying domain: None

gulB (AIT55259.1)
Module 2
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: A-group
Scaffold-modifying domain: None

gulC (AIT55260.1)
Module 3
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: None

gulD (AIT55261.1)
Module 4
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: None

gulE (AIT55262.1)
Module 5
AT specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Scaffold-modifying domain: None

gulF (AIT55263.1)
Module 6
AT specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
KR stereochemistry: B-group
Scaffold-modifying domain: None

Gene cluster description

gulmirecin (BGC0000072). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KM361622. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Markus Nett (Hans-Knoell-Institute)

Literature references

1. Schieferdecker S et al. (2014) Structure and biosynthetic assembly of gulmirecins, macrolide antibiotics from the predatory bacterium Pyxidicoccus fallax. Chemistry 20(48):15933-40. doi: 10.1002/chem.201404291. Epub 2014