BGC0000080 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000080 (Sorangium cellulosum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	67,323	ambruticin	Polyketide	50%

BGC0000080 - Region 1 - T1PKS

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Location: 1 - 67,323 nt. (total: 67,323 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 67,324
Label		BGC0000080

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000080.1	0.67	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000041.1	0.29	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002057.1	0.26	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0000014.1	0.21	Polyketide	ambruticin	Sorangium cellulosum
BGC0000067.1	0.21	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.1	0.20	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001235.1	0.20	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001276.1	0.19	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.19	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.19	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000080.1	0.87	Polyketide	jerangolid A, jerangolid D	Sorangium cellulosum
BGC0000041.1	0.62	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002057.1	0.59	Polyketide	pateamine	Kiritimatiellaeota bacterium
BGC0000014.1	0.53	Polyketide	ambruticin	Sorangium cellulosum
BGC0000067.1	0.53	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001012.1	0.53	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001235.1	0.52	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001276.1	0.52	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001273.1	0.51	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001275.1	0.51	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 67323:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal) + (Me-ohmal - redmal) + (ccmal) + (Me-ccmal - ccmal) + (ohmal - pk)
Non-colinear ordering:: jerA + jerB + jerD + jerC + jerE

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

jerA

PKS_AT (574..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 189.2
Ethylmalonyl-CoA: 180.8
Methoxymalonyl-CoA: 156.6
2-Methylbutyryl-CoA: 121.9
Isobutyryl-CoA: 105.4
Malonyl-CoA: 101.2
Propionyl-CoA: 100.2
trans-1,2-CPDA: 87.4
CHC-CoA: 78.1
Benzoyl-CoA: 58.3
fatty_acid: 54.5
Acetyl-CoA: 51.5
3-Methylbutyryl-CoA: 25.9
inactive: 19.6

jerB

PKS_AT (564..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 199.9
Ethylmalonyl-CoA: 188.2
Methoxymalonyl-CoA: 161.2
2-Methylbutyryl-CoA: 129.6
Malonyl-CoA: 106.5
Propionyl-CoA: 99.1
trans-1,2-CPDA: 97.5
Isobutyryl-CoA: 96.5
CHC-CoA: 86.0
Acetyl-CoA: 62.9
Benzoyl-CoA: 57.4
fatty_acid: 49.0
3-Methylbutyryl-CoA: 33.1
inactive: 30.3

PKS_AT (2048..2349): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.8
inactive: 104.0
Methoxymalonyl-CoA: 67.7
Methylmalonyl-CoA: 61.1
Propionyl-CoA: 42.8
Isobutyryl-CoA: 37.4
2-Methylbutyryl-CoA: 33.5
Benzoyl-CoA: 27.9
Acetyl-CoA: 24.7
Ethylmalonyl-CoA: 23.3
trans-1,2-CPDA: 16.3
fatty_acid: 10.6
CHC-CoA: 9.2
3-Methylbutyryl-CoA: 8.5

jerC

PKS_AT (571..868): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 87.5%; Methoxymalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.4
Ethylmalonyl-CoA: 196.5
Methoxymalonyl-CoA: 169.2
2-Methylbutyryl-CoA: 132.7
Isobutyryl-CoA: 113.6
Malonyl-CoA: 110.5
Propionyl-CoA: 109.9
trans-1,2-CPDA: 98.0
CHC-CoA: 92.8
Benzoyl-CoA: 69.0
Acetyl-CoA: 65.7
fatty_acid: 46.0
3-Methylbutyryl-CoA: 35.6
inactive: 30.9

PKS_AT (2352..2653): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 70.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.4
inactive: 104.8
Methoxymalonyl-CoA: 69.3
Methylmalonyl-CoA: 60.7
Propionyl-CoA: 41.7
Isobutyryl-CoA: 36.3
2-Methylbutyryl-CoA: 31.5
Benzoyl-CoA: 26.8
Acetyl-CoA: 24.7
Ethylmalonyl-CoA: 22.1
trans-1,2-CPDA: 15.4
fatty_acid: 9.9
CHC-CoA: 8.9
3-Methylbutyryl-CoA: 7.9

jerD

PKS_AT (571..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.8
inactive: 130.6
Methoxymalonyl-CoA: 72.4
Methylmalonyl-CoA: 60.6
Propionyl-CoA: 33.4
Isobutyryl-CoA: 29.7
Ethylmalonyl-CoA: 27.9
Acetyl-CoA: 24.6
2-Methylbutyryl-CoA: 24.3
Benzoyl-CoA: 23.0
trans-1,2-CPDA: 14.5
CHC-CoA: 10.8
fatty_acid: 6.5
3-Methylbutyryl-CoA: 0.0

jerE

PKS_AT (574..875): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 79.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.6
inactive: 128.4
Methoxymalonyl-CoA: 69.8
Methylmalonyl-CoA: 58.8
Propionyl-CoA: 35.6
Isobutyryl-CoA: 28.4
Ethylmalonyl-CoA: 26.5
2-Methylbutyryl-CoA: 25.8
Acetyl-CoA: 23.4
Benzoyl-CoA: 21.8
CHC-CoA: 14.8
trans-1,2-CPDA: 13.9
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2131..2428): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.6
Methylmalonyl-CoA: 217.3
Methoxymalonyl-CoA: 187.3
trans-1,2-CPDA: 144.6
2-Methylbutyryl-CoA: 144.4
CHC-CoA: 109.5
Propionyl-CoA: 108.6
Malonyl-CoA: 101.4
Isobutyryl-CoA: 92.9
Benzoyl-CoA: 74.3
Acetyl-CoA: 64.1
fatty_acid: 45.4
3-Methylbutyryl-CoA: 38.5
inactive: 33.1