BGC0000094 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000094 (Streptomyces venezuelae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	37,948	lasalocid	Polyketide	40%

BGC0000094 - Region 1 - T1PKS

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Location: 1 - 37,948 nt. (total: 37,948 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 37,949
Label		BGC0000094

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000094.1	0.81	Polyketide, Saccharide	methymycin	Streptomyces venezuelae
BGC0000899.1	0.44	Other	desosamine	Streptomyces narbonensis
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.30	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.27	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000018.1	0.26	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001235.1	0.24	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001012.1	0.24	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001342.1	0.23	NRP, Polyketide	Cmc-thuggacin A, Cmc-thuggacin B	Chondromyces crocatus
BGC0000030.1	0.23	Polyketide	bikaverin	Fusarium fujikuroi IMI 58289

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000094.1	0.93	Polyketide, Saccharide	methymycin	Streptomyces venezuelae
BGC0000899.1	0.75	Other	desosamine	Streptomyces narbonensis
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001164.1	0.63	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000067.1	0.60	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000018.1	0.60	Polyketide	angolamycin	Streptomyces eurythermus
BGC0001235.1	0.57	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001012.1	0.57	NRP, Polyketide	meridamycin	Streptomyces violaceusniger
BGC0001342.1	0.56	NRP, Polyketide	Cmc-thuggacin A, Cmc-thuggacin B	Chondromyces crocatus
BGC0000030.1	0.56	Polyketide	bikaverin	Fusarium fujikuroi IMI 58289

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 37948:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - Me-ccmal - ccmal) + (Me-ohmal - Me-redmal) + (Me-ohmal) + (Me-mal)
Non-colinear ordering:: pikAI + pikAII + pikAIII + pikAIV

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

pikAI

PKS_AT (634..917): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.0
Ethylmalonyl-CoA: 184.9
Methoxymalonyl-CoA: 156.8
2-Methylbutyryl-CoA: 132.7
Propionyl-CoA: 109.5
trans-1,2-CPDA: 100.5
CHC-CoA: 90.2
Malonyl-CoA: 81.3
Isobutyryl-CoA: 53.7
Acetyl-CoA: 40.5
Benzoyl-CoA: 39.6
fatty_acid: 34.8
3-Methylbutyryl-CoA: 18.0
inactive: 13.3

PKS_AT (1650..1934): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 211.4
Ethylmalonyl-CoA: 186.1
Methoxymalonyl-CoA: 157.4
2-Methylbutyryl-CoA: 134.3
Propionyl-CoA: 112.0
trans-1,2-CPDA: 104.2
CHC-CoA: 92.8
Malonyl-CoA: 84.7
Isobutyryl-CoA: 52.7
Acetyl-CoA: 40.7
Benzoyl-CoA: 33.8
fatty_acid: 33.4
3-Methylbutyryl-CoA: 15.8
inactive: 13.5

PKS_AT (3180..3474): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 232.8
inactive: 116.9
Methoxymalonyl-CoA: 79.7
Methylmalonyl-CoA: 73.8
Propionyl-CoA: 44.1
Isobutyryl-CoA: 41.0
Ethylmalonyl-CoA: 36.9
2-Methylbutyryl-CoA: 31.2
Acetyl-CoA: 29.6
Benzoyl-CoA: 20.3
CHC-CoA: 19.0
fatty_acid: 16.9
trans-1,2-CPDA: 16.1
3-Methylbutyryl-CoA: 0.0

pikAII

PKS_AT (572..856): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.6
Ethylmalonyl-CoA: 185.2
Methoxymalonyl-CoA: 158.3
2-Methylbutyryl-CoA: 125.3
Propionyl-CoA: 104.8
trans-1,2-CPDA: 100.8
CHC-CoA: 89.7
Malonyl-CoA: 75.5
Isobutyryl-CoA: 52.6
Benzoyl-CoA: 34.1
fatty_acid: 33.3
Acetyl-CoA: 31.3
3-Methylbutyryl-CoA: 14.9
inactive: 12.5

PKS_AT (2069..2353): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.3
Ethylmalonyl-CoA: 184.2
Methoxymalonyl-CoA: 158.5
2-Methylbutyryl-CoA: 130.7
Propionyl-CoA: 105.9
trans-1,2-CPDA: 101.6
CHC-CoA: 88.0
Malonyl-CoA: 80.4
Isobutyryl-CoA: 49.9
fatty_acid: 39.0
Benzoyl-CoA: 37.9
Acetyl-CoA: 35.3
3-Methylbutyryl-CoA: 22.2
inactive: 13.2

pikAIII

PKS_AT (565..848): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 206.2
Ethylmalonyl-CoA: 182.3
Methoxymalonyl-CoA: 154.8
2-Methylbutyryl-CoA: 128.9
Propionyl-CoA: 110.6
trans-1,2-CPDA: 103.6
CHC-CoA: 88.8
Malonyl-CoA: 72.4
Isobutyryl-CoA: 45.5
fatty_acid: 33.8
Acetyl-CoA: 30.8
Benzoyl-CoA: 29.5
3-Methylbutyryl-CoA: 13.6
inactive: 12.8

pikAIV

PKS_AT (562..843): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 210.5
Ethylmalonyl-CoA: 185.1
Methoxymalonyl-CoA: 158.7
2-Methylbutyryl-CoA: 124.6
Propionyl-CoA: 104.4
trans-1,2-CPDA: 99.1
CHC-CoA: 88.5
Malonyl-CoA: 77.2
Isobutyryl-CoA: 50.2
Benzoyl-CoA: 32.3
fatty_acid: 31.5
Acetyl-CoA: 29.4
3-Methylbutyryl-CoA: 13.3
inactive: 12.8