BGC0000098 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000098 (Monascus pilosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	45,000	monacolin K	Polyketide	47%

BGC0000098 - Region 1 - T1PKS

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Location: 1 - 45,000 nt. (total: 45,000 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 45,001
Label		BGC0000098

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000098.1	0.90	Polyketide	monacolin K	Monascus pilosus
BGC0001909.1	0.55	Polyketide	strobilurin	Strobilurus tenacellus
BGC0001858.1	0.54	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000088.1	0.53	Polyketide	monacolin K	Aspergillus terreus
BGC0000056.1	0.45	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000003.1	0.44	Polyketide	AF-toxin	Alternaria alternata
BGC0000039.1	0.43	Polyketide	compactin	Penicillium citrinum
BGC0001068.1	0.41	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.
BGC0000673.1	0.38	Terpene	pimara-8(14),15-diene	Aspergillus nidulans FGSC A4
BGC0001254.1	0.37	Polyketide	ACT-Toxin II	Alternaria alternata

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000098.1	0.87	Polyketide	monacolin K	Monascus pilosus
BGC0001858.1	0.67	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000088.1	0.63	Polyketide	monacolin K	Aspergillus terreus
BGC0000039.1	0.62	Polyketide	compactin	Penicillium citrinum
BGC0000003.1	0.58	Polyketide	AF-toxin	Alternaria alternata
BGC0000056.1	0.56	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000286.1	0.55	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0001899.1	0.55	Polyketide	abscisic acid	Leptosphaeria maculans JN3
BGC0001998.1	0.55	Polyketide	aspernidgulene A1, aspernidgulene A2, aspernidgulene B1	Aspergillus nidulans FGSC A4

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 1534 - 45000:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-pk)
Non-colinear ordering:: mkB + mkA

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 1534 - 26725:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 11418 - 45000:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Me-pk)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

mkB

PKS_AT (544..869): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 81.5
Methoxymalonyl-CoA: 57.8
Methylmalonyl-CoA: 57.3
Isobutyryl-CoA: 28.0
Propionyl-CoA: 26.3
Benzoyl-CoA: 16.1
inactive: 9.8
2-Methylbutyryl-CoA: 9.0
Ethylmalonyl-CoA: 7.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

mkA

PKS_AT (602..924): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 75.0%; Methylmalonyl-CoA: 62.5%; Ethylmalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 73.7
Methoxymalonyl-CoA: 56.1
Ethylmalonyl-CoA: 54.8
Isobutyryl-CoA: 26.8
Propionyl-CoA: 25.7
Malonyl-CoA: 25.3
2-Methylbutyryl-CoA: 22.6
fatty_acid: 19.9
trans-1,2-CPDA: 18.2
Benzoyl-CoA: 14.8
CHC-CoA: 9.6
inactive: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0