BGC0000110 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000110 (Streptomyces orinoci)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	38,365	aureothin	Polyketide:Modular type I	88%

BGC0000110 - Region 1 - T1PKS

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Location: 1 - 38,365 nt. (total: 38,365 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 38,366
Label		BGC0000110

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000110.1	0.83	Polyketide	spectinabilin, orinocin, SNF4435C, SNF4435D	Streptomyces orinoci
BGC0000041.1	0.43	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000024.1	0.43	Polyketide	aureothin	Streptomyces thioluteus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0002031.1	0.30	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001266.1	0.29	Polyketide	grayanic acid	Cladonia grayi
BGC0001304.1	0.29	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001276.1	0.29	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.29	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000110.1	0.94	Polyketide	spectinabilin, orinocin, SNF4435C, SNF4435D	Streptomyces orinoci
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000024.1	0.74	Polyketide	aureothin	Streptomyces thioluteus
BGC0001244.1	0.64	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0002031.1	0.63	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001273.1	0.63	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001266.1	0.63	Polyketide	grayanic acid	Cladonia grayi
BGC0001304.1	0.63	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0001276.1	0.63	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.62	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 38365:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (Me-ccmal - Me-ccmal) + (redmal) + (pk - mal)
Non-colinear ordering:: norA + norA_ + norB + norC

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

norE

Search NORINE for peptide: strict or relaxed

AMP-binding (127..513): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: val, leu, ile, abu, iva
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: hcwFVAvlLK
Nearest Stachelhaus code:: ala
Stachelhaus code match:: 50% (weak)

norA

PKS_AT (644..942): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.5
Ethylmalonyl-CoA: 219.7
Methoxymalonyl-CoA: 184.4
2-Methylbutyryl-CoA: 151.0
trans-1,2-CPDA: 137.5
Propionyl-CoA: 127.1
Malonyl-CoA: 121.8
CHC-CoA: 109.1
Isobutyryl-CoA: 82.5
Benzoyl-CoA: 74.9
Acetyl-CoA: 49.8
fatty_acid: 45.8
3-Methylbutyryl-CoA: 35.7
inactive: 30.7

norA_

PKS_AT (564..862): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 221.1
Ethylmalonyl-CoA: 214.4
Methoxymalonyl-CoA: 181.5
2-Methylbutyryl-CoA: 118.6
trans-1,2-CPDA: 115.5
Malonyl-CoA: 110.3
CHC-CoA: 107.3
Propionyl-CoA: 102.8
Isobutyryl-CoA: 95.4
Benzoyl-CoA: 73.9
Acetyl-CoA: 59.2
3-Methylbutyryl-CoA: 44.4
fatty_acid: 33.5
inactive: 30.6

PKS_AT (2337..2636): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 217.4
Ethylmalonyl-CoA: 211.3
Methoxymalonyl-CoA: 174.0
2-Methylbutyryl-CoA: 147.7
trans-1,2-CPDA: 128.7
Propionyl-CoA: 110.7
Malonyl-CoA: 104.1
CHC-CoA: 103.2
Benzoyl-CoA: 92.8
Isobutyryl-CoA: 92.2
Acetyl-CoA: 50.1
fatty_acid: 28.4
inactive: 27.0
3-Methylbutyryl-CoA: 21.7

norB

PKS_AT (567..865): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.8
inactive: 103.3
Methoxymalonyl-CoA: 55.1
Methylmalonyl-CoA: 37.8
Propionyl-CoA: 29.1
Acetyl-CoA: 17.1
Isobutyryl-CoA: 16.2
Ethylmalonyl-CoA: 14.3
Benzoyl-CoA: 9.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -2.2

norC

PKS_AT (578..876): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Methoxymalonyl-CoA: 91.7%; Malonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 218.7
Methylmalonyl-CoA: 215.4
Methoxymalonyl-CoA: 182.7
2-Methylbutyryl-CoA: 131.1
trans-1,2-CPDA: 128.6
Propionyl-CoA: 113.3
Malonyl-CoA: 101.6
CHC-CoA: 97.8
Isobutyryl-CoA: 94.5
Benzoyl-CoA: 75.4
Acetyl-CoA: 64.0
fatty_acid: 42.5
3-Methylbutyryl-CoA: 41.3
inactive: 36.8

PKS_AT (1608..1778): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 20.6
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0