BGC0000123 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000123 (Streptomyces sp. HK803)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	76,196	fostriecin	Polyketide	52%

BGC0000123 - Region 1 - T1PKS

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Location: 1 - 76,196 nt. (total: 76,196 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 76,197
Label		BGC0000123

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000123.1	0.76	Polyketide	phoslactomycin B	Streptomyces sp. HK803
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001302.1	0.35	Other	lomofungin	Streptomyces lomondensis
BGC0000018.1	0.33	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000160.1	0.31	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000120.1	0.31	Polyketide	patulin	Penicillium expansum
BGC0000003.1	0.31	Polyketide	AF-toxin	Alternaria alternata
BGC0001275.1	0.31	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.31	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000123.1	0.91	Polyketide	phoslactomycin B	Streptomyces sp. HK803
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001302.1	0.68	Other	lomofungin	Streptomyces lomondensis
BGC0000018.1	0.67	Polyketide	angolamycin	Streptomyces eurythermus
BGC0000160.1	0.65	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000120.1	0.65	Polyketide	patulin	Penicillium expansum
BGC0000003.1	0.64	Polyketide	AF-toxin	Alternaria alternata
BGC0001275.1	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 76196:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - ccmal) + (ohemal) + (ccmal) + (ccmal - ohmal) + (ohemal) + (ohmal)
Non-colinear ordering:: plm1 + plm4 + plm5 + plm2-3 + plm6 + plm7

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

plm4

PKS_AT (511..809): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methylmalonyl-CoA: 79.2%; Malonyl-CoA: 75.0%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 236.0
Methylmalonyl-CoA: 191.5
Methoxymalonyl-CoA: 153.7
trans-1,2-CPDA: 120.3
2-Methylbutyryl-CoA: 114.3
Propionyl-CoA: 96.0
Malonyl-CoA: 91.3
CHC-CoA: 84.6
Isobutyryl-CoA: 75.9
Benzoyl-CoA: 65.9
Acetyl-CoA: 45.7
inactive: 32.0
3-Methylbutyryl-CoA: 30.6
fatty_acid: 24.5

plm5

PKS_AT (566..866): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 188.0
inactive: 106.2
Methoxymalonyl-CoA: 54.7
Methylmalonyl-CoA: 44.8
Propionyl-CoA: 35.8
Acetyl-CoA: 18.6
Ethylmalonyl-CoA: 17.4
Isobutyryl-CoA: 17.1
2-Methylbutyryl-CoA: 16.9
Benzoyl-CoA: 16.8
fatty_acid: 11.4
trans-1,2-CPDA: 8.5
CHC-CoA: 2.1
3-Methylbutyryl-CoA: 0.0

plm6

PKS_AT (545..842): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methylmalonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 237.6
Methylmalonyl-CoA: 179.9
Methoxymalonyl-CoA: 154.8
trans-1,2-CPDA: 119.1
2-Methylbutyryl-CoA: 115.9
CHC-CoA: 107.0
Propionyl-CoA: 99.7
Malonyl-CoA: 87.1
Benzoyl-CoA: 77.6
Isobutyryl-CoA: 76.0
Acetyl-CoA: 50.6
3-Methylbutyryl-CoA: 31.9
fatty_acid: 31.7
inactive: 24.8

plm7

PKS_AT (549..821): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 191.7
inactive: 89.6
Methylmalonyl-CoA: 78.5
Methoxymalonyl-CoA: 78.3
Ethylmalonyl-CoA: 44.6
Propionyl-CoA: 38.3
CHC-CoA: 34.0
2-Methylbutyryl-CoA: 32.3
Benzoyl-CoA: 30.2
Acetyl-CoA: 29.6
trans-1,2-CPDA: 28.9
fatty_acid: 21.1
Isobutyryl-CoA: 21.1
3-Methylbutyryl-CoA: 11.5

plm1

PKS_AT (202..495): pk

ATSignature: CHC-CoA

Top 3 matches:: CHC-CoA: 100.0%; Propionyl-CoA: 66.7%; Methylmalonyl-CoA: 66.7%

minowa: CHC-CoA

Prediction, score:

CHC-CoA: 271.0
Methylmalonyl-CoA: 147.7
Ethylmalonyl-CoA: 137.3
2-Methylbutyryl-CoA: 122.7
Methoxymalonyl-CoA: 120.3
Propionyl-CoA: 105.6
trans-1,2-CPDA: 94.0
Malonyl-CoA: 74.6
Isobutyryl-CoA: 57.8
Benzoyl-CoA: 46.3
fatty_acid: 27.0
Acetyl-CoA: 25.9
inactive: 15.7
3-Methylbutyryl-CoA: 13.1

PKS_AT (1187..1459): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 180.8
Methoxymalonyl-CoA: 81.2
Methylmalonyl-CoA: 80.7
inactive: 79.3
Ethylmalonyl-CoA: 52.6
Isobutyryl-CoA: 45.6
Propionyl-CoA: 43.3
CHC-CoA: 43.3
2-Methylbutyryl-CoA: 36.8
Acetyl-CoA: 35.3
Benzoyl-CoA: 31.9
trans-1,2-CPDA: 29.0
fatty_acid: 22.1
3-Methylbutyryl-CoA: 14.6

plm2-3

PKS_AT (563..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 185.7
inactive: 94.8
Methoxymalonyl-CoA: 82.2
Methylmalonyl-CoA: 77.9
Propionyl-CoA: 46.9
Ethylmalonyl-CoA: 42.4
CHC-CoA: 33.3
2-Methylbutyryl-CoA: 31.5
Isobutyryl-CoA: 29.7
trans-1,2-CPDA: 27.3
Benzoyl-CoA: 26.6
Acetyl-CoA: 26.0
fatty_acid: 17.4
3-Methylbutyryl-CoA: 6.1

PKS_AT (2308..2578): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 199.0
inactive: 90.4
Methylmalonyl-CoA: 77.7
Methoxymalonyl-CoA: 77.6
Ethylmalonyl-CoA: 41.9
CHC-CoA: 37.8
Propionyl-CoA: 37.2
Acetyl-CoA: 31.6
2-Methylbutyryl-CoA: 31.3
trans-1,2-CPDA: 30.4
Benzoyl-CoA: 30.2
Isobutyryl-CoA: 23.7
fatty_acid: 18.1
3-Methylbutyryl-CoA: 13.7

plmJK

Search NORINE for peptide: strict or relaxed

AMP-binding (470..900): X

NRPSPredictor2: (unknown)

SVM prediction details:

NOTE: outside applicability domain

Predicted physicochemical class:: hydrophilic
Large clusters prediction:: asp, asn, glu, gln, aad
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: qTyqVtaLgK
Nearest Stachelhaus code:: lys-b
Stachelhaus code match:: 40% (weak)