BGC0000120: patulin biosynthetic gene cluster from Penicillium expansum
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Location: 1 - 40,217 nt. (total: 40,217 nt).
This entry is originally from NCBI GenBank KF899892.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000120
Short description patulin biosynthetic gene cluster from Penicillium expansum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "The patulin genes cluster and its boudaries have been validated by the deletetion of patL (AIG62143), gene encoding the specific transcription factor (PMID: 26582186 ).\n\nThe patulin cluster has been described in A. clavatus (PMID:19383676)\n\nThe role of PatH (AIG62144) , PatI (AIG62145) and PatG (AIG62133) has been determined by heterologous expression studies (PMID:19383676 and PMID:24334092)\n\nThe role of PatE (AIG62134) has been determined by knock-out (27913847)."
Biosynthetic class(es)
  • PKS (Iterative type I)
Loci
KF899892.1
via Knock-out studies, Heterologous expression, Gene expression correlated with compound production
Compounds
  • patulin
Species Penicillium expansum [taxonomy]
References
Chemical products information
patulin Evidence:
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C7H6O4
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AIG62144.1
  • patH
 195 - 2035 (-) M-cresol hydroxylase
  • Tailoring
  • Heterologous expression
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  • AIG62133.1
  • patG
 2810 - 3834 (-) 6-methylsalicylic decarboxylase
  • Tailoring
  • Heterologous expression
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  • AIG62137.1
  • patF
 4350 - 4949 (-) hypothetical protein
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    • AIG62134.1
    • patE
    		 5362 - 7362 (+) patulin synthase
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      • AIG62135.1
      • patD
      		 7640 - 9147 (-) hypothetical protein
      • Tailoring
      • Knock-out
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      • AIG62136.1
      • patC
      		 9636 - 11387 (-) MFS transporter
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        • AIG62138.1
        • patB
        		 12080 - 14006 (+) carboxylesterase family protein
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          • AIG62139.1
          • patA
          		 14650 - 15690 (-) acetate transporter
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            • AIG62140.1
            • patM
            		 16342 - 20894 (-) ABC transporter
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              • AIG62141.1
              • patN
              		 21354 - 22249 (+) isoepoxydon dehydrogenase
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                • AIG62142.1
                • patO
                		 22914 - 24873 (+) isoamyl alcohol oxidase
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                  • AIG62143.1
                  • patL
                  		 26056 - 28511 (-) C6 transcription activator
                  • Regulation
                  • Knock-out
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                  • AIG62145.1
                  • patI
                  		 30147 - 32032 (-) M-hydroxybenzyl alcohol hydroxylase
                  • Tailoring
                  • Heterologous expression
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                  • AIG62147.1
                  • patJ
                  		 32661 - 33776 (-) hypothetical protein
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                    • AIG62146.1
                    • patK
                    		 34613 - 40016 (+) 6-methylsalicylic acid synthase
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                      Biosynthesis information

                      Biosynthetic modules

                      Name
                      1
                      Type
                      pks-modular
                      Genes
                      patK
                      Substrates
                      Integrated Monomers
                      Domains
                      acyltransferase, ketosynthase, acyltransferase, dehydratase, ketoreductase, carrier (ACP)
                      Annotation changelog

                      Entry version: 4

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-10-07
                      Update chemical activity to schema version 2.11
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 3

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2022-09-15
                      Cleaned up synonym list
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 2

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2019-10-16
                      Migrated from v1.4
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (MIBiG Annotathon)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      2019-10-16
                      Updated compound(s) information (NPAtlas curation)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                      Entry version: 1

                      Date
                      Changes
                      Submitters
                      Reviewers
                      2015-06-12
                      Submitted
                      • (ID: 7M4BGWDEABIQBOJEBD7LO4YZ)
                      • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                      Detailed domain annotation
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