BGC0000144: salinomycin biosynthetic gene cluster from Streptomyces albus
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Location: 1 - 127,961 nt. (total: 127,961 nt).
This entry is originally from NCBI GenBank JN033543.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000144
Short description salinomycin biosynthetic gene cluster from Streptomyces albus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Polyether)
Loci NCBI GenBank: JN033543.1
Compounds
  • salinomycin
Species Streptomyces albus [taxonomy]
References
Chemical products information
salinomycin
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C42H70O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AEZ53933.1
 239 - 694 (-) putative alkyl hydroperoxide reductase subunit C protein
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  • AEZ53934.1
 824 - 1201 (-) putative membrane protein
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  • AEZ53935.1
 1418 - 1918 (+) putative transcription regulator
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  • AEZ53936.1
 2137 - 2913 (+) putative amidinotransferase
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  • AEZ53937.1
 2910 - 4139 (+) putative ornithine aminotransferase
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  • AEZ53938.1
 4218 - 5267 (-) putative zinc-binding dehydrogenase family oxidoreductase
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  • AEZ53939.1
 5560 - 7008 (+) putative glucose-6-phosphate 1-dehydrogenase
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  • AEZ53940.1
 7005 - 8204 (+) putative membrane protein
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  • AEZ53941.1
 8477 - 9460 (-) putative regulatory protein
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  • AEZ53942.1
 10037 - 10519 (+) putative transcriptional regulator
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  • AEZ53943.1
 10611 - 12329 (-) putative 3-hydroxybutyryl-CoA dehydrogenase
  • Precursor biosynthesis
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  • AEZ53944.1
 12326 - 13354 (-) putative 3-oxoacyl-(acyl-carrier-protein ) synthase III
  • Precursor biosynthesis
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  • AEZ53945.1
  • slnA1
 13658 - 28435 (+) polyketide synthase
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  • AEZ53946.1
  • slnA2
 28468 - 40221 (+) polyketide synthase
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  • AEZ53947.1
  • slnA3
 40244 - 48322 (+) polyketide synthase
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  • AEZ53948.1
  • slnA4
 48450 - 53378 (+) polyketide synthase
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  • AEZ53949.1
  • slnA5
 53431 - 64683 (+) polyketide synthase
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  • AEZ53950.1
  • slnA6
 64798 - 69105 (+) polyketide synthase
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  • AEZ53951.1
  • slnA7
 69148 - 74082 (+) polyketide synthase
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  • AEZ53952.1
  • slnA8
 74150 - 85324 (+) polyketide synthase
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  • AEZ53953.1
  • slnA9
 85352 - 92290 (+) polyketide synthase
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  • AEZ53954.1
  • slnBI
 92379 - 92765 (+) putative epoxide hydrolase
  • Unknown
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  • AEZ53955.1
  • slnDI
 92807 - 93604 (+) putative thioesterase
  • Scaffold biosynthesis
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  • AEZ53956.1
  • slnM
 93645 - 94460 (+) putative O-methyltransferase-like protein
  • Unknown
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  • AEZ53957.1
  • slnE
 94655 - 94936 (-) putative ferridoxin protein
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  • AEZ53958.1
  • slnF
 94933 - 96156 (-) putative cytochrome P450
  • Tailoring (Hydroxylation)
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  • AEZ53959.1
  • slnTI
 96333 - 97292 (+) putative ABC transporter ATP-binding protein
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  • AEZ53960.1
  • slnTII
 97289 - 98929 (+) putative antibiotic ABC transporter efflux pump
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  • AEZ53961.1
  • slnBII
 99101 - 99550 (-) putative epoxide hydrolase
  • Tailoring (Hydrolysis)
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  • AEZ53962.1
  • slnBIII
 99543 - 100004 (-) putative epoxide hydrolase
  • Tailoring (Hydrolysis)
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  • AEZ53963.1
  • slnC
 100184 - 101638 (+) epoxidase
  • Tailoring (Oxidation)
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  • AEZ53964.1
  • slnR
 102168 - 104888 (+) putative transcriptional regulator
  • Regulation
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  • AEZ53965.1
  • slnDII
 105116 - 105877 (+) putative thioesterase
  • Scaffold biosynthesis
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  • AEZ53966.1
 106029 - 108617 (+) putative peptide synthetase
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  • AEZ53967.1
 108679 - 108927 (-) hypothetical protein
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  • AEZ53968.1
 109104 - 111671 (-) putative SARP family transcriptional regulator
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  • AEZ53969.1
 111987 - 113780 (+) putative AMP-binding domain-containing protein
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  • AEZ53970.1
 113774 - 115492 (+) putative acyl-CoA dehydrogenase
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  • AEZ53971.1
 115524 - 115814 (+) putative peptide carrier protein
  • Unknown
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  • AEZ53972.1
 115811 - 116650 (+) putative 4'-phosphopantetheinyl transferase
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  • AEZ53973.1
 116675 - 117658 (-) putative gamma-butyrolactone biosynthesis protein
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  • AEZ53974.1
 117832 - 118878 (-) hypothetical protein
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  • AEZ53975.1
 119021 - 120190 (-) putative secreted protein
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  • AEZ53976.1
 120227 - 121783 (-) putative beta-hexosaminidase
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  • AEZ53977.1
 121828 - 122730 (-) putative sugar transporter membrane protein
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  • AEZ53978.1
 122727 - 123713 (-) putative sugar transporter membrane protein
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  • AEZ53979.1
 123761 - 125026 (-) putative sugar transporter sugar binding protein
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  • AEZ53980.1
 125286 - 126194 (-) putative hydrolase
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  • AEZ53981.1
 126616 - 127455 (+) putative transcriptional regulator
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Polyketide-specific information
Subclass Polyether
Starter unit Malonyl-CoA
Cyclic? no
Polyketide-synthases
Genes Properties Modules
slnA9
+
slnA8
+
slnA5
+
slnA7
+
slnA2
+
slnA6
+
slnA1
+
slnA4
+
slnA3 		Synthase subclass: Modular type I
Module 0
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA1
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA2
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 4
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA2
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA3
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 6
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA3
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA4
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 8
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA5
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA5
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA6
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Thiolation (ACP/PCP)
Module 11
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA7
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 12
Specificity: Methylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA8
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 13
Specificity: Malonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA8
Core domains: Ketosynthase, Acyltransferase, Dehydratase, Enoylreductase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 14
Specificity: Ethylmalonyl-CoA
Evidence for specificity: Structure-based inference
Genes: slnA9
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 15
Genes: slnA9
Core domains: Ketosynthase
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: 67IIUGVPORSPZSAXSJ6T72RE, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
  • Removed duplicate gene name
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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