BGC0000144 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000144 (Streptomyces albus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,butyrolactone	1	127,961	lasalocid	Polyketide	54%

BGC0000144 - Region 1 - T1PKS,butyrolactone

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Location: 1 - 127,961 nt. (total: 127,961 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
butyrolactone: AfsA

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 127,962
Label		BGC0000144

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000144.1	0.84	Polyketide	salinomycin	Streptomyces albus
BGC0001164.1	0.45	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000122.1	0.39	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001235.1	0.37	NRP, Polyketide	antalid	Polyangium spumosum
BGC0001704.1	0.37	Other	nocuolin A	Nodularia sp. HBU26
BGC0000067.1	0.35	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.34	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000393.1	0.34	NRP, Polyketide	myxoprincomide-c506	Myxococcus xanthus DK 1622
BGC0001160.1	0.33	Polyketide	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001162.1	0.33	Polyketide	1-heptadecene	Moorea producens JHB

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000144.1	0.93	Polyketide	salinomycin	Streptomyces albus
BGC0000067.1	0.69	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000041.1	0.67	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001283.1	0.67	Polyketide	arsono-polyketide	Streptomyces lividans 1326
BGC0001062.1	0.67	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0001164.1	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000286.1	0.66	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0000120.1	0.65	Polyketide	patulin	Penicillium expansum
BGC0002031.1	0.64	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 122658:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - redmal) + (Me-ccmal - redmal) + (mal - ohmal) + (Me-ohmal) + (Me-redmal - pk) + (Me-mal) + (Me-ohmal - redmal) + (pk) + (pk)
Non-colinear ordering:: slnA1 + slnA2 + slnA3 + slnA4 + slnA5 + slnA6 + slnA8 + slnA7 + slnA9

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 112290:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - redmal) + (Me-ccmal - redmal) + (mal - ohmal) + (Me-ohmal) + (Me-redmal - pk) + (Me-mal) + (Me-ohmal - redmal) + (pk) + (pk)
Non-colinear ordering:: slnA1 + slnA2 + slnA3 + slnA4 + slnA5 + slnA6 + slnA8 + slnA7 + slnA9

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

slnA1

PKS_AT (545..834): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 87.5%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 224.6
inactive: 100.7
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 57.9
Isobutyryl-CoA: 41.8
Propionyl-CoA: 35.0
Ethylmalonyl-CoA: 34.6
2-Methylbutyryl-CoA: 30.0
Benzoyl-CoA: 25.0
Acetyl-CoA: 24.3
CHC-CoA: 16.6
trans-1,2-CPDA: 14.4
fatty_acid: 11.8
3-Methylbutyryl-CoA: 0.0

PKS_AT (1554..1854): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 182.2
Ethylmalonyl-CoA: 173.7
Methoxymalonyl-CoA: 147.1
2-Methylbutyryl-CoA: 125.1
trans-1,2-CPDA: 93.0
Propionyl-CoA: 89.9
CHC-CoA: 89.4
Malonyl-CoA: 71.6
Isobutyryl-CoA: 68.4
3-Methylbutyryl-CoA: 38.0
fatty_acid: 34.9
Benzoyl-CoA: 33.3
Acetyl-CoA: 32.6
inactive: 14.9

PKS_AT (3311..3598): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.2
inactive: 112.3
Methoxymalonyl-CoA: 68.2
Methylmalonyl-CoA: 66.1
Isobutyryl-CoA: 32.3
Ethylmalonyl-CoA: 29.1
Propionyl-CoA: 25.0
Benzoyl-CoA: 21.1
Acetyl-CoA: 20.6
2-Methylbutyryl-CoA: 16.0
fatty_acid: 14.7
CHC-CoA: 14.7
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

slnA2

PKS_AT (571..867): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.2
Ethylmalonyl-CoA: 215.8
Methoxymalonyl-CoA: 182.0
2-Methylbutyryl-CoA: 152.1
trans-1,2-CPDA: 131.1
Propionyl-CoA: 111.9
Malonyl-CoA: 97.0
CHC-CoA: 94.6
Isobutyryl-CoA: 70.3
3-Methylbutyryl-CoA: 57.6
Benzoyl-CoA: 48.7
Acetyl-CoA: 47.0
inactive: 34.9
fatty_acid: 33.9

PKS_AT (2307..2595): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 215.1
inactive: 108.3
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 61.8
Isobutyryl-CoA: 28.1
Propionyl-CoA: 26.8
Ethylmalonyl-CoA: 25.6
Acetyl-CoA: 19.8
Benzoyl-CoA: 18.5
CHC-CoA: 11.4
fatty_acid: 9.5
2-Methylbutyryl-CoA: 5.2
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

slnA3

PKS_AT (573..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 218.2
inactive: 112.9
Methoxymalonyl-CoA: 69.0
Methylmalonyl-CoA: 60.6
Ethylmalonyl-CoA: 27.5
Propionyl-CoA: 24.6
Isobutyryl-CoA: 24.2
Acetyl-CoA: 18.7
Benzoyl-CoA: 17.7
CHC-CoA: 14.2
fatty_acid: 8.9
2-Methylbutyryl-CoA: 6.1
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (1627..1915): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 216.4
inactive: 112.4
Methoxymalonyl-CoA: 71.1
Methylmalonyl-CoA: 64.0
Isobutyryl-CoA: 33.0
Propionyl-CoA: 28.6
Ethylmalonyl-CoA: 25.6
Acetyl-CoA: 19.4
Benzoyl-CoA: 18.7
CHC-CoA: 11.4
fatty_acid: 9.5
2-Methylbutyryl-CoA: 4.8
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

slnA4

PKS_AT (576..872): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 228.5
Ethylmalonyl-CoA: 224.6
Methoxymalonyl-CoA: 190.4
2-Methylbutyryl-CoA: 161.8
trans-1,2-CPDA: 146.2
Propionyl-CoA: 121.4
CHC-CoA: 108.5
Malonyl-CoA: 107.2
Isobutyryl-CoA: 79.0
Benzoyl-CoA: 63.3
fatty_acid: 47.9
3-Methylbutyryl-CoA: 47.0
Acetyl-CoA: 38.4
inactive: 31.1

slnA5

PKS_AT (588..884): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 224.3
Ethylmalonyl-CoA: 219.0
Methoxymalonyl-CoA: 181.9
2-Methylbutyryl-CoA: 154.1
trans-1,2-CPDA: 140.9
Propionyl-CoA: 115.4
CHC-CoA: 102.1
Malonyl-CoA: 102.0
Isobutyryl-CoA: 78.6
Benzoyl-CoA: 63.4
3-Methylbutyryl-CoA: 47.4
Acetyl-CoA: 40.5
inactive: 36.0
fatty_acid: 24.9

PKS_AT (2683..2983): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 183.0
Ethylmalonyl-CoA: 173.4
Methoxymalonyl-CoA: 147.5
2-Methylbutyryl-CoA: 129.8
trans-1,2-CPDA: 95.7
CHC-CoA: 92.2
Propionyl-CoA: 90.1
Isobutyryl-CoA: 72.7
Malonyl-CoA: 70.1
3-Methylbutyryl-CoA: 40.8
fatty_acid: 38.6
Acetyl-CoA: 38.5
Benzoyl-CoA: 36.0
inactive: 14.5

slnA6

PKS_AT (586..882): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 223.7
Ethylmalonyl-CoA: 219.2
Methoxymalonyl-CoA: 185.6
2-Methylbutyryl-CoA: 165.4
trans-1,2-CPDA: 144.0
Propionyl-CoA: 122.9
CHC-CoA: 114.4
Malonyl-CoA: 101.8
Isobutyryl-CoA: 81.2
Benzoyl-CoA: 59.8
fatty_acid: 43.7
Acetyl-CoA: 40.8
3-Methylbutyryl-CoA: 39.0
inactive: 35.6

slnA7

PKS_AT (563..859): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 222.3
Methylmalonyl-CoA: 221.4
Methoxymalonyl-CoA: 169.4
2-Methylbutyryl-CoA: 154.1
trans-1,2-CPDA: 145.6
CHC-CoA: 109.1
Propionyl-CoA: 107.9
Malonyl-CoA: 103.0
Isobutyryl-CoA: 73.6
Benzoyl-CoA: 63.5
inactive: 43.0
Acetyl-CoA: 42.5
3-Methylbutyryl-CoA: 38.8
fatty_acid: 30.8

slnA8

PKS_AT (572..868): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 223.7
Ethylmalonyl-CoA: 221.0
Methoxymalonyl-CoA: 176.8
2-Methylbutyryl-CoA: 153.0
trans-1,2-CPDA: 148.3
Propionyl-CoA: 109.6
CHC-CoA: 108.5
Malonyl-CoA: 98.9
Isobutyryl-CoA: 85.3
Benzoyl-CoA: 72.7
3-Methylbutyryl-CoA: 52.4
Acetyl-CoA: 42.7
inactive: 38.4
fatty_acid: 29.4

PKS_AT (2103..2400): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 219.0
inactive: 113.8
Methoxymalonyl-CoA: 65.6
Methylmalonyl-CoA: 60.8
Propionyl-CoA: 37.5
Isobutyryl-CoA: 35.7
Ethylmalonyl-CoA: 23.7
2-Methylbutyryl-CoA: 21.8
Acetyl-CoA: 18.3
Benzoyl-CoA: 17.3
fatty_acid: 14.2
CHC-CoA: 11.6
trans-1,2-CPDA: 10.3
3-Methylbutyryl-CoA: 9.6

slnA9

PKS_AT (566..866): pk

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 79.2%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 183.1
Ethylmalonyl-CoA: 175.4
Methoxymalonyl-CoA: 148.3
2-Methylbutyryl-CoA: 125.1
trans-1,2-CPDA: 93.3
Propionyl-CoA: 90.1
CHC-CoA: 88.4
Malonyl-CoA: 73.5
Isobutyryl-CoA: 67.6
fatty_acid: 38.3
3-Methylbutyryl-CoA: 37.4
Acetyl-CoA: 32.7
Benzoyl-CoA: 32.4
inactive: 14.8

AEZ53969.1

CAL_domain (29..468): pk

minowa: fatty_acid

Prediction, score:

fatty_acid: 22.6
AHBA: 17.3
NH2: 9.4
shikimic_acid: 8.3
Acetyl-CoA: 0.2