BGC0001215 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001215 (Streptomyces conglobatus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS,NRPS-like	1	41,097	oxazolepoxidomycin A	Polyketide	33%

BGC0001215 - Region 1 - NRPS-like,T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 41,097 nt. (total: 41,097 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
NRPS-like: cds((PP-binding or NAD_binding_4) and (AMP-binding or A-OX))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 41,098
Label		BGC0001215

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001215.1	1.25	NRP	conglobatin	Streptomyces conglobatus
BGC0000427.1	0.69	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000979.1	0.69	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.69	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0000041.1	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000375.1	0.61	NRP	indigoidine	Streptomyces chromofuscus
BGC0000900.1	0.56	Other	ferrichrome	Aspergillus oryzae
BGC0001794.1	0.53	Polyketide	swainsonine	Alternaria oxytropis
BGC0000348.1	0.52	NRP	ergovaline	Epichloe festucae var. lolii
BGC0000876.1	0.50	Other	neopolyoxin C	Streptomyces tendae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001215.1	0.94	NRP	conglobatin	Streptomyces conglobatus
BGC0000041.1	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000427.1	0.68	NRP	shinorine, 4-deoxygadusol, mycosporine glycine	Trichormus variabilis ATCC 29413
BGC0000979.1	0.67	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 10E9
BGC0000980.1	0.67	NRP, Polyketide	cylindrospermopsin	Aphanizomenon sp. 22D11
BGC0001647.1	0.65	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000375.1	0.64	NRP	indigoidine	Streptomyces chromofuscus
BGC0000876.1	0.62	Other	neopolyoxin C	Streptomyces tendae
BGC0000900.1	0.62	Other	ferrichrome	Aspergillus oryzae
BGC0000348.1	0.61	NRP	ergovaline	Epichloe festucae var. lolii

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 41097:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly) + (emal - Me-ohmal - redmal) + (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 11317 - 41097:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (gly) + (emal - Me-ohmal - redmal) + (Me-ccmal)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

congD

PKS_AT (582..877): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.6
Ethylmalonyl-CoA: 213.9
2-Methylbutyryl-CoA: 181.2
Methoxymalonyl-CoA: 172.9
trans-1,2-CPDA: 136.4
Propionyl-CoA: 120.9
CHC-CoA: 119.8
Malonyl-CoA: 110.6
Isobutyryl-CoA: 91.6
Benzoyl-CoA: 77.5
Acetyl-CoA: 40.8
fatty_acid: 37.6
inactive: 35.4
3-Methylbutyryl-CoA: 20.6

congC

PKS_AT (277..573): emal

ATSignature: Malonyl-CoA, Isobutyryl-CoA, Ethylmalonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%; Isobutyryl-CoA: 54.2%; Ethylmalonyl-CoA: 54.2%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 127.6
Methylmalonyl-CoA: 124.9
Methoxymalonyl-CoA: 116.0
2-Methylbutyryl-CoA: 113.9
CHC-CoA: 101.3
Propionyl-CoA: 97.3
Malonyl-CoA: 75.9
trans-1,2-CPDA: 67.3
Isobutyryl-CoA: 50.1
Benzoyl-CoA: 30.0
3-Methylbutyryl-CoA: 14.6
inactive: 13.3
Acetyl-CoA: 12.9
fatty_acid: 12.5

PKS_AT (1293..1590): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 213.3
Ethylmalonyl-CoA: 201.5
Methoxymalonyl-CoA: 186.0
2-Methylbutyryl-CoA: 139.3
trans-1,2-CPDA: 120.6
Malonyl-CoA: 119.1
Propionyl-CoA: 112.0
CHC-CoA: 106.1
Isobutyryl-CoA: 95.3
Benzoyl-CoA: 67.9
Acetyl-CoA: 51.9
3-Methylbutyryl-CoA: 40.6
inactive: 36.9
fatty_acid: 33.7

PKS_AT (2831..3119): mal

ATSignature: (unknown)

No matches above 50%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.5
Methylmalonyl-CoA: 17.8
Methoxymalonyl-CoA: 15.6
inactive: 13.9
Ethylmalonyl-CoA: 2.7
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Propionyl-CoA: 0.0
Isobutyryl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

congA

Search NORINE for peptide: strict or relaxed

AMP-binding (599..992): gly

NRPSPredictor2: gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: gly

Stachelhaus prediction details:

Stachelhaus sequence:: DILQLGLIWK
Nearest Stachelhaus code:: gly
Stachelhaus code match:: 100% (strong)