BGC0001357 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001357 (Nostoc sp. CAVN2)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS,T3PKS	1	26,932	cylindrocyclophane	Polyketide	75%

BGC0001357 - Region 1 - PKS-like,T1PKS,T3PKS

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Location: 1 - 26,932 nt. (total: 26,932 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T3PKS: (Chal_sti_synt_C or Chal_sti_synt_N)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 26,933
Label		BGC0001357

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001357.1	3.00	Polyketide	carbamidocyclophane A, carbamidocyclophane B, carbamidocyclophane C, carbamidocyclophane D, carbamidocyclophane E, carbamidocyclophane F, carbamidocyclophane H, carbamidocyclophane M, carbamidocyclophane N, carbamidocyclophane O, carbamidocyclophane P, carbamidocyclophane Q, carbamidocyclophane R, carbamidocyclophane S, carbamidocyclophane T, carbamidocyclophane U	Nostoc sp. CAVN2
BGC0001064.1	1.55	Polyketide	cylindrocyclophane D, cylindrocyclophane E, cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014
BGC0001566.1	1.27	Polyketide	cylindrocyclophane	Cylindrospermum licheniforme UTEX B 2014
BGC0000282.1	1.02	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1	0.96	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000205.1	0.88	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0001161.1	0.76	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.76	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.75	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001068.1	0.74	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001357.1	1.00	Polyketide	carbamidocyclophane A, carbamidocyclophane B, carbamidocyclophane C, carbamidocyclophane D, carbamidocyclophane E, carbamidocyclophane F, carbamidocyclophane H, carbamidocyclophane M, carbamidocyclophane N, carbamidocyclophane O, carbamidocyclophane P, carbamidocyclophane Q, carbamidocyclophane R, carbamidocyclophane S, carbamidocyclophane T, carbamidocyclophane U	Nostoc sp. CAVN2
BGC0001064.1	0.80	Polyketide	cylindrocyclophane D, cylindrocyclophane E, cylindrocyclophane F	Cylindrospermum licheniforme UTEX B 2014
BGC0001566.1	0.74	Polyketide	cylindrocyclophane	Cylindrospermum licheniforme UTEX B 2014
BGC0000282.1	0.67	Polyketide	alkylresorcinol	Streptomyces griseus subsp. griseus NBRC 13350
BGC0001962.1	0.65	Polyketide	hierridin B, hierridin C	Cyanobium sp. LEGE 06113
BGC0000205.1	0.63	Polyketide	bryostatin	Candidatus Endobugula sertula
BGC0001161.1	0.59	Polyketide	1-heptadecene	Moorea bouillonii PNG
BGC0001163.1	0.59	Polyketide	1-heptadecene	Moorea producens 3L
BGC0001162.1	0.59	Polyketide	1-heptadecene	Moorea producens JHB
BGC0001068.1	0.58	Terpene, Polyketide	pyripyropene A	unidentified unclassified sequences.

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 26932:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (mal)
Non-colinear ordering:: cabD + cabH

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

cabA

CAL_domain (41..486): pk

minowa: NH2

Prediction, score:

NH2: 27.8
fatty_acid: 19.8
AHBA: 14.7
shikimic_acid: 0.0
Acetyl-CoA: -2.5

cabD

PKS_AT (532..829): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 100.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.6
inactive: 184.0
Methoxymalonyl-CoA: 64.2
Methylmalonyl-CoA: 54.4
Propionyl-CoA: 42.4
Isobutyryl-CoA: 34.8
Acetyl-CoA: 32.1
Benzoyl-CoA: 28.3
2-Methylbutyryl-CoA: 23.8
trans-1,2-CPDA: 18.6
CHC-CoA: 15.3
Ethylmalonyl-CoA: 15.0
fatty_acid: 11.1
3-Methylbutyryl-CoA: 7.4

cabH

PKS_AT (1271..1566): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 95.8%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 182.0
inactive: 172.8
Methoxymalonyl-CoA: 53.7
Methylmalonyl-CoA: 47.8
Propionyl-CoA: 29.1
Benzoyl-CoA: 26.1
Isobutyryl-CoA: 24.9
Acetyl-CoA: 21.3
CHC-CoA: 11.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0