BGC0001649 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001649 (Streptomyces lavendulae)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	55,095	lavendiol	Polyketide	100%

BGC0001649 - Region 1 - T1PKS

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Location: 1 - 55,095 nt. (total: 55,095 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 55,096
Label		BGC0001649

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001916.1	0.86	Polyketide	lavendiol	Streptomyces lavendulae
BGC0001649.1	0.86	Polyketide	lavendiol	Streptomyces lavendulae
BGC0001273.1	0.33	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.33	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.32	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001909.1	0.31	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000068.1	0.31	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001275.1	0.31	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000170.1	0.30	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001280.1	0.30	Polyketide	betaenone C, betaenone A	Phoma betae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001916.1	0.95	Polyketide	lavendiol	Streptomyces lavendulae
BGC0001649.1	0.95	Polyketide	lavendiol	Streptomyces lavendulae
BGC0001273.1	0.66	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001909.1	0.65	Polyketide	strobilurin	Strobilurus tenacellus
BGC0000068.1	0.65	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0001275.1	0.64	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000170.1	0.64	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001280.1	0.63	Polyketide	betaenone C, betaenone A	Phoma betae

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 55095:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal - ccmal - ccmal) + (ohmal) + (ohmal)
Non-colinear ordering:: lavA + lavB + lavC

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

lavC

PKS_AT (563..842): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 187.9
inactive: 90.0
Methoxymalonyl-CoA: 68.7
Methylmalonyl-CoA: 62.8
Isobutyryl-CoA: 44.9
Propionyl-CoA: 35.5
Acetyl-CoA: 28.2
trans-1,2-CPDA: 23.9
Benzoyl-CoA: 23.5
Ethylmalonyl-CoA: 20.4
2-Methylbutyryl-CoA: 14.4
fatty_acid: 12.2
CHC-CoA: 9.7
3-Methylbutyryl-CoA: 0.0

lavB

PKS_AT (569..857): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 150.8
Methylmalonyl-CoA: 62.5
Methoxymalonyl-CoA: 62.3
inactive: 61.2
Propionyl-CoA: 33.3
Isobutyryl-CoA: 26.3
Benzoyl-CoA: 26.1
Ethylmalonyl-CoA: 22.9
Acetyl-CoA: 15.9
fatty_acid: 14.5
2-Methylbutyryl-CoA: 14.2
CHC-CoA: 10.5
trans-1,2-CPDA: 9.8
3-Methylbutyryl-CoA: 9.2

lavA

PKS_AT (1135..1413): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 174.9
inactive: 82.2
Methoxymalonyl-CoA: 64.7
Methylmalonyl-CoA: 52.4
Isobutyryl-CoA: 32.4
Ethylmalonyl-CoA: 24.4
Propionyl-CoA: 23.8
Acetyl-CoA: 16.1
Benzoyl-CoA: 13.5
fatty_acid: 10.5
2-Methylbutyryl-CoA: 5.6
CHC-CoA: 5.0
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2798..3099): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 95.8%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.4
inactive: 114.9
Methylmalonyl-CoA: 55.5
Methoxymalonyl-CoA: 50.4
Propionyl-CoA: 30.8
Isobutyryl-CoA: 29.2
Ethylmalonyl-CoA: 22.0
2-Methylbutyryl-CoA: 20.6
Benzoyl-CoA: 17.0
CHC-CoA: 15.1
Acetyl-CoA: 8.9
trans-1,2-CPDA: 5.7
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4452..4742): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 66.7%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.1
inactive: 92.6
Methylmalonyl-CoA: 68.8
Methoxymalonyl-CoA: 64.4
Propionyl-CoA: 43.7
Isobutyryl-CoA: 35.3
Ethylmalonyl-CoA: 28.9
Acetyl-CoA: 24.0
2-Methylbutyryl-CoA: 22.9
CHC-CoA: 22.5
Benzoyl-CoA: 16.2
fatty_acid: 12.8
trans-1,2-CPDA: 11.1
3-Methylbutyryl-CoA: 0.0