BGC0001653 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0001653 (Microbispora sp. GMKU363)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	66,233	nanchangmycin	Polyketide	30%

BGC0001653 - Region 1 - T1PKS

Download region GenBank file

Download region SVG

Location: 1 - 66,233 nt. (total: 66,233 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 66,234
Label		BGC0001653

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001653.1	0.56	Polyketide	linfuranone B, linfuranone C	Microbispora sp. GMKU363
BGC0000041.1	0.36	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276.1	0.32	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.32	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273.1	0.32	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002031.1	0.32	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001275.1	0.32	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001304.1	0.31	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000067.1	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000120.1	0.30	Polyketide	patulin	Penicillium expansum

Reference	Similarity score	Type	Compound(s)	Organism
BGC0001653.1	0.82	Polyketide	linfuranone B, linfuranone C	Microbispora sp. GMKU363
BGC0000041.1	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001276.1	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001273.1	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0002031.1	0.65	Alkaloid	kitasetaline	Kitasatospora setae KM-6054
BGC0001275.1	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001304.1	0.64	Polyketide	aflavarin	Aspergillus flavus NRRL3357
BGC0000067.1	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0000120.1	0.63	Polyketide	patulin	Penicillium expansum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 66233:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ohmal) + (Me-mal - redmal) + (Me-ccmal - Me-ohmal) + (redmal - ccmal - Me-ohmal) + (ccmal - ccmal)
Non-colinear ordering:: AP234_RS38635 + AP234_RS14725 + AP234_RS38650 + AP234_RS38645 + AP234_RS14715

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AP234_RS38635

PKS_AT (0..283): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 70.8%; Malonyl-CoA: 62.5%; Methoxymalonyl-CoA: 62.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 152.5
Ethylmalonyl-CoA: 127.4
Methoxymalonyl-CoA: 121.4
Malonyl-CoA: 94.5
2-Methylbutyryl-CoA: 84.3
Propionyl-CoA: 76.2
trans-1,2-CPDA: 69.3
Isobutyryl-CoA: 67.7
CHC-CoA: 58.1
Benzoyl-CoA: 36.2
inactive: 34.1
Acetyl-CoA: 32.7
fatty_acid: 29.0
3-Methylbutyryl-CoA: 23.8

AP234_RS38645

PKS_AT (562..833): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 201.0
inactive: 84.5
Methoxymalonyl-CoA: 76.3
Methylmalonyl-CoA: 55.6
Propionyl-CoA: 39.1
Acetyl-CoA: 30.1
Isobutyryl-CoA: 28.9
fatty_acid: 16.9
CHC-CoA: 15.6
Ethylmalonyl-CoA: 15.2
Benzoyl-CoA: 14.9
2-Methylbutyryl-CoA: 11.9
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (2562..2832): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.7
inactive: 80.8
Methoxymalonyl-CoA: 74.4
Methylmalonyl-CoA: 54.1
Propionyl-CoA: 33.7
Isobutyryl-CoA: 25.8
Acetyl-CoA: 24.6
fatty_acid: 16.5
Ethylmalonyl-CoA: 14.8
CHC-CoA: 14.7
Benzoyl-CoA: 14.4
2-Methylbutyryl-CoA: 9.0
trans-1,2-CPDA: 4.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (4285..4577): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 215.2
Ethylmalonyl-CoA: 199.2
Methoxymalonyl-CoA: 178.4
2-Methylbutyryl-CoA: 166.4
trans-1,2-CPDA: 126.9
Malonyl-CoA: 124.3
Propionyl-CoA: 119.4
CHC-CoA: 92.6
Isobutyryl-CoA: 82.1
Benzoyl-CoA: 68.2
Acetyl-CoA: 45.9
fatty_acid: 38.2
3-Methylbutyryl-CoA: 36.4
inactive: 36.2

AP234_RS14715

PKS_AT (566..837): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 203.2
inactive: 85.0
Methoxymalonyl-CoA: 77.0
Methylmalonyl-CoA: 55.9
Propionyl-CoA: 39.7
Acetyl-CoA: 30.2
Isobutyryl-CoA: 29.0
Ethylmalonyl-CoA: 17.5
fatty_acid: 16.9
CHC-CoA: 16.0
Benzoyl-CoA: 14.9
2-Methylbutyryl-CoA: 10.6
trans-1,2-CPDA: 8.6
3-Methylbutyryl-CoA: 0.0

PKS_AT (2278..2549): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 87.5%; inactive: 70.8%; Methylmalonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.0
inactive: 90.5
Methoxymalonyl-CoA: 77.3
Methylmalonyl-CoA: 57.7
Propionyl-CoA: 38.7
Isobutyryl-CoA: 30.3
Acetyl-CoA: 25.3
fatty_acid: 20.0
Ethylmalonyl-CoA: 17.8
Benzoyl-CoA: 14.0
CHC-CoA: 13.8
2-Methylbutyryl-CoA: 9.3
trans-1,2-CPDA: 6.5
3-Methylbutyryl-CoA: 0.0

AP234_RS38650

PKS_AT (851..1136): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.3
Ethylmalonyl-CoA: 173.9
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 132.9
trans-1,2-CPDA: 132.7
Propionyl-CoA: 106.6
Malonyl-CoA: 102.5
CHC-CoA: 90.0
Isobutyryl-CoA: 62.8
Acetyl-CoA: 43.0
3-Methylbutyryl-CoA: 32.7
inactive: 31.7
fatty_acid: 28.5
Benzoyl-CoA: 26.4

PKS_AT (2550..2835): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 197.0
Ethylmalonyl-CoA: 181.2
Methoxymalonyl-CoA: 162.0
trans-1,2-CPDA: 134.5
2-Methylbutyryl-CoA: 133.9
Propionyl-CoA: 109.3
Malonyl-CoA: 108.3
CHC-CoA: 92.6
Isobutyryl-CoA: 69.8
Acetyl-CoA: 43.4
3-Methylbutyryl-CoA: 36.1
inactive: 32.8
fatty_acid: 27.9
Benzoyl-CoA: 27.1

AP234_RS37235

PKS_AT (526..811): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 91.7%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 193.3
Ethylmalonyl-CoA: 173.9
Methoxymalonyl-CoA: 160.5
2-Methylbutyryl-CoA: 132.9
trans-1,2-CPDA: 132.7
Propionyl-CoA: 106.6
Malonyl-CoA: 102.5
CHC-CoA: 90.0
Isobutyryl-CoA: 62.8
Acetyl-CoA: 43.0
3-Methylbutyryl-CoA: 32.7
inactive: 31.7
fatty_acid: 28.5
Benzoyl-CoA: 26.4

AP234_RS14725

PKS_AT (539..825): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 95.8%; Malonyl-CoA: 83.3%; Methoxymalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 186.1
Ethylmalonyl-CoA: 181.6
Methoxymalonyl-CoA: 151.4
2-Methylbutyryl-CoA: 140.2
trans-1,2-CPDA: 108.5
Propionyl-CoA: 106.9
Malonyl-CoA: 94.3
CHC-CoA: 91.3
Isobutyryl-CoA: 78.4
Benzoyl-CoA: 73.2
inactive: 40.5
Acetyl-CoA: 35.6
3-Methylbutyryl-CoA: 31.1
fatty_acid: 16.7

PKS_AT (1530..1820): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 220.2
inactive: 102.0
Methoxymalonyl-CoA: 81.3
Methylmalonyl-CoA: 70.1
Isobutyryl-CoA: 40.7
Propionyl-CoA: 37.7
Ethylmalonyl-CoA: 32.3
Acetyl-CoA: 22.5
2-Methylbutyryl-CoA: 20.5
Benzoyl-CoA: 18.6
fatty_acid: 15.8
CHC-CoA: 15.5
trans-1,2-CPDA: 8.1
3-Methylbutyryl-CoA: 0.0