BGC0000001 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000001 (Micromonospora maris AB-18-032)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	59,320	abyssomicin C/atrop-abyssomicin C	PKS:Type I	100%

BGC0000001 - Region 1 - T1PKS

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Location: 1 - 59,320 nt. (total: 59,320 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 59,321
Label		BGC0000001

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000001	0.96	Polyketide	abyssomicin C, atrop-abyssomicin C	Verrucosispora maris AB-18-032
BGC0000041	0.37	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002631	0.32	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000160	0.31	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000677	0.31	Terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002229	0.31	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000844	0.30	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001273	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000067	0.30	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000001	0.99	Polyketide	abyssomicin C, atrop-abyssomicin C	Verrucosispora maris AB-18-032
BGC0000041	0.69	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002631	0.66	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000160	0.65	Polyketide	terreic acid	Aspergillus terreus NIH2624
BGC0000677	0.65	Terpene	cyclooctatin	Streptomyces melanosporofaciens
BGC0002229	0.64	Polyketide	6-MSA, aculin A	Aspergillus aculeatus ATCC 16872
BGC0000844	0.64	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001273	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0000067	0.64	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 59320:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - ccmal - ccmal - ccmal) + (Me-ccmal - Me-redmal) + (mal)
Non-colinear ordering:: abyB1 + abyB2 + abyB3

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

abyB1

PKS_AT (510..791): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 194.2
inactive: 86.6
Methylmalonyl-CoA: 84.4
Methoxymalonyl-CoA: 82.1
Propionyl-CoA: 43.3
Ethylmalonyl-CoA: 37.1
Isobutyryl-CoA: 35.1
CHC-CoA: 34.7
2-Methylbutyryl-CoA: 26.2
Benzoyl-CoA: 25.6
Acetyl-CoA: 22.6
fatty_acid: 19.3
trans-1,2-CPDA: 15.2
3-Methylbutyryl-CoA: 5.9

PKS_AT (1477..1760): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.1
inactive: 77.3
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 45.5
Propionyl-CoA: 22.9
Acetyl-CoA: 17.3
fatty_acid: 13.8
Ethylmalonyl-CoA: 11.9
2-Methylbutyryl-CoA: 9.5
CHC-CoA: 9.4
Benzoyl-CoA: 9.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (3061..3344): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 91.7%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 165.1
inactive: 77.3
Methoxymalonyl-CoA: 60.9
Methylmalonyl-CoA: 45.5
Propionyl-CoA: 22.9
Acetyl-CoA: 17.3
fatty_acid: 13.8
Ethylmalonyl-CoA: 11.9
2-Methylbutyryl-CoA: 9.5
CHC-CoA: 9.4
Benzoyl-CoA: 9.3
trans-1,2-CPDA: 0.0
Isobutyryl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (4661..4926): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 173.0
inactive: 82.7
Methoxymalonyl-CoA: 51.8
Methylmalonyl-CoA: 46.7
Propionyl-CoA: 23.7
Acetyl-CoA: 22.8
fatty_acid: 18.8
Isobutyryl-CoA: 16.3
Benzoyl-CoA: 14.7
CHC-CoA: 12.6
Ethylmalonyl-CoA: 9.1
trans-1,2-CPDA: 7.9
3-Methylbutyryl-CoA: 7.4
2-Methylbutyryl-CoA: 7.0

abyB2

PKS_AT (573..845): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 200.3
Ethylmalonyl-CoA: 188.7
Methoxymalonyl-CoA: 171.2
2-Methylbutyryl-CoA: 140.8
trans-1,2-CPDA: 121.1
Propionyl-CoA: 113.4
Malonyl-CoA: 106.1
CHC-CoA: 95.7
Isobutyryl-CoA: 77.7
Acetyl-CoA: 61.6
Benzoyl-CoA: 52.4
3-Methylbutyryl-CoA: 46.5
fatty_acid: 39.9
inactive: 38.6

PKS_AT (2160..2445): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 195.4
Ethylmalonyl-CoA: 181.3
Methoxymalonyl-CoA: 158.2
trans-1,2-CPDA: 123.8
Malonyl-CoA: 105.8
2-Methylbutyryl-CoA: 103.7
Propionyl-CoA: 98.5
CHC-CoA: 86.3
Isobutyryl-CoA: 41.0
Benzoyl-CoA: 38.8
Acetyl-CoA: 38.4
3-Methylbutyryl-CoA: 36.3
inactive: 30.5
fatty_acid: 29.3

abyB3

PKS_AT (550..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 79.2%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 172.9
inactive: 94.0
Methoxymalonyl-CoA: 47.5
Methylmalonyl-CoA: 40.3
Isobutyryl-CoA: 32.1
Propionyl-CoA: 16.6
CHC-CoA: 9.2
Acetyl-CoA: 2.2
Benzoyl-CoA: 0.8
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -1.5
Ethylmalonyl-CoA: -3.3