BGC0000017: anatoxin-a biosynthetic gene cluster from [Oscillatoria] sp. PCC 6506
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Location: 1 - 28,910 nt. (total: 28,910 nt).
This entry is originally from NCBI GenBank FJ477836.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000017
Short description anatoxin-a biosynthetic gene cluster from [Oscillatoria] sp. PCC 6506
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
  • Alkaloid
Loci NCBI GenBank: FJ477836.1
Compounds
  • anatoxin-a
  • homoanatoxin-a
Species [Oscillatoria] sp. PCC 6506 [taxonomy]
References
Chemical products information
anatoxin-a
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C10H15N1O1
Chemical database entries
PubCHEM
homoanatoxin-a
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C11H17N1O1
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ACR33072.1
 877 - 1596 (+) cyclase-like protein
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  • ACR33073.1
  • anaA
 1986 - 2741 (+) thioesterase
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  • ACR33074.1
  • anaB
 3652 - 4797 (+) Prolyl-ACP oxidase
  • Other enzymatic
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  • ACR33075.1
  • anaC
 4810 - 6426 (+) Proline adenylation protein
  • Precursor biosynthesis
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Heterologous expression
Sequence-based prediction
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  • ACR33076.1
  • anaD
 6449 - 6712 (+) Acyl carrier protein
  • Precursor biosynthesis
Activity assay
Heterologous expression
Sequence-based prediction
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  • ACR33077.1
  • anaE
 6866 - 13306 (+) polyketide synthase
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  • ACR33078.1
  • anaF
 13308 - 18905 (+) polyketide synthase
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  • ACR33079.1
  • anaG
 19181 - 24082 (+) polyketide synthase
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  • ACR33080.1
  • anaH
 24527 - 25009 (+) transposase
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  • ACR33081.1
 25283 - 25630 (+) putative ATP synthase beta subunit
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  • ACR33082.1
 25504 - 26589 (-) putative serine/threonine protein kinase
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  • ACR33083.1
 26759 - 27457 (+) putative SAM-dependent methyltransferase
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  • ACR33084.1
 27369 - 27713 (+) putative acyl-CoA dehydrogenase
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  • ACR33085.1
 27485 - 27763 (-) hypothetical conserved protein
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  • ACR33086.1
 28215 - 28862 (+) putative phosphoglycerate mutase
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Polyketide-specific information
Subclass Other
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
anaA
+
anaG
+
anaF
+
anaE 		Synthase subclass: Modular type I
Thioesterases:
  • anaA (Type II)
Module 1
Genes: anaE
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Genes: anaF
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Genes: anaG
Core domains: Ketosynthase, Acyltransferase
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: GTMWOIPTWIF6ILYNEBGWTDRO, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Added AMP-binding domain substrate specificities
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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