BGC0000017 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000017 ([Oscillatoria] sp. PCC 6506 (Oscillatoria sp. PCC 9029 = Lyngbya kuetzingii UTEX B 1547))

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	28,910	microcystin	NRP + Polyketide	33%

BGC0000017 - Region 1 - T1PKS

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Location: 1 - 28,910 nt. (total: 28,910 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 28,911
Label		BGC0000017

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000017.1	0.77	Polyketide, Alkaloid	anatoxin-a, homoanatoxin-a	[Oscillatoria] sp. PCC 6506
BGC0000041.1	0.31	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.30	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.30	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.30	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.30	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000068.1	0.28	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000170.1	0.26	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001858.1	0.26	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000891.1	0.26	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000017.1	0.92	Polyketide, Alkaloid	anatoxin-a, homoanatoxin-a	[Oscillatoria] sp. PCC 6506
BGC0000041.1	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001273.1	0.64	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001276.1	0.64	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001244.1	0.63	Polyketide	(-)-Mellein	Parastagonospora nodorum
BGC0001275.1	0.63	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000068.1	0.62	Polyketide	geldanamycin	Streptomyces hygroscopicus
BGC0000170.1	0.60	Polyketide	yanuthone D	Aspergillus niger ATCC 1015
BGC0001858.1	0.59	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000891.1	0.59	Other, , (, A, m, i, n, o, c, o, u, m, a, r, i, n, )	pentabromopseudilin	Pseudoalteromonas luteoviolacea 2ta16

Similar known gene clusters

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 28910:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (ccmal) + (redmal) + (Me-mal)
Non-colinear ordering:: anaF + anaE + anaG

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

anaC

Search NORINE for peptide: strict or relaxed

AMP-binding (11..433): ala

NRPSPredictor2: ala

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic
Large clusters prediction:: gly, ala, val, leu, ile, abu, iva
Small clusters prediction:: gly, ala
Single AA prediction:: ala

Stachelhaus prediction details:

Stachelhaus sequence:: DLfYLAlV-K
Nearest Stachelhaus code:: iva
Stachelhaus code match:: 70% (weak)

anaE

PKS_AT (551..848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 95.8%; inactive: 91.7%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 177.6
inactive: 170.2
Methoxymalonyl-CoA: 49.5
Methylmalonyl-CoA: 42.0
Propionyl-CoA: 28.3
Isobutyryl-CoA: 25.7
Benzoyl-CoA: 17.3
2-Methylbutyryl-CoA: 12.1
Ethylmalonyl-CoA: 10.9
CHC-CoA: 10.9
3-Methylbutyryl-CoA: 9.8
trans-1,2-CPDA: 9.4
fatty_acid: 0.0
Acetyl-CoA: 0.0

anaF

PKS_AT (559..852): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 100.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.7
inactive: 188.7
Methylmalonyl-CoA: 67.6
Methoxymalonyl-CoA: 66.3
Propionyl-CoA: 52.1
2-Methylbutyryl-CoA: 39.8
Ethylmalonyl-CoA: 34.5
Isobutyryl-CoA: 33.7
Acetyl-CoA: 26.0
CHC-CoA: 25.4
Benzoyl-CoA: 23.4
trans-1,2-CPDA: 21.1
3-Methylbutyryl-CoA: 11.6
fatty_acid: 0.0

anaG

PKS_AT (566..859): mal

ATSignature: Malonyl-CoA, inactive

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 100.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 210.8
inactive: 185.7
Methoxymalonyl-CoA: 73.8
Methylmalonyl-CoA: 72.5
Propionyl-CoA: 51.2
Isobutyryl-CoA: 42.9
CHC-CoA: 35.3
Ethylmalonyl-CoA: 34.5
2-Methylbutyryl-CoA: 31.7
Acetyl-CoA: 24.3
Benzoyl-CoA: 22.8
trans-1,2-CPDA: 19.8
3-Methylbutyryl-CoA: 13.5
fatty_acid: 0.0