BGC0000024 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000024 (Streptomyces thioluteus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	29,132	High	aureothin	PKS:Type I

BGC0000024 - Region 1 - T1PKS

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Location: 1 - 29,132 nt. (total: 29,132 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 29,133
Label		BGC0000024

Tailoring functions

Oxidoreductases: oxygenase

aurH: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Transferases: acylase

aurA: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Isomerases: isomerase

aurG: isochorismate synthase

smcogs: SMCOG1018: isochorismate synthase

Ligases: ligase synthase

aurB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

aurC: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

aurE: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000024.5	0.98	PKS	aureothin	Streptomyces thioluteus
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000024.5	0.98	PKS	aureothin	Streptomyces thioluteus
BGC0001273.3	0.77	PKS	asperlactone	Aspergillus ochraceus
BGC0001244.3	0.76	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001275.3	0.75	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0000041.3	0.73	PKS	oronofacic acid	Pseudomonas syringae
BGC0001257.3	0.67	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.66	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001258.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 29132:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-ccmal) + (redmal) + (Me-mal)
Non-colinear ordering:: aurA + aurB + aurC

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

aurE: X

AMP-binding (19..402): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: TFNFVAVLLK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

aurA: mmal

PKS_AT (648..945): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 216.0
Ethylmalonyl-CoA: 208.0
Methoxymalonyl-CoA: 176.2
2-Methylbutyryl-CoA: 155.0
trans-1,2-CPDA: 130.7
Propionyl-CoA: 124.7
Malonyl-CoA: 111.8
CHC-CoA: 106.8
Isobutyryl-CoA: 75.2
Benzoyl-CoA: 56.3
Acetyl-CoA: 55.0
fatty_acid: 39.8
3-Methylbutyryl-CoA: 30.0
inactive: 20.3

aurB: mal

PKS_AT (564..861): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 87.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.8
inactive: 109.7
Methoxymalonyl-CoA: 61.8
Methylmalonyl-CoA: 41.2
Propionyl-CoA: 28.9
Isobutyryl-CoA: 17.4
Acetyl-CoA: 16.2
2-Methylbutyryl-CoA: 11.2
Benzoyl-CoA: 11.1
Ethylmalonyl-CoA: 8.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
CHC-CoA: -2.2

aurC: mmal

PKS_AT (573..871): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 214.0
Ethylmalonyl-CoA: 212.2
Methoxymalonyl-CoA: 175.8
2-Methylbutyryl-CoA: 132.0
trans-1,2-CPDA: 120.4
Propionyl-CoA: 106.3
Malonyl-CoA: 101.2
Isobutyryl-CoA: 96.4
CHC-CoA: 92.3
Benzoyl-CoA: 71.9
Acetyl-CoA: 67.0
fatty_acid: 48.3
inactive: 40.2
3-Methylbutyryl-CoA: 36.4

Link to PARAS substrate predictor