BGC0000025: avermectin biosynthetic gene cluster from Streptomyces avermitilis
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Location: 1 - 9,530 nt. (total: 9,530 nt).
This entry is originally from NCBI GenBank AB032523.1.

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core biosynthetic genes
additional biosynthetic genes
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000025
Short description avermectin biosynthetic gene cluster from Streptomyces avermitilis
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AB032523.1
Compounds
  • avermectin
Species Streptomyces avermitilis [taxonomy]
References
Chemical products information
avermectin
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C48H72O14
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAA84591.1
  • orf-1
 160 - 873 (+) reductase
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  • BAA84592.1
  • aveBI
 931 - 2169 (+) glycosyl transferase
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  • BAA84593.1
  • aveBII
 2075 - 3142 (-) dTDP-glucose 4,6-dehydratase
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  • BAA84594.1
  • aveBIII
 3139 - 4038 (-) glucose-1-phosphate thymidyltransferase
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  • BAA84595.1
  • aveBIV
 4164 - 5195 (+) dTDP-4-keto-6-deoxy-L-hexose 4-reductase
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  • BAA84596.1
  • aveBV
 5249 - 5926 (-) dTDP-4-keto-6-deoxyhexose 3,5-epimerase
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  • BAA84597.1
  • aveBVI
 5988 - 7397 (-) dTDP-4-keto-6-deoxy-L-hexose2,3-dehydratase
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  • BAA84598.1
  • aveBVII
 7394 - 8167 (-) dTDP-6-deoxy-L-hexose 3-O-methyltransferase
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  • BAA84599.1
  • aveBVIII
 8254 - 9297 (-) dTDP-4-keto-6-deoxy-L-hexose 2,3-reductase
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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