Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000027.1:
Cluster 1Polyketide180000

BGC0000027, azaphilone biosynthetic gene cluster from Monascus pilosus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: ankaflavin
PubChem ID: 15294091
SMILES string: Copy to clipboard
Molecular formula: C23H30O5
Average molecular mass: 386.488 Da
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Iterative type I
Starter unit:
Acetoacetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
KC148521,2362MPPKS5
Iterative PKS subtype:
Non-reducing
Number of iterations:
5
C2-C7 first
Thioesterase type:
Unknown
Release / cyclization type:
Hydrolysis

Gene cluster description

azaphilone (BGC0000027). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank KC148521, positions 13800-76200. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Domain annotation

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Hyung-Jin Kwon (Myongji University)

Literature references

1. Balakrishnan B et al. (2013) Genetic localization and in vivo characterization of a Monascus azaphilone pigment biosynthetic gene cluster. Appl Microbiol Biotechnol 97(14):6337-45. doi: