BGC0000028: bafilomycin B1 biosynthetic gene cluster from Streptomyces lohii
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Location: 1 - 74,009 nt. (total: 74,009 nt).
This entry is originally from NCBI GenBank GU390405.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000028
Short description bafilomycin B1 biosynthetic gene cluster from Streptomyces lohii
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Macrolide)
Loci NCBI GenBank: GU390405.1
Compounds
  • bafilomycin B1
Species Streptomyces lohii [taxonomy]
References
Chemical products information
bafilomycin B1
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C44H65N1O13
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADC79613.1
 1 - 1587 (-) BafX
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  • ADC79614.1
 1595 - 3139 (-) BafY
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  • ADC79615.1
 3350 - 4594 (+) BafZ
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  • ADC79616.1
 4831 - 19485 (+) BafAI
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  • ADC79617.1
 19502 - 34939 (+) BafAII
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  • ADC79618.1
 34977 - 46883 (+) BafAIII
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  • ADC79619.1
 46933 - 57468 (+) BafAIV
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  • ADC79620.1
 57521 - 63832 (+) BafAV
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  • ADC79621.1
 63829 - 64719 (+) BafB
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  • ADC79622.1
 64742 - 65023 (+) BafC
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  • ADC79623.1
 65040 - 66131 (+) BafD
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  • ADC79624.1
 66167 - 67264 (+) BafE
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  • ADC79625.1
 67307 - 67969 (-) BafF
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  • ADC79626.1
 68094 - 69923 (-) BafG
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  • ADC79627.1
 70537 - 71298 (+) BafH
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  • ADC79628.1
 71332 - 71685 (+) putative LuxR-like protein
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  • ADC79629.1
 71939 - 72901 (+) putative malonyl transferase
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  • ADC79630.1
 72979 - 73977 (+) putative CoA ligase
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Polyketide-specific information
Subclass Macrolide
Starter unit Isobutyryl-CoA
Cyclic? yes
Release type
  • Macrolactamization
Polyketide-synthases
Genes Properties Modules
ADC79618.1
+
ADC79617.1
+
ADC79620.1
+
ADC79619.1
+
ADC79616.1 		Synthase subclass: Modular type I
Module 0
Specificity: Methylmalonyl-CoA
Genes: ADC79616.1
Core domains: Acyltransferase, Thiolation (ACP/PCP)
Module 1
Specificity: Methylmalonyl-CoA
Genes: ADC79616.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 2
Specificity: Methylmalonyl-CoA
Genes: ADC79616.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 3
Specificity: Methylmalonyl-CoA
Genes: ADC79616.1
Core domains: Ketosynthase, Acyltransferase, Thiolation (ACP/PCP)
Module 4
Specificity: Methylmalonyl-CoA
Genes: ADC79617.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 5
Specificity: Methylmalonyl-CoA
Genes: ADC79617.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 6
Specificity: Methylmalonyl-CoA
Genes: ADC79617.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 7
Specificity: Methylmalonyl-CoA
Genes: ADC79618.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 8
Specificity: Methylmalonyl-CoA
Genes: ADC79618.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Enoylreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 9
Specificity: Methylmalonyl-CoA
Genes: ADC79619.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 10
Specificity: Methylmalonyl-CoA
Genes: ADC79619.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Module 11
Specificity: Methoxymalonyl-CoA
Genes: ADC79620.1
Core domains: Ketosynthase, Acyltransferase, Ketoreductase, Dehydratase, Thiolation (ACP/PCP)
KR-domain stereochemistry: Unknown
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: RIBLHRV4YSJAGJ5EVZV4GS2Z, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed ketoreductase stereochemistry annotation from modules without ketoreductases
  • Corrected gene identifiers
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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