BGC0000029 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000029 (Streptomyces sp. DSM 21069)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	85,059	BE-14106	PKS:Type I	100%

BGC0000029 - Region 1 - T1PKS

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Location: 1 - 85,059 nt. (total: 85,059 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 85,060
Label		BGC0000029

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000029	1.00	Polyketide	BE-14106	Streptomyces sp. DSM 21069
BGC0000097	0.55	Polyketide	ML-449	Streptomyces sp. MP39-85
BGC0002101	0.54	Polyketide	heronamide C, heronamide A, heronamide B	Streptomyces sp. CMB-0406 CBM-0406
BGC0001349	0.42	NRP, Polyketide	heronamide A, heronamide B, heronamide C, heronamide D, heronamide E, heronamide F	Streptomyces sp. SCSIO 03032
BGC0000016	0.37	Other	amphotericin B	Streptomyces nodosus
BGC0000122	0.34	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001925	0.33	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002084	0.33	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001647	0.31	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000041	0.30	Polyketide	oronofacic acid	Pseudomonas syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000029	1.00	Polyketide	BE-14106	Streptomyces sp. DSM 21069
BGC0000097	0.81	Polyketide	ML-449	Streptomyces sp. MP39-85
BGC0002101	0.81	Polyketide	heronamide C, heronamide A, heronamide B	Streptomyces sp. CMB-0406 CBM-0406
BGC0001349	0.73	NRP, Polyketide	heronamide A, heronamide B, heronamide C, heronamide D, heronamide E, heronamide F	Streptomyces sp. SCSIO 03032
BGC0000016	0.70	Other	amphotericin B	Streptomyces nodosus
BGC0000122	0.67	Polyketide	phenylnannolone A, phenylnannolone B, phenylnannolone C	Nannocystis pusilla
BGC0001925	0.66	Alkaloid	altemicidin, SB-203207, SB-203208	Streptomyces sp.
BGC0002084	0.66	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0001647	0.65	Polyketide	lagunapyrone A, lagunapyrone B, lagunapyrone C	Streptomyces sp. MP131-18
BGC0000041	0.64	Polyketide	oronofacic acid	Pseudomonas syringae

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 85059:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - ccmal - ccmal) + (ccmal - Me-ccmal) + (ccmal - ccmal) + (ccmal) + (pk - ccmal) + (ccmal)
Non-colinear ordering:: becA + becB + becD + becE + becF + becG

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

becA

PKS_AT (541..834): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 216.1
Methylmalonyl-CoA: 207.3
Methoxymalonyl-CoA: 173.9
2-Methylbutyryl-CoA: 150.0
trans-1,2-CPDA: 114.6
Propionyl-CoA: 114.1
Malonyl-CoA: 96.9
CHC-CoA: 94.5
Isobutyryl-CoA: 75.1
Benzoyl-CoA: 58.1
Acetyl-CoA: 47.7
3-Methylbutyryl-CoA: 42.9
inactive: 36.5
fatty_acid: 25.6

PKS_AT (1559..1848): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.5
inactive: 111.4
Methoxymalonyl-CoA: 65.2
Methylmalonyl-CoA: 56.2
Propionyl-CoA: 37.0
Isobutyryl-CoA: 22.6
Acetyl-CoA: 22.0
Benzoyl-CoA: 9.3
2-Methylbutyryl-CoA: 8.2
CHC-CoA: 7.4
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -2.7

PKS_AT (3329..3625): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 222.6
inactive: 114.2
Methoxymalonyl-CoA: 64.1
Methylmalonyl-CoA: 54.0
Propionyl-CoA: 30.3
Isobutyryl-CoA: 20.7
Acetyl-CoA: 16.8
Benzoyl-CoA: 11.0
CHC-CoA: 10.3
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.0

PKS_AT (5101..5386): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 193.9
inactive: 102.8
Methoxymalonyl-CoA: 75.3
Methylmalonyl-CoA: 56.7
Isobutyryl-CoA: 56.7
Propionyl-CoA: 26.9
Acetyl-CoA: 21.4
fatty_acid: 20.5
Benzoyl-CoA: 15.6
Ethylmalonyl-CoA: 15.1
CHC-CoA: 13.3
2-Methylbutyryl-CoA: 10.4
trans-1,2-CPDA: 0.0
3-Methylbutyryl-CoA: 0.0

becB

PKS_AT (643..936): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.6
inactive: 110.8
Methoxymalonyl-CoA: 64.7
Methylmalonyl-CoA: 51.7
Isobutyryl-CoA: 41.4
Propionyl-CoA: 35.6
Ethylmalonyl-CoA: 28.1
Benzoyl-CoA: 20.9
Acetyl-CoA: 16.6
2-Methylbutyryl-CoA: 15.9
trans-1,2-CPDA: 8.1
CHC-CoA: 7.5
fatty_acid: 0.0
3-Methylbutyryl-CoA: 0.0

PKS_AT (2330..2628): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 208.7
Ethylmalonyl-CoA: 207.5
Methoxymalonyl-CoA: 173.4
trans-1,2-CPDA: 151.0
2-Methylbutyryl-CoA: 142.7
Propionyl-CoA: 114.7
Malonyl-CoA: 101.1
CHC-CoA: 83.2
Benzoyl-CoA: 78.0
Isobutyryl-CoA: 71.7
Acetyl-CoA: 45.8
3-Methylbutyryl-CoA: 33.8
fatty_acid: 32.7
inactive: 32.1

becJ

AMP-binding (23..436): X

nrpys: Val, Leu, Ile, Abu, Ival

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DFFDTSGAAK
Nearest Stachelhaus code(s):: dn-dohHep DVFDFGGVAK (44% 8Å match)
Stachelhaus code match:: 60% (weak)

becK

PKS_AT (14..277): pk

ATSignature: (unknown)

No matches above 50%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 12.4
trans-1,2-CPDA: 0.0
inactive: 0.0
fatty_acid: 0.0
Methylmalonyl-CoA: 0.0
Methoxymalonyl-CoA: 0.0
Malonyl-CoA: 0.0
Isobutyryl-CoA: 0.0
Ethylmalonyl-CoA: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0

becL

AMP-binding (21..406): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Aliphatic, branched hydrophobic (Val, Leu, Ile, Abu, Ival)
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DCFFFALVTK
Nearest Stachelhaus code(s):: Ala DCFFFALITK (82% 8Å match); bMe-Asp DCFFFALITK (79% 8Å match)
Stachelhaus code match:: 90% (moderate)

becD

PKS_AT (559..838): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 209.4
inactive: 99.5
Methoxymalonyl-CoA: 52.5
Methylmalonyl-CoA: 45.9
Propionyl-CoA: 38.2
Isobutyryl-CoA: 26.9
Acetyl-CoA: 23.9
Ethylmalonyl-CoA: 22.8
fatty_acid: 19.3
CHC-CoA: 19.1
Benzoyl-CoA: 18.7
2-Methylbutyryl-CoA: 17.2
trans-1,2-CPDA: 5.1
3-Methylbutyryl-CoA: 0.0

PKS_AT (2171..2442): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 208.2
inactive: 106.5
Methoxymalonyl-CoA: 65.3
Methylmalonyl-CoA: 52.4
Isobutyryl-CoA: 34.1
Propionyl-CoA: 30.2
Benzoyl-CoA: 28.0
Acetyl-CoA: 24.0
Ethylmalonyl-CoA: 21.5
fatty_acid: 16.0
CHC-CoA: 14.3
2-Methylbutyryl-CoA: 14.3
trans-1,2-CPDA: 10.6
3-Methylbutyryl-CoA: 0.0

becG

PKS_AT (551..823): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.8
inactive: 102.5
Methoxymalonyl-CoA: 58.1
Methylmalonyl-CoA: 52.0
Propionyl-CoA: 33.6
Isobutyryl-CoA: 28.5
Ethylmalonyl-CoA: 26.6
Acetyl-CoA: 23.6
Benzoyl-CoA: 22.5
trans-1,2-CPDA: 22.2
2-Methylbutyryl-CoA: 18.2
fatty_acid: 17.4
CHC-CoA: 14.7
3-Methylbutyryl-CoA: 0.0

becF

PKS_AT (556..834): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 222.4
Methylmalonyl-CoA: 210.9
Methoxymalonyl-CoA: 166.2
2-Methylbutyryl-CoA: 153.7
trans-1,2-CPDA: 121.1
Propionyl-CoA: 120.2
CHC-CoA: 103.5
Malonyl-CoA: 82.0
Isobutyryl-CoA: 79.9
Benzoyl-CoA: 63.5
Acetyl-CoA: 54.7
3-Methylbutyryl-CoA: 35.6
fatty_acid: 30.0
inactive: 20.5

PKS_AT (2201..2465): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.8
inactive: 106.2
Methoxymalonyl-CoA: 72.4
Methylmalonyl-CoA: 65.5
Propionyl-CoA: 46.6
Isobutyryl-CoA: 32.9
Acetyl-CoA: 28.3
Ethylmalonyl-CoA: 27.6
2-Methylbutyryl-CoA: 24.8
CHC-CoA: 23.6
trans-1,2-CPDA: 19.0
fatty_acid: 17.6
Benzoyl-CoA: 16.6
3-Methylbutyryl-CoA: 0.0

becE

PKS_AT (527..798): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; 2-Rhyd-Malonyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.4
inactive: 102.4
Methoxymalonyl-CoA: 66.9
Methylmalonyl-CoA: 50.3
Isobutyryl-CoA: 33.3
Propionyl-CoA: 29.5
Benzoyl-CoA: 26.5
Acetyl-CoA: 25.7
Ethylmalonyl-CoA: 19.0
fatty_acid: 14.7
CHC-CoA: 14.7
2-Methylbutyryl-CoA: 12.5
trans-1,2-CPDA: 9.2
3-Methylbutyryl-CoA: 0.0