Gene cluster description
Homologous known gene clusters
General MIBiG information on this cluster
|Complete gene cluster sequence?||complete|
|Evidence for cluster-compound connection:||Knock-out studies, Enzymatic assays, Heterologous expression, Gene expression correlated with compound production, Sequence-based prediction|
|Contact for this cluster:||Zhenhua Tian (Shanghai Institute of Organic Chemistry, Chinese Academy of Science)|
1. Jia XY et al. (2006) Genetic characterization of the chlorothricin gene cluster as a model for spirotetronate antibiotic biosynthesis. Chem Biol 13(6):575-85. doi: 10.1016/j.chembiol.2006.03.008.
2. Shao L et al. (2006) Cloning and characterization of a bacterial iterative type I polyketide synthase gene encoding the 6-methylsalicyclic acid synthase. Biochem Biophys Res Commun 345(1):133-9. doi:
3. Ding W et al. (2010) Insights into bacterial 6-methylsalicylic acid synthase and its engineering to orsellinic acid synthase for spirotetronate generation. Chem Biol 17(5):495-503. doi: 10.1016/j.chembiol.2010.04.009.
4. He QL et al. (2009) Dissection of two acyl-transfer reactions centered on acyl-S-carrier protein intermediates for incorporating 5-chloro-6-methyl-O-methylsalicyclic acid into chlorothricin. Chembiochem 10(5):813-9. doi: 10.1002/cbic.200800714.