BGC0000036 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000036 (Streptomyces antibioticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS	1	111,968	maklamicin	Polyketide	45%

BGC0000036 - Region 1 - PKS-like,T1PKS

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Location: 1 - 111,968 nt. (total: 111,968 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 111,969
Label		BGC0000036

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000036.1	1.42	Polyketide, Saccharide	chlorothricin, deschlorothricin	Streptomyces antibioticus
BGC0002081.1	1.05	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0001280.1	0.81	Polyketide	betaenone C, betaenone A	Phoma betae
BGC0001264.1	0.81	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0000046.1	0.79	Polyketide	depudecin	Alternaria brassicicola
BGC0001858.1	0.78	Polyketide	alternapyrone B, alternapyrone C, alternapyrone D, alternapyrone E, alternapyrone F	Parastagonospora nodorum SN15
BGC0000041.1	0.77	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000224.1	0.76	Polyketide	fredericamycin A	Streptomyces griseus
BGC0001405.1	0.76	Polyketide	chaetoviridin E, 11-epichaetomugilin A	Chaetomium globosum CBS 148.51
BGC0000217.1	0.73	Polyketide	daunorubicin	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000036.1	0.93	Polyketide, Saccharide	chlorothricin, deschlorothricin	Streptomyces antibioticus
BGC0000041.1	0.74	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0002081.1	0.68	Polyketide	streptoketide A, streptoketide B, streptoketide C, S2502, S2507, UWM5	Streptomyces sp. Tue6314
BGC0001164.1	0.66	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001276.1	0.66	Polyketide	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.1	0.65	Polyketide	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001273.1	0.65	Polyketide	asperlactone	Aspergillus ochraceus
BGC0001062.1	0.65	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000120.1	0.65	Polyketide	patulin	Penicillium expansum
BGC0001244.1	0.65	Polyketide	(-)-Mellein	Parastagonospora nodorum

Similar known gene clusters

Module view

Legend

NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 0 - 111968:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - ccmal) + (ccmal - redmal) + (redmal - ccmal - ccmal) + (redmal - pk) + (ohmal) + (ccmal) + (pk)
Non-colinear ordering:: AAZ77693.1 + AAZ77694.1 + AAZ77696.1 + AAZ77698.1 + AAZ77699.1 + AAZ77697.1 + AAZ77673.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 35794:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - ccmal) + (pk)
Non-colinear ordering:: AAZ77693.1 + AAZ77673.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location <0 - 29477:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (pk)

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 11480 - 111968:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal - pk - ccmal) + (ccmal - redmal) + (redmal - ccmal - ccmal) + (redmal - pk) + (ohmal) + (ccmal)
Non-colinear ordering:: AAZ77693.1 + AAZ77694.1 + AAZ77696.1 + AAZ77698.1 + AAZ77699.1 + AAZ77697.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

AAZ77673.1

PKS_AT (557..849): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 83.3%; Methylmalonyl-CoA: 75.0%; Ethylmalonyl-CoA: 70.8%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 125.6
Methoxymalonyl-CoA: 98.7
Ethylmalonyl-CoA: 96.3
Malonyl-CoA: 91.9
Propionyl-CoA: 55.8
trans-1,2-CPDA: 54.7
2-Methylbutyryl-CoA: 54.1
Benzoyl-CoA: 47.4
Isobutyryl-CoA: 44.1
inactive: 40.1
Acetyl-CoA: 30.8
3-Methylbutyryl-CoA: 30.4
CHC-CoA: 26.1
fatty_acid: 24.1

AAZ77693.1

PKS_AT (587..885): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 83.3%; 2-Rhyd-Malonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 207.9
inactive: 123.8
Methoxymalonyl-CoA: 69.1
Methylmalonyl-CoA: 57.3
Propionyl-CoA: 33.7
Isobutyryl-CoA: 30.4
Ethylmalonyl-CoA: 22.6
Benzoyl-CoA: 21.7
Acetyl-CoA: 20.2
2-Methylbutyryl-CoA: 14.0
CHC-CoA: 12.6
trans-1,2-CPDA: 10.1
fatty_acid: 8.3
3-Methylbutyryl-CoA: 0.0

PKS_AT (1639..1938): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 95.8%; Ethylmalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 240.7
Methylmalonyl-CoA: 233.4
Methoxymalonyl-CoA: 194.5
2-Methylbutyryl-CoA: 172.4
trans-1,2-CPDA: 139.6
Propionyl-CoA: 128.1
Malonyl-CoA: 115.4
CHC-CoA: 115.4
Isobutyryl-CoA: 94.8
Benzoyl-CoA: 69.7
3-Methylbutyryl-CoA: 52.9
Acetyl-CoA: 46.7
fatty_acid: 43.6
inactive: 28.9

PKS_AT (3425..3710): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.6
inactive: 80.2
Methoxymalonyl-CoA: 73.0
Methylmalonyl-CoA: 59.4
Propionyl-CoA: 35.1
Isobutyryl-CoA: 26.5
Acetyl-CoA: 19.5
Benzoyl-CoA: 18.0
fatty_acid: 16.9
trans-1,2-CPDA: 13.1
CHC-CoA: 12.1
2-Methylbutyryl-CoA: 0.1
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -3.1

AAZ77694.1

PKS_AT (573..858): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 204.5
inactive: 79.1
Methoxymalonyl-CoA: 74.2
Methylmalonyl-CoA: 59.7
Propionyl-CoA: 39.4
Isobutyryl-CoA: 37.9
Acetyl-CoA: 19.5
Benzoyl-CoA: 18.9
fatty_acid: 17.2
trans-1,2-CPDA: 15.0
CHC-CoA: 12.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.1
Ethylmalonyl-CoA: -3.1

PKS_AT (2322..2610): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 202.4
inactive: 88.6
Methoxymalonyl-CoA: 82.9
Methylmalonyl-CoA: 67.5
Isobutyryl-CoA: 44.1
Propionyl-CoA: 37.3
Benzoyl-CoA: 21.9
trans-1,2-CPDA: 18.8
Acetyl-CoA: 17.7
fatty_acid: 16.8
CHC-CoA: 12.2
3-Methylbutyryl-CoA: 7.6
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

AAZ77696.1

PKS_AT (565..850): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.4
inactive: 76.3
Methoxymalonyl-CoA: 73.0
Methylmalonyl-CoA: 59.1
Propionyl-CoA: 36.7
Isobutyryl-CoA: 28.0
Benzoyl-CoA: 20.4
Acetyl-CoA: 20.1
fatty_acid: 15.6
CHC-CoA: 12.4
trans-1,2-CPDA: 12.3
2-Methylbutyryl-CoA: 7.6
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -4.5

PKS_AT (2674..2959): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 205.3
inactive: 75.4
Methoxymalonyl-CoA: 74.3
Methylmalonyl-CoA: 59.4
Propionyl-CoA: 41.0
Isobutyryl-CoA: 39.1
Benzoyl-CoA: 21.2
Acetyl-CoA: 20.1
fatty_acid: 16.0
trans-1,2-CPDA: 14.1
CHC-CoA: 12.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

PKS_AT (4429..4713): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.0
Methoxymalonyl-CoA: 83.0
inactive: 77.1
Methylmalonyl-CoA: 64.7
Isobutyryl-CoA: 38.2
Propionyl-CoA: 37.3
Benzoyl-CoA: 22.5
Acetyl-CoA: 20.0
trans-1,2-CPDA: 18.7
fatty_acid: 16.5
CHC-CoA: 12.1
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

AAZ77697.1

PKS_AT (566..854): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 197.2
inactive: 83.6
Methoxymalonyl-CoA: 81.6
Methylmalonyl-CoA: 63.1
Propionyl-CoA: 40.0
Isobutyryl-CoA: 34.8
Benzoyl-CoA: 16.7
fatty_acid: 15.1
Acetyl-CoA: 14.5
trans-1,2-CPDA: 13.9
CHC-CoA: 9.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: -0.8
Ethylmalonyl-CoA: -4.5

AAZ77698.1

PKS_AT (564..849): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 75.0%; Propionyl-CoA: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.6
inactive: 80.2
Methoxymalonyl-CoA: 80.0
Methylmalonyl-CoA: 59.3
Propionyl-CoA: 36.5
Isobutyryl-CoA: 29.4
Benzoyl-CoA: 16.7
fatty_acid: 15.4
Acetyl-CoA: 14.8
trans-1,2-CPDA: 13.7
CHC-CoA: 9.4
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -4.5

PKS_AT (2659..2955): pk

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.5
Methylmalonyl-CoA: 217.5
Methoxymalonyl-CoA: 182.4
trans-1,2-CPDA: 150.1
2-Methylbutyryl-CoA: 146.1
CHC-CoA: 129.6
Propionyl-CoA: 119.2
Malonyl-CoA: 108.8
Isobutyryl-CoA: 86.4
Benzoyl-CoA: 65.4
Acetyl-CoA: 64.5
fatty_acid: 37.3
3-Methylbutyryl-CoA: 36.7
inactive: 35.7

AAZ77699.1

PKS_AT (568..856): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 91.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 200.3
inactive: 113.4
Methoxymalonyl-CoA: 56.6
Methylmalonyl-CoA: 44.3
Isobutyryl-CoA: 20.1
Acetyl-CoA: 17.5
Ethylmalonyl-CoA: 16.9
Propionyl-CoA: 15.7
Benzoyl-CoA: 14.2
2-Methylbutyryl-CoA: 13.8
fatty_acid: 12.8
CHC-CoA: 11.2
trans-1,2-CPDA: 11.0
3-Methylbutyryl-CoA: 0.0