BGC0000039 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000039 (Penicillium citrinum)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	38,231	High	compactin	PKS

BGC0000039 - Region 1 - T1PKS

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Location: 1 - 38,231 nt. (total: 38,231 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 38,232
Label		BGC0000039

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase reductase

mlcC: cytochrome P450

smcogs: SMCOG1034: cytochrome P450

mlcD: hydroxymethylglutaryl-CoA reductase

smcogs: SMCOG1187: hydroxymethylglutaryl-CoA reductase

mlcG: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Hydrolases: hydrolase

mlcH: beta-lactamase

smcogs: SMCOG1053: beta-lactamase

Ligases: synthase

mlcA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

mlcB: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000039.3	0.99	PKS	compactin	Penicillium citrinum
BGC0002192.3	0.80	PKS	FR901512	fungal sp. No.14919
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.75	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.70	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000098.3	0.69	PKS	monacolin K	Monascus pilosus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000039.3	0.99	PKS	compactin	Penicillium citrinum
BGC0002192.3	0.80	PKS	FR901512	fungal sp. No.14919
BGC0002191.2	0.76	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.75	PKS	ACT-Toxin II	Alternaria alternata
BGC0001268.4	0.70	NRPS, PKS	fusarin C	Fusarium fujikuroi
BGC0000098.3	0.69	PKS	monacolin K	Monascus pilosus
BGC0001273.3	0.66	PKS	asperlactone	Aspergillus ochraceus
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001276.3	0.66	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.66	PKS	6-methylsalicyclic acid	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 38231:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-redmal) + (Me-pk)
Non-colinear ordering:: mlcB + mlcA

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

mlcA: pk

PKS_AT (559..880): pk

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; Methylmalonyl-CoA: 62.5%; Methoxymalonyl-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 68.6
Methoxymalonyl-CoA: 55.9
Propionyl-CoA: 18.5
fatty_acid: 17.1
Malonyl-CoA: 15.5
2-Methylbutyryl-CoA: 11.3
Benzoyl-CoA: 9.2
Isobutyryl-CoA: 8.0
inactive: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.4
trans-1,2-CPDA: -3.7

mlcB: mal

PKS_AT (567..894): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 79.2%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 56.3
Methoxymalonyl-CoA: 46.9
Methylmalonyl-CoA: 41.1
inactive: 25.0
Benzoyl-CoA: 19.0
Isobutyryl-CoA: 18.4
Propionyl-CoA: 9.4
fatty_acid: 8.9
trans-1,2-CPDA: 0.0
CHC-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0
2-Methylbutyryl-CoA: 0.0
Ethylmalonyl-CoA: -0.6

Link to PARAS substrate predictor