BGC0000041 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000041 (Pseudomonas syringae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T1PKS	1	14,402	High	oronofacic acid	PKS

BGC0000041 - Region 1 - T1PKS

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Location: 1 - 14,402 nt. (total: 14,402 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 14,403
Label		BGC0000041

Tailoring functions

Ligases: synthase

cfa6: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

cfa7: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041.3	1.00	PKS	oronofacic acid	Pseudomonas syringae
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000041.3	1.00	PKS	oronofacic acid	Pseudomonas syringae
BGC0001273.3	0.67	PKS	asperlactone	Aspergillus ochraceus
BGC0001276.3	0.67	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0002154.2	0.66	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001257.3	0.66	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001284.4	0.66	PKS	alternariol	Parastagonospora nodorum SN15
BGC0002191.2	0.66	PKS	prolipyrone B, gibepyrone D	Fusarium graminearum PH-1
BGC0001254.3	0.64	PKS	ACT-Toxin II	Alternaria alternata
BGC0002192.3	0.64	PKS	FR901512	fungal sp. No.14919
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822

Similar known clusters from MIBiG 4.0

Module view

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Detailed domain annotation

Selected features only

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NRPS/PKS products

NRPS/PKS substrates

Predicted core structure(s)

For candidate cluster 1, location 0 - 14402:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (Me-mal - redemal) + (ccmal)
Non-colinear ordering:: cfa6 + cfa7

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

cfa6: mmal - emal

PKS_AT (150..431): mmal

ATSignature: Propionyl-CoA, Ethylmalonyl-CoA, CHC-CoA, Methylmalonyl-CoA, 2-Methylbutyryl-CoA

Top 3 matches:: Propionyl-CoA: 58.3%; Ethylmalonyl-CoA: 58.3%; CHC-CoA: 58.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 89.6
Methoxymalonyl-CoA: 83.6
Ethylmalonyl-CoA: 73.4
CHC-CoA: 67.6
Propionyl-CoA: 61.1
2-Methylbutyryl-CoA: 55.9
trans-1,2-CPDA: 54.2
Isobutyryl-CoA: 26.5
Benzoyl-CoA: 22.9
3-Methylbutyryl-CoA: 21.0
Malonyl-CoA: 16.6
inactive: 15.7
fatty_acid: 8.1
Acetyl-CoA: 7.0

PKS_AT (1138..1435): emal

ATSignature: Ethylmalonyl-CoA

Top 3 matches:: Ethylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Methylmalonyl-CoA: 87.5%

minowa: Ethylmalonyl-CoA

Prediction, score:

Ethylmalonyl-CoA: 227.5
Methylmalonyl-CoA: 172.8
Methoxymalonyl-CoA: 134.0
2-Methylbutyryl-CoA: 102.1
Malonyl-CoA: 100.2
trans-1,2-CPDA: 92.5
Propionyl-CoA: 79.7
CHC-CoA: 74.3
Isobutyryl-CoA: 62.4
Benzoyl-CoA: 57.6
inactive: 26.3
Acetyl-CoA: 25.8
3-Methylbutyryl-CoA: 25.4
fatty_acid: 19.7

cfa7: mal

PKS_AT (573..872): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; Methylmalonyl-CoA: 66.7%; Propionyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 192.8
Methoxymalonyl-CoA: 96.3
Methylmalonyl-CoA: 94.2
inactive: 75.5
Propionyl-CoA: 66.7
Isobutyryl-CoA: 54.7
Ethylmalonyl-CoA: 51.8
Acetyl-CoA: 45.9
2-Methylbutyryl-CoA: 41.5
trans-1,2-CPDA: 34.1
CHC-CoA: 29.3
fatty_acid: 25.7
Benzoyl-CoA: 17.2
3-Methylbutyryl-CoA: 15.0

Link to PARAS substrate predictor