BGC0000054: erythromycin biosynthetic gene cluster from Aeromicrobium erythreum
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Location: 1 - 61,845 nt. (total: 61,845 nt).
This entry is originally from NCBI GenBank AY623658.2.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000054
Short description erythromycin biosynthetic gene cluster from Aeromicrobium erythreum
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Unknown)
Loci
AY623658.2
via
Compounds
  • erythromycin
Species Aeromicrobium erythreum [taxonomy]
References
Chemical products information
erythromycin Evidence:
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C37H67N1O13
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAU93784.2
 228 - 869 (-) putative transcriptional repressor
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    • AAU93785.1
    		 925 - 1746 (+) putative dehydrogenase/reductase
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      • AAU93786.2
      		 2172 - 2729 (+) unknown
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        • AAU93787.1
        • eryD1
        		 2920 - 3813 (+) dTDP-glucose synthase
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          • AAU93788.2
          • eryC1
          		 3822 - 4937 (+) transaminase
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            • AAU93789.1
            • eryBVII
            		 4934 - 5527 (-) dTDP-4-keto-6-deoxyglucose 3,5-epimerase
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              • AAU93790.1
              • eryCV
              		 5530 - 6969 (-) deoxyhexose reductase
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                • AAU93791.1
                • eryCIV
                		 6997 - 8202 (-) deoxyhexose dehydratase
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                  • AAU93792.1
                  • eryBVI
                  		 8199 - 9635 (-) deoxyhexose dehydratase
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                    • AAU93793.1
                    • eryTII
                    		 9706 - 10446 (-) thioesterase type II
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                      • AAU93794.1
                      • eryP
                      		 10443 - 11132 (-) phosphopantetheinyl transferase
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                        • AAU93795.1
                        • eryK
                        		 11160 - 12323 (-) erythromycin C-12 hydroxylase
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                          • AAU93796.1
                          • ermR
                          		 12450 - 13472 (+) ribosomal RNA methyltransferase
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                            • AAU93797.1
                            • eryBI
                            		 13469 - 15913 (-) beta-glucosidase
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                              • AAU93798.1
                              • eryBIII
                              		 16039 - 17274 (+) methyltransferase
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                                • AAU93799.1
                                • eryF
                                		 17271 - 18491 (+) cytochrome P450 oxidoreductase
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                                  • AAU93800.1
                                  • eryTI
                                  		 18495 - 19229 (+) thioesterase
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                                    • AAU93801.1
                                    • eryG
                                    		 19226 - 20140 (-) methylase
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                                      • AAU93802.1
                                      • eryBII
                                      		 20203 - 21198 (-) deoxyhexose reductase
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                                        • AAU93803.1
                                        • eryCIII
                                        		 21195 - 22466 (-) L-desosaminyltransferase
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                                          • AAU93804.1
                                          • eryCII
                                          		 22468 - 23553 (-) deoxyhexose isomerase
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                                            • AAU93805.2
                                            • eryAIII
                                            		 23550 - 33137 (-) polyketide synthase modules 5 and 6
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                                              • AAU93806.2
                                              • eryAII
                                              		 33185 - 43909 (-) polyketide synthase modules 3 and 4
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                                                • AAU93807.2
                                                • eryAI
                                                		 43959 - 54545 (-) polyketide synthase modules 1 and 2
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                                                  • AAU93808.1
                                                  • eryBIV
                                                  		 54874 - 55818 (+) deoxyhexose dehydratase
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                                                    • AAU93809.2
                                                    • eryBV
                                                    		 55820 - 57058 (+) L-mycarosyltransferase
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                                                      • AAU93810.1
                                                      • eryCVI
                                                      		 57099 - 57815 (+) N-methyltransferase
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                                                        • AAU93811.1
                                                        		 57857 - 58300 (-) marR family transcriptional regulator
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                                                          • AAU93812.1
                                                          		 58328 - 59569 (-) putative oxidoreductase
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                                                            • AAU93813.2
                                                            		 59714 - 60817 (+) LipN
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                                                              • AAU93814.2
                                                              		 60814 - >61845 (+) monoamine oxidase
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                                                                Biosynthesis information
                                                                Annotation changelog

                                                                Entry version: 4

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-10-07
                                                                Update chemical activity to schema version 2.11
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 3

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2022-09-15
                                                                Updated bioactivity data
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 2

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2019-10-16
                                                                Migrated from v1.4
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                Entry version: 1

                                                                Date
                                                                Changes
                                                                Submitters
                                                                Reviewers
                                                                2015-06-12
                                                                Submitted
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
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