BGC0000054: erythromycin biosynthetic gene cluster from Aeromicrobium erythreum
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Location: 1 - 61,845 nt. (total: 61,845 nt).
This entry is originally from NCBI GenBank AY623658.2.

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General
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NRPS/PKS domains
General information about the BGC
MIBiG accession BGC0000054
Short description erythromycin biosynthetic gene cluster from Aeromicrobium erythreum
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AY623658.2
Compounds
  • erythromycin
Species Aeromicrobium erythreum [taxonomy]
References
Chemical products information
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erythromycin
Molecular Formula C37H67NO13
Chemical database entries PubCHEM  
List of genes involved in compound(s) production
Identifiers Position Product Functions Extra
  • AAU93784.2
228 869 - putative transcriptional repressor
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  • AAU93785.1
925 1746 + putative dehydrogenase/reductase
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  • AAU93786.2
2172 2729 + unknown
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  • AAU93787.1
  • eryD1
2920 3813 + dTDP-glucose synthase
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  • AAU93788.2
  • eryC1
3822 4937 + transaminase
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  • AAU93789.1
  • eryBVII
4934 5527 - dTDP-4-keto-6-deoxyglucose 3,5-epimerase
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  • AAU93790.1
  • eryCV
5530 6969 - deoxyhexose reductase
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  • AAU93791.1
  • eryCIV
6997 8202 - deoxyhexose dehydratase
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  • AAU93792.1
  • eryBVI
8199 9635 - deoxyhexose dehydratase
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  • AAU93793.1
  • eryTII
9706 10446 - thioesterase type II
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  • AAU93794.1
  • eryP
10443 11132 - phosphopantetheinyl transferase
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  • AAU93795.1
  • eryK
11160 12323 - erythromycin C-12 hydroxylase
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  • AAU93796.1
  • ermR
12450 13472 + ribosomal RNA methyltransferase
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  • AAU93797.1
  • eryBI
13469 15913 - beta-glucosidase
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  • AAU93798.1
  • eryBIII
16039 17274 + methyltransferase
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  • AAU93799.1
  • eryF
17271 18491 + cytochrome P450 oxidoreductase
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  • AAU93800.1
  • eryTI
18495 19229 + thioesterase
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  • AAU93801.1
  • eryG
19226 20140 - methylase
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  • AAU93802.1
  • eryBII
20203 21198 - deoxyhexose reductase
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  • AAU93803.1
  • eryCIII
21195 22466 - L-desosaminyltransferase
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  • AAU93804.1
  • eryCII
22468 23553 - deoxyhexose isomerase
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  • AAU93805.2
  • eryAIII
23550 33137 - polyketide synthase modules 5 and 6
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  • AAU93806.2
  • eryAII
33185 43909 - polyketide synthase modules 3 and 4
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  • AAU93807.2
  • eryAI
43959 54545 - polyketide synthase modules 1 and 2
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  • AAU93808.1
  • eryBIV
54874 55818 + deoxyhexose dehydratase
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  • AAU93809.2
  • eryBV
55820 57058 + L-mycarosyltransferase
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  • AAU93810.1
  • eryCVI
57099 57815 + N-methyltransferase
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  • AAU93811.1
57857 58300 - marR family transcriptional regulator
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  • AAU93812.1
58328 59569 - putative oxidoreductase
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  • AAU93813.2
59714 60817 + LipN
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  • AAU93814.2
60814 >61845 + monoamine oxidase
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Annotation changelog
MIBiG version Notes
1.0
  • Submitted
2.0
  • Migrated from v1.4
Detailed domain annotation
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