BGC0000054 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000054 (Aeromicrobium erythreum)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T1PKS	1	61,845	erythromycin A / erythromycin B / erythromycin C / erythromycin D	Polyketide:Modular type I + Saccharide:Hybrid/tailoring	86%

BGC0000054 - Region 1 - T1PKS

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Location: 1 - 61,845 nt. (total: 61,845 nt) Show pHMM detection rules used

Region on contig edge.

T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

External annotation

Name		MIBiG
Version		3.0

Type		Subregion
Location		1 - 61,846
Label		BGC0000054

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000054.1	0.86	Polyketide	erythromycin	Aeromicrobium erythreum
BGC0000041.1	0.41	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001892.1	0.28	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0000043.1	0.28	Polyketide	curacin A	Moorea producens 19L
BGC0001223.1	0.28	Other	hydroxysporine	uncultured bacterium
BGC0001062.1	0.28	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000067.1	0.27	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.27	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000201.1	0.26	Polyketide, Saccharide	auricin	Streptomyces aureofaciens
BGC0000719.1	0.26	Saccharide	tobramycin	Streptoalloteichus hindustanus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000054.1	0.96	Polyketide	erythromycin	Aeromicrobium erythreum
BGC0000041.1	0.73	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001892.1	0.62	Polyketide	botcinic acid	Botrytis cinerea B05.10
BGC0000043.1	0.62	Polyketide	curacin A	Moorea producens 19L
BGC0001223.1	0.61	Other	hydroxysporine	uncultured bacterium
BGC0001062.1	0.61	Polyketide	TLN-05220	Micromonospora echinospora subsp. challisensis
BGC0000067.1	0.61	Polyketide	geldanamycin	Streptomyces hygroscopicus subsp. duamyceticus
BGC0001164.1	0.60	Polyketide	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000201.1	0.60	Polyketide, Saccharide	auricin	Streptomyces aureofaciens
BGC0000719.1	0.59	Saccharide	tobramycin	Streptoalloteichus hindustanus

Similar known gene clusters

Module view

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NRPS/PKS products

NRPS/PKS monomers

Predicted core structure(s)

For candidate cluster 1, location 3549 - 61845:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (pk - Me-ccmal - Me-ohmal) + (Me-ohmal - Me-redmal) + (Me-ohmal - Me-ohmal)
Non-colinear ordering:: eryAI + eryAII + eryAIII

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS monomer predictions

eryAIII

PKS_AT (564..858): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 205.9
Ethylmalonyl-CoA: 187.7
2-Methylbutyryl-CoA: 156.9
Methoxymalonyl-CoA: 154.8
trans-1,2-CPDA: 130.1
Propionyl-CoA: 110.4
CHC-CoA: 97.2
Malonyl-CoA: 93.2
Benzoyl-CoA: 84.6
Isobutyryl-CoA: 76.9
3-Methylbutyryl-CoA: 43.3
Acetyl-CoA: 35.8
fatty_acid: 29.7
inactive: 23.7

PKS_AT (2044..2334): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 159.9
Methoxymalonyl-CoA: 157.4
2-Methylbutyryl-CoA: 130.4
Malonyl-CoA: 114.0
trans-1,2-CPDA: 97.7
CHC-CoA: 95.3
Propionyl-CoA: 94.9
Isobutyryl-CoA: 60.3
Benzoyl-CoA: 50.5
inactive: 35.9
Acetyl-CoA: 34.2
3-Methylbutyryl-CoA: 29.9
fatty_acid: 27.0

eryAII

PKS_AT (562..861): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Malonyl-CoA: 91.7%; Methoxymalonyl-CoA: 91.7%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.8
Ethylmalonyl-CoA: 195.6
Methoxymalonyl-CoA: 165.2
2-Methylbutyryl-CoA: 131.0
trans-1,2-CPDA: 104.0
Malonyl-CoA: 103.1
CHC-CoA: 95.9
Propionyl-CoA: 89.2
Isobutyryl-CoA: 84.0
Benzoyl-CoA: 79.5
3-Methylbutyryl-CoA: 44.2
Acetyl-CoA: 40.0
inactive: 37.6
fatty_acid: 19.8

PKS_AT (2015..2311): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Malonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 202.7
Ethylmalonyl-CoA: 193.7
Methoxymalonyl-CoA: 157.3
2-Methylbutyryl-CoA: 115.4
trans-1,2-CPDA: 113.2
CHC-CoA: 107.1
Malonyl-CoA: 80.8
Propionyl-CoA: 80.3
Benzoyl-CoA: 61.4
Isobutyryl-CoA: 56.1
Acetyl-CoA: 34.7
fatty_acid: 29.2
inactive: 21.9
3-Methylbutyryl-CoA: 16.2

eryAI

PKS_AT (68..363): pk

ATSignature: Propionyl-CoA

Top 3 matches:: Propionyl-CoA: 100.0%; 2-Methylbutyryl-CoA: 70.8%; Methylmalonyl-CoA: 66.7%

minowa: Propionyl-CoA

Prediction, score:

Propionyl-CoA: 218.7
2-Methylbutyryl-CoA: 139.0
Methylmalonyl-CoA: 118.7
Methoxymalonyl-CoA: 103.9
Ethylmalonyl-CoA: 92.1
Malonyl-CoA: 78.8
trans-1,2-CPDA: 71.3
CHC-CoA: 64.8
Acetyl-CoA: 44.0
fatty_acid: 33.0
Benzoyl-CoA: 28.1
Isobutyryl-CoA: 24.3
inactive: 23.6
3-Methylbutyryl-CoA: 15.4

PKS_AT (1036..1336): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 91.7%; Ethylmalonyl-CoA: 87.5%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 194.2
Ethylmalonyl-CoA: 171.6
Methoxymalonyl-CoA: 158.3
2-Methylbutyryl-CoA: 118.7
trans-1,2-CPDA: 95.4
Malonyl-CoA: 85.2
Propionyl-CoA: 85.1
Isobutyryl-CoA: 82.5
CHC-CoA: 81.1
3-Methylbutyryl-CoA: 55.8
Benzoyl-CoA: 44.9
Acetyl-CoA: 39.9
fatty_acid: 27.2
inactive: 21.7

PKS_AT (2512..2806): mmal

ATSignature: Methylmalonyl-CoA

Top 3 matches:: Methylmalonyl-CoA: 100.0%; Methoxymalonyl-CoA: 87.5%; Ethylmalonyl-CoA: 83.3%

minowa: Methylmalonyl-CoA

Prediction, score:

Methylmalonyl-CoA: 191.4
Ethylmalonyl-CoA: 159.9
Methoxymalonyl-CoA: 157.4
2-Methylbutyryl-CoA: 130.4
Malonyl-CoA: 114.0
trans-1,2-CPDA: 97.7
CHC-CoA: 95.3
Propionyl-CoA: 94.9
Isobutyryl-CoA: 60.3
Benzoyl-CoA: 50.5
inactive: 35.9
Acetyl-CoA: 34.2
3-Methylbutyryl-CoA: 29.9
fatty_acid: 27.0